Functional antagonism of β-arrestin isoforms balance IGF-1R expression and signalling with distinct cancer-related biological outcomes

Structural mechanism of GPCR-arrestin interaction: recent breakthroughs

(2016) Ji Young Park et al.   ARCHIVES OF PHARMACAL RESEARCH

The dichotomy of the Insulin-like growth factor 1 receptor: RTK and GPCR: friend or foe for cancer treatment?

(2015) Caitrin Crudden et al.   GROWTH HORMONE & IGF RESEARCH

Emerging Functional Divergence of β-Arrestin Isoforms in GPCR Function

(2015) Ashish Srivastava et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Visualization of arrestin recruitment by a G-protein-coupled receptor

(2014) Arun K. Shukla et al.   NATURE

Pharmacological blockade of a β2AR-β-arrestin-1 signaling cascade prevents the accumulation of DNA damage in a behavioral stress model

(2013) Makoto R. Hara et al.   CELL CYCLE

Something old, something new and something borrowed: emerging paradigm of insulin-like growth factor type 1 receptor (IGF-1R) signaling regulation

(2013) Leonard Girnita et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Recent developments in biased agonism

(2013) James W Wisler et al.   CURRENT OPINION IN CELL BIOLOGY

Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide

(2013) Arun K. Shukla et al.   NATURE

β-Arrestin-Mediated Signaling Improves the Efficacy of Therapeutics

(2012) Islam A.A.E.-H. Ibrahim et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

 -Arrestin-biased agonism as the central mechanism of action for insulin-like growth factor 1 receptor-targeting antibodies in Ewing's sarcoma

(2012) H. Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective recruitment of G protein-coupled receptor kinases (GRKs) controls signaling of the insulin-like growth factor 1 receptor

(2012) H. Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Mechanism of β-Arrestin-Biased Agonism at Seven-Transmembrane Receptors

(2011) Eric Reiter et al.   Annual Review of Pharmacology and Toxicology

Two Phases of Mitogenic Signaling Unveil Roles for p53 and EGR1 in Elimination of Inconsistent Growth Signals

(2011) Yaara Zwang et al.   MOLECULAR CELL

A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1

(2011) Makoto R. Hara et al.   NATURE

Identification of the cathelicidin peptide LL-37 as agonist for the type I insulin-like growth factor receptor

(2011) A Girnita et al.   ONCOGENE

β-arrestin-mediated receptor trafficking and signal transduction

(2011) Sudha K. Shenoy et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

β-Arrestin 1 and 2 stabilize the angiotensin II type I receptor in distinct high-affinity conformations

(2010) SJ Sanni et al.   BRITISH JOURNAL OF PHARMACOLOGY

Loss of βarrestin1 and βarrestin2 contributes to pulmonary hypoplasia and neonatal lethality in mice

(2010) Mingfeng Zhang et al.   DEVELOPMENTAL BIOLOGY

Therapeutic potential of β-arrestin- and G protein-biased agonists

(2010) Erin J. Whalen et al.   TRENDS IN MOLECULAR MEDICINE

Identification of c-Cbl as a New Ligase for Insulin-like Growth Factor-I Receptor with Distinct Roles from Mdm2 in Receptor Ubiquitination and Endocytosis

(2008) B. Sehat et al.   CANCER RESEARCH