Lysine-52 stabilizes the MYC oncoprotein through an SCFFbxw7-independent mechanism

MYC Deregulation in Primary Human Cancers

(2017) Manpreet Kalkat et al.   Genes

Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer

(2016) Shaokun Shu et al.   NATURE

ELL targets c-Myc for proteasomal degradation and suppresses tumour growth

(2016) Yu Chen et al.   Nature Communications

PIAS1 Promotes Lymphomagenesis through MYC Upregulation

(2016) Andrea Rabellino et al.   Cell Reports

Myc and its interactors take shape

(2015) William B. Tu et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Small-molecule inhibitors of the Myc oncoprotein

(2015) Steven Fletcher et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

MYC Is a Major Determinant of Mitotic Cell Fate

(2015) Caroline Topham et al.   CANCER CELL

Usp28 Counteracts Fbw7 in Intestinal Homeostasis and Cancer

(2015) M. E. Diefenbacher et al.   CANCER RESEARCH

Pre-Anchoring of Pin1 to Unphosphorylated c-Myc in a Fuzzy Complex Regulates c-Myc Activity

(2015) Sara Helander et al.   STRUCTURE

Taming of the beast: shaping Myc-dependent amplification

(2015) Elmar Wolf et al.   TRENDS IN CELL BIOLOGY

Identification of c-MYC SUMOylation by Mass Spectrometry

(2014) Manpreet Kalkat et al.   PLoS One

Therapeutic Strategies to Inhibit MYC

(2014) M. R. McKeown et al.   Cold Spring Harbor Perspectives in Medicine

MYC Phosphorylation at Novel Regulatory Regions Suppresses Transforming Activity

(2013) A. R. Wasylishen et al.   CANCER RESEARCH

CDK-mediated activation of the SCFFBXO28ubiquitin ligase promotes MYC-driven transcription and tumourigenesis and predicts poor survival in breast cancer

(2013) Diana Cepeda et al.   EMBO Molecular Medicine

Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15

(2013) S. Inoue et al.   GENES & DEVELOPMENT

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

MYC activity is negatively regulated by a C-terminal lysine cluster

(2013) A R Wasylishen et al.   ONCOGENE

Domain-specific c-Myc ubiquitylation controls c-Myc transcriptional and apoptotic activity

(2013) Q. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptional Amplification in Tumor Cells with Elevated c-Myc

(2012) Charles Y. Lin et al.   CELL

MYC on the Path to Cancer

(2012) Chi V. Dang   CELL

The ubiquitin ligase CHIP regulates c-Myc stability and transcriptional activity

(2012) I Paul et al.   ONCOGENE

BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

(2011) Jake E. Delmore et al.   CELL

Systematic and Quantitative Assessment of the Ubiquitin-Modified Proteome

(2011) Woong Kim et al.   MOLECULAR CELL

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

(2011) Johannes Zuber et al.   NATURE

New model systems provide insights into Myc-induced transformation

(2011) A R Wasylishen et al.   ONCOGENE

Role of Pirh2 in Mediating the Regulation of p53 and c-Myc

(2011) Anne Hakem et al.   PLoS Genetics

Myc protein is stabilized by suppression of a novel E3 ligase complex in cancer cells

(2010) S. H. Choi et al.   GENES & DEVELOPMENT

Ubiquitylation of the amino terminus of Myc by SCFβ-TrCP antagonizes SCFFbw7-mediated turnover

(2010) Nikita Popov et al.   NATURE CELL BIOLOGY

Myc proteins as therapeutic targets

(2010) W C Gustafson et al.   ONCOGENE

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

(2009) Teresa A. Soucy et al.   NATURE

A Versatile Viral System for Expression and Depletion of Proteins in Mammalian Cells

(2009) Eric Campeau et al.   PLoS One

Isoform- and cell cycle–dependent substrate degradation by the Fbw7 ubiquitin ligase

(2008) Jonathan E. Grim et al.   JOURNAL OF CELL BIOLOGY

The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein

(2008) Xudong Zhao et al.   NATURE CELL BIOLOGY