Loss of claudin-3 expression induces IL6/gp130/Stat3 signaling to promote colon cancer malignancy by hyperactivating Wnt/β-catenin signaling

Insertional Mutagenesis Identifies a STAT3/Arid1b/β-catenin Pathway Driving Neurofibroma Initiation

(2016) Jianqiang Wu et al.   Cell Reports

Claudins and cancer: Fall of the soldiers entrusted to protect the gate and keep the barrier intact

(2015) Amar B. Singh et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Inhibition of β-Catenin signaling suppresses pancreatic tumor growth by disrupting nuclear β-Catenin/TCF-1 complex: critical role of STAT-3

(2015) Kartick C. Pramanik et al.   Oncotarget

CLDN3 inhibits cancer aggressiveness via Wnt-EMT signaling and is a potential prognostic biomarker for hepatocellular carcinoma

(2015) Lei Jiang et al.   Oncotarget

Targeted colonic claudin-2 expression renders resistance to epithelial injury, induces immune suppression and protects from colitis

(2014) R Ahmad et al.   Mucosal Immunology

Claudin-7 expression induces mesenchymal to epithelial transformation (MET) to inhibit colon tumorigenesis

(2014) A A Bhat et al.   ONCOGENE

Disturbed function of the blood–cerebrospinal fluid barrier aggravates neuro-inflammation

(2013) Gijs Kooij et al.   ACTA NEUROPATHOLOGICA

The IL-6 Trans-Signaling-STAT3 Pathway Mediates ECM and Cellular Proliferation in Fibroblasts from Hypertrophic Scar

(2013) Sutapa Ray et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Claudin-3 Overexpression Increases the Malignant Potential of Colorectal Cancer Cells: Roles of ERK1/2 and PI3K-Akt as Modulators of EGFR signaling

(2013) Waldemir F. de Souza et al.   PLoS One

HDAC1 and HDAC2 Restrain the Intestinal Inflammatory Response by Regulating Intestinal Epithelial Cell Differentiation

(2013) Naomie Turgeon et al.   PLoS One

Signal Transducer and Activator of Transcription 3 (STAT3) Protein Suppresses Adenoma-to-carcinoma Transition inApcmin/+Mice via Regulation of Snail-1 (SNAI) Protein Stability

(2012) Jongdae Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epidermal growth factor receptor inhibits colitis-associated cancer in mice

(2012) Philip E. Dubé et al.   JOURNAL OF CLINICAL INVESTIGATION

β-catenin confers resistance to PI3K and AKT inhibitors and subverts FOXO3a to promote metastasis in colon cancer

(2012) Stephan P Tenbaum et al.   NATURE MEDICINE

Probiotic Bacteria Induce Maturation of Intestinal Claudin 3 Expression and Barrier Function

(2011) Ravi M. Patel et al.   AMERICAN JOURNAL OF PATHOLOGY

Epithelial cell polarity: a major gatekeeper against cancer?

(2011) C Royer et al.   CELL DEATH AND DIFFERENTIATION

Immunohistochemical profiles of claudin-3 in primary and metastatic prostatic adenocarcinoma

(2011) Tanner L Bartholow et al.   Diagnostic Pathology

Claudin-2 expression increases tumorigenicity of colon cancer cells: role of epidermal growth factor receptor activation

(2011) P Dhawan et al.   ONCOGENE

Dietary methionine restriction improves colon tight junction barrier function and alters claudin expression pattern

(2010) Arivudainambi Ramalingam et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Derepression of CLDN3 and CLDN4 during ovarian tumorigenesis is associated with loss of repressive histone modifications

(2010) Mi Jeong Kwon et al.   CARCINOGENESIS

PI3K/Akt and GSK-3β prevents in a differential fashion the malignant phenotype of colorectal cancer cells

(2010) Wallace Martins de Araújo et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer

(2009) Sergei Grivennikov et al.   CANCER CELL

Efficient killing of SW480 colon carcinoma cells by a signal transducer and activator of transcription (STAT) 3 hairpin decoy oligodeoxynucleotide - interference with interferon-γ-STAT1-mediated killing

(2009) Ali Tadlaoui Hbibi et al.   FEBS Journal

DNMT1 Silencing Affects Locus Specific DNA Methylation and Increases Prostate Cancer Derived PC3 Cell Invasiveness

(2009) Ahmed Yaqinuddin et al.   JOURNAL OF UROLOGY

HDAC inhibitors regulate claudin-1 expression in colon cancer cells through modulation of mRNA stability

(2009) M Krishnan et al.   ONCOGENE

Epigenetics of cancer progression

(2008) Emily A Vucic et al.   PHARMACOGENOMICS

Tight junction and polarity interaction in the transporting epithelial phenotype

(2007) Marcelino Cereijido et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

MyD88 signalling plays a critical role in host defence by controlling pathogen burden and promoting epithelial cell homeostasis during Citrobacter rodentium-induced colitis

(2007) D. L. Gibson et al.   CELLULAR MICROBIOLOGY

Characterization of HCT116 Human Colon Cancer Cells in an Orthotopic Model

(2007) Ashwani Rajput et al.   JOURNAL OF SURGICAL RESEARCH