Epidermal growth factor receptor inhibits colitis-associated cancer in mice

TNF-α induces upregulation of EGFR expression and signaling in human colonic myofibroblasts

(2012) James Yoo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Interleukin 21 controls tumour growth and tumour immunosurveillance in colitis-associated tumorigenesis in mice

(2011) D. Jauch et al.   GUT

Relative role of methylator and tumor suppressor pathways in ulcerative colitis-associated colon cancer

(2011) Julian A. Sanchez et al.   INFLAMMATORY BOWEL DISEASES

Colon-specific delivery of a probiotic-derived soluble protein ameliorates intestinal inflammation in mice through an EGFR-dependent mechanism

(2011) Fang Yan et al.   JOURNAL OF CLINICAL INVESTIGATION

Involvement of interleukin-21 in the regulation of colitis-associated colon cancer

(2011) Carmine Stolfi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Vemurafenib

(2011) Keith. T Flaherty et al.   NATURE REVIEWS DRUG DISCOVERY

Characterization of Chromosomal Instability in Murine Colitis-Associated Colorectal Cancer

(2011) Marco Gerling et al.   PLoS One

The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations

(2011) K. S. Yan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lifestyle as risk factor for cancer: Evidence from human studies

(2010) Naghma Khan et al.   CANCER LETTERS

Colorectal cancer molecular biology moves into clinical practice

(2010) C. C. Pritchard et al.   GUT

Ulcerative colitis-associated colorectal cancer shows a poorer survival than sporadic colorectal cancer: A nationwide Japanese study

(2010) Toshiaki Watanabe et al.   INFLAMMATORY BOWEL DISEASES

Molecular Mechanisms of Resistance to Cetuximab and Panitumumab in Colorectal Cancer

(2010) Alberto Bardelli et al.   JOURNAL OF CLINICAL ONCOLOGY

Intestinal Cancer Risk in Crohn’s Disease: A Meta-Analysis

(2010) Mike Georg Laukoetter et al.   JOURNAL OF GASTROINTESTINAL SURGERY

Infant colitis—it's in the genes

(2010) Erik-Oliver Glocker et al.   LANCET

Understanding resistance to EGFR inhibitors—impact on future treatment strategies

(2010) Deric L. Wheeler et al.   Nature Reviews Clinical Oncology

MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands

(2010) K. Brandl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interleukin 10 (IL-10) gene variants and susceptibility for paediatric onset Crohn’s disease

(2009) D. K. AMRE et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer

(2009) Sergei Grivennikov et al.   CANCER CELL

Epidermal growth factor competes with EGF receptor inhibitors to induce cell death in EGFR-overexpressing tumor cells

(2009) Ji-young Song et al.   CANCER LETTERS

Epidermal Growth Factor Receptor Is Required for Colonic Tumor Promotion by Dietary Fat in the Azoxymethane/Dextran Sulfate Sodium Model: Roles of Transforming Growth Factor-  and PTGS2

(2009) U. Dougherty et al.   CLINICAL CANCER RESEARCH

Down-regulation of Epidermal Growth Factor Receptor by Selective Expansion of a 5'-End Regulatory Dinucleotide Repeat in Colon Cancer with Microsatellite Instability

(2009) S. Baranovskaya et al.   CLINICAL CANCER RESEARCH

Activating mutations within the EGFR kinase domain: a molecular predictor of disease-free survival in resected pulmonary adenocarcinoma

(2009) Young Joo Lee et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Analysis of PTEN, BRAF, and EGFR Status in Determining Benefit From Cetuximab Therapy in Wild-Type KRAS Metastatic Colon Cancer

(2009) Pierre Laurent-Puig et al.   JOURNAL OF CLINICAL ONCOLOGY

Murine models of colorectal cancer

(2009) Joshua M. Uronis et al.   MAMMALIAN GENOME

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Inflammatory Bowel Disease and Mutations Affecting the Interleukin-10 Receptor

(2009) Erik-Oliver Glocker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Decoding epithelial signals: critical role for the epidermal growth factor receptor in controlling intestinal transport function

(2008) D. F. McCole et al.   Acta Physiologica

B-RafV600E Cooperates With Alternative Spliced Rac1b to Sustain Colorectal Cancer Cell Survival

(2008) Paulo Matos et al.   GASTROENTEROLOGY

Targeted Epithelial Tight Junction Dysfunction Causes Immune Activation and Contributes to Development of Experimental Colitis

(2008) Liping Su et al.   GASTROENTEROLOGY

Dual inhibition of VEGFR and EGFR signaling reduces the incidence and size of intestinal adenomas in ApcMin/+ mice

(2008) D. Alferez et al.   MOLECULAR CANCER THERAPEUTICS

Crypt stem cells as the cells-of-origin of intestinal cancer

(2008) Nick Barker et al.   NATURE

Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility

(2008) Andre Franke et al.   NATURE GENETICS

Bmi1 is expressed in vivo in intestinal stem cells

(2008) Eugenio Sangiorgi et al.   NATURE GENETICS

Transactivation of EGF receptor and ErbB2 protects intestinal epithelial cells from TNF-induced apoptosis

(2008) T. Yamaoka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA