Sox2 is not required for melanomagenesis, melanoma growth and melanoma metastasis in vivo

A new water soluble MAPK activator exerts antitumor activity in melanoma cells resistant to the BRAF inhibitor vemurafenib

(2015) Grazia Graziani et al.   BIOCHEMICAL PHARMACOLOGY

SOX17 Is a Critical Specifier of Human Primordial Germ Cell Fate

(2015) Naoko Irie et al.   CELL

Immunohistochemical molecular phenotypes of gastric cancer based on SOX2 and CDX2 predict patient outcome

(2014) Vânia Camilo et al.   BMC CANCER

SOX2 controls tumour initiation and cancer stem-cell functions in squamous-cell carcinoma

(2014) Soufiane Boumahdi et al.   NATURE

SOX2 regulates self-renewal and tumorigenicity of human melanoma-initiating cells

(2014) R Santini et al.   ONCOGENE

Increased SOX2 Gene Copy Number Is Associated with FGFR1 and PIK3CA Gene Gain in Non-Small Cell Lung Cancer and Predicts Improved Survival in Early Stage Disease

(2014) Luca Toschi et al.   PLoS One

SOX2 Expression Is Regulated by BRAF and Contributes to Poor Patient Prognosis in Colorectal Cancer

(2014) Ida V. Lundberg et al.   PLoS One

BRAF Inhibitors Induce Metastasis in RAS Mutant or Inhibitor-Resistant Melanoma Cells by Reactivating MEK and ERK Signaling

(2014) B. Sanchez-Laorden et al.   Science Signaling

Sox2 Cooperates with Lkb1 Loss in a Mouse Model of Squamous Cell Lung Cancer

(2014) Anandaroop Mukhopadhyay et al.   Cell Reports

The stem cell factor SOX2 regulates the tumorigenic potential in human gastric cancer cells

(2013) Katharina Hütz et al.   CARCINOGENESIS

The Sox Family of Transcription Factors: Versatile Regulators of Stem and Progenitor Cell Fate

(2013) Abby Sarkar et al.   Cell Stem Cell

The Prognostic Value of SOX2 Expression in Non-Small Cell Lung Cancer: A Meta-Analysis

(2013) Yansu Chen et al.   PLoS One

Essential Role of Sox2 for the Establishment and Maintenance of the Germ Cell Line

(2013) Federica Campolo et al.   STEM CELLS

Melanoma: from mutations to medicine

(2012) H. Tsao et al.   GENES & DEVELOPMENT

EGFR/Src/Akt signaling modulates Sox2 expression and self-renewal of stem-like side-population cells in non-small cell lung cancer

(2012) Sandeep Singh et al.   Molecular Cancer

Sox10 promotes the formation and maintenance of giant congenital naevi and melanoma

(2012) Olga Shakhova et al.   NATURE CELL BIOLOGY

Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer

(2012) Charles M Rudin et al.   NATURE GENETICS

β-Catenin Signaling Controls Metastasis in Braf-Activated Pten-Deficient Melanomas

(2011) William E. Damsky et al.   CANCER CELL

SOX2 and nestin expression in human melanoma: an immunohistochemical and experimental study

(2011) Alvaro C. Laga et al.   EXPERIMENTAL DERMATOLOGY

SOX2 contributes to melanoma cell invasion

(2011) Sasha D Girouard et al.   LABORATORY INVESTIGATION

SOX2 gene amplification and protein overexpression are associated with better outcome in squamous cell lung cancer

(2011) Theresia Wilbertz et al.   MODERN PATHOLOGY

Sox2 expression in breast tumours and activation in breast cancer stem cells

(2011) O Leis et al.   ONCOGENE

SOX2 Is an Oncogene Activated by Recurrent 3q26.3 Amplifications in Human Lung Squamous Cell Carcinomas

(2010) Thomas Hussenet et al.   PLoS One

Expression of The Embryonic Stem Cell Transcription Factor SOX2 in Human Skin

(2009) Alvaro C. Laga et al.   AMERICAN JOURNAL OF PATHOLOGY

Loss of Class III β-Tubulin Induced by Histone Deacetylation Is Associated with Chemosensitivity to Paclitaxel in Malignant Melanoma Cells

(2009) Kiyomi Akasaka et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas

(2009) Adam J Bass et al.   NATURE GENETICS

BrafV600E cooperates with Pten loss to induce metastatic melanoma

(2009) David Dankort et al.   NATURE GENETICS

Hippocampal development and neural stem cell maintenance require Sox2-dependent regulation of Shh

(2009) Rebecca Favaro et al.   NATURE NEUROSCIENCE

The gene expression profiles of primary and metastatic melanoma yields a transition point of tumor progression and metastasis

(2008) Adam I Riker et al.   BMC Medical Genomics

SOX2 is frequently downregulated in gastric cancers and inhibits cell growth through cell-cycle arrest and apoptosis

(2008) T Otsubo et al.   BRITISH JOURNAL OF CANCER