Article
Clinical Neurology
Antonia M. Werner, Mareike Ernst, Elmar Braehler, Ana N. Tibubos, Danielle Otten, Iris Reiner, Joerg Wiltink, Matthias Michal, Andreas Schulz, Philipp S. Wild, Thomas Muenzel, Jochem Koenig, Karl J. Lackner, Norbert Pfeiffer, Manfred E. Beutel
Summary: This study aimed to investigate the impact of depressive symptoms on bodyweight change in adults and its association with other psychosocial and biomedical factors. The results showed that depressive symptoms were associated with weight gain, while factors such as female gender, younger age, lower socioeconomic status, and smoking cessation were also associated with weight gain. In terms of weight loss, depressive symptoms did not have a significant effect, but factors such as female gender, diabetes, less physical activity, and higher BMI at baseline were associated with weight loss.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Medicine, General & Internal
Parco M. Siu, Angus P. Yu, Edwin C. Chin, Doris S. Yu, Stanley S. Hui, Jean Woo, Daniel Y. Fong, Gao X. Wei, Michael R. Irwin
Summary: Tai chi is an effective approach to reduce waist circumference in adults with central obesity aged 50 years or older. The study results showed positive changes in waist circumference, body weight, and blood lipid levels in both the tai chi group and exercise group compared to the control group.
ANNALS OF INTERNAL MEDICINE
(2021)
Review
Food Science & Technology
Chandana Deekshith, Markandeya Jois, Jessica Radcliffe, Jency Thomas
Summary: This article systematically reviewed literature on the effects of culinary herbs and spices on obesity in adults, finding eight herbs/spices to be beneficial in regards to obesity, with significant improvements in BMI, weight, and waist circumference.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Endocrinology & Metabolism
Carel-Peter L. van Erpecum, Sander K. R. van Zon, Tian Xie, Harold Snieder, Ute Bultmann, Nynke Smidt
Summary: This study investigated the associations between exposure to fast-food outlets and BMI and BMI change. The results showed that participants who lived within 1 km of ≥1 fast-food outlet had higher BMI, and those who lived within 1 km of ≥2 fast-food outlets had greater increases in BMI. The effects were largest among young adults, especially those with medium or high genetic predisposition.
Article
Nutrition & Dietetics
Yair Lahav, Aviv Kfir, Yftach Gepner
Summary: This study evaluated the prevalence of excessive adiposity among normal-weight individuals and their cardiometabolic risk, and found that higher adiposity, even within normal weight, increases cardiometabolic risk.
FRONTIERS IN NUTRITION
(2023)
Review
Nutrition & Dietetics
Farah J. Alsharif, Yara A. Almuhtadi
Summary: With the global prevalence of obesity increasing dramatically, it has become a serious public health threat associated with comorbid conditions and psychological disorders. While lifestyle interventions and dietary adjustments may help with weight loss, maintaining these changes long-term can be challenging. Spices like turmeric, ginger, and pepper have shown promise in obesity management, with curcumin in particular gaining interest for its health benefits. Studies have shown potential favorable effects of curcumin supplementation on anthropometric indices, warranting further investigation for overweight or obese adults.
Review
Cardiac & Cardiovascular Systems
Rosana G. Bianchettin, Carl J. Lavie, Francisco Lopez-Jimenez
Summary: Diagnosing and treating cardiovascular disease (CVD) in overweight/obese individuals presents unique challenges. Physicians also face complications when managing obesity in patients with CVD. The presence of obesity can hinder diagnostic accuracy of CVD and require careful adjustment of pharmacological treatments or cardiac procedures. The obesity paradox and the limitations of body mass index as a measure are important considerations. Lifestyle modifications, cardiac rehabilitation programs, and bariatric surgery are potential interventions for addressing obesity and CVD.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Review
Nutrition & Dietetics
Azizah Ugusman, Syarifah Amirah Syed Shahrin, Nurul Hana Azizan, Siva Balan Pillai, Khamini Krishnan, Norizam Salamt, Amilia Aminuddin, Adila A. Hamid, Jaya Kumar, Mohd Helmy Mokhtar
Summary: The study systematically reviewed the effects of honey on obesity, finding that honey showed anti-obesity effects in animal studies but had conflicting results in clinical trials. While honey supplementation did not show significant weight reduction in some trials, there was also no evidence that it increased body weight.
FRONTIERS IN NUTRITION
(2022)
Review
Food Science & Technology
Yiyi Zhang, Nie Tang, Wei Xia, Shaikh Sanjid Seraj, Marcos Pereira, Periyannan Velu, Hui Zhou, Hanshu Yang, Guanggang Du
Summary: A meta-analysis revealed that green tea supplementation has a significant impact on weight, BMI, and waist circumference in overweight and obese women.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Chemistry, Applied
Yi Zhang, Himali Balasooriya, Sameera Sirisena, Ken Ng
Summary: Polyphenols are effective in managing obesity in certain adults, leading to reductions in body weight, body mass index, and waist circumference. However, there is no significant effect on body fat percentage. The effectiveness of polyphenols varies based on age, ethnicity, health conditions, duration, and dosage.
Article
Respiratory System
Tao Wang, Yunping Zhou, Nan Kong, Jianzhong Zhang, Guo Cheng, Yuxin Zheng
Summary: This study investigated the association between weight change from early to middle adulthood and the risk of incident asthma. Results showed that weight gain during this period was associated with a higher risk of developing asthma, emphasizing the importance of maintaining normal weight for preventing adult-onset asthma.
RESPIRATORY RESEARCH
(2021)
Article
Endocrinology & Metabolism
Elin Meyer, Knut Loennroth, Yvonne Forsell, Ylva Trolle Lagerros
Summary: In individuals with obesity, desired BMI and discrepancies between current, desired, and ideal BMI are associated with current BMI, sex, and presence of major depression. This highlights the importance of a patient-centered approach in obesity management, where the goals and needs of each patient should be considered.
Article
Endocrinology & Metabolism
Ted D. Adams, Huong Meeks, Alison Fraser, Lance E. Davidson, John Holmen, Michael Newman, Anna R. Ibele, Mary Playdon, Sheetal Hardikar, Nathan Richards, Steven C. Hunt, Jaewhan Kim
Summary: This study found that bariatric surgery patients had a 25% lower risk of developing cancer compared to a nonsurgical comparison group. Among female patients, the risk of developing cancer was reduced by 67% and cancer mortality was significantly lower by 53% after surgery.
Article
Biochemistry & Molecular Biology
Damoon Ashtary-Larky, Sara Niknam, Meysam Alipour, Reza Bagheri, Omid Asbaghi, Mehrnaz Mohammadian, Salvador J. Jaime, Julien S. Baker, Alexei Wong, Katsuhiko Suzuki, Reza Afrisham
Summary: This study aimed to evaluate the cardiometabolic abnormalities in women with normal-weight obesity (NWO) in comparison with lean, overweight, and obese women. Significant differences were observed in HDL concentrations between NWO, lean, and obese participants. Individuals with NWO had a significantly higher incidence of cardiometabolic abnormalities when compared to lean participants.
Article
Clinical Neurology
Jinlei Li, Chunyu Liu, Ting Fang Alvin Ang, Rhoda Au
Summary: This study found that decreasing BMI trends in late life were associated with higher risk of developing dementia. Among them, individuals with an initial increase and subsequent decline in BMI during mid-life had a greater risk of dementia.
ALZHEIMERS & DEMENTIA
(2022)
Review
Clinical Neurology
Roger S. Mcintyre, Leslie Citrome, Hannah Cummings, Mark S. Todtenkopf, Laura A. Tan, Marni White, Sarah Akerman
Summary: The endogenous opioid system plays an important role in weight and metabolism regulation. Targeting this system may help mitigate antipsychotic-induced weight gain and metabolic dysregulation.
Review
Clinical Neurology
Oloruntoba J. Oluboka, Martin A. Katzman, Jeffrey Habert, Atul Khullar, Margaret A. Oakander, Diane McIntosh, Roger S. McIntyre, Claudio N. Soares, Raymond W. Lam, Larry J. Klassen, Robert Tanguay
Summary: Major depressive disorder (MDD) is the leading cause of disability worldwide, and comorbid chronic pain exacerbates disability and healthcare burden. Managing patients with both MDD and chronic pain can be challenging due to shared underlying mechanisms. Current treatment guidelines address comorbid conditions such as anxiety and cardiovascular disease, but not chronic pain. Rapidly and aggressively treating depression according to guideline recommendations, using antidepressants with analgesic properties, while also addressing pain, is recommended based on clinical experience.
Article
Clinical Neurology
Roger S. McIntyre, David G. Daniel, Eduard Vieta, Istvan Laszlovszky, Pascal J. Goetghebeur, Willie R. Earley, Mehul D. Patel
Summary: Post hoc analyses suggest that cariprazine may have potential benefits in improving cognitive symptoms in patients with bipolar I disorder and schizophrenia.
Review
Psychiatry
Smadar V. Tourjman, Gabriella Buck, Didier Jutras-Aswad, Atul Khullar, Shane McInerney, Gayatri Saraf, Jairo V. Pinto, Stephane Potvin, Marie-Josee Poulin, Benicio N. Frey, Sidney H. Kennedy, Raymond W. Lam, Glenda MacQueen, Roumen Milev, Sagar V. Parikh, Arun Ravindran, Roger S. McIntyre, Ayal Schaffer, Valerie H. Taylor, Michael van Ameringen, Lakshmi N. Yatham, Serge Beaulieu
Summary: This task force report examines the association between cannabis use and bipolar disorder, major depressive disorder, and comorbid cannabis use disorder. The results indicate that cannabis use is associated with worsened course and functioning of both mood disorders, particularly in bipolar disorder. However, the treatment of comorbid cannabis use disorder and major depressive disorder did not show significant results.
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE
(2023)
Review
Psychiatry
Joshua D. Rosenblat, M. Ishrat Husain, Yena Lee, Roger S. McIntyre, Rodrigo B. Mansur, David Castle, Hilary Offman, Sagar Parikh, Benicio N. Frey, Ayal Schaffer, Kyle T. Greenwaym, Nicolas Garel, Serge Beaulieu, Sidney H. Kennedy, Raymond W. Lam, Roumen Milev, Arun Ravindran, Valerie Tourjman, Michael Van Ameringen, Lakshmi N. Yatham, Valerie Taylor
Summary: There is currently only low-level evidence to support the efficacy and safety of psychedelics for major depressive disorder.
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE
(2023)
Article
Clinical Neurology
William S. H. Kim, Mikaela K. Dimick, Danielle Omrin, Rachel H. B. Mitchell, Daniel Riegert, Anthony Levitt, Ayal Schaffer, Susan Belo, John Iazzetta, Garfield Detzler, Mabel Choi, Stephen Choi, Nathan Herrmann, Roger S. McIntyre, Bradley J. MacIntosh, Beverley A. Orser, Benjamin I. Goldstein
Summary: A study found that an anesthetic gas containing nitrous oxide can significantly reduce depression severity in patients with bipolar disorder. Patients who used nitrous oxide had greater reductions in depression severity on the same day compared to the placebo group. Baseline cerebral blood flow predicted the decrease in depression severity with nitrous oxide, but not with midazolam. The findings suggest differential associations of nitrous oxide versus midazolam with bipolar depression severity and cerebral hemodynamics.
Article
Clinical Neurology
Farhan Fancy, Nelson B. Rodrigues, Joshua D. Di Vincenzo, Edmond H. Chau, Rickinder Sethi, Muhammad I. Husain, Hartej Gill, Aniqa Tabassum, Andrea Mckenzie, Lee Phan, Roger S. McIntyre, Joshua D. Rosenblat
Summary: This study observed the real-world effectiveness of repeated ketamine infusions for treatment-resistant bipolar depression. Results showed that ketamine significantly reduced depressive symptoms, suicidal thoughts, and anxiety, while improving functioning. The more infusions received, the more significant the reduction in symptoms.
Article
Clinical Neurology
Giovanni Martinotti, Bernardo Dell'Osso, Giorgio Di Lorenzo, Giuseppe Maina, Alessandro Bertolino, Massimo Clerici, Stefano Barlati, Gianluca Rosso, Marco Di Nicola, Matteo Marcatili, Giacomo d'Andrea, Clara Cavallotto, Stefania Chiappini, Sergio De Filippis, Giuseppe Nicolo, Pasquale De Fazio, Ileana Andriola, Raffaella Zanardi, Domenica Nucifora, Stefania Di Mauro, Roberta Bassetti, Mauro Pettorruso, Roger S. McIntyre, Stefano L. Sensi, Massimo di Giannantonio, Antonio Vita
Summary: This study aimed to compare the efficacy of esketamine in treating unipolar and bipolar treatment-resistant depression (TRD) and provide preliminary evidence of its effectiveness in bipolar TRD (B-TRD). The results showed that esketamine significantly reduced depressive symptoms in B-TRD patients compared to TRD patients, and it had a better anxiolytic action in B-TRD patients. The low risk of side effects confirmed the safety of this treatment.
Article
Psychiatry
Christoph U. Correll, Marco Solmi, Samuele Cortese, Maurizio Fava, Mikkel Hojlund, Helena C. Kraemer, Roger S. McIntyre, Daniel S. Pine, Lon S. Schneider, John M. Kane
Summary: Despite progress in pharmacotherapy, many mental disorders remain insufficiently treated due to limited knowledge of pathophysiology, lack of biological markers, and challenges in drug development and testing. This paper discusses promising drugs and innovative mechanisms of action undergoing testing for various psychiatric disorders, as well as the clinical trial parameters that need to be considered for successful drug development. It also highlights the hurdles and perils in new drug development and testing and emphasizes the importance of considering these factors for increased chances of success.
Article
Environmental Sciences
Yuxiao Zhao, Yueying Zhang, Kayla M. Teopiz, Leanna M. W. Lui, Roger S. McIntyre, Bing Cao
Summary: This study investigated the association between depression, vascular diseases (hypertension, myocardial infarction, stroke), diabetes mellitus, and functional impairment in middle-aged and elderly Chinese people. The results showed that depression was associated with functional decline in individuals with vascular disease/diabetes mellitus, highlighting the importance of treating depression in addition to managing vascular diseases.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Article
Clinical Neurology
Yanzhi Li, Lu Cheng, Lan Guo, Liwan Zhu, Hao Zhao, Caiyun Zhang, Manjun Shen, Yifeng Liu, Muhammad Youshay Jawad, Lingjiang Li, Wanxin Wang, Ciyong Lu, Roger S. McIntyre
Summary: This study explores the mediating role of personality traits in the relationship between adverse childhood experiences (ACEs) and depressive symptoms in older adults. The results suggest that maltreatment and household dysfunction induce depressive symptoms by increasing neuroticism, while poor parent-child bonding induces depressive symptoms by increasing neuroticism and reducing conscientiousness and extraversion.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychiatry
Michael E. Thase, Zahinoor Ismail, Stine R. Meehan, Catherine Weiss, Stephane Alexandre Regnier, Klaus Groes Larsen, Roger S. McIntyre
Summary: In this study, a subset of 10 items from the IDS-SR was identified that can measure life engagement in MDD. Different approaches, including expert selection, patient interviews, and PCA, consistently identified these items. These findings suggest the potential for creating an IDS-SR life engagement subscale.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Review
Neurosciences
Muhammad Youshay Jawad, Saleha Qasim, Menglu Ni, Ziji Guo, Joshua D. Di Vincenzo, Giacomo d'Andrea, Aniqa Tabassum, Andrea Mckenzie, Sebastian Badulescu, Iria Grande, Roger S. McIntyre
Summary: The scoping review synthesized the current literature on the use of ketamine in bipolar depression. The preliminary evidence suggests that ketamine is a promising treatment with minimal risk and some effectiveness. Future studies should focus on ketamine's role in acute and maintenance treatment phases, as well as its effects on recurrence prevention and anti-suicidal measures.
Article
Neurosciences
Joanna K. Szmyd, Karol Lewczuk, Kayla M. Teopiz, Roger S. McIntyre, Adam Wichniak
Summary: This pilot study assessed patients' cognitive functioning with the Polish version of the THINC-it tool and analyzed its association with self-reported quality of life. The results suggest that the THINC-it tool has utility as a cognitive measure in adults with schizophrenia in both clinical and research settings.
Article
Psychiatry
Elysha Ringin, David W. Dunstan, Roger S. McIntyre, Neville Owen, Michael Berk, Susan L. Rossell, Mats Hallgren, Tamsyn E. Van Rheenen
Summary: This study examined the impact of physical activity and sedentary behavior on cognitive function in individuals with bipolar disorder. The results showed a negative association between physical activity and passive sedentary behavior with cognitive function, and a positive association between mentally-active sedentary behavior and cognitive function. These associations were stronger in individuals with bipolar disorder.
MENTAL HEALTH AND PHYSICAL ACTIVITY
(2023)
