Article
Nutrition & Dietetics
Ammar Hassanzadeh Keshteli, Rosica Valcheva, Cheryl Nickurak, Heekuk Park, Rupasri Mandal, Kendall van Diepen, Karen I. Kroeker, Sander Veldhuyzen van Zanten, Brendan Halloran, David S. Wishart, Karen L. Madsen, Levinus A. Dieleman
Summary: The study reveals that dietary modifications, including increased intake of anti-inflammatory foods and decreased intake of pro-inflammatory foods, are associated with metabolic and microbial changes in ulcerative colitis patients in clinical remission, effectively preventing subclinical inflammation.
Article
Microbiology
Bowei Zhang, Congying Zhao, Xuejiao Zhang, Xiang Li, Yunhui Zhang, Xiaoxia Liu, Jia Yin, Xinyang Li, Jin Wang, Shuo Wang
Summary: The prevalence of inflammatory bowel disease is increasing, causing a global burden. Certain amino acids have been found to be beneficial for mucosal healing and colitis remission. This study investigated the effects of diets enriched in amino acids and intact proteins on colitis in mice, revealing the critical role of gut microbiota in the prevention of colitis by an elemental diet.
Review
Food Science & Technology
Katarzyna Tarnowska, Eliza Gruczynska-Sekowska, Dorota Kowalska, Ewa Majewska, Mariola Kozlowska, Renata Winkler
Summary: Autism spectrum disorders are highly variable neurodevelopmental disorders. The exact cause is still unknown, but a commonly used intervention is the gluten-free casein-free diet based on the opioid excess theory.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Gastroenterology & Hepatology
Tetsuo Shoda, Margaret H. Collins, Mark Rochman, Ting Wen, Julie M. Caldwell, Lydia E. Mack, Garrett A. Osswald, John A. Besse, Yael Haberman, Seema S. Aceves, Nicoleta C. Arva, Kelley E. Capocelli, Mirna Chehade, Carla M. Davis, Evan S. Dellon, Gary W. Falk, Nirmala Gonsalves, Sandeep K. Gupta, Ikuo Hirano, Paneez Khoury, Amy Klion, Calies Menard-Katcher, John Leung, Vincent A. Mukkada, Philip E. Putnam, Jonathan M. Spergel, Joshua B. Wechsler, Guang-Yu Yang, Glenn T. Furuta, Lee A. Denson, Marc E. Rothenberg
Summary: This study identified distinct transcriptional profiles of colonic eosinophilia (EoC) compared to other gastrointestinal diseases, showing minimal overlap with other EGIDs and evidence of a strong allergic type 2 immune response in EoC. These findings suggest that EoC is a separate disease entity from other EGIDs and IBD, providing insight for improved diagnosis and treatment.
Review
Food Science & Technology
Sara Moazzen, Kimberley J. W. van der Sloot, Geertruida H. de Bock, Behrooz Z. Alizadeh
Summary: The study found that high diet quality is associated with reduced risk of colorectal cancer, particularly with low Diet Inflammatory Index score and high Mediterranean Diet Score. However, concerns over inconsistency and imprecision led to the pooled results of all dietary indices being rated as low quality.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Review
Nutrition & Dietetics
Marcelina Radziszewska, Joanna Smarkusz-Zarzecka, Lucyna Ostrowska, Damian Pogodzinski
Summary: This review analyzed scientific research to determine the impact of different nutritional plans and dietary supplements on the course of ulcerative colitis (UC). The study found that certain components in food can greatly influence UC, with the Mediterranean diet showing promising results in treatment. It also discussed the potential effects of the UC Exclusion Diet (UCED) and unconventional diets, as well as the uncertain therapeutic effects of omega-3 fatty acids and probiotic supplementation.
Article
Biology
Areej A. Eskandrani
Summary: The study demonstrated that dietary supplementation with fava bean could significantly improve the incidence of UC in rats, correct impaired oxidative and inflammatory biomarker levels, and modulate histological features and DNA alterations.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Pathology
Erika Hissong, Maria Mostyka, Rhonda K. Yantiss
Summary: Tacrolimus, a common immunosuppressant, can cause colonic injury in solid organ transplant recipients. Most patients experience mild symptoms such as diarrhea. This study found that colonic injury related to tacrolimus often features regenerative crypts and scattered apoptotic debris. The colitis is usually resolved by reducing the dosage of tacrolimus.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2022)
Article
Medicine, General & Internal
Irene Marafini, Silvia Salvatori, Irene Rocchetti, Norma Alfieri, Patrizio Scarozza, Emma Calabrese, Livia Biancone, Giovanni Monteleone
Summary: UC patients with coexisting colonic diverticulosis are less likely to have an extensive disease and to be steroid-dependent, with lower use of immunosuppressants and biologics compared to UC patients without concomitant colonic diverticulosis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, Research & Experimental
Paulo da Silva Watanabe, Andreza Manzato Cavichioli, Joana D'Arc de Lima Mendes, Rubina Aktar, Madusha Peiris, L. Ashley Blackshaw, Eduardo Jose de Almeida Araujo
Summary: This study evaluated the anatomical and functional changes in the colon during the development of acute and chronic DSS-induced UC in mice. The results showed that UC caused thickening of the colonic wall, fibrosis, and reduction in tuft cells, leading to abnormal colonic motility. Further studies may focus on stimulating tuft cell hyperplasia to reduce damage caused by UC.
Review
Gastroenterology & Hepatology
Sinan Sadalla, Andrea Lisotti, Lorenzo Fuccio, Pietro Fusaroli
Summary: Colonoscopy poses a risk for colon ischemia due to various factors such as impaired splanchnic circulation, medications used for sedation, bowel preparation, bowel wall ischemia from insufflation, and endoscope insertion. Gastroenterologists should be aware of these risk factors to minimize risks, facilitate early diagnosis, and administer appropriate treatment.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Pengfei Xu, Yue Xi, Junjie Zhu, Min Zhang, Zigmund Luka, Donna B. Stolz, Xinran Cai, Yang Xie, Meishu Xu, Songrong Ren, Zhiying Huang, Da Yang, John D. York, Xiaochao Ma, Wen Xie
Summary: The study revealed a decrease in PAPSS2 expression in colon cancer and its correlation with worse survival in patients. Papss2(Delta IE) mice showed heightened sensitivity to colitis and colon cancer due to damaged intestinal mucosal barrier and increased bacterial infiltration.
Article
Immunology
Yao-Yao Chang, Qiu-Chan Huan, Jiao Peng, Wen-Chun Bi, Li-Xiang Zhai, Yan Chen, Jonathan R. Lamb, Xiang-Chun Shen, Zhao-Xiang Bian, Hai-qiang Wu, Yong-Xian Cheng, Hai-Tao Xiao
Summary: This study found that P2Y1R deficiency can suppress Th17 cell differentiation in an AMPK-dependent manner to ameliorate colitis, and P2Y1R can act as an important regulator of Th17 cell differentiation to control colonic inflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Laura D. Manzanares, Joseph David, Xingsheng Ren, Lenore K. Yalom, Enzo B. Piccolo, Yalda Dehghan, Aidan J. David, Stephen B. Hanauer, Ronen Sumagin
Summary: This study demonstrates the potential therapeutic role of atovaquone in promoting resolution of mucosal inflammation in ulcerative colitis by reducing neutrophil accumulation and suppressing their migration.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Nutrition & Dietetics
Pablo Jose Gonzalez-Domenech, Francisco Diaz-Atienza, Luis Gutierrez-Rojas, Maria Luisa Fernandez-Soto, Carmen Maria Gonzalez-Domenech
Summary: This narrative review concludes that there is insufficient scientific evidence to support a general recommendation of dietary intervention in children with ASD. Future research should focus on protocols and procedures for assessing risk and safety, as well as larger sample sizes and longer follow-up times to obtain more reliable results.
Article
Food Science & Technology
Eunyeong Ahn, Jimin Lee, Young-Hee Jeon, Sang-Won Choi, Eunjung Kim
FOOD SCIENCE AND BIOTECHNOLOGY
(2017)
Review
Gastroenterology & Hepatology
Francois Blachier, Mireille Andriamihaja, Pierre Larraufie, Eunyeong Ahn, Annaig Lan, Eunjung Kim
Summary: Hydrogen sulfide (H2S) is a bacterial metabolite that affects the intestinal physiology and physiopathology through multiple sources and metabolic pathways in colonocytes. Different concentrations of H2S production have different effects on colon mucosa, playing a crucial role in cellular energy metabolism and development.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2021)