Article
Immunology
Liangfei Niu, Geyang Luo, Rui Liang, Chenli Qiu, Jianwei Yang, Lingling Xie, Kaile Zhang, Yu Tian, Decheng Wang, Shu Song, Howard E. Takiff, Ka-Wing Wong, Xiaoyong Fan, Qian Gao, Bo Yan
Summary: This study reveals the important role of nlrc3-like in the regulation of macrophage homeostasis, early bacterial burden control, and inflammation response. Overexpression or deficiency of nlrc3-like leads to abnormal inflammation response and bacterial burden, highlighting the importance of balanced innate immune response during mycobacterial infection.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Chia George Hsu, Wenjia Li, Mark Sowden, Camila Lage Chavez, Bradford C. Berk
Summary: Pnpt1 plays critical roles in mitochondrial homeostasis and is involved in inflammation by regulating IL-1β and IL-18 secretion. The study demonstrates that Pnpt1 controls NLRP3 inflammasome activation through glycolysis and mt-ROS in macrophages.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Article
Immunology
Do-Wan Shim, Hyo-Joung Cho, Inhwa Hwang, Taek-Yeol Jung, Hyun-Seok Kim, Ju Hee Ryu, Je-Wook Yu
Summary: The depletion of NAD(+) affects the innate immune potential of macrophages and has an impact on NLRP3 activation. FK866 facilitates NLRP3 activation by promoting perinuclear clustering of mitochondria, while supplementation with NAD(+) can counteract the FK866-induced caspase-1 cleavage.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Clinical Neurology
Basem Ishak, Amir Abdul-Jabbar, Gregory B. Moss, Emre Yilmaz, Alexander von Glinski, Sven Frieler, Andreas W. Unterberg, Ronan Blecher, Juan Altafulla, Jeffrey Roh, Robert A. Hart, Rod J. Oskouian, Jens R. Chapman
Summary: This retrospective study compared outcomes and risk factors between de novo MRSA and MSSA vertebral osteomyelitis (VO). It was found that patients with chronic renal insufficiency and malnutrition are more at risk for MRSA infection, with MRSA patients having more severe neurological deficits. Despite this, there was no significant difference in final clinical outcomes between the two groups.
NEUROSURGICAL REVIEW
(2021)
Review
Pharmacology & Pharmacy
M. John Chapman, R. Preston Mason
Summary: The stability of atherosclerotic plaques is related to cholesterol crystal formation, and eicosapentaenoic acid (EPA) helps increase plaque stability by reducing lipid volume, attenuating intraplaque inflammation, and increasing fibrous cap thickness. Imaging trials in patients with cardiovascular disease have shown the positive impact of EPA on vulnerable plaques.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Multidisciplinary Sciences
Rafael Rivera-Lugo, Samuel H. Light, Nicholas E. Garelis, Daniel A. Portnoy
Summary: The study shows that L. monocytogenes requires scavenging FMN and FAD from host cells to grow, rather than acquiring them from external sources. In the absence of RibU, the bacterium is unable to grow in environments lacking riboflavin.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Immunology
Asta Luciunaite, Indre Dalgediene, Rapolas Zilionis, Kristina Masalaite, Milda Norkiene, Andrius Sinkunas, Alma Gedvilaite, Indre Kucinskaite-Kodze, Aurelija Zvirbliene
Summary: This study investigates the effect of viral oligomeric proteins on the inflammatory response in macrophages. It finds that filamentous proteins do not induce inflammation, while spherical proteins mediate an inflammatory response and activate the NLRP3 inflammasome.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Haoyu Yin, Lei Fang, Lifeng Wang, Yu Xia, Jiaqi Tian, Lan Ma, Jing Zhang, Ning Li, Weixiu Li, Sanqiao Yao, Lin Zhang
Summary: Silica is essential for various materials and inhaling silica can lead to pulmonary diseases associated with macrophage pyroptosis. The internalization of silica nanoparticles induces membrane rupture and increased intracellular vacuoles. Silica suppresses cell viability and proliferation. Silica-exposed macrophages generate higher levels of ROS and upregulated expression of NLRP3, ASC, Caspase-1, GSDMD, IL-1 beta, and IL-6. Removal of ROS or NLRP3 suppresses the expression of these proteins. Silica exposure increases the expression of TLR4 and NF-kappa B, which are responsible for silica recognition and pyroptosis priming.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Min-Qi Ma, Si-Si Zheng, Hui-Long Chen, Hong-Bo Xu, Dan-Lu Zhang, Ye-An Zhang, Shu-Yang Xiang, Bi-Huan Cheng, Sheng-Wei Jin, Pan-Han Fu
Summary: PCTR1 inhibits the activation of NLRP3 inflammasome and pyroptosis. It blocks the interaction between NLRP3 and ASC and restricts the formation of NLRP3 inflammasome. PCTR1 also exerts inhibitory effects through the cAMP-PKA signaling pathway and shows potential as a treatment option.
LABORATORY INVESTIGATION
(2023)
Article
Pharmacology & Pharmacy
Chia-Cheng Su, Shu-Chi Wang, I-Chen Chen, Fang-Yen Chiu, Po-Len Liu, Chi-Han Huang, Kuan-Hua Huang, Shih-Hua Fang, Wei-Chung Cheng, Shu-Pin Huang, Hsin-Chih Yeh, Ching-Chih Liu, Po-Yen Lee, Ming-Yii Huang, Chia-Yang Li
Summary: The study demonstrated that zerumbone effectively attenuates LPS-induced inflammatory response in macrophages both in vitro and ex vivo by suppressing the activation of the ERK-MAPK and NF-kappa B signaling pathways as well as blocking the activation of the NLRP3 inflammasome, suggesting its potential benefits for treating sepsis and inflammasome-related diseases.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Food Science & Technology
Xusheng Li, Haiwei Li, Dongbao Cai, Ping Li, Jietian Jin, Xinwei Jiang, Zhenhua Li, Lingmin Tian, Guobing Chen, Jianxia Sun, Weibin Bai
Summary: Pubertal mice exposed to low-dose cadmium exhibit liver inflammation and severe injury, including inflammatory hepatocyte infiltration, increased apoptotic cells, and upregulation of cytokine expression.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Chemistry, Medicinal
Xiuzhu Weng, Xing Luo, Xinyu Dai, Ying Lv, Shan Zhang, Xiaoxuan Bai, Xiaoyi Bao, Ying Wang, Chen Zhao, Ming Zeng, Sining Hu, Ji Li, Haibo Jia, Bo Yu
Summary: The aim of this study was to investigate the effect of apigenin on pyroptosis and explore its potential against inflammatory diseases. The results showed that apigenin exhibited a preventive effect on macrophage pyroptosis by reducing oxidative stress and inhibiting the NF-κB pathway. These findings suggest apigenin to be a promising therapeutic agent for inflammatory diseases.
PHYTOTHERAPY RESEARCH
(2023)
Article
Microbiology
Ankit Pandeya, Yan Zhang, Jian Cui, Ling Yang, Jeffery Li, Guoying Zhang, Congqing Wu, Zhenyu Li, Yinan Wei
Summary: Inflammasome activation is crucial in defending against bacterial infection. In this study, we discovered that inflammasome activation plays a critical role in the pathogenesis of Salmonella systemic infection. Deficiency of caspase-1 or gasdermin-D prolonged survival, reduced proinflammatory cytokine concentrations, and protected against coagulopathy during Salmonella infection. The activation of NAIP/NLRC4 inflammasome and SPI1 was found to trigger Salmonella-induced coagulopathy, while the caspase-11/NLRP3 pathway was also involved.
MICROBIOLOGICAL RESEARCH
(2023)
Article
Immunology
Hao Wang, Xueyue Zheng, Bingnan Liu, Yaoyao Xia, Zhongquan Xin, Baichuan Deng, Liuqin He, Jinping Deng, Wenkai Ren
Summary: The study reveals a previously unknown role of aspartate metabolism in directing M1 macrophage polarization, showing that aspartate and its metabolites play crucial roles in the secretion and inflammatory responses of M1 macrophages.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Takuya Yashiro, Machiko Yamamoto, Sanae Araumi, Mutsuko Hara, Kyoko Yogo, Koichiro Uchida, Kazumi Kasakura, Chiharu Nishiyama
Summary: The study revealed that PU.1 and IRF8 are involved in the monocytic lineage-specific expression of NLRP3 by binding to regulatory elements within its promoter. Knockdown of PU.1 and IRF8 suppresses the activity of the NLRP3 inflammasome.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Nutrition & Dietetics
Thacianna Barreto Da Costa, Natalia Gomes De Morais, Joana Maria Bezerra De Lira, Thays Miranda De Almeida, Suenia Da Cunha Gocalves-De-Albuquerque, Valeria Rego Alves Pereira, Milena De Paiva Cavalcanti, Celia Maria Machado Barbosa De Castro
EUROPEAN JOURNAL OF NUTRITION
(2017)
Article
Pharmacology & Pharmacy
Maria do D. Rodrigues, Priscila B. G. S. Santiago, Karla M. R. Marques, Valeria R. A. Pereira, Maria C. A. B. de Castro, Jeanne C. L. L. Cantalice, Teresinha G. da Silva, Monica L. Adam, Silene C. do Nascimento, Julianna F. C. de Albuquerque, Gardenia C. G. Militao
PHARMACOLOGICAL REPORTS
(2018)
Article
Immunology
Maria Carolina Accioly Brelaz-de-Castro, Thays Miranda de Almeida, Amanda Ferreira de Almeida, Marina de Assis Souza, Andresa Pereira de Oliveira Mendes, Rafael de Freitas e Silva, Maria Edileuza Felinto de Brito, Valeria Rego Alves Pereira
MICROBIAL PATHOGENESIS
(2018)
Article
Chemistry, Medicinal
Sebastiao Jose de Melo, Zenaide Severina do Monte, Aline Caroline da Silva Santos, Ana Catarina Cristovao Silva, Luiz Felipe Gomes Rebello Ferreira, Marcelo Zaldini Hernandes, Ricardo Oliveira Silva, Emerson Peter da Silva Falcao, Maria Carolina Accioly Brelaz-de-Castro, Rajendra M. Srivastava, Valeria Rego Alves Pereira
MEDICINAL CHEMISTRY RESEARCH
(2018)
Article
Biochemical Research Methods
Elis D. Silva, Beatriz C. Oliveira, Andresa P. Oliveira, Wagner J. T. Santos, George T. Diniz, Osvaldo P. de Melo Neto, Carlos H. N. Costa, Mauro R. B. Silva, Luiz D. Andrade, Zulma M. Medeiros, Valeria R. A. Pereira
JOURNAL OF IMMUNOLOGICAL METHODS
(2019)
Article
Immunology
Natalia Gomes de Morais, Thacianna Barreto da Costa, Luiz Felipe Ferreira de Lima, Dyowani dos Santos Basilio, Nadja Nara Gomes de Morais, Milena de Paiva Cavalcanti, Valeria Rego Alves Pereira, Celia Maria Machado Barbosa de Castro
MICROBIAL PATHOGENESIS
(2019)
Article
Immunology
Paulin Sonon, Renan G. Gomes, Maria C. A. Brelaz-de-Castro, Lais A. B. da Costa, Valeria R. A. Pereira, Maria E. F. de Brito, Alain J. J. Dessein, George T. N. Diniz, Eduardo A. Donadi, Norma Lucena-Silva
Article
Biochemistry & Molecular Biology
Cynarha Cardoso da Silva, Cristiane Moutinho Lagos Melo, Elba Veronica Matoso Maciel Carvalho, Mercia Andrea Lino da Silva, Rosiely Felix Bezerra, Athie Jorge Guerra dos Santos, Valeria Rego Alves Pereira, Luana Cassandra Breitenbach Barroso Coelho
PROTEIN AND PEPTIDE LETTERS
(2019)
Editorial Material
Pharmacology & Pharmacy
Ana Catarina Cristovao-Silva, Maria Carolina Accioly Brelaz-de-Castro, Ana Cristina Lima Leite, Valeria Rego Alves Pereira, Marcelo Zaldini Hernandes
FRONTIERS IN PHARMACOLOGY
(2019)
Article
Infectious Diseases
Andresa Pereira Oliveira Mendes, Beatriz Coutinho Oliveira, Allana Maria S. Pereira, Maria Carolina Accioly Brelaz Castro, Marina Assis Souza, Maria Edileuza Felinto Brito, Fernanda Fortes Araujo, Andrea Teixeira-Carvalho, Olindo Assis Martins-Filho, Valeria Rego Alves Pereira
BMC INFECTIOUS DISEASES
(2019)
Article
Chemistry, Medicinal
Marcos Verissimo de Oliveira Cardoso, Gevanio Bezerra de Oliveira Filho, Lucianna Rabelo Pessoa de Siqueira, Jose Wanderlan Pontes Espindola, Elany Barbosa da Silva, Andresa Pereira de Oliveira Mendes, Valeria Rego Alves Pereira, Maria Carolina Accioly Brelaz de Castro, Rafaela Salgado Ferreira, Filipe Silva Villela, Francielly Morais Rodrigues da Costa, Cassio Santana Meira, Diogo Rodrigo Magalhaes Moreira, Milena Botelho Pereira Soares, Ana Cristina Lima Leite
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2019)
Article
Chemistry, Medicinal
Amelia Galdino Ribeiro, Sinara Monica Vitalino de Almeida, Jamerson Ferreira de Oliveira, Tulio Ricardo Couto de Lima Souza, Keriolaine Lima dos Santos, Amanda Pinheiro de Barros Albuquerque, Mariane Cajuba de Britto Lira Nogueira, Luiz Bezerra de Carvalho Junior, Ricardo Olimpio de Moura, Aline Caroline da Silva, Valeria Rego Alves Pereira, Maria Carolina Accioly Brelaz de Castro, Maria do Carmo Alves de Lima
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2019)
Article
Biochemistry & Molecular Biology
Paula Roberta da Silva, Jamerson Ferreira de Oliveira, Anekecia Lauro da Silva, Camila Marques Queiroz, Ana Paula Sampaio Feitosa, Denise Maria Figueiredo Araujo Duarte, Aline Caroline da Silva, Maria Carolina Accioly Brelaz de Castro, Valeria Rego Alves Pereira, Rosali Maria Ferreira da Silva, Luiz Carlos Alves, Fabio Andre Brayner dos Santos, Maria do Carmo Alves de Lima
CHEMICO-BIOLOGICAL INTERACTIONS
(2020)
Article
Chemistry, Multidisciplinary
Muhammad Haroon, Tashfeen Akhtar, Aline C. S. da Santos, Valeria R. A. Pereira, Luiz F. G. R. Ferreira, Marcelo Z. Hernandes, Rafael E. O. Rocha, Rafaela S. Ferreira, Paulo A. T. de M. Gomes, Fabiano A. de Sousa, Mabilly C. H. de B. Dias, Muhammad N. Tahir, Shahid Hameed, Ana C. L. Leite
Article
Nutrition & Dietetics
Sarah Maria Barneze Costa, Raghavendra Lakshmana Shetty Hallur, David Rafael Abreu Reyes Postdoc, Juliana Ferreira Floriano Postdoc, Maria Antonieta de Barros Leite Carvalhaes, Helio Rubens de Carvalho Nunes, Luis Sobrevia, Paola Valero, Angelica Mercia Pascon Barbosa, Marilza Cunha Vieira Rudge
Summary: This study aimed to assess maternal dietary intake patterns, anthropometric measures, and biochemical markers in women with gestational diabetes mellitus and pregnancy-specific urinary incontinence. The results showed that pregnant women in the gestational diabetes mellitus pregnancy-specific urinary incontinence group had higher body mass index, arm circumference, and triceps skinfold than the other groups, indicating an obesogenic maternal environment. Significant differences in dietary food intake were also observed. The study emphasizes the need for a comprehensive strategy for pregnant women with gestational diabetes mellitus and pregnancy-specific urinary incontinence to address obesity and micronutrient deficiencies.
Article
Nutrition & Dietetics
Aikaterina Vasileiou, Dominique Searle, Sofus C. Larsen, Faidon Magkos, Graham Horgan, R. James Stubbs, Ines Santos, Antonio L. Palmeira, Berit L. Heitmann
Summary: The study compared self-reported total energy intake with total energy expenditure estimated from Fitbit Charge 2 algorithms. The results showed that self-reported energy intake was generally lower than energy expenditure, and the degree of underestimation varied among different populations.
Article
Nutrition & Dietetics
Ziya Erokay Metin, Ozge Mengi Celik, Nevra Koc
Summary: This study demonstrates a significant relationship between climate change awareness and sustainable and healthy eating behaviors as well as adherence to the Mediterranean diet.
Article
Nutrition & Dietetics
Carolline Santos Miranda, Flavia Maria Silva-Veiga, Daiana Araujo Santana-Oliveira, Isabela Macedo Lopes Vasques-Monteiro, Julio Beltrame Daleprane, Vanessa Souza-Mello
Summary: This study investigates the role of peroxisome proliferator-activated receptor (PPAR) activation on thermogenic pathways and mitochondrial metabolism in mouse adipose tissue. The results show that activation of PPARa and dual PPARa/y can reduce body mass, mitigate insulin resistance, and induce browning in white adipose tissue. Preserved mitochondrial metabolism emerges as a potential target for obesity treatment using PPAR agonists, with possible clinical applications.
Article
Nutrition & Dietetics
Qi Ren, Hao-Fan Wu, Ding-Ye Yu, Feng-Min Zhang, Zi-Le Shen, Guo-Wei Huang, Feng Lin, Wei-Zhe Chen, Zhen Yu
Summary: The study aimed to develop a nomogram incorporating preoperative factors for predicting low skeletal muscle mass index and low skeletal muscle radiodensity. The models were calibrated and assessed for their predictive ability using training and validation cohorts, and the clinical usefulness was evaluated using decision curve analysis.
Article
Nutrition & Dietetics
Ruben Castillo-Ortega, Juan Vega-Vargas, Samuel Duran-Aguero
Summary: This study found that during the COVID-19 pandemic, patients with type 1 diabetes experienced decreased adherence to diabetes care, leading to an increase in HbA1c levels, BMI, impaired linear growth, and more hospitalizations. The shift to telemedicine as the main healthcare service also had significant effects on diabetes management.
Article
Nutrition & Dietetics
Yi-Hsiu Chen, Jung-An Lin, Jiun-Rong Chen, Ya-Ling Chen, Suh-Ching Yang
Summary: Regular nutrition consultations have been shown to have significant effects on reducing cardiovascular disease risk factors, especially for individuals with obesity.
Article
Nutrition & Dietetics
Jacinta Winderlich, Bridget Little, Felix Oberender, Tessa Bollard, Tamara Farrell, Samantha Jenkins, Emma Landorf, Andrea McCall, Jessica Menzies, Katie O. ' Brien, Carla Rowe, Kirsten Sim, Melanie van der Wilk, Jemma Woodgate, Eldho Paul, Andrew A. Udy, Emma J. Ridley
Summary: The study aims to describe nutrition provision in Australian and New Zealand pediatric intensive care units, assess the adequacy of enteral nutrition, and evaluate the methods for estimating energy and protein requirements.
Article
Nutrition & Dietetics
Xi Zhang, Jia-Xin Huang, Meng Tang, Qi Zhang, Li Deng, Chun-Hua Song, Wei Li, Han-Ping Shi, Ming-Hua Cong
Summary: The study found that the modified Controlling Nutritional Status system, which includes C-reactive protein as an inflammatory parameter, is more accurate than the traditional system in predicting the survival of patients with cancer cachexia. High Controlling Nutritional Status and modified Controlling Nutritional Status are both independent risk factors for survival and have a negative impact on survival in patients with advanced-stage cancers, such as esophagogastric and colorectal cancer.
Article
Nutrition & Dietetics
Karolien Dams, Gregory R. A. De Meyer, Rita Jacobs, Tom Schepens, Stany Perkisas, Greta Moorkens, Philippe Jorens
Summary: The study aimed to investigate the development of muscle atrophy in COVID-19 intensive care unit patients and its relationship with hospital outcomes. The results showed that the difference in muscle thickness was linked to the outcome, with the best survival observed in the group with stable muscle thickness.
Article
Nutrition & Dietetics
Bruna Clemente Cota, Mariana de Santis Filgueiras, Patricia Feliciano Pereira, Leidjaira Lopes Juvanhol, Juliana Farias de Novaes
Summary: This study found that higher consumption of ultra-processed food (UPF) and a diet consisting of high proinflammatory foods were associated with the normal-weight obesity (NWO) phenotype in children.
Article
Nutrition & Dietetics
Victor Nogueira da Cruz Silveira, Cleber Lopes Campelo, Antonio Luis Rodrigues da Costa, Patricia Maria Abreu Machado, Ana Karina Teixeira da Cunha Franca, Alcione Miranda dos Santos
Summary: This psychometric study proposed a scale for estimating the consumption of ultra processed foods using item response theory. The study used data from a representative sample of 2515 adolescents aged 18 and 19 from Brazilian Birth Cohorts Consortium. The findings demonstrated that the proposed scale can accurately estimate the consumption of ultra processed foods and is correlated with latent traits related to food consumption.
Article
Nutrition & Dietetics
Dehao Yang, Jiaqi Huang, Jingyu Hu, Minyue Zhang, Haobo Xie, Yilin Chen, Yining Jin, Zerui Jiang, Yanchu Wang, Jinrong Zhu, Xin Lu, Siqi Chen, Yiyun Weng, Guangyong Chen
Summary: This study investigates the association between malnutrition and 6-month outcomes in acute ischemic stroke patients with or without intravenous thrombolysis. The results show a significant association between malnutrition and poor functional outcome.
Article
Nutrition & Dietetics
Ainoa Cristina de Oliveira Candido, Felipe Silva Neves, Vanessa Sequeira Fontes, Adriana Soares Torres Melo, Eliane Rodrigues de Faria, Michele Pereira Netto, Renata Maria Souza Oliveira, George Luiz Lins Machado-Coelho, Ana Paula Carlos Candido
Summary: This study investigated the frequency of breakfast consumption and its associations with the consumption of food at different degrees of industrial processing and with overweight indicators in Brazilian adolescents. The results showed that 20% of adolescents skipped breakfast and 46% of their caloric intake came from ultra-processed foods. Skipping breakfast was associated with increased consumption of ultra-processed foods, higher BMI-for-age, and higher body fat percentage.