In vivoevidence that eIF3 stays bound to ribosomes elongating and terminating on short upstream ORFs to promote reinitiation

Upstream ORFs are prevalent translational repressors in vertebrates

(2016) Timothy G Johnstone et al.   EMBO JOURNAL

In-depth analysis ofcis-determinants that either promote or inhibit reinitiation onGCN4mRNA after translation of its four short uORFs

(2016) Stanislava Gunišová et al.   RNA

Improved Ribosome-Footprint and mRNA Measurements Provide Insights into Dynamics and Regulation of Yeast Translation

(2016) David E. Weinberg et al.   Cell Reports

Eukaryotic translation initiation factor 3 plays distinct roles at the mRNA entry and exit channels of the ribosomal preinitiation complex

(2016) Colin Echeverría Aitken et al.   eLife

Ribosome profiling reveals the rhythmic liver translatome and circadian clock regulation by upstream open reading frames

(2015) Peggy Janich et al.   GENOME RESEARCH

Conformational Differences between Open and Closed States of the Eukaryotic Translation Initiation Complex

(2015) Jose L. Llácer et al.   MOLECULAR CELL

Structure of mammalian eIF3 in the context of the 43S preinitiation complex

(2015) Amedee des Georges et al.   NATURE

Structure of a Yeast 40S–eIF1–eIF1A–eIF3–eIF3j initiation complex

(2015) Christopher H S Aylett et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Translation initiation factor eIF3 promotes programmed stop codon readthrough

(2015) Petra Beznosková et al.   NUCLEIC ACIDS RESEARCH

Comprehensive translational control of tyrosine kinase expression by upstream open reading frames

(2015) K Wethmar et al.   ONCOGENE

Structure of a Yeast 40S–eIF1–eIF1A–eIF3–eIF3j initiation complex

(2015) Christopher H S Aylett et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Scanning Mechanism of Eukaryotic Translation Initiation

(2014) Alan G. Hinnebusch   Annual Review of Biochemistry

Structural integrity of the PCI domain of eIF3a/TIF32 is required for mRNA recruitment to the 43S pre-initiation complexes

(2014) Sohail Khoshnevis et al.   NUCLEIC ACIDS RESEARCH

Fail-safe mechanism of GCN4 translational control—uORF2 promotes reinitiation by analogous mechanism to uORF1 and thus secures its key role in GCN4 expression

(2014) Stanislava Gunišová et al.   NUCLEIC ACIDS RESEARCH

A single inhibitory upstream open reading frame (uORF) is sufficient to regulate Candida albicans GCN4 translation in response to amino acid starvation conditions

(2014) A. Sundaram et al.   RNA

The regulatory potential of upstream open reading frames in eukaryotic gene expression

(2014) Klaus Wethmar   Wiley Interdisciplinary Reviews-RNA

A perspective on mammalian upstream open reading frame function

(2013) Joanna Somers et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Human Eukaryotic Initiation Factor 4G (eIF4G) Protein Binds to eIF3c, -d, and -e to Promote mRNA Recruitment to the Ribosome

(2013) Nancy Villa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reinitiation and Other Unconventional Posttermination Events during Eukaryotic Translation

(2013) Maxim A. Skabkin et al.   MOLECULAR CELL

uORFdb—a comprehensive literature database on eukaryotic uORF biology

(2013) Klaus Wethmar et al.   NUCLEIC ACIDS RESEARCH

Translation Initiation Factors eIF3 and HCR1 Control Translation Termination and Stop Codon Read-Through in Yeast Cells

(2013) Petra Beznosková et al.   PLoS Genetics

Gene Expression Regulation by Upstream Open Reading Frames and Human Disease

(2013) Cristina Barbosa et al.   PLoS Genetics

‘Ribozoomin’ – Translation Initiation from the Perspective of the Ribosome-bound Eukaryotic Initiation Factors (eIFs)

(2012) Leos Shivaya Valasek   CURRENT PROTEIN & PEPTIDE SCIENCE

Small Ribosomal Protein RPS0 Stimulates Translation Initiation by Mediating 40S-Binding of eIF3 via Its Direct Contact with the eIF3a/TIF32 Subunit

(2012) Tomáš Kouba et al.   PLoS One

Global mapping of translation initiation sites in mammalian cells at single-nucleotide resolution

(2012) S. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation of eIF2 Facilitates Ribosomal Bypass of an Inhibitory Upstream ORF to EnhanceCHOPTranslation

(2011) Lakshmi Reddy Palam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Common conformational changes induced in type 2 picornavirus IRESs by cognate trans-acting factors

(2011) Y. Yu et al.   NUCLEIC ACIDS RESEARCH

High-Resolution View of the Yeast Meiotic Program Revealed by Ribosome Profiling

(2011) G. A. Brar et al.   SCIENCE

Translation Reinitiation Relies on the Interaction between eIF3a/TIF32 and Progressively Folded cis-Acting mRNA Elements Preceding Short uORFs

(2011) Vanda Munzarová et al.   PLoS Genetics

The C-Terminal Region of Eukaryotic Translation Initiation Factor 3a (eIF3a) Promotes mRNA Recruitment, Scanning, and, Together with eIF3j and the eIF3b RNA Recognition Motif, Selection of AUG Start Codons

(2010) W.-L. Chiu et al.   MOLECULAR AND CELLULAR BIOLOGY

Translational Regulation of Gene Expression during Conditions of Cell Stress

(2010) Keith A. Spriggs et al.   MOLECULAR CELL

Upstream sequence elements direct post-transcriptional regulation of gene expression under stress conditions in yeast

(2009) Craig Lawless et al.   BMC GENOMICS

An Upstream Open Reading Frame Regulates Translation of GADD34 during Cellular Stresses That Induce eIF2α Phosphorylation

(2009) Yun-Young Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Translational Control of Protein Kinase C  by Two Upstream Open Reading Frames

(2009) H. Raveh-Amit et al.   MOLECULAR AND CELLULAR BIOLOGY

Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans

(2009) S. E. Calvo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-Wide Analysis in Vivo of Translation with Nucleotide Resolution Using Ribosome Profiling

(2009) N. T. Ingolia et al.   SCIENCE

eIF3a cooperates with sequences 5' of uORF1 to promote resumption of scanning by post-termination ribosomes for reinitiation on GCN4 mRNA

(2008) B. Szamecz et al.   GENES & DEVELOPMENT