Single-molecule kinetic analysis of HP1-chromatin binding reveals a dynamic network of histone modification and DNA interactions

Structure and Dynamics of a 197 bp Nucleosome in Complex with Linker Histone H1

(2017) Jan Bednar et al.   MOLECULAR CELL

Phase separation drives heterochromatin domain formation

(2017) Amy R. Strom et al.   NATURE

Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin

(2017) Adam G. Larson et al.   NATURE

Single-Molecule Studies of the Linker Histone H1 Binding to DNA and the Nucleosome

(2016) Hongjun Yue et al.   BIOCHEMISTRY

Structural insights of nucleosome and the 30-nm chromatin fiber

(2016) Ping Zhu et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Modulations of DNA Contacts by Linker Histones and Post-translational Modifications Determine the Mobility and Modifiability of Nucleosomal H3 Tails

(2016) Alexandra Stützer et al.   MOLECULAR CELL

A two-state activation mechanism controls the histone methyltransferase Suv39h1

(2016) Manuel M Müller et al.   Nature Chemical Biology

A bromodomain–DNA interaction facilitates acetylation-dependent bivalent nucleosome recognition by the BET protein BRDT

(2016) Thomas C. R. Miller et al.   Nature Communications

Dynamic and flexible H3K9me3 bridging via HP1β dimerization establishes a plastic state of condensed chromatin

(2016) Kyoko Hiragami-Hamada et al.   Nature Communications

Extended string-like binding of the phosphorylated HP1α N-terminal tail to the lysine 9-methylated histone H3 tail

(2016) Hideaki Shimojo et al.   Scientific Reports

The H1 linker histones: multifunctional proteins beyond the nucleosomal core particle

(2015) S. P. Hergeth et al.   EMBO REPORTS

A Matlab toolbox for Global Sensitivity Analysis

(2015) Francesca Pianosi et al.   ENVIRONMENTAL MODELLING & SOFTWARE

Multivalency governs HP1α association dynamics with the silent chromatin state

(2015) Sinan Kilic et al.   Nature Communications

Subnucleosomal Structures and Nucleosome Asymmetry across a Genome

(2014) Ho Sung Rhee et al.   CELL

Human Heterochromatin Protein 1α Promotes Nucleosome Associations That Drive Chromatin Condensation

(2014) Abdelhamid M. Azzaz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

N-terminal phosphorylation of HP1α increases its nucleosome-binding specificity

(2014) Gohei Nishibuchi et al.   NUCLEIC ACIDS RESEARCH

Cryo-EM Study of the Chromatin Fiber Reveals a Double Helix Twisted by Tetranucleosomal Units

(2014) F. Song et al.   SCIENCE

Nucleosome-binding activities within JARID2 and EZH1 regulate the function of PRC2 on chromatin

(2013) J. Son et al.   GENES & DEVELOPMENT

Functional impact of Aurora A-mediated phosphorylation of HP1γ at serine 83 during cell cycle progression

(2013) Adrienne Grzenda et al.   Epigenetics & Chromatin

Asymmetrically Modified Nucleosomes

(2012) Philipp Voigt et al.   CELL

Streamlined Expressed Protein Ligation Using Split Inteins

(2012) Miquel Vila-Perelló et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

New insights into nucleosome and chromatin structure: an ordered state or a disordered affair?

(2012) Karolin Luger et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Direct Method for Site-Specific Protein Acetylation

(2011) Fupeng Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Detection of Steps in Single Molecule Data

(2011) Tanuj Aggarwal et al.   Cellular and Molecular Bioengineering

Parameter Estimation Using Metaheuristics in Systems Biology: A Comprehensive Review

(2011) Jianyong Sun et al.   IEEE-ACM Transactions on Computational Biology and Bioinformatics

N-Terminal Phosphorylation of HP1  Promotes Its Chromatin Binding

(2011) K. Hiragami-Hamada et al.   MOLECULAR AND CELLULAR BIOLOGY

Chromodomain-Mediated Oligomerization of HP1 Suggests a Nucleosome-Bridging Mechanism for Heterochromatin Assembly

(2011) Daniele Canzio et al.   MOLECULAR CELL

Histone H2B ubiquitylation disrupts local and higher-order chromatin compaction

(2011) Beat Fierz et al.   Nature Chemical Biology

The Chromatin Signaling Pathway: Diverse Mechanisms of Recruitment of Histone-Modifying Enzymes and Varied Biological Outcomes

(2010) Edwin Smith et al.   MOLECULAR CELL

The effects of histone H4 tail acetylations on cation-induced chromatin folding and self-association

(2010) Abdollah Allahverdi et al.   NUCLEIC ACIDS RESEARCH

Identification of Functional Elements and Regulatory Circuits by Drosophila modENCODE

(2010) et al.   SCIENCE

HP1γ function is required for male germ cell survival and spermatogenesis

(2010) Jeremy P Brown et al.   Epigenetics & Chromatin

Multiscale Analysis of Dynamics and Interactions of Heterochromatin Protein 1 by Fluorescence Fluctuation Microscopy

(2009) Katharina P. Müller et al.   BIOPHYSICAL JOURNAL

Quantitative Transcription Factor Binding Kinetics at the Single-Molecule Level

(2009) Yufang Wang et al.   BIOPHYSICAL JOURNAL

Heterochromatin Protein 1 Is Extensively Decorated with Histone Code-like Post-translational Modifications

(2009) Gary LeRoy et al.   MOLECULAR & CELLULAR PROTEOMICS

HP1-β mobilization promotes chromatin changes that initiate the DNA damage response

(2008) Nabieh Ayoub et al.   NATURE

Nucleosome repeat length and linker histone stoichiometry determine chromatin fiber structure

(2008) Andrew Routh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA