Cancer-causing mutations in the tumor suppressor PALB2 reveal a novel cancer mechanism using a hidden nuclear export signal in the WD40 repeat motif

Roles for APRIN (PDS5B) in homologous recombination and in ovarian cancer prediction

(2016) Anthony M. Couturier et al.   NUCLEIC ACIDS RESEARCH

A mechanism for the suppression of homologous recombination in G1 cells

(2015) Alexandre Orthwein et al.   NATURE

Nuclear domain ‘knock-in’ screen for the evaluation and identification of small molecule enhancers of CRISPR-based genome editing

(2015) Jordan Pinder et al.   NUCLEIC ACIDS RESEARCH

Selective inhibitors of nuclear export (SINE) as novel therapeutics for prostate cancer

(2015) Janet Mendonca et al.   Oncotarget

Exploring the roles of PALB2 at the crossroads of DNA repair and cancer

(2014) Joris Pauty et al.   BIOCHEMICAL JOURNAL

Nucleo-cytoplasmic transport as a therapeutic target of cancer

(2014) Giovanni Luca Gravina et al.   Journal of Hematology & Oncology

Breast-Cancer Risk in Families with Mutations in PALB2

(2014) Antonis C. Antoniou et al.   NEW ENGLAND JOURNAL OF MEDICINE

SMART: recent updates, new developments and status in 2015

(2014) Ivica Letunic et al.   NUCLEIC ACIDS RESEARCH

Breast Cancer Proteins PALB2 and BRCA2 Stimulate Polymerase η in Recombination-Associated DNA Synthesis at Blocked Replication Forks

(2014) Rémi Buisson et al.   Cell Reports

A cancer-associated BRCA2 mutation reveals masked nuclear export signals controlling localization

(2013) Anand D Jeyasekharan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair

(2013) J-Y Park et al.   ONCOGENE

PALB2 Interacts with KEAP1 To Promote NRF2 Nuclear Accumulation and Function

(2012) J. Ma et al.   MOLECULAR AND CELLULAR BIOLOGY

Sequence and structural analyses of nuclear export signals in the NESdb database

(2012) Darui Xu et al.   MOLECULAR BIOLOGY OF THE CELL

PALB2 self-interaction controls homologous recombination

(2012) Rémi Buisson et al.   NUCLEIC ACIDS RESEARCH

ChAM, a novel motif that mediates PALB2 intrinsic chromatin binding and facilitates DNA repair

(2011) Jean-Yves Bleuyard et al.   EMBO REPORTS

PALB2 mutations in familial breast and pancreatic cancer

(2011) Erin W. Hofstatter et al.   Familial Cancer

Germline mutations in the PALB2 gene are population specific and occur with low frequencies in familial breast cancer

(2011) Heide Hellebrand et al.   HUMAN MUTATION

Protein localization in disease and therapy

(2011) M.-C. Hung et al.   JOURNAL OF CELL SCIENCE

Structure and function of WD40 domain proteins

(2011) Chao Xu et al.   Protein & Cell

A novel germline PALB2 deletion in Polish breast and ovarian cancer patients

(2010) Agnieszka Dansonka-Mieszkowska et al.   BMC Medical Genetics

NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1

(2010) Thomas Güttler et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombination

(2010) Rémi Buisson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2

(2010) Eloïse Dray et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

WD40 proteins propel cellular networks

(2010) Christian U. Stirnimann et al.   TRENDS IN BIOCHEMICAL SCIENCES

PALB2 Links BRCA1 and BRCA2 in the DNA-Damage Response

(2009) Feng Zhang et al.   CURRENT BIOLOGY

Structural basis for recruitment of BRCA2 by PALB2

(2009) Antony W Oliver et al.   EMBO REPORTS

PALB2 Regulates Recombinational Repair through Chromatin Association and Oligomerization

(2009) Shirley M.-H. Sy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PALB2 Functionally Connects the Breast Cancer Susceptibility Proteins BRCA1 and BRCA2

(2009) F. Zhang et al.   MOLECULAR CANCER RESEARCH

PALB2 is an integral component of the BRCA complex required for homologous recombination repair

(2009) S. M. H. Sy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA