MutSβ abundance and Msh3 ATP hydrolysis activity are important drivers of CTG•CAG repeat expansions

A polymorphism in the MSH3 mismatch repair gene is associated with the levels of somatic instability of the expanded CTG repeat in the blood DNA of myotonic dystrophy type 1 patients

(2016) Fernando Morales et al.   DNA REPAIR

Absence of MutSβ leads to the formation of slipped-DNA for CTG/CAG contractions at primate replication forks

(2016) Meghan M. Slean et al.   DNA REPAIR

A MutSβ-Dependent Contribution of MutSα to Repeat Expansions in Fragile X Premutation Mice?

(2016) Xiao-Nan Zhao et al.   PLoS Genetics

The Repeat Expansion Diseases: The dark side of DNA repair

(2015) Xiao-Nan Zhao et al.   DNA REPAIR

MSH3 Promotes Dynamic Behavior of Trinucleotide Repeat Tracts In Vivo

(2015) Gregory M. Williams et al.   GENETICS

MSH3 Promotes Dynamic Behavior of Trinucleotide Repeat Tracts In Vivo

(2015) Gregory M. Williams et al.   GENETICS

Length-dependent CTG{middle dot}CAG triplet-repeat expansion in myotonic dystrophy patient-derived induced pluripotent stem cells

(2013) J. Du et al.   HUMAN MOLECULAR GENETICS

The Mismatch Repair Protein MSH2 is Rate Limiting for Repeat Expansion in a Fragile X Premutation Mouse Model

(2013) Rachel Adihe Lokanga et al.   HUMAN MUTATION

Mismatch Repair Genes Mlh1 and Mlh3 Modify CAG Instability in Huntington's Disease Mice: Genome-Wide and Candidate Approaches

(2013) Ricardo Mouro Pinto et al.   PLoS Genetics

MSH3 Polymorphisms and Protein Levels Affect CAG Repeat Instability in Huntington's Disease Mice

(2013) Stéphanie Tomé et al.   PLoS Genetics

MutSβ and histone deacetylase complexes promote expansions of trinucleotide repeats in human cells

(2012) Anne-Marie M. Gannon et al.   NUCLEIC ACIDS RESEARCH

Msh2-Msh3 Interferes with Okazaki Fragment Processing to Promote Trinucleotide Repeat Expansions

(2012) Athena Kantartzis et al.   Cell Reports

Histone Deacetylase Complexes Promote Trinucleotide Repeat Expansions

(2012) Kim Debacker et al.   PLOS BIOLOGY

MSH3 Mediates Sensitization of Colorectal Cancer Cells to Cisplatin, Oxaliplatin, and a Poly(ADP-ribose) Polymerase Inhibitor

(2011) Masanobu Takahashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanism of mismatch recognition revealed by human MutSβ bound to unpaired DNA loops

(2011) Shikha Gupta et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Conformational trapping of Mismatch Recognition Complex MSH2/MSH3 on repair-resistant DNA loops

(2011) W. H. Lang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of trinucleotide repeat instability during human development

(2010) Cynthia T. McMurray   NATURE REVIEWS GENETICS

Repeat instability as the basis for human diseases and as a potential target for therapy

(2010) Arturo López Castel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A distinct first replication cycle of DNA introduced in mammalian cells

(2010) G. S. Chandok et al.   NUCLEIC ACIDS RESEARCH

Distinct Nucleotide Binding/Hydrolysis Properties and Molar Ratio of MutSα and MutSβ Determine Their Differential Mismatch Binding Activities

(2009) Lei Tian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MSH2 ATPase Domain Mutation Affects CTG•CAG Repeat Instability in Transgenic Mice

(2009) Stéphanie Tomé et al.   PLoS Genetics

Intergenerational and striatal CAG repeat instability in Huntington's disease knock-in mice involve different DNA repair genes

(2008) Ella Dragileva et al.   NEUROBIOLOGY OF DISEASE