Abasic and oxidized ribonucleotides embedded in DNA are processed by human APE1 and not by RNase H2

Defining the RNaseH2 enzyme-initiated ribonucleotide excision repair pathway in Archaea

(2017) Margaret R. Heider et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quality control of chemically damaged RNA

(2016) Carrie L. Simms et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Structural Impact of Single Ribonucleotide Residues in DNA

(2016) Marina Evich et al.   CHEMBIOCHEM

Processing ribonucleotides incorporated during eukaryotic DNA replication

(2016) Jessica S. Williams et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Impact of ribonucleotide incorporation by DNA polymerases β and λ on oxidative base excision repair

(2016) Emmanuele Crespan et al.   Nature Communications

Analysis of Ribonucleotide Removal from DNA by Human Nucleotide Excision Repair

(2015) Laura A. Lindsey-Boltz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Formation and Repair of Mismatches Containing Ribonucleotides and Oxidized Bases at Repeated DNA Sequences

(2015) Piera Cilli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human Apurinic/Apyrimidinic Endonuclease 1 (APE1) Has 3′ RNA Phosphatase and 3′ Exoribonuclease Activities

(2015) Manbir Chohan et al.   JOURNAL OF MOLECULAR BIOLOGY

Inhibitors of the apurinic/apyrimidinic endonuclease 1 (APE1)/nucleophosmin (NPM1) interaction that display anti-tumor properties

(2015) Mattia Poletto et al.   MOLECULAR CARCINOGENESIS

Ribonucleotides in DNA: Origins, repair and consequences

(2014) Jessica S. Williams et al.   DNA REPAIR

RNA intrusions change DNA elastic properties and structure

(2014) Hsiang-Chih Chiu et al.   Nanoscale

Avoidance of ribonucleotide-induced mutations by RNase H2 and Srs2-Exo1 mechanisms

(2014) Catherine J. Potenski et al.   NATURE

ATP insertion opposite 8-oxo-deoxyguanosine by Pol4 mediates error-free tolerance in Schizosaccharomyces pombe

(2014) Guillermo Sastre-Moreno et al.   NUCLEIC ACIDS RESEARCH

Mycobacterium smegmatis DinB2 misincorporates deoxyribonucleotides and ribonucleotides during templated synthesis and lesion bypass

(2014) Heather Ordonez et al.   NUCLEIC ACIDS RESEARCH

Prognostic Value of Human Apurinic/Apyrimidinic Endonuclease 1 (APE1) Expression in Breast Cancer

(2014) Joohyun Woo et al.   PLoS One

Ribose--An Internal Threat to DNA

(2014) K. W. Caldecott   SCIENCE

Human Apurinic/Apyrimidinic Endonuclease 1

(2013) Mengxia Li et al.   ANTIOXIDANTS & REDOX SIGNALING

Synonymous Mutations inRNASEH2ACreate Cryptic Splice Sites Impairing RNase H2 Enzyme Function in Aicardi-Goutières Syndrome

(2013) Gillian I. Rice et al.   HUMAN MUTATION

Topoisomerase 1-Mediated Removal of Ribonucleotides from Nascent Leading-Strand DNA

(2013) Jessica S. Williams et al.   MOLECULAR CELL

RNase H2 roles in genome integrity revealed by unlinking its activities

(2013) Hyongi Chon et al.   NUCLEIC ACIDS RESEARCH

Uracil in duplex DNA is a substrate for the nucleotide incision repair pathway in human cells

(2013) P. Prorok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insight into mechanisms of 3'-5' exonuclease activity and removal of bulky 8,5'-cyclopurine adducts by apurinic/apyrimidinic endonucleases

(2013) A. Mazouzi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Removal of Misincorporated Ribonucleotides from Prokaryotic Genomes: An Unexpected Role for Nucleotide Excision Repair

(2013) Alexandra Vaisman et al.   PLoS Genetics

Enzymatic Removal of Ribonucleotides from DNA Is Essential for Mammalian Genome Integrity and Development

(2012) Martin A.M. Reijns et al.   CELL

Ribonucleotide incorporation, proofreading and bypass by human DNA polymerase δ

(2012) Anders R. Clausen et al.   DNA REPAIR

Mammalian RNase H2 removes ribonucleotides from DNA to maintain genome integrity

(2012) Bjoern Hiller et al.   JOURNAL OF EXPERIMENTAL MEDICINE

RNase H2-Initiated Ribonucleotide Excision Repair

(2012) Justin L. Sparks et al.   MOLECULAR CELL

The DNA Damage Response Induces IFN

(2011) Sabrina Brzostek-Racine et al.   JOURNAL OF IMMUNOLOGY

Repair of persistent strand breaks in the mitochondrial genome

(2011) Peter Sykora et al.   MECHANISMS OF AGEING AND DEVELOPMENT

USP47 Is a Deubiquitylating Enzyme that Regulates Base Excision Repair by Controlling Steady-State Levels of DNA Polymerase β

(2011) Jason L. Parsons et al.   MOLECULAR CELL

RNA-driven genetic changes in bacteria and in human cells

(2011) Ying Shen et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Mispaired rNMPs in DNA are mutagenic and are targets of mismatch repair and RNases H

(2011) Ying Shen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mutagenic Processing of Ribonucleotides in DNA by Yeast Topoisomerase I

(2011) N. Kim et al.   SCIENCE

Human apurinic/apyrimidinic endonuclease (APE1) is a prognostic factor in ovarian, gastro-oesophageal and pancreatico-biliary cancers

(2010) A Al-Attar et al.   BRITISH JOURNAL OF CANCER

Crystal Structures of RNase H2 in Complex with Nucleic Acid Reveal the Mechanism of RNA-DNA Junction Recognition and Cleavage

(2010) Monika P. Rychlik et al.   MOLECULAR CELL

Critical lysine residues within the overlooked N-terminal domain of human APE1 regulate its biological functions

(2010) Damiano Fantini et al.   NUCLEIC ACIDS RESEARCH

Abundant ribonucleotide incorporation into DNA by yeast replicative polymerases

(2010) S. A. Nick McElhinny et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ribonuclease H: the enzymes in eukaryotes

(2009) Susana M. Cerritelli et al.   FEBS Journal

Intrusion of a DNA Repair Protein in the RNome World: Is This the Beginning of a New Era?

(2009) G. Tell et al.   MOLECULAR AND CELLULAR BIOLOGY

APE1/Ref-1 Interacts with NPM1 within Nucleoli and Plays a Role in the rRNA Quality Control Process

(2009) C. Vascotto et al.   MOLECULAR AND CELLULAR BIOLOGY

Identification of Apurinic/apyrimidinic endonuclease 1 (APE1) as the endoribonuclease that cleaves c-myc mRNA

(2009) T. Barnes et al.   NUCLEIC ACIDS RESEARCH

Genome-wide analysis and proteomic studies reveal APE1/Ref-1 multifunctional role in mammalian cells

(2009) Carlo Vascotto et al.   PROTEOMICS

Nucleic acid oxidation in Alzheimer disease

(2008) Paula I. Moreira et al.   FREE RADICAL BIOLOGY AND MEDICINE

Characterization of Abasic Endonuclease Activity of Human Ape1 on Alternative Substrates, as Well as Effects of ATP and Sequence Context on AP Site Incision

(2008) Brian R. Berquist et al.   JOURNAL OF MOLECULAR BIOLOGY

Contributions of the two accessory subunits, RNASEH2B and RNASEH2C, to the activity and properties of the human RNase H2 complex

(2008) Hyongi Chon et al.   NUCLEIC ACIDS RESEARCH