CXCL12/CXCR4/CXCR7 Chemokine Axis in the Central Nervous System: Therapeutic Targets for Remyelination in Demyelinating Diseases

Blood–brain barrier and blood–cerebrospinal fluid barrier in normal and pathological conditions

(2016) Masaki Ueno et al.   Brain Tumor Pathology

New insights into the role of stromal cell-derived factor 1 (SDF-1/CXCL12) in the pathophysiology of multiple sclerosis

(2016) Hossein Khorramdelazad et al.   JOURNAL OF NEUROIMMUNOLOGY

Post-CNS-inflammation expression of CXCL12 promotes the endogenous myelin/neuronal repair capacity following spontaneous recovery from multiple sclerosis-like disease

(2016) Rina Zilkha-Falb et al.   Journal of Neuroinflammation

CXCR7 Is Involved in Human Oligodendroglial Precursor Cell Maturation

(2016) David Kremer et al.   PLoS One

Oligodendrocyte precursors migrate along vasculature in the developing nervous system

(2016) H.-H. Tsai et al.   SCIENCE

Reduced perfusion in white matter lesions in multiple sclerosis

(2015) Piotr Sowa et al.   EUROPEAN JOURNAL OF RADIOLOGY

Pattern of CXCR7 Gene Expression in Mouse Brain Under Normal and Inflammatory Conditions

(2015) Ghazal Banisadr et al.   Journal of Neuroimmune Pharmacology

Anatomy and physiology of the blood–brain barrier

(2015) Yonatan Serlin et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

CXCR7 Mediates Neural Progenitor Cells Migration to CXCL12 Independent of CXCR4

(2015) Qiang Chen et al.   STEM CELLS

Diversity and Inter-Connections in the CXCR4 Chemokine Receptor/Ligand Family: Molecular Perspectives

(2015) Lukas Pawig et al.   Frontiers in Immunology

Astrocyte transplantation for spinal cord injury: Current status and perspective

(2014) Tianci Chu et al.   BRAIN RESEARCH BULLETIN

Oligodendrocyte-Encoded HIF Function Couples Postnatal Myelination and White Matter Angiogenesis

(2014) Tracy J. Yuen et al.   CELL

Targeting CXCR7/ACKR3 as a therapeutic strategy to promote remyelination in the adult central nervous system

(2014) Jessica L. Williams et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Insufficient OPC migration into demyelinated lesions is a cause of poor remyelination in MS and mouse models

(2013) Amanda Boyd et al.   ACTA NEUROPATHOLOGICA

The peculiarities of the SDF-1/CXCL12 system: in some cells, CXCR4 and CXCR7 sing solos, in others, they sing duets

(2013) Malte Puchert et al.   CELL AND TISSUE RESEARCH

Regulation of oligodendrocyte precursor migration during development, in adulthood and in pathology

(2013) Fernando de Castro et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Myelin loss and oligodendrocyte pathology in white matter tracts following traumatic brain injury in the rat

(2013) J. Flygt et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

CXCR4 signaling regulates radial glial morphology and cell fate during embryonic spinal cord development

(2013) Divakar S. Mithal et al.   GLIA

Remyelination: The True Regeneration of the Central Nervous System

(2013) A.H. Crawford et al.   JOURNAL OF COMPARATIVE PATHOLOGY

The CXCL12/CXCR4/CXCR7 ligand-receptor system regulates neuro-glio-vascular interactions and vessel growth during human brain development

(2013) Daniela Virgintino et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Towards Clinical Application of Mesenchymal Stem Cells for Treatment of Neurological Diseases of the Central Nervous System

(2013) Alice Laroni et al.   Journal of Neuroimmune Pharmacology

CXCL12-Mediated Murine Neural Progenitor Cell Movement Requires PI3Kβ Activation

(2013) Borja L. Holgado et al.   MOLECULAR NEUROBIOLOGY

Neural Stem Cells: Generating and Regenerating the Brain

(2013) Fred H. Gage et al.   NEURON

Chemokine CXCL12 and its receptors in the developing central nervous system: Emerging themes and future perspectives

(2012) Yan Zhu et al.   Developmental Neurobiology

The biochemistry and biology of the atypical chemokine receptors

(2012) G.J. Graham et al.   IMMUNOLOGY LETTERS

CXCL12 Signaling in the Development of the Nervous System

(2012) Divakar S. Mithal et al.   Journal of Neuroimmune Pharmacology

The Energetics of CNS White Matter

(2012) J. J. Harris et al.   JOURNAL OF NEUROSCIENCE

Overexpression of CXCR4 in mesenchymal stem cells promotes migration, neuroprotection and angiogenesis in a rat model of stroke

(2012) Xiaolan Yu et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Mesenchymal stem cells as treatment for MS – progress to date

(2012) Antonio Uccelli et al.   Multiple Sclerosis Journal

Progressive multiple sclerosis: pathology and pathogenesis

(2012) Hans Lassmann et al.   Nature Reviews Neurology

Microfluidic Investigation of BDNF-Enhanced Neural Stem Cell Chemotaxis in CXCL12 Gradients

(2012) Hui Xu et al.   Small

CXCR7 impact on CXCL12 biology and disease

(2012) Lorena Sánchez-Martín et al.   TRENDS IN MOLECULAR MEDICINE

Concise Review: The Potential of Stromal Cell-Derived Factor 1 and Its Receptors to Promote Stem Cell Functions in Spinal Cord Repair

(2012) Anne Jaerve et al.   Stem Cells Translational Medicine

Computational Protein Design to Reengineer Stromal Cell-Derived Factor-1  Generates an Effective and Translatable Angiogenic Polypeptide Analog

(2011) W. Hiesinger et al.   CIRCULATION

Atypical chemokine receptors

(2011) Maria Helena Ulvmar et al.   EXPERIMENTAL CELL RESEARCH

CXCR4 signaling regulates remyelination by endogenous oligodendrocyte progenitor cells in a viral model of demyelination

(2011) Kevin S. Carbajal et al.   GLIA

The presumed atypical chemokine receptor CXCR7 signals through Gi/o proteins in primary rodent astrocytes and human glioma cells

(2011) Veysel Ödemis et al.   GLIA

CXCR7/CXCR4 Heterodimer Constitutively Recruits β-Arrestin to Enhance Cell Migration

(2011) Fabien M. Décaillot et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CXCR7 influences leukocyte entry into the CNS parenchyma by controlling abluminal CXCL12 abundance during autoimmunity

(2011) Lillian Cruz-Orengo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Vascular Gene Transfer of SDF-1 Promotes Endothelial Progenitor Cell Engraftment and Enhances Angiogenesis in Ischemic Muscle

(2011) Michael A Kuliszewski et al.   MOLECULAR THERAPY

Cxcr7 Controls Neuronal Migration by Regulating Chemokine Responsiveness

(2011) Juan Antonio Sánchez-Alcañiz et al.   NEURON

Reelin Controls Progenitor Cell Migration in the Healthy and Pathological Adult Mouse Brain

(2011) Sandrine Courtès et al.   PLoS One

The mesenchymal stem cells in multiple sclerosis (MSCIMS) trial protocol and baseline cohort characteristics: an open-label pre-test: post-test study with blinded outcome assessments

(2011) Peter Connick et al.   Trials

The CXCR4 Antagonist AMD3100 Has Dual Effects on Survival and Proliferation of Myeloma CellsIn Vitro

(2011) Ha-Yon Kim et al.   Cancer Research and Treatment

Longterm quiescent cells in the aged human subventricular neurogenic system specifically express GFAP-δ

(2010) Simone A. Van Den Berge et al.   AGING CELL

Activation of CXCR7 receptor promotes oligodendroglial cell maturation

(2010) Peter Göttle et al.   ANNALS OF NEUROLOGY

Safety and Immunological Effects of Mesenchymal Stem Cell Transplantation in Patients With Multiple Sclerosis and Amyotrophic Lateral Sclerosis

(2010) Dimitrios Karussis et al.   ARCHIVES OF NEUROLOGY

Demyelination versus remyelination in progressive multiple sclerosis

(2010) Stephan Bramow et al.   BRAIN

CXCL12 / CXCR4 / CXCR7 chemokine axis and cancer progression

(2010) Xueqing Sun et al.   CANCER AND METASTASIS REVIEWS

Continuous Delivery of Stromal Cell-Derived Factor-1 from Alginate Scaffolds Accelerates Wound Healing

(2010) Sina Y. Rabbany et al.   CELL TRANSPLANTATION

Update on clinical experience with AMD3100, an SDF-1/CXCL12–CXCR4 inhibitor, in mobilization of hematopoietic stem and progenitor cells

(2010) Iskra Pusic et al.   CURRENT OPINION IN HEMATOLOGY

CXCR7 is an active component of SDF-1 signalling in astrocytes and Schwann cells

(2010) V. Odemis et al.   JOURNAL OF CELL SCIENCE

Lipid metabolism in myelinating glial cells: lessons from human inherited disorders and mouse models

(2010) Roman Chrast et al.   JOURNAL OF LIPID RESEARCH

Expression and Effects of Hyaluronan and of the Hyaluronan-Binding Protein Hyaluronectin in Newborn Rat Brain Glial Cell Cultures

(2010) Stéphane Marret et al.   JOURNAL OF NEUROCHEMISTRY

Myelination and support of axonal integrity by glia

(2010) Klaus-Armin Nave   NATURE

Constitutive and chemokine-dependent internalization and recycling of CXCR7 in breast cancer cells to degrade chemokine ligands

(2010) K E Luker et al.   ONCOGENE

Migration of engrafted neural stem cells is mediated by CXCL12 signaling through CXCR4 in a viral model of multiple sclerosis

(2010) K. S. Carbajal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hyaluronan blocks oligodendrocyte progenitor maturation and remyelination through TLR2

(2010) J. A. Sloane et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CXCR4 promotes differentiation of oligodendrocyte progenitors and remyelination

(2010) J. R. Patel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential Regulation of Proliferation and Differentiation in Neural Precursor Cells by the Jak Pathway

(2010) Yun Hee Kim et al.   STEM CELLS

Functional diversity of SDF-1 splicing variants

(2010) Miroslaw Janowski   Cell Adhesion & Migration

Imaging Correlates of Leukocyte Accumulation and CXCR4/CXCL12 in Multiple Sclerosis

(2009) Natalia M. Moll et al.   ARCHIVES OF NEUROLOGY

CXCR7 heterodimerizes with CXCR4 and regulates CXCL12-mediated G protein signaling

(2009) A. Levoye et al.   BLOOD

D6 and the atypical chemokine receptor family: Novel regulators of immune and inflammatory processes

(2009) Gerard J. Graham   EUROPEAN JOURNAL OF IMMUNOLOGY

CXCL12 increases human neural progenitor cell proliferation through Akt-1/FOXO3a signaling pathway

(2009) Yumei Wu et al.   JOURNAL OF NEUROCHEMISTRY

Remyelination capacity of the MS brain decreases with disease chronicity

(2009) T. Goldschmidt et al.   NEUROLOGY

 -arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7

(2009) S. Rajagopal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Notch1 signaling plays a role in regulating precursor differentiation during CNS remyelination

(2009) Yueting Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heterologous quaternary structure of CXCL12 and its relationship to the CC chemokine family

(2009) James W. Murphy et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Pathological Expression of CXCL12 at the Blood-Brain Barrier Correlates with Severity of Multiple Sclerosis

(2008) Erin E. McCandless et al.   AMERICAN JOURNAL OF PATHOLOGY

Multiple Sclerosis: An Immune or Neurodegenerative Disorder?

(2008) Bruce D. Trapp et al.   Annual Review of Neuroscience

Differentiation block of oligodendroglial progenitor cells as a cause for remyelination failure in chronic multiple sclerosis

(2008) T. Kuhlmann et al.   BRAIN

Control of Chemokine-Guided Cell Migration by Ligand Sequestration

(2008) Bijan Boldajipour et al.   CELL

Enhanced expression of the CXCl12/SDF-1 chemokine receptor CXCR7 after cerebral ischemia in the rat brain

(2008) Bastian Schönemeier et al.   JOURNAL OF NEUROIMMUNOLOGY

SDF-1 stimulates neurite growth on inhibitory CNS myelin

(2008) Jessica Opatz et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Chemokines and leukocyte traffic

(2008) Federica Sallusto et al.   NATURE IMMUNOLOGY

Remyelination in the CNS: from biology to therapy

(2008) Robin J. M. Franklin et al.   NATURE REVIEWS NEUROSCIENCE

Intranasal HB-EGF administration favors adult SVZ cell mobilization to demyelinated lesions in mouse corpus callosum

(2007) Cristina Cantarella et al.   Developmental Neurobiology

The therapeutic plasticity of neural stem/precursor cells in multiple sclerosis

(2007) Stefano Pluchino et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Multiple roles of chemokine CXCL12 in the central nervous system: A migration from immunology to neurobiology

(2007) M LI et al.   PROGRESS IN NEUROBIOLOGY