Article
Pharmacology & Pharmacy
Vittoria Borgonetti, Nicoletta Galeotti
Summary: Combining HDAC and BET inhibitors can effectively alleviate pain sensitivity in a mouse model of neuropathic pain and inhibit neuroinflammation in the spinal cord. This combination therapy shows potential as a new therapeutic option for targeting neuropathic pain.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Immunology
Ao Guo, Jingfan Li, Lan Luo, Chunyi Chen, Qing Lu, Jianjuan Ke, Xiaobo Feng
Summary: This study shows that VPA alleviates neuropathic pain by suppressing proinflammatory cytokines, promoting M2 microglial polarization, reducing spinal cell apoptosis, and regulating the STAT1/NF-kappa B and JAK2/STAT3 signaling pathways to modulate microglial function and suppress spinal neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Waimei Si, Xin Li, Bei Jing, Shiquan Chang, Yachun Zheng, Zhenni Chen, Guoping Zhao, Di Zhang
Summary: This study investigates the potential therapeutic use of stigmasterol for treating neuropathic pain. It finds that stigmasterol can regulate microglial M1/M2 polarization to alleviate neuropathic pain. The research demonstrates the modulatory effects of stigmasterol on pain-related markers and inflammatory factors in animal and cell experiments.
PHYTOTHERAPY RESEARCH
(2023)
Article
Neurosciences
Jiang Bian, Bangjian Zhang, Ying Zhang, Yunyun Tian, Li Yin, Wanyun Zou
Summary: The study demonstrates the role of Fibroblast Growth Factor 10 (FGF 10) in neuropathic pain and its underlying mechanisms. FGF 10 is shown to suppress microglial polarization and relieve hyperalgesia in rats with peripheral nerve injury. The study also reveals the involvement of PPAR-gamma/NF kappa B signaling in FGF 10-regulated anti-microgliosis. These findings highlight the potential of FGF 10 as a therapeutic target for neuropathic pain.
Article
Cell Biology
Jianjian Dong, Xun Wang, Chenchen Xu, Manli Gao, Shijing Wang, Jin Zhang, Haiyang Tong, Lulu Wang, Yongzhu Han, Nan Cheng, Yongsheng Han
Summary: The study demonstrates that copper-mediated neuroinflammation is associated with the activation of the NLRP3 inflammasome, contributing to progressive neuropathology in a murine model of WD. Blocking the activation of the NLRP3 inflammasome effectively mitigates cognitive decline, locomotor behavior impairment, and neurodegeneration in the mice.
CELL DEATH & DISEASE
(2021)
Article
Plant Sciences
Yu-cheng Liao, Jing-wen Wang, Juan-li Zhang, Chao Guo, Xin-liang Xu, Kai Wang, Chao Zhao, Ai-dong Wen, Rui-li Li, Yi Ding
Summary: QFZTC contains seven active ingredients identified through HPLC, with network pharmacology analysis revealing TLR4, TNF, IL6, IL1 beta, and c-Fos as core targets. Through regulating the TLR4/MyD88/NF-kappa B signaling pathway in spinal microglia, QFZTC significantly alleviated neuropathic pain in mice models.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Pathanin Chantree, Pongsakorn Martviset, Nattaya Thongsepee, Kant Sangpairoj, Phornphan Sornchuer
Summary: This study investigated the anti-inflammatory effect of garcinol isolated from Garcinia dulcis fruit in LPS-activated THP-1 and Raw 264.7 macrophages. The results showed that garcinol inhibited the production of pro-inflammatory cytokines and mediators and affected the NF-kappa B signaling pathway. Therefore, garcinol has the potential to be used as an anti-inflammatory agent for inflammation-related diseases.
Article
Chemistry, Medicinal
Yuyan Bai, Jin Zhou, Han Zhu, Yanlin Tao, Lupeng Wang, Liu Yang, Hui Wu, Fei Huang, Hailian Shi, Xiaojun Wu
Summary: This study found that Isoliquiritigenin (ISL) can inhibit microglia-mediated neuroinflammation in Parkinson's disease (PD) by deactivating JNK/AKT/NFκB signaling pathways. These findings suggest the therapeutic potential of ISL for microglia-mediated neuroinflammation in PD.
PHYTOTHERAPY RESEARCH
(2023)
Article
Immunology
Kazue Hisaoka-Nakashima, Kodai Moriwaki, Natsuki Yoshimoto, Toshiki Yoshii, Yoki Nakamura, Yukio Ago, Norimitsu Morioka
Summary: Neuropathic pain causes severe pain and comorbidities such as cognitive impairment, which are not effectively treated with current analgesics. This study demonstrates the role of interleukin-6 (IL-6) in neuropathic pain and cognitive impairment. Blocking the IL-6 receptor improves cognitive impairment, while inhibiting IL-6 activity reduces allodynia.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Clinical Neurology
Vittoria Borgonetti, Elisabetta Meacci, Federica Pierucci, Maria Novella Romanelli, Nicoletta Galeotti
Summary: Studies have shown that the combination of HDAC and BET inhibitors can have synergistic effects in neuropathic pain treatment. The new dual HDAC/BRD4 inhibitors, SUM52 and SUM35, administered through intranasal administration, can alleviate thermal and mechanical hypersensitivity and reduce inflammation and pro-inflammatory cytokines.
Article
Neurosciences
Philippa Malko, Xiaoling Jia, Ian Wood, Lin-Hua Jiang
Summary: Microglial cell function and inflammation are regulated by the activation of Piezo1 channel. This study found that the activation of Piezo1 channel can inhibit the pro-inflammatory activation and production of pro-inflammatory cytokines in microglial cells by initiating intracellular Ca2+ signaling to inhibit the NF-kappa B inflammatory signaling pathway.
Article
Pharmacology & Pharmacy
Xue-Fei Wu, Chun Li, Guang Yang, Ying-Zi Wang, Yan Peng, Dan-Dan Zhu, Ao-Ran Sui, Qiong Wu, Qi-Fa Li, Bin Wang, Na Li, Yue Zhang, Bi-Ying Ge, Jie Zhao, Shao Li
Summary: The study demonstrates that SVHRP can inhibit neuroinflammation and microglia activation, potentially explaining the therapeutic effects of BmK-derived materials and suggesting that BmK venom could be a potential source for CNS drug development.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Yoshinori Aoki, Hongmei Dai, Fumika Furuta, Tomohisa Akamatsu, Takuya Oshima, Naoto Takahashi, Yu-ichi Goto, Akira Oka, Masayuki Itoh
Summary: Microglial cells have an important role in the brain's immune system. LOX-1 expression was confirmed in microglial cells in the neonatal hypoxic-ischemic encephalopathy model brain. LOX-1 activates cytokines and chemokines through intracellular pathways. This study investigated the role and molecular mechanism of LOX-1 gene transcription in microglial cells under hypoxic and ischemic conditions.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Clinical Neurology
Sofia Ibarburu, Mariangeles Kovacs, Valentina Varela, Jorge Rodriguez-Duarte, Mariana Ingold, Paulina Invernizzi, Williams Porcal, Ana Paula Arevalo, Karen Perelmuter, Mariela Bollati-Fogolin, Carlos Escande, Gloria V. Lopez, Peter King, Ying Si, Yuri Kwon, Carlos Batthyany, Luis Barbeito, Emiliano Trias
Summary: These findings indicate a potential therapeutic effect of BANA in ALS patients, as it can slow down paralysis progression by inhibiting microglial NF-kappa B activation. Experimental results demonstrate that administration of BANA to SOD1(G93A) rats after paralysis onset can improve spinal motor neuron pathology and preserve neuromuscular junction innervation, thus prolonging post-paralysis survival.
Article
Biochemistry & Molecular Biology
So-Ra Kim, Kyung-Joo Seong, Won-Jae Kim, Ji-Yeon Jung
Summary: EGCG protects microglia from hypoxia-induced inflammation and oxidative stress through inhibition of the NF-κB pathway and activation of the Nrf-2/HO-1 pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)