Article
Cell Biology
Hao Yu, Xiaojie Liu, Bixuan Chen, Casey R. Vickstrom, Vladislav Friedman, Thomas J. Kelly, Xiaowen Bai, Li Zhao, Cecilia J. Hillard, Qing-Song Liu
Summary: The selective CB2 agonist GW842166x has protective effects against 6-OHDA-induced loss of dopamine neurons and associated motor deficits in mice, potentially through modulation of dopamine neuron firing activity. The neuroprotective effects of GW842166x were prevented by the CB2 receptor antagonist AM630, indicating a CB2-dependent mechanism. Electrophysiological recordings suggest that GW842166x may reduce dopamine neuron vulnerability to 6-OHDA by decreasing action potential firing and associated calcium load.
Review
Pharmacology & Pharmacy
Yiqiu Liu, Junyu Deng, Ye Liu, Wei Li, Xuqiang Nie
Summary: Parkinson's disease is a neurodegenerative disorder characterized by motor dysfunction, autonomic dysfunction, and other non-motor symptoms. Pathologically, it involves degeneration of dopaminergic neurons, formation of Lewy bodies, and neuroinflammation. Treatment options mainly focus on increasing dopamine levels or stimulating dopamine receptors, with research showing potential benefits from fibroblast growth factor and its receptor in protecting dopaminergic neurons and reducing neuroinflammation in PD.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Mauricio dos Santos Pereira, Gabriel Henrique Dias Abreu, Jeremy Rocca, Sabah Hamadat, Rita Raisman-Vozari, Patrick Pierre Michel, Elaine Del Bel
Summary: The study aimed to characterize mechanisms regulating neuroinflammation in L-DOPA-induced dyskinesia in mice, finding that astrocytic and microglial responses, as well as increased pro-inflammatory cytokine levels, were associated with LID development. Treatment with cannabidiol and capsazepine reduced LID severity and TNF-alpha levels, suggesting a potential therapeutic approach. Glutamate-induced TNF-alpha release from astrocytes may contribute to LID by modulating corticostriatal glutamatergic inputs, with cannabidiol + capsazepine attenuating this effect.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Genetics & Heredity
Han-Lin Chiang, Yih-Ru Wu, Yi-Chun Chen, Hon-Chung Fung, Chiung-Mei Chen
Summary: In the Taiwanese/Chinese populations, the SNP rs591323 near the FGF20 gene may play a protective role in Parkinson's disease, with the minor allele and certain genotypes significantly less frequent in PD patients compared to controls. Meta-analysis across multiple studies further confirmed the association between rs591323 and the risk of PD, indicating a potential genetic factor in the development of the disease in this population.
Article
Biochemistry & Molecular Biology
Ana Gomes, Sandra M. Monteiro, Carlos Venacio, Luis Felix
Summary: This study investigated the effects of 24-Epibrassinolide (24-EPI) on 6-hydroxydopamine (6-OHDA)-induced toxicity. The results showed that 6-OHDA caused developmental abnormalities and Parkinson's disease-like symptoms in embryos, which were reversed by 24-EPI. These findings support further investigation of the neuroprotective effects of 24-EPI.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Helena Berlamont, Arnout Bruggeman, Eva Bauwens, Charysse Vandendriessche, Elien Clarebout, Junhua Xie, Sofie De Bruyckere, Griet Van Imschoot, Elien Van Wonterghem, Richard Ducatelle, Patrick Santens, Annemieke Smet, Freddy Haesebrouck, Roosmarijn E. Vandenbroucke
Summary: Research suggests that gastric H. suis infection may have a neuroprotective effect on Parkinson's disease pathology by reducing 6-OHDA-induced cell loss and improving motor function. This effect is potentially mediated through changes in oxidative stress, as indicated by higher expression levels of antioxidant genes in infected mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Anatomy & Morphology
S. Petryszyn, L. Saidi, D. Gagnon, A. Parent, M. Parent
Summary: The study investigated the changes in morphology and distribution of striatal interneurons expressing calretinin in a mouse model of Parkinson's disease. It found that medium-sized calretinin-positive interneurons are specifically targeted by dopamine denervation, while small and intensely immunoreactive calretinin-positive cells remain unaffected. These results suggest that the expression of calretinin may play a protective role against altered corticostriatal transmission in Parkinson's disease.
BRAIN STRUCTURE & FUNCTION
(2021)
Article
Neurosciences
Farideh Iravanpour, Leila Dargahi, Mohsen Rezaei, Masoud Haghani, Reza Heidari, Neda Valian, Abolhassan Ahmadiani
Summary: The study investigated the effects of intranasal insulin treatment in a rat model of Parkinson's disease, showing significant improvements in motor dysfunction and dopaminergic cell death associated with the disease. The findings suggest that intranasal insulin may be a promising therapeutic approach for Parkinson's disease, potentially targeting mitochondrial dysfunction and modulating inflammation in the brain.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Hui-Chen Su, Yuan-Ting Sun, Ming-Yu Yang, Ching-Yuan Wu, Cheng-Ming Hsu
Summary: This study investigated the effect of a compound extracted from Danshen, dihydroisotanshinone I (DT), on Parkinson's disease (PD) using an in vitro-based cell model. The results showed that DT attenuated cell death, suppressed reactive oxygen species (ROS) and caspase-3 levels, and regulated circadian genes in the PD cell model. These findings suggest that DT has potential as a novel therapeutic agent for PD, but further in vivo studies are needed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Rupinder Kaur Sodhi, Yashika Bansal, Raghunath Singh, Priyanka Saroj, Ranjana Bhandari, Baldeep Kumar, Anurag Kuhad
Summary: In this study, 1-Methyltryptophan (1-MT) was tested in a murine model of PD, showing improvements in locomotion, motor coordination, oxidative stress, neuroinflammatory markers, mitochondrial dysfunction, neuronal apoptosis, neurotransmitter levels, and BDNF levels in the striatum. These findings suggest that 1-MT could be a potential candidate for further studies as an alternative in the pharmacotherapy of PD.
Article
Multidisciplinary Sciences
Mohammad Shabani, Monavareh Soti, Hoda Ranjbar, Reyhaneh Naderi
Summary: Parkinson's disease is characterized by motor disabilities and cognitive impairments. Abscisic acid (ABA) has been found in various brain regions of mammals and has neuroprotective properties. A mouse model of PD was used to investigate the effects of ABA on motor and cognitive disorders. The results showed that ABA significantly improved balance and muscle strength deficits caused by 6-OHDA, but did not improve cognitive impairment or rearing in Parkinsonism mice.
Article
Cell Biology
Daniel Rees, Amy L. Beynon, Mariah J. Lelos, Gaynor A. Smith, Luke D. Roberts, Lyndsey Phelps, Stephen B. Dunnett, Alwena H. Morgan, Rowan M. Brown, Timothy Wells, Jeffrey S. Davies
Summary: The feeding-related hormone, acyl-ghrelin, has a potential protective effect on dopamine neurons in experimental models of Parkinson's disease. However, its effect on dopaminergic neurons in the 6-OHDA rat medial forebrain bundle lesion model is unknown.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Article
Cell Biology
Wen-Wen Wang, Ruiyu Han, Hai-Jun He, Jia Li, Si-Yan Chen, Yingying Gu, Chenglong Xie
Summary: Studies show that quercetin can improve mitochondrial quality control, reduce oxidative stress, increase levels of mitophagy markers PINK1 and Parkin, and decrease alpha-synuclein expression in 6-OHDA-treated cells. In vivo, quercetin also helps alleviate PD-like motor behaviors, decrease neuronal death, reduce mitochondrial damage, and control alpha-synuclein accumulation in PD rats. The neuroprotective effect of quercetin is compromised when either Pink1 or Parkin is knocked down.
Article
Biochemistry & Molecular Biology
Xiaojie Liu, Hao Yu, Bixuan Chen, Vladislav Friedman, Lianwei Mu, Thomas J. Kelly, Gonzalo Ruiz-Perez, Li Zhao, Xiaowen Bai, Cecilia J. Hillard, Qing-song Liu
Summary: The study found that CB2 agonists ameliorate anxiogenic and depressive-like behaviors in Parkinson's disease models, possibly through neuroprotective mechanisms.
Article
Biochemistry & Molecular Biology
Dai-di Li, Guo-qing Wang, Qin Wu, Jing-Shan Shi, Feng Zhang
Summary: DNLA, an active component extracted from Dendrobium nobile Lindl, shows neuroprotective effects on 6-OHDA-induced DA neurotoxicity by inhibiting the release of proinflammatory cytokines, which could be a potential compound for PD treatment.
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
(2021)
Article
Computer Science, Artificial Intelligence
Ruiheng Zhang, Shuo Yang, Qi Zhang, Lixin Xu, Yang He, Fan Zhang
Summary: The paper proposes a method to transform features extracted by a pre-trained self-supervised feature extractor into a Gaussian-like distribution to reduce feature distribution mis-match, and to solve incorrect class allocation through computing an optimal class allocation matrix.
Article
Computer Science, Artificial Intelligence
Yang He, Ping Liu, Linchao Zhu, Yi Yang
Summary: Filter pruning is an effective method to reduce computational costs in neural networks. However, existing methods often overlook the interdependencies between filters and rely solely on magnitude information. To address this issue, the proposed meta-attribute-based filter pruning approach considers the geometric distance between filters and adaptively selects pruning criteria based on the current state of the network.
IEEE TRANSACTIONS ON NEURAL NETWORKS AND LEARNING SYSTEMS
(2023)
Article
Anesthesiology
Xingzhi Guo, Chen Hou, Peng Tang, Rui Li
Summary: This study found a causal relationship between chronic pain and cognitive function, and patients with dementia had lower exposure to analgesics.
ANESTHESIA AND ANALGESIA
(2023)
Article
Clinical Neurology
Xingzhi Guo, Peng Tang, Lina Zhang, Junhao Cui, Rui Li
Summary: Two-sample Mendelian randomization (MR) analysis suggested that there may not be a causal relationship between fetal gestational age and the risk of epilepsy.
Article
Cell Biology
Xingzhi Guo, Peng Tang, Xin Zhang, Rui Li
Summary: In this study, it was found that H. pylori VacA antibody is the only factor associated with the risk of stroke, and C-reactive protein may mediate this association. This study suggests that inhibition of the CRP signaling pathway may reduce the risk of stroke in patients with VacA-positive H. pylori infection.
INFLAMMATION RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Xingzhi Guo, Peng Tang, Lina Zhang, Rui Li
Summary: Tobacco use, but not alcohol drinking, significantly increases the risk of frailty and falling, according to a two-sample Mendelian randomisation analysis using genetic instruments. Genetically determined initiation of smoking and cigarettes consumption per day were both positively associated with frailty and falling, while there was no significant causal association between alcohol use and the risk of frailty and falling.
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
(2023)
Article
Clinical Neurology
Xingzhi Guo, Peng Tang, Chen Hou, Rui Li
Summary: Observational studies have suggested a relationship between selenium status and mental disorders (MDs). This study used Mendelian randomization analysis to investigate the causal effects of selenium levels on seven MDs. The results showed that genetically predicted blood selenium levels were associated with a decreased risk of schizophrenia and anorexia nervosa, while both blood and blood-toenail selenium levels were linked to an increased risk of major depressive disorder and autism spectrum disorder.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Immunology
Peng Tang, Xingzhi Guo, Li Chong, Rui Li
Summary: This Mendelian randomization study suggests that asthma is causally associated with an increased risk of epilepsy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Xingzhi Guo, Peng Tang, Chen Hou, Yue Liu, Rui Li
Summary: This study using Mendelian randomization analysis found that preterm birth is causally associated with cardioembolic stroke and large artery stroke, and pulmonary dysfunction mediates the causal impact of preterm birth on stroke.
EPIDEMIOLOGY AND HEALTH
(2023)
Article
Geriatrics & Gerontology
Xingzhi Guo, Xin Zhang, Peng Tang, Li Chong, Rui Li
Summary: The gut microbiome dysbiosis is associated with Alzheimer's disease (AD) and the causal relationship has been confirmed through observational studies and genome-wide association studies (GWAS) using Mendelian randomization (MR) analysis.
Article
Radiology, Nuclear Medicine & Medical Imaging
Cheng Yuan, Qing Shi, Xinyun Huang, Li Wang, Yang He, Biao Li, Weili Zhao, Dahong Qian
Summary: In this study, a multimodal deep learning (MDL) model was constructed using interim PET/CT imaging data to predict possible primary treatment failure (PTF) in low-risk DLBCL patients. The best model, optimized with a contrastive training objective, showed good prediction performance and generalization ability in both the primary and external dataset.
EUROPEAN RADIOLOGY
(2023)
Article
Medicine, General & Internal
Tianwen Yuan, Yang He, Zhixing Zhu, Qi Yang, Peng Kong, Saibo Wang, Xing Zhou, Jun Cao
Summary: This study aims to investigate the effectiveness, safety, adverse events, and outcomes of percutaneous radiologic gastrostomy in patients with dysphagia caused by cerebral infarction. The results demonstrate that percutaneous radiologic gastrostomy can improve the nutritional status of patients, reduce the incidence of adverse events, and improve comfort levels.
JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN
(2022)
Proceedings Paper
Computer Science, Artificial Intelligence
Yang He, Ravi Garg, Amber Roy Chowdhury
Summary: Graph-based approaches are increasingly popular in road network extraction. This paper proposes a novel top-down approach called TD-Road, which generates road network graphs by using graph structures as training supervisions. The effectiveness and simplicity of the proposed method are demonstrated through extensive experiments.
COMPUTER VISION, ECCV 2022, PT IX
(2022)
Proceedings Paper
Computer Science, Software Engineering
Yao Wan, Yang He, Zhangqian Bi, Jianguo Zhang, Yulei Sui, Hongyu Zhang, Kazuma Hashimoto, Hai Jin, Guandong Xu, Caiming Xiong, Philip S. Yu
Summary: NATURALCC is an efficient and extensible open-source toolkit for machine-learning-based source code analysis. It provides a wide range of features and a modular framework, and demonstrates its usability across various tasks through a graphical user interface.
2022 ACM/IEEE 44TH INTERNATIONAL CONFERENCE ON SOFTWARE ENGINEERING: COMPANION PROCEEDINGS (ICSE-COMPANION 2022)
(2022)
Article
Nutrition & Dietetics
Jiaqi Lei, Yuanyang Dong, Qihang Hou, Yang He, Yujiao Lai, Chaoyong Liao, Yoichiro Kawamura, Junyou Li, Bingkun Zhang
Summary: The intestinal microbiota has a significant impact on the water-holding capacity of muscles in broilers, influencing meat quality. When raised in the same environment, two native breeds of broilers exhibit similarities in muscle water-holding capacity and gut bacteria compositions. Fecal microbiota transplantation experiments show that remodeling the intestinal microbiota can lead to improvements in muscle characteristics.
FRONTIERS IN NUTRITION
(2022)
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.
