Effects of Suvorexant, a Dual Orexin/Hypocretin Receptor Antagonist, on Impulsive Behavior Associated with Cocaine

Mechanisms of activation of nucleus accumbens neurons by cocaine via sigma-1 receptor–inositol 1,4,5-trisphosphate–transient receptor potential canonical channel pathways

(2015) Jeffrey L. Barr et al.   CELL CALCIUM

Orexin Receptor Antagonists: New Therapeutic Agents for the Treatment of Insomnia

(2015) Anthony J. Roecker et al.   JOURNAL OF MEDICINAL CHEMISTRY

Novel Octahydropyrrolo[3,4-c]pyrroles Are Selective Orexin-2 Antagonists: SAR Leading to a Clinical Candidate

(2015) Michael A. Letavic et al.   JOURNAL OF MEDICINAL CHEMISTRY

Do Orexins contribute to impulsivity-driven binge consumption of rewarding stimulus and transition to drug/food dependence?

(2015) Manuel Alcaraz-Iborra et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Hypocretin/Orexin Regulation of Dopamine Signaling and Cocaine Self-Administration Is Mediated Predominantly by Hypocretin Receptor 1

(2014) Courtney D. Prince et al.   ACS Chemical Neuroscience

Orexin/Hypocretin Based Pharmacotherapies for the Treatment of Addiction: DORA or SORA?

(2014) Shaun Yon-Seng Khoo et al.   CNS DRUGS

The role of orexin in motivated behaviours

(2014) Takeshi Sakurai   NATURE REVIEWS NEUROSCIENCE

Temperament and Impulsivity Predictors of Smoking Cessation Outcomes

(2014) Francisca López-Torrecillas et al.   PLoS One

Hypocretin (orexin) facilitates reward by attenuating the antireward effects of its cotransmitter dynorphin in ventral tegmental area

(2014) J. W. Muschamp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional wiring of hypocretin and LC-NE neurons: implications for arousal

(2013) Matthew E. Carter et al.   Frontiers in Behavioral Neuroscience

Orexin Receptors: Pharmacology and Therapeutic Opportunities

(2011) Thomas E. Scammell et al.   Annual Review of Pharmacology and Toxicology

Orexin/Hypocretin Modulates Response of Ventral Tegmental Dopamine Neurons to Prefrontal Activation: Diurnal Influences

(2010) D. E. Moorman et al.   JOURNAL OF NEUROSCIENCE

Hypocretin 1/orexin A in the ventral tegmental area enhances dopamine responses to cocaine and promotes cocaine self-administration

(2010) Rodrigo A. España et al.   PSYCHOPHARMACOLOGY

Dopaminergic Network Differences in Human Impulsivity

(2010) J. W. Buckholtz et al.   SCIENCE

Orexin A/Hypocretin-1 Selectively Promotes Motivation for Positive Reinforcers

(2009) S. L. Borgland et al.   JOURNAL OF NEUROSCIENCE

Systemic and intrabasalis administration of the orexin-1 receptor antagonist, SB-334867, disrupts attentional performance in rats

(2009) Karen E. Boschen et al.   PSYCHOPHARMACOLOGY

Impulsivity as a determinant and consequence of drug use: a review of underlying processes

(2008) Harriet de Wit   ADDICTION BIOLOGY

Behavioural characterisation of high impulsivity on the 5-choice serial reaction time task: Specific deficits in ‘waiting’ versus ‘stopping’

(2008) E.S.J. Robinson et al.   BEHAVIOURAL BRAIN RESEARCH

The application of the 5-choice serial reaction time task for the assessment of visual attentional processes and impulse control in rats

(2008) Andrea Bari et al.   Nature Protocols

Neurobehavioral mechanisms of impulsivity: Fronto-striatal systems and functional neurochemistry

(2007) Jeffrey W. Dalley et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR