Genome-Wide Expression Profiles Drive Discovery of Novel Compounds that Reduce Binge Drinking in Mice

Genetic regulation of gene expression in the epileptic human hippocampus

(2017) Nasir Mirza et al.   HUMAN MOLECULAR GENETICS

Analysis of genome-wide association data highlights candidates for drug repositioning in psychiatry

(2017) Hon-Cheong So et al.   NATURE NEUROSCIENCE

The role of neuroimmune signaling in alcoholism

(2017) Fulton T. Crews et al.   NEUROPHARMACOLOGY

Reversal of cancer gene expression correlates with drug efficacy and reveals therapeutic targets

(2017) Bin Chen et al.   Nature Communications

Existing and Future Drugs for the Treatment of the Dark Side of Addiction

(2016) George F. Koob et al.   Annual Review of Pharmacology and Toxicology

Molecular Liver Cancer Prevention in Cirrhosis by Organ Transcriptome Analysis and Lysophosphatidic Acid Pathway Inhibition

(2016) Shigeki Nakagawa et al.   CANCER CELL

Leveraging big data to transform target selection and drug discovery

(2016) B Chen et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Can you teach old drugs new tricks?

(2016) Nicola Nosengo   NATURE

Translating genome-wide association findings into new therapeutics for psychiatry

(2016) Gerome Breen et al.   NATURE NEUROSCIENCE

Analysis of Post-Traumatic Brain Injury Gene Expression Signature Reveals Tubulins, Nfe2l2, Nfkb, Cd44 and S100a4 as Treatment Targets

(2016) Anssi Lipponen et al.   Scientific Reports

Commonalities and Distinctions Among Mechanisms of Addiction to Alcohol and Other Drugs

(2015) Angela R. Ozburn et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Bioinformatics methods in drug repurposing for Alzheimer’s disease

(2015) John C. Siavelis et al.   BRIEFINGS IN BIOINFORMATICS

Treatment of Obesity with Celastrol

(2015) Junli Liu et al.   CELL

Connectivity mapping uncovers small molecules that modulate neurodegeneration in Huntington’s disease models

(2015) Joshua L. Smalley et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Drugs that reverse disease transcriptomic signatures are more effective in a mouse model of dyslipidemia

(2015) A. Wagner et al.   Molecular Systems Biology

Mapping the effects of drugs on the immune system

(2015) Brian A Kidd et al.   NATURE BIOTECHNOLOGY

Psychiatric Comorbidity in Alcohol Dependence

(2015) George Fein   NEUROPSYCHOLOGY REVIEW

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Gene-Set Local Hierarchical Clustering (GSLHC)—A Gene Set-Based Approach for Characterizing Bioactive Compounds in Terms of Biological Functional Groups

(2015) Feng-Hsiang Chung et al.   PLoS One

Bruton’s tyrosine kinase is essential for NLRP3 inflammasome activation and contributes to ischaemic brain injury

(2015) Minako Ito et al.   Nature Communications

Leveraging existing data sets to generate new insights into Alzheimer’s disease biology in specific patient subsets

(2015) Kevin D. Fowler et al.   Scientific Reports

Prioritizing Therapeutics for Lung Cancer: An Integrative Meta-analysis of Cancer Gene Signatures and Chemogenomic Data

(2015) Kristen Fortney et al.   PLoS Computational Biology

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Prevalence of Alcohol Dependence Among US Adult Drinkers, 2009–2011

(2014) Marissa B. Esser et al.   Preventing Chronic Disease

High Drinking in the Dark Mice: A genetic model of drinking to intoxication

(2013) Amanda M. Barkley-Levenson et al.   ALCOHOL

Selection for Drinking in the Dark Alters Brain Gene Coexpression Networks

(2013) Ovidiu D. Iancu et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Discovery of the neuroprotective effects of alvespimycin by computational prioritization of potential anti-parkinson agents

(2013) Li Gao et al.   FEBS Journal

Progress in a replicated selection for elevated blood ethanol concentrations in HDID mice

(2013) J. C. Crabbe et al.   GENES BRAIN AND BEHAVIOR

Differential antibacterial properties of the MurA inhibitors terreic acid and fosfomycin

(2013) Sanne H. Olesen et al.   JOURNAL OF BASIC MICROBIOLOGY

A Novel Brain Penetrant NPS Receptor Antagonist, NCGC00185684, Blocks Alcohol-Induced ERK-Phosphorylation in the Central Amygdala and Decreases Operant Alcohol Self-Administration in Rats

(2013) A. Thorsell et al.   JOURNAL OF NEUROSCIENCE

Transcriptional data: a new gateway to drug repositioning?

(2012) Francesco Iorio et al.   DRUG DISCOVERY TODAY

Alcohol preference drinking in a mouse line selectively bred for high drinking in the dark

(2010) John C. Crabbe et al.   ALCOHOL

The Fungal Product Terreic Acid Is a Covalent Inhibitor of the Bacterial Cell Wall Biosynthetic Enzyme UDP-N-Acetylglucosamine 1-Carboxyvinyltransferase (MurA),

(2010) Huijong Han et al.   BIOCHEMISTRY

Heat shock protein 90 inhibitors attenuate inflammatory responses in atherosclerosis

(2010) Julio Madrigal-Matute et al.   CARDIOVASCULAR RESEARCH

Genipin inhibits the inflammatory response of rat brain microglial cells

(2010) Kyong Nyon Nam et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

lumi: a pipeline for processing Illumina microarray

(2008) P. Du et al.   BIOINFORMATICS

A Line of Mice Selected for High Blood Ethanol Concentrations Shows Drinking in the Dark to Intoxication

(2008) John C. Crabbe et al.   BIOLOGICAL PSYCHIATRY

Anti-inflammatory neuropeptides: A new class of endogenous immunoregulatory agents

(2008) Mario Delgado et al.   BRAIN BEHAVIOR AND IMMUNITY