Mapping the effects of drugs on the immune system

Clioquinol Decreases Amyloid-β Burden and Reduces Working Memory Impairment in a Transgenic Mouse Model of Alzheimer's Disease

(2017) Cristina Grossi et al.   JOURNAL OF ALZHEIMERS DISEASE

Principles of regulatory information conservation between mouse and human

(2014) Yong Cheng et al.   NATURE

Comparison of the transcriptional landscapes between human and mouse tissues

(2014) Shin Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Zebrafish Compound Screen Reveals Modulation of Neutrophil Reverse Migration as an Anti-Inflammatory Mechanism

(2014) A. L. Robertson et al.   Science Translational Medicine

Cross-reactivity to Acetaminophen and Celecoxib According to the Type of Nonsteroidal Anti-inflammatory Drug Hypersensitivity

(2014) Yoon-Jeong Kim et al.   Allergy Asthma & Immunology Research

Antibiotic Allergies in Children and Adults: From Clinical Symptoms to Skin Testing Diagnosis

(2014) Antonino Romano et al.   Journal of Allergy and Clinical Immunology-In Practice

Gene Sets Net Correlations Analysis (GSNCA): a multivariate differential coexpression test for gene sets

(2013) Yasir Rahmatallah et al.   BIOINFORMATICS

Effector Kinase Coupling Enables High-Throughput Screens for Direct HIV-1 Nef Antagonists with Antiretroviral Activity

(2013) Lori A. Emert-Sedlak et al.   CHEMISTRY & BIOLOGY

Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects in 2013

(2013) Scott H. Sicherer et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Neutrophil mobilization via plerixafor-mediated CXCR4 inhibition arises from lung demargination and blockade of neutrophil homing to the bone marrow

(2013) Sapna Devi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Identification of transcriptional regulators in the mouse immune system

(2013) Vladimir Jojic et al.   NATURE IMMUNOLOGY

Copper/zinc chelation by clioquinol reduces spinal cord white matter damage and behavioral deficits in a murine MOG-induced multiple sclerosis model

(2013) Bo Young Choi et al.   NEUROBIOLOGY OF DISEASE

Quantitative set analysis for gene expression: a method to quantify gene set differential expression including gene-gene correlations

(2013) Gur Yaari et al.   NUCLEIC ACIDS RESEARCH

Conservation and divergence in the transcriptional programs of the human and mouse immune systems

(2013) T. Shay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lenalidomide Causes Selective Degradation of IKZF1 and IKZF3 in Multiple Myeloma Cells

(2013) J. Kronke et al.   SCIENCE

A Drug Repositioning Approach Identifies Tricyclic Antidepressants as Inhibitors of Small Cell Lung Cancer and Other Neuroendocrine Tumors

(2013) N. S. Jahchan et al.   Cancer Discovery

CytoSPADE: high-performance analysis and visualization of high-dimensional cytometry data

(2012) M. D. Linderman et al.   BIOINFORMATICS

Tyrosine kinase pathways modulate tumor susceptibility to natural killer cells

(2012) Roberto Bellucci et al.   JOURNAL OF CLINICAL INVESTIGATION

DNA Damage Repair Pathways in Cancer Stem Cells

(2012) M. Maugeri-Sacca et al.   MOLECULAR CANCER THERAPEUTICS

Deciphering the transcriptional network of the dendritic cell lineage

(2012) Jennifer C Miller et al.   NATURE IMMUNOLOGY

Camera: a competitive gene set test accounting for inter-gene correlation

(2012) Di Wu et al.   NUCLEIC ACIDS RESEARCH

Immunomodulatory effects of clozapine and their clinical implications: What have we learned so far?

(2012) Rasmus Røge et al.   SCHIZOPHRENIA RESEARCH

Data-Driven Prediction of Drug Effects and Interactions

(2012) N. P. Tatonetti et al.   Science Translational Medicine

Neutrophil heterogeneity in health and disease: a revitalized avenue in inflammation and immunity

(2012) M. Beyrau et al.   Open Biology

Densely Interconnected Transcriptional Circuits Control Cell States in Human Hematopoiesis

(2011) Noa Novershtern et al.   CELL

Structural Alert/Reactive Metabolite Concept as Applied in Medicinal Chemistry to Mitigate the Risk of Idiosyncratic Drug Toxicity: A Perspective Based on the Critical Examination of Trends in the Top 200 Drugs Marketed in the United States

(2011) Antonia F. Stepan et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Antiepileptic drugs and the immune system

(2011) Ettore Beghi et al.   EPILEPSIA

Transcriptomes of the B and T Lineages Compared by Multiplatform Microarray Profiling

(2011) M. W. Painter et al.   JOURNAL OF IMMUNOLOGY

Extracting a cellular hierarchy from high-dimensional cytometry data with SPADE

(2011) Peng Qiu et al.   NATURE BIOTECHNOLOGY

Computational Repositioning of the Anticonvulsant Topiramate for Inflammatory Bowel Disease

(2011) J. T. Dudley et al.   Science Translational Medicine

Discovery and Preclinical Validation of Drug Indications Using Compendia of Public Gene Expression Data

(2011) M. Sirota et al.   Science Translational Medicine

High Throughput Screens Yield Small Molecule Inhibitors of Leishmania CRK3:CYC6 Cyclin-Dependent Kinase

(2011) Roderick G. Walker et al.   PLoS Neglected Tropical Diseases

Severe adverse skin reactions to nonsteroidal antiinflammatory drugs: A review of the literature

(2010) K. E. Ward et al.   AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY

De-correlating expression in gene-set analysis

(2010) D. Nam   BIOINFORMATICS

Comparison of multiplex meta analysis techniques for understanding the acute rejection of solid organ transplants

(2010) Alexander A Morgan et al.   BMC BIOINFORMATICS

A side effect resource to capture phenotypic effects of drugs

(2010) Michael Kuhn et al.   Molecular Systems Biology

Discovery of drug mode of action and drug repositioning from transcriptional responses

(2010) F. Iorio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutrophil kinetics in health and disease

(2010) Charlotte Summers et al.   TRENDS IN IMMUNOLOGY

Fewer permutations, more accurate P-values

(2009) Theo A. Knijnenburg et al.   BIOINFORMATICS

Identifying Network of Drug Mode of Action by Gene Expression Profiling

(2009) Francesco Iorio et al.   JOURNAL OF COMPUTATIONAL BIOLOGY

Drug-induced immune hemolytic anemia

(2009) G. Garratty   Hematology-American Society of Hematology Education Program

DNA repair and cancer stem-like cells – Potential partners in glioma drug resistance?

(2008) Tor-Christian Aase Johannessen et al.   CANCER TREATMENT REVIEWS

Human neutrophils switch to an activated phenotype after homing to the lung irrespective of inflammatory disease

(2008) E. Fortunati et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Will 2008 Mark the Start of A New Clinical Trial Era in Gastroenterology?

(2008) James D. Lewis   GASTROENTEROLOGY

The Immunological Genome Project: networks of gene expression in immune cells

(2008) Tracy S P Heng et al.   NATURE IMMUNOLOGY