The physiological phosphorylation of tau is critically changed in fetal brains of individuals with Down syndrome

Tau: From research to clinical development

(2016) David M. Holtzman et al.   Alzheimers & Dementia

The α1, α2, α3, and γ2 subunits of GABAA receptors show characteristic spatial and temporal expression patterns in rhombencephalic structures during normal human brain development

(2015) Tamara Stojanovic et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Reversing excitatory GABAAR signaling restores synaptic plasticity and memory in a mouse model of Down syndrome

(2015) Gabriele Deidda et al.   NATURE MEDICINE

Prefibrillar Tau oligomers alter the nucleic acid protective function of Tau in hippocampal neurons in vivo

(2015) Marie Violet et al.   NEUROBIOLOGY OF DISEASE

Loss of Striatonigral GABAergic Presynaptic Inhibition Enables Motor Sensitization in Parkinsonian Mice

(2015) Anders Borgkvist et al.   NEURON

Invited review: Neuropathology of tauopathies: principles and practice

(2015) G. G. Kovacs   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Reducing Gabaergic Inhibition Restores Cognitive Functions in a Mouse Model of Down Syndrome

(2014) Marie-Claude Potier et al.   CNS & Neurological Disorders-Drug Targets

Linking pathways in the developing and aging brain with neurodegeneration

(2014) G.G. Kovacs et al.   NEUROSCIENCE

Treating enhanced GABAergic inhibition in Down syndrome: Use of GABA α5-selective inverse agonists

(2014) Carmen Martínez-Cué et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Specificity of Anti-Tau Antibodies when Analyzing Mice Models of Alzheimer's Disease: Problems and Solutions

(2014) Franck R. Petry et al.   PLoS One

Non-neuronal cell responses differ between normal and Down syndrome developing brains

(2013) Takeshi Kanaumi et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Phosphorylation of tau protein at sites Ser396-404is one of the earliest events in Alzheimer's disease and Down syndrome

(2013) S. Mondragón-Rodríguez et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

The Importance of Tau Phosphorylation for Neurodegenerative Diseases

(2013) Wendy Noble et al.   Frontiers in Neurology

Human fetal tau protein isoform: Possibilities for Alzheimer's disease treatment

(2012) Nataša Jovanov-Milošević et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

γ-Aminobutyric Acid Type A (GABAA) Receptor Activation Modulates Tau Phosphorylation

(2012) Niko-Petteri Nykänen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A peculiar constellation of tau pathology defines a subset of dementia in the elderly

(2011) Gabor G. Kovacs et al.   ACTA NEUROPATHOLOGICA

APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP

(2011) Sascha W Weyer et al.   EMBO JOURNAL

Impaired myelination of the human hippocampal formation in Down syndrome

(2011) Hajnalka Ábrahám et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Phosphorylation in the amino terminus of tau prevents inhibition of anterograde axonal transport

(2011) Nicholas M. Kanaan et al.   NEUROBIOLOGY OF AGING

The Many Faces of Tau

(2011) Meaghan Morris et al.   NEURON

Regulation of the alternative splicing of tau exon 10 by SC35 and Dyrk1A

(2011) W. Qian et al.   NUCLEIC ACIDS RESEARCH

Protein coding of neurodegenerative dementias: the neuropathological basis of biomarker diagnostics

(2010) Gabor G. Kovacs et al.   ACTA NEUROPATHOLOGICA

Updated national birth prevalence estimates for selected birth defects in the United States, 2004-2006

(2010) Samantha E. Parker et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

Nuclear Tau, a Key Player in Neuronal DNA Protection

(2010) Audrey Sultan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Communication breaks-Down: From neurodevelopment defects to cognitive disabilities in Down syndrome

(2010) Andrea Contestabile et al.   PROGRESS IN NEUROBIOLOGY

Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A

(2010) Yasushi Ogawa et al.   Nature Communications

The Effects of Amyloid Precursor Protein on Postsynaptic Composition and Activity

(2009) Hyang-Sook Hoe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interaction of Reelin with Amyloid Precursor Protein Promotes Neurite Outgrowth

(2009) H.-S. Hoe et al.   JOURNAL OF NEUROSCIENCE

Presynaptic and Postsynaptic Interaction of the Amyloid Precursor Protein Promotes Peripheral and Central Synaptogenesis

(2009) Z. Wang et al.   JOURNAL OF NEUROSCIENCE

Axonal Transport Defects in Neurodegenerative Diseases

(2009) G. A. Morfini et al.   JOURNAL OF NEUROSCIENCE

The role of overexpressed DYRK1A protein in the early onset of neurofibrillary degeneration in Down syndrome

(2008) Jerzy Wegiel et al.   ACTA NEUROPATHOLOGICA

Overexpression of Dyrk1A contributes to neurofibrillary degeneration in Down syndrome

(2008) Fei Liu et al.   FASEB JOURNAL

Phosphorylation of tau regulates its axonal transport by controlling its binding to kinesin

(2008) Inmaculada Cuchillo-Ibanez et al.   FASEB JOURNAL

Knock-out and transgenic mouse models of tauopathies

(2007) Franziska Denk et al.   NEUROBIOLOGY OF AGING