4.8 Article

A Meta-Analysis Suggests Different Neural Correlates for Implicit and Explicit Learning

Journal

NEURON
Volume 96, Issue 2, Pages 521-+

Publisher

CELL PRESS
DOI: 10.1016/j.neuron.2017.09.032

Keywords

-

Categories

Funding

  1. NIMH [R37MH087027, R01MH065252]
  2. Picower Institute Innovation Fund

Ask authors/readers for more resources

A meta-analysis of non-human primates performing three different tasks (Object-Match, CategoryMatch, and Category-Saccade associations) revealed signatures of explicit and implicit learning. Performance improved equally following correct and error trials in the Match (explicit) tasks, but it improved more after correct trials in the Saccade (implicit) task, a signature of explicit versus implicit learning. Likewise, error-related negativity, a marker for error processing, was greater in the Match (explicit) tasks. All tasks showed an increase in alpha/beta (10-30 Hz) synchrony after correct choices. However, only the implicit task showed an increase in theta (3-7 Hz) synchrony after correct choices that decreased with learning. In contrast, in the explicit tasks, alpha/beta synchrony increased with learning and decreased thereafter. Our results suggest that explicit versus implicit learning engages different neural mechanisms that rely on different patterns of oscillatory synchrony.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.8
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

Article Clinical Neurology

Bayesian Modelling of Induced Responses and Neuronal Rhythms

Dimitris A. Pinotsis, Roman Loonis, Andre M. Bastos, Earl K. Miller, Karl J. Friston

BRAIN TOPOGRAPHY (2019)

Article Neurosciences

Working Memory Load Modulates Neuronal Coupling

Dimitris A. Pinotsis, Timothy J. Buschman, Earl K. Miller

CEREBRAL CORTEX (2019)

Biographical-Item Neurosciences

Charles Gordon Gross (1936-2019) Obituary

Earl K. Miller, Robert Desimone

NEURON (2019)

Editorial Material Psychiatry

Targeting Cognition and Networks Through Neural Oscillations: Next-Generation Clinical Brain Stimulation

Alik S. Widge, Earl K. Miller

JAMA PSYCHIATRY (2019)

Article Biochemistry & Molecular Biology

Extracellular Spike Waveform Dissociates Four Functionally Distinct Cell Classes in Primate Cortex

Caterina Trainito, Constantin von Nicolai, Earl K. Miller, Markus Siegel

CURRENT BIOLOGY (2019)

Article Neurosciences

Sensory processing and categorization in cortical and deep neural networks

Dimitris A. Pinotsis, Markus Siegel, Earl K. Miller

NEUROIMAGE (2019)

Article Biochemical Research Methods

Achieving stable dynamics in neural circuits

Leo Kozachkov, Mikael Lundqvist, Jean-Jacques Slotine, Earl K. Miller

PLOS COMPUTATIONAL BIOLOGY (2020)

Article Biochemical Research Methods

Task-evoked activity quenches neural correlations and variability across cortical areas

Takuya Ito, Scott L. Brincat, Markus Siegel, Ravi D. Mill, Biyu J. He, Earl K. Miller, Horacio G. Rotstein, Michael W. Cole

PLOS COMPUTATIONAL BIOLOGY (2020)

Article Biochemical Research Methods

A hidden Markov model reliably characterizes ketamine-induced spectral dynamics in macaque local field potentials and human electroencephalograms

Indie C. Garwood, Sourish Chakravarty, Jacob Donoghue, Meredith Mahnke, Pegah Kahali, Shubham Chamadia, Oluwaseun Akeju, Earl K. Miller, Emery N. Brown

Summary: This study quantified the neural activity induced by Ketamine and provided detailed descriptions of the spectroscopic features in non-human primates and human patients. The findings can facilitate the development of neurophysiological mechanistic models of Ketamine and biomarker discovery for clinical anesthesia monitoring.

PLOS COMPUTATIONAL BIOLOGY (2021)

Editorial Material Neurosciences

A call for more clarity around causality in neuroscience

David L. Baracka, Earl K. Miller, Christopher Moore, Adam M. Packer, Luiz Pessoa, Lauren N. Ross, Nicole C. Rust

Summary: This article discusses the various concepts and naming of "causality" in neuroscience and proposes four ways to enhance clarity around causality.

TRENDS IN NEUROSCIENCES (2022)

Article Biochemical Research Methods

Robust and brain-like working memory through short-term synaptic plasticity

Leo Kozachkov, John Tauber, Mikael Lundqvist, Scott L. Brincat, Jean-Jacques Slotine, Earl K. Miller

Summary: Research suggests that short-term synaptic plasticity (STSP) is important for maintaining working memory and making neural networks more brain-like. Artificial neural networks with STSP showed better performance in maintaining memories and resisting network degradation compared to networks without STSP.

PLOS COMPUTATIONAL BIOLOGY (2022)

Article Neurosciences

A physical neural mass model framework for the analysis of oscillatory generators from laminar electrophysiological recordings

Roser Sanchez-Todo, Andre M. Bastos, Edmundo Lopez-Sola, Borja Mercadal, Emiliano Santarnecchi, Earl K. Miller, Gustavo Deco, Giulio Ruffini

Summary: In this study, a new framework called laminar neural mass models (LaNMM) is proposed to simulate electrophysiological measurements by combining conduction physics with NMMs. Using this framework, the location of oscillatory generators in the prefrontal cortex of the macaque monkey is inferred from laminar-resolved data. A minimal model capable of generating coupled slow and fast oscillations is defined, and LaNMM-specific parameters are optimized to fit the recorded data. The functional connectivity (FC) of the model and data are evaluated using an optimization function, and the family of best solutions reproduces the observed FC by selecting specific locations of pyramidal cells and their synapses.

NEUROIMAGE (2023)

Article Multidisciplinary Sciences

Multifunctional fibers enable modulation of cortical and deep brain activity during cognitive behavior in macaques

Indie C. Garwood, Alex J. Major, Marc-Joseph Antonini, Josefina Correa, Youngbin Lee, Atharva Sahasrabudhe, Meredith K. Mahnke, Earl K. Miller, Emery N. Brown, Polina Anikeeva

Summary: This study successfully translates multifunctional fiber neurotechnology from rodent studies to macaque studies, enabling cortical and subcortical neural recording and modulation. By recording and analyzing the electrophysiological changes during a working memory task, the researchers uncover the reshaping process of neural activity under local inhibition.

SCIENCE ADVANCES (2023)

Article Multidisciplinary Sciences

Closed-loop control of anesthetic state in nonhuman primates

Sourish Chakravarty, Jacob Donoghue, Ayan S. Waite, Meredith Mahnke, Indie C. Garwood, Sebastian Gallo, Earl K. Miller, Emery N. Brown

Summary: Research has shown that unconsciousness under general anesthesia can be reliably tracked using real-time electroencephalogram processing. To aid patient management during surgery, a closed-loop anesthesia delivery system was implemented in nonhuman primates, which accurately controlled the level of unconsciousness. The system demonstrated superior performance and established critical steps for designing and testing closed-loop anesthesia delivery systems in humans.

PNAS NEXUS (2023)

Article Neurosciences

Conjunctive representation of what and when in monkey hippocampus and lateral prefrontal cortex during an associative memory task

Nathanael A. Cruzado, Zoran Tiganj, Scott L. Brincat, Earl K. Miller, Marc W. Howard

HIPPOCAMPUS (2020)

No Data Available