Article
Psychology, Multidisciplinary
Chorong Oh, Richard Morris, Xianhui Wang, Morgan S. Raskin
Summary: This pilot research examines if prosodic features can be used to differentiate between dementia of the Alzheimer's type (DAT), vascular dementia (VaD), mild cognitive impairment (MCI), and healthy cognition. The study utilizes both acoustic measurements and listeners' perception of emotional prosody differences. The results indicate that both the acoustic data and perceptual data can successfully distinguish between the four groups. This study suggests that using acoustic measures of prosodic features may be a useful method for differentiating these cognitive conditions.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Psychology, Multidisciplinary
Sandro Iannaccone, Elise Houdayer, Alfio Spina, Gianluca Nocera, Federica Alemanno
Summary: This study investigated the use of electroencephalography quantified with statistical pattern recognition (qEEG-SPR) as a tool for diagnosing dementia and differentiating dementia with Lewy bodies (DLB). The results showed that qEEG-SPR had high sensitivity and specificity for identifying dementia and DLB. It is a non-invasive, low-cost, and environmentally friendly method that can be implemented in healthcare settings.
FRONTIERS IN PSYCHOLOGY
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Chao Han, Lina Zhu, Xiang Liu, Shuai Ma, Yi Liu, Xiaoying Wang
Summary: The differential diagnosis of prostate abnormalities covers a wide range of common and less common conditions; recent advances in MRI technology and imaging guidelines have greatly improved the ability to distinguish common abnormalities; radiologists need to consider various factors when diagnosing prostate abnormalities for an accurate assessment.
INSIGHTS INTO IMAGING
(2021)
Review
Medical Laboratory Technology
Laurie M. Griesinger, Julianne M. Szczepanski, Emily R. McMullen, Stephanie L. Skala
Summary: This article reviews the morphologic features of uncommon cervical lesions, the utility of immunohistochemistry for distinguishing between these entities, and the clinical and prognostic implications of accurate diagnosis.
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Laura Ferre-Gonzalez, Carmen Pena-Bautista, Miguel Baquero, Consuelo Chafer-Pericas
Summary: The prevalence of Alzheimer's disease (AD) and other dementias is increasing in the older population, and there is a need for affordable and non-invasive biomarkers for early diagnosis. This study found that peroxidation by-products derived from the oxidation of brain lipids could be potential biomarkers for AD, as they are involved in inflammation, neurotoxicity, and cell death mechanisms in AD pathology. Analysis of these lipid peroxidation compounds in plasma samples showed significant differences between different groups, indicating their potential diagnostic value. Additionally, certain compounds and total parameters showed prognostic value for AD disease progression. These findings suggest that lipid peroxidation compounds could be promising biomarkers for differential diagnosis and prognosis of AD.
Article
Medicine, General & Internal
Antonio Cabrera-Arcas, Jose-Francisco Montes-Carmona, Luis-Miguel Gonzalez-Perez
Summary: The diagnosis and treatment of maxillofacial cystic lesions require careful evaluation and correlation of clinical presentation and radiological studies. This study presents a new case of the uncommon Pindborg tumor and describes its clinicopathological features along with a review of reported cases.
Review
Geriatrics & Gerontology
Leo Sokolovic, Markus J. Hofmann, Nadia Mohammad, Juraj Kukolja
Summary: This study aimed to identify diagnostic instruments that distinguish between Alzheimer's disease (AD) and vascular dementia (VaD). The findings showed that AD patients performed worse in episodic memory and better in working memory compared to VaD patients. There was little support for other differences proposed by diagnostic systems and guidelines. The utility of cognitive, behavioral, psychiatric, and functional measures in differential diagnosis is limited and should be complemented by other information.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Neurosciences
Luca Gentile, Massimo Russo, Federica Taioli, Moreno Ferrarini, M'Hammed Aguennouz, Carmelo Rodolico, Antonio Toscano, Gian Maria Fabrizi, Anna Mazzeo
Summary: This study presents records of 17 CMT patients from 8 unrelated families with mutations in rare genes, expanding the spectrum of CMT phenotypes. Genetic testing is crucial for accurate diagnosis and potential eligibility for future treatments.
Article
Mathematical & Computational Biology
Jian Yang, Liqi Shu, Huilong Duan, Haomin Li
Summary: This study proposes a phenotype-based differential diagnosis process for rare diseases, aiming to achieve rapid and accurate diagnosis by optimizing patient phenotype information. The process involves constructing a phenotype hierarchical network and a disease-phenotype differential network, calculating phenotype co-occurrence relationships, and designing a visual comparative analysis method to explore correlations and differences between disease phenotypes.
INTERDISCIPLINARY SCIENCES-COMPUTATIONAL LIFE SCIENCES
(2022)
Article
Health Care Sciences & Services
Rosa Montero-Macias, Pluvio J. Coronado, Nicolas Robillard, David Veyer, Vincent Villefranque, Marie-Aude Le Frere-Belda, Elisabeth Auberger, Pauline Bitolog, Ivana Stankovic, Laurent Belec, Anne-Sophie Bats, Fabrice Lecuru, Helene Pere
Summary: The objective of this study was to determine if an easy-to-use HPV molecular genotyping assay could differentiate HPV tumor metastasis from a new independent primary non-HPV-induced tumor. Using routine multiplex real-time PCR, we found that HPV DNA was detected in the biopsy of distant lesions in 7 out of 8 cases with primary cervical cancer and a new secondary lesion, confirming the diagnosis of cervical cancer metastasis. In the remaining case, no HPV was detected in the lung biopsy, confirming the diagnosis of a new primary lung cancer.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Clinical Neurology
Ugur Uygunoglu, Aksel Siva
Summary: Behcet's Syndrome (BS) can manifest with neurological problems, either directly or indirectly related to BS. Neuro-Behcet's syndrome (NBS) includes two major subtypes: Parenchymal-NBS and Extra parenchymal neuro-vascular involvement, with CVST being a common manifestation. Other forms include cognitive and behavioral syndromes, as well as peripheral nervous system involvement.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Geriatrics & Gerontology
Matej Perovnik, An Vo, Nha Nguyen, Jan Jamsek, Tomaz Rus, Chris C. C. Tang, Maja Trost, David Eidelberg
Summary: This study aimed to differentiate common dementia syndromes using machine learning classifiers based on FDG PET-derived features, and showed that classifiers based on metabolic brain patterns and ROI glucose uptake had higher diagnostic accuracy compared to experts.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Computer Science, Information Systems
Niamh McCombe, Shuo Liu, Xuemei Ding, Girijesh Prasad, Magda Bucholc, David P. Finn, Stephen Todd, Paula L. McClean, Kongfatt Wong-Lin
Summary: This study focuses on extreme missingness in clinical data and evaluates imputation and classification workflows. The results show that iterative imputation on the training dataset combined with a reduced-feature classification model provides the best approach in terms of speed and accuracy when dealing with extreme missing data.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2022)
Article
Multidisciplinary Sciences
Tobias Lindig, Benjamin Bender, Eva Buerkle, Vinod Kumar, Ulrike Ernemann, Ludger Schoels, Tim W. Rattay
Summary: This study tested the usability of automated data analysis in patients with hereditary spastic paraplegia type 4 (SPG4). The results showed that quantitative imaging reports can serve as easily accessible and fully automatic screening tools for clinicians, providing information about brain regions affected by the disease.
SCIENTIFIC REPORTS
(2022)
Review
Microbiology
Oscar Gil, Juan Camilo Hernandez-Pabon, Bryan Tabares, Carlos Lugo-Sanchez, Carolina Firacative
Summary: Systemic infections caused by rare yeasts are increasing in Latin America. The review collects data from 495 cases of infection caused by rare yeasts in the region, identifying 32 species of rare yeasts distributed in 8 Latin American countries. The most common species found were Trichosporon asahii, Rhodotorula mucilaginosa, and Saccharomyces cerevisiae.
Article
Geriatrics & Gerontology
Pietro Cappelletto, Cristina Polito, Valentina Berti, Gemma Lombardi, Giulia Lucidi, Valentina Bessi, Sandro Sorbi, Camilla Ferrari
Summary: Alzheimer's disease (AD) has a high incidence in the elderly population, with behavioural and psychological symptoms of dementia (BPSD) being common. This study found that positive BPSD, including aggression/agitation and psychotic symptoms, were frequently observed in AD patients, with the temporal lobes identified as a key region involved in these symptoms and FDG-PET showing potential in predicting their development.
Article
Biology
Paolo Garagnani, Julien Marquis, Massimo Delledonne, Chiara Pirazzini, Elena Marasco, Katarzyna Malgorzata Kwiatkowska, Vincenzo Iannuzzi, Maria Giulia Bacalini, Armand Valsesia, Jerome Carayol, Frederic Raymond, Alberto Ferrarini, Luciano Xumerle, Sebastiano Collino, Daniela Mari, Beatrice Arosio, Martina Casati, Evelyn Ferri, Daniela Monti, Benedetta Nacmias, Sandro Sorbi, Donata Luiselli, Davide Pettener, Gastone Castellani, Claudia Sala, Giuseppe Passarino, Francesco De Rango, Patrizia D'Aquila, Luca Bertamini, Nicola Martinelli, Domenico Girelli, Oliviero Olivieri, Cristina Giuliani, Patrick Descombes, Claudio Franceschi
Summary: People who reach extreme ages have a unique genetic background associated with efficient DNA repair mechanisms, which helps delay aging and protect from cardiovascular events. This genetic trait is characterized by lower mutation load compared to younger individuals, as shown in both germline and somatic mutation patterns.
Article
Clinical Neurology
Emilio Portaccio, Angelo Bellinvia, Elio Prestipino, Benedetta Nacmias, Silvia Bagnoli, Lorenzo Razzolini, Luisa Pasto, Claudia Niccolai, Benedetta Goretti, Mattia Fonderico, Giovanni Bosco Zimatore, Nunzia Alessandra Losignore, Sandro Sorbi, Maria Pia Amato
Summary: The study suggests a potential protective effect of BDNF Val66Met polymorphism against cognitive impairment in MS patients, possibly due to the detrimental effect of increased BDNF concentration in a neuroinflammatory environment. Higher EDSS score is associated with a progressive disease course, with a marginal association with the presence of the BDNF Val66Met polymorphism.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Alberto Benussi, Antonella Alberici, Kiran Samra, Lucy L. Russell, Caroline Greaves, Martina Bocchetta, Simon Ducharme, Elizabeth Finger, Giorgio Fumagalli, Daniela Galimberti, Lize C. Jiskoot, Isabelle Le Ber, Mario Masellis, Benedetta Nacmias, James B. Rowe, Raquel Sanchez-Valle, Harro Seelaar, Matthis Synofzik, Jonathan D. Rohrer, Barbara Borroni
Summary: The presymptomatic stages of frontotemporal dementia (FTD) have not been clearly defined, indicating a need for a consensus lexicon to comprehensively describe the stages that anticipate dementia and to formulate a better strategy for characterizing these disease stages.
ALZHEIMERS & DEMENTIA
(2022)
Meeting Abstract
Clinical Neurology
Giulia Giacomucci, Salvatore Mazzeo, Sonia Padiglioni, Silvia Bagnoli, Camilla Ferrari, Laura Bracco, Benedetta Nacmias, Sandro Sorbi, Valentina Bessi
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Meeting Abstract
Clinical Neurology
Salvatore Mazzeo, Cristina Polito, Marta Mattei, Sonia Padiglioni, Valentina Berti, Silvia Bagnoli, Gemma Lombardi, Marco Carraro, Maria Teresa De Cristofaro, Alessandro Passeri, Camilla Ferrari, Benedetta Nacmias, Sandro Sorbi, Valentina Bessi
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Meeting Abstract
Clinical Neurology
Filippo Emiliani, Salvatore Mazzeo, Silvia Bagnoli, Vittoria Conti, Giulia Giacomucci, Assunta Ingannato, Camilla Ferrari, Sonia Padiglioni, Sandro Sorbi, Valentina Bessi, Benedetta Nacmias
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ermelinda De Meo, Emilio Portaccio, Elio Prestipino, Benedetta Nacmias, Silvia Bagnoli, Lorenzo Razzolini, Luisa Pasto, Claudia Niccolai, Benedetta Goretti, Angelo Bellinvia, Mattia Fonderico, Antonio Giorgio, Maria Laura Stromillo, Massimo Filippi, Sandro Sorbi, Nicola De Stefano, Maria Pia Amato
Summary: The BDNF Val66Met polymorphism may have a protective role in multiple sclerosis patients against both hippocampal atrophy and cognitive impairment.
MOLECULAR PSYCHIATRY
(2022)
Article
Clinical Neurology
Matilde Nerattini, Federica Rubino, Annachiara Arnone, Cristina Polito, Salvatore Mazzeo, Gemma Lombardi, Giulia Puccini, Benedetta Nacmias, Maria Teresa De Cristofaro, Sandro Sorbi, Alberto Pupi, Roberto Sciagra, Valentina Bessi, Valentina Berti
Summary: The study aims to interpret discrepancies between amyloid PET and CSF biomarkers in Alzheimer's disease diagnosis, utilizing a combination of different imaging and biomarker analysis techniques to improve diagnostic accuracy.
NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Giulia Giacomucci, Salvatore Mazzeo, Sonia Padiglioni, Silvia Bagnoli, Laura Belloni, Camilla Ferrari, Laura Bracco, Benedetta Nacmias, Sandro Sorbi, Valentina Bessi
Summary: The study found that women with SCD were younger and had less education, lower intelligence test scores, and more cognitive complaints compared to men. Intelligence tests were directly related to age of onset for both genders, while years of education were only inversely related to age of onset in women. Gender independently affected intelligence tests, with intelligence tests being directly related to cognitive complaints in men.
NEUROLOGICAL SCIENCES
(2022)
Correction
Cell & Tissue Engineering
Yuriy Pomeshchik, Oxana Klementieva, Jeovanis Gil, Isak Martinsson, Marita Gronning Hansen, Tessa de Vries, Anna Sancho-Balsells, Kaspar Russ, Ekaterina Savchenko, Anna Collin, Ana Rita Vaz, Silvia Bagnoli, Benedetta Nacmias, Claire Rampon, Sandro Sorbi, Dora Brites, Gyorgy Marko-Varga, Zaal Kokaia, Melinda Rezeli, Gunnar K. Gouras, Laurent Roybon
Article
Health Care Sciences & Services
Salvatore Mazzeo, Filippo Emiliani, Silvia Bagnoli, Sonia Padiglioni, Lorenzo Maria Del Re, Giulia Giacomucci, Juri Balestrini, Assunta Ingannato, Valentina Moschini, Carmen Morinelli, Giulia Galdo, Cristina Polito, Camilla Ferrari, Gastone Pansini, Alessandro Della Puppa, Sandro Sorbi, Benedetta Nacmias, Valentina Bessi
Summary: Patients with idiopathic normal pressure hydrocephalus (iNPH) and Alzheimer's Disease (AD) show similar levels of CSF A beta(42), but the levels of A beta(42)/A beta(40), p-tau, and t-tau are significantly different and can accurately distinguish iNPH from AD. A beta(42)/A beta(40) is the most important variable for differentiation. Positive A beta(42)/A beta(40) in iNPH, especially when associated with positive p-tau, may indicate the presence of coexistent AD pathology.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Editorial Material
Clinical Neurology
Nils Peters, Benedetta Nacmias
Article
Health Care Sciences & Services
Giulia Giacomucci, Cristina Polito, Valentina Berti, Sonia Padiglioni, Giulia Galdo, Salvatore Mazzeo, Enrico Bergamin, Valentina Moschini, Carmen Morinelli, Claudia Nuti, Maria Teresa De Cristofaro, Assunta Ingannato, Silvia Bagnoli, Benedetta Nacmias, Sandro Sorbi, Valentina Bessi
Summary: The study aimed to assess empathy deficit and neuronal correlates in patients with logopenic primary progressive aphasia (lv-PPA) and compare it with amnesic Alzheimer's disease (AD). The findings showed that both lv-PPA and AD patients had decreased cognitive empathy and increased personal distress over time. The study also found that specific brain regions with metabolic dysfunction were associated with empathy deficits.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
M. Nerattini, F. Rubino, A. Arnone, C. Polito, S. Mazzeo, G. Lombardi, B. Nacmias, G. Puccini, S. Sorbi, M. De Cristofaro, R. Sciagra, V. Bessi, V. Berti
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)