Preclinical Screening for Treatments for Infantile Spasms in the Multiple Hit Rat Model of Infantile Spasms: An Update

Safety and effectiveness of hormonal treatment versus hormonal treatment with vigabatrin for infantile spasms (ICISS): a randomised, multicentre, open-label trial

(2017) Finbar J K O'Callaghan et al.   LANCET NEUROLOGY

Combination therapy for treatment of infantile spasms

(2017) Raili Riikonen   LANCET NEUROLOGY

Response to treatment in a prospective national infantile spasms cohort

(2016) Kelly G. Knupp et al.   ANNALS OF NEUROLOGY

Brain MRI findings with vigabatrin therapy: case report and literature review

(2016) Kaiser Hussain et al.   CLINICAL IMAGING

Response to second treatment after initial failed treatment in a multicenter prospective infantile spasms cohort

(2016) Kelly G. Knupp et al.   EPILEPSIA

Estradiol does not affect spasms in the betamethasone-NMDA rat model of infantile spasms

(2016) Tamar Chachua et al.   EPILEPSIA

Adjunctive everolimus therapy for treatment-resistant focal-onset seizures associated with tuberous sclerosis (EXIST-3): a phase 3, randomised, double-blind, placebo-controlled study

(2016) Jacqueline A French et al.   LANCET

Efficacy and safety of Everolimus in children with TSC - associated epilepsy – Pilot data from an open single-center prospective study

(2016) Sharon Samueli et al.   Orphanet Journal of Rare Diseases

Long-term outcome in children with infantile spasms treated with vigabatrin: A cohort of 180 patients

(2015) Raili Riikonen   EPILEPSIA

mTOR is involved in 17β-estradiol-induced, cultured immature boar Sertoli cell proliferation via regulating the expression ofSKP2,CCND1, andCCNE1

(2015) Wei-Rong Yang et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Pathogenesis and new candidate treatments for infantile spasms and early life epileptic encephalopathies: A view from preclinical studies

(2015) Aristea S. Galanopoulou et al.   NEUROBIOLOGY OF DISEASE

Recent Advances in the Pharmacotherapy of Infantile Spasms

(2014) Raili Riikonen   CNS DRUGS

Mechanisms of Epileptogenesis in Pediatric Epileptic Syndromes: Rasmussen Encephalitis, Infantile Spasms, and Febrile Infection-related Epilepsy Syndrome (FIRES)

(2014) Carlos A. Pardo et al.   Neurotherapeutics

Neonatal Estradiol Stimulation Prevents Epilepsy in Arx Model of X-Linked Infantile Spasms Syndrome

(2014) P. R. Olivetti et al.   Science Translational Medicine

CPP-115, a vigabatrin analogue, decreases spasms in the multiple-hit rat model of infantile spasms

(2013) Stephen W. Briggs et al.   EPILEPSIA

Efficacy and tolerability of the galanin analog NAX 5055 in the multiple-hit rat model of symptomatic infantile spasms

(2013) Marine Jequier Gygax et al.   EPILEPSY RESEARCH

Pharmacological blockade of IL-1β/IL-1 receptor type 1 axis during epileptogenesis provides neuroprotection in two rat models of temporal lobe epilepsy

(2013) F.M. Noe et al.   NEUROBIOLOGY OF DISEASE

Identification of new epilepsy treatments: Issues in preclinical methodology

(2012) Aristea S. Galanopoulou et al.   EPILEPSIA

Diagnosis delay in West syndrome: misdiagnosis and consequences

(2012) Stéphane Auvin et al.   EUROPEAN JOURNAL OF PEDIATRICS

Efficacy of antiepileptic drugs in adults predicts efficacy in children: A systematic review

(2012) J. M. Pellock et al.   NEUROLOGY

Evidence-based guideline update: Medical treatment of infantile spasms: Report of the Guideline Development Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society

(2012) C. Y. Go et al.   NEUROLOGY

Seizure outcome in infantile spasms-A retrospective study

(2011) Basheer Peer Mohamed et al.   EPILEPSIA

The effect of lead time to treatment and of age of onset on developmental outcome at 4 years in infantile spasms: Evidence from the United Kingdom Infantile Spasms Study

(2011) Finbar J. K. O’Callaghan et al.   EPILEPSIA

Carisbamate acutely suppresses spasms in a rat model of symptomatic infantile spasms

(2011) Tomonori Ono et al.   EPILEPSIA

(1S, 3S)-3-Amino-4-difluoromethylenyl-1-cyclopentanoic Acid (CPP-115), a Potent γ-Aminobutyric Acid Aminotransferase Inactivator for the Treatment of Cocaine Addiction

(2011) Yue Pan et al.   JOURNAL OF MEDICINAL CHEMISTRY

A pulse rapamycin therapy for infantile spasms and associated cognitive decline

(2011) Emmanuel Raffo et al.   NEUROBIOLOGY OF DISEASE

Interleukin-1β Biosynthesis Inhibition Reduces Acute Seizures and Drug Resistant Chronic Epileptic Activity in Mice

(2011) Mattia Maroso et al.   Neurotherapeutics

Extrapolation of Adult Data and Other Data in Pediatric Drug-Development Programs

(2011) J. Dunne et al.   PEDIATRICS

Developmental and epilepsy outcomes at age 4 years in the UKISS trial comparing hormonal treatments to vigabatrin for infantile spasms: a multi-centre randomised trial

(2010) K. Darke et al.   ARCHIVES OF DISEASE IN CHILDHOOD

Infantile spasms: Toward a selective diagnostic and therapeutic approach

(2010) Olivier Dulac et al.   EPILEPSIA

Infantile spasms: A U.S. consensus report

(2010) John M. Pellock et al.   EPILEPSIA

Effect of Price Increase of Adrenocorticotropic Hormone on Treatment Practices of Infantile Spasms

(2010) Carter D. Wray et al.   PEDIATRIC NEUROLOGY

Estrogen Rapidly Activates the PI3K/AKT Pathway and Hypoxia-Inducible Factor 1 and Induces Vascular Endothelial Growth Factor A Expression in Luminal Epithelial Cells of the Rat Uterus1

(2009) Armina A. Kazi et al.   BIOLOGY OF REPRODUCTION

Vigabatrin: 2008 Update

(2009) L. James Willmore et al.   EPILEPSIA

Multicenter long-term follow-up of children with idiopathic West syndrome: ACTH versus vigabatrin

(2009) S. Cohen-Sadan et al.   EUROPEAN JOURNAL OF NEUROLOGY

A Triplet Repeat Expansion Genetic Mouse Model of Infantile Spasms Syndrome, Arx(GCG)10+7, with Interneuronopathy, Spasms in Infancy, Persistent Seizures, and Adult Cognitive and Behavioral Impairment

(2009) M. G. Price et al.   JOURNAL OF NEUROSCIENCE

A model of symptomatic infantile spasms syndrome

(2009) Morris H. Scantlebury et al.   NEUROBIOLOGY OF DISEASE

Infantile Spasms and Down Syndrome: A New Animal Model

(2009) Miguel A Cortez et al.   PEDIATRIC RESEARCH

Interleukin Converting Enzyme inhibition impairs kindling epileptogenesis in rats by blocking astrocytic IL-1β production

(2008) Teresa Ravizza et al.   NEUROBIOLOGY OF DISEASE