Presenilin-1 Targeted Morpholino Induces Cognitive Deficits, Increased Brain Aβ1−42 and Decreased Synaptic Marker PSD-95 in Zebrafish Larvae

Alzheimer Presenilin-1 Mutations Dramatically Reduce Trimming of Long Amyloid β-Peptides (Aβ) by γ-Secretase to Increase 42-to-40-Residue Aβ

(2014) Marty A. Fernandez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Brain Intraventricular Injection of Amyloid-β in Zebrafish Embryo Impairs Cognition and Increases Tau Phosphorylation, Effects Reversed by Lithium

(2014) Laura Roesler Nery et al.   PLoS One

Sustained behavioral effects of lithium exposure during early development in zebrafish: Involvement of the Wnt-β-catenin signaling pathway

(2014) Laura R. Nery et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Zebrafish as an emerging model for studying complex brain disorders

(2014) Allan V. Kalueff et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Animal models of Alzheimer disease: historical pitfalls and a path forward

(2014) Sarah E. Cavanaugh   ALTEX-Alternatives to Animal Experimentation

DHA-PC and PSD-95 decrease after loss of synaptophysin and before neuronal loss in patients with Alzheimer's disease

(2014) Dai Yuki et al.   Scientific Reports

Changed membrane integration and catalytic site conformation are two mechanisms behind the increased Aβ42/Aβ40 ratio by presenilin 1 familial Alzheimer-linked mutations

(2014) Johanna Wanngren et al.   FEBS Open Bio

Differential, dominant activation and inhibition of Notch signalling and APP cleavage by truncations of PSEN1 in human disease

(2013) Morgan Newman et al.   HUMAN MOLECULAR GENETICS

Genomic editing opens new avenues for zebrafish as a model for neurodegeneration

(2013) Bettina Schmid et al.   JOURNAL OF NEUROCHEMISTRY

Presenilin1 Regulates Histamine Neuron Development and Behavior in Zebrafish, Danio rerio

(2013) M. Sundvik et al.   JOURNAL OF NEUROSCIENCE

The zebrafish reference genome sequence and its relationship to the human genome

(2013) Kerstin Howe et al.   NATURE

Efficient genome editing in zebrafish using a CRISPR-Cas system

(2013) Woong Y Hwang et al.   NATURE BIOTECHNOLOGY

Alzheimer Mechanisms and Therapeutic Strategies

(2012) Yadong Huang et al.   CELL

A novel high-throughput imaging system for automated analyses of avoidance behavior in zebrafish larvae

(2011) Sean D. Pelkowski et al.   BEHAVIOURAL BRAIN RESEARCH

Measuring thigmotaxis in larval zebrafish

(2011) S.J. Schnörr et al.   BEHAVIOURAL BRAIN RESEARCH

Animal models in the drug discovery pipeline for Alzheimer's disease

(2011) Debby Van Dam et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease

(2011) Sergio T. Ferreira et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Amyloid oligomers: formation and toxicity of Aβ oligomers

(2010) Masafumi Sakono et al.   FEBS Journal

Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration

(2010) Brian R. Hoover et al.   NEURON

Presenilin mouse and zebrafish models for dementia: Focus on neurogenesis

(2010) Paula van Tijn et al.   PROGRESS IN NEUROBIOLOGY

Automated analysis of behavior in zebrafish larvae

(2009) Robbert Creton   BEHAVIOURAL BRAIN RESEARCH

Independent and cooperative action of Psen2 with Psen1 in zebrafish embryos

(2009) Svanhild Nornes et al.   EXPERIMENTAL CELL RESEARCH

A Primer for Morpholino Use in Zebrafish

(2009) Brent R. Bill et al.   Zebrafish

β-catenin is required for memory consolidation

(2008) Kimberly A Maguschak et al.   NATURE NEUROSCIENCE