Article
Biochemistry & Molecular Biology
Felipe Mora-Bermudez, Elena Taverna, Wieland B. Huttner
Summary: Comparing the neural cells of hominids reveals significant differences in the regulation of processes such as proliferation and differentiation of neural stem and progenitor cells (NSPCs) and maturation of neurons, with the timing of these processes emerging as a foundational difference in neocortex development among hominids.
Article
Biochemistry & Molecular Biology
Jon I. Arellano, Yury M. Morozov, Nicola Micali, Pasko Rakic
Summary: Radial glial cells (RGC) play a crucial role in brain development in vertebrates, originating from neuroepithelial cells and becoming the main progenitor in the developing cerebrum. Questions remain regarding the transformation of NEC into RGC, the function of glial fibrillary acidic protein (GFAP) in RGCs, and the dynamic behavior of RGCs during neurogenesis.
NEUROCHEMICAL RESEARCH
(2021)
Article
Developmental Biology
Alfonso Lavado, Ruchika Gangwar, Joshua Pare, Shibiao Wan, Yiping Fan, Xinwei Cao
Summary: The Hippo pathway regulates the expression of YAP/TAZ genes during brain development, playing a crucial role in maintaining the proliferation and structural organization of radial glial cells. Depletion of YAP/TAZ can lead to abnormalities in brain development.
DEVELOPMENTAL BIOLOGY
(2021)
Review
Physiology
Chia-Yu Yeh, Kuan-Yu Wu, Guo-Jen Huang, Alexei Verkhratsky
Summary: Adult neurogenesis is an important process that contributes to adaptive network remodelling in the brain. This review focuses on the cellular characteristics and roles of radial astrocytes (RSA) and parenchymal astrocytes in adult neurogenesis in different brain regions. The potential therapeutic applications of RSA and astrocytes in cell replacement and regeneration strategies are also discussed.
Review
Neurosciences
Chiara Ossola, Nereo Kalebic
Summary: The development of the cerebral cortex is a complex process, and disturbances in the characteristics of neural progenitor cells are associated with cortical developmental abnormalities that can lead to neurodevelopmental disorders.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Clinical Neurology
Vasiliki Gkini, Takashi Namba
Summary: Multiple types of neural progenitor cells contribute to the development of the neocortex, and their metabolisms, especially glutaminolysis, play a critical role in neocortical development, evolution, and neurodevelopmental disorders.
Article
Neurosciences
Felipe Mora-Bermudez, Wieland B. Huttner
Summary: This article discusses the potentially human-specific aspects of neocortical stem and progenitor cells (NSPCs) and proposes experimental approaches to answer relevant questions, aiming to further understand key issues in human cortical development.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Cell Biology
Ugo Tomasello, Esther Klingler, Mathieu Niquille, Nandkishor Mule, Antonio J. Santinha, Laura de Vevey, Julien Prados, Randall J. Platt, Victor Borrell, Denis Jabaudon, Alexandre Dayer
Summary: This study reveals the regulatory role of the outer subventricular zone (oSVZ) and two microRNAs (miR-137 and miR-122) in cortical expansion, enhancing our understanding of cortical development and evolution.
Article
Biotechnology & Applied Microbiology
Chen Li, Maria C. Virgilio, Kathleen L. Collins, Joshua D. Welch
Summary: This paper introduces a model called MultiVelo, which extends the RNA velocity framework using differential equations to incorporate epigenomic data. The model improves the accuracy of cell fate prediction by estimating the temporal relationship between chromatin accessibility and gene expression. The study reveals different classes of genes and cell states, and identifies time lags between transcription factor expression and binding site accessibility, as well as disease-associated SNP accessibility and linked gene expression.
NATURE BIOTECHNOLOGY
(2023)
Article
Neurosciences
Jaime Fabra-Beser, Jessica Alves Medeiros de Araujo, Diego Marques-Coelho, Loyal A. Goff, Marcos R. Costa, Ulrich Muller, Cristina Gil-Sanz
Summary: Our study using single-cell RNA sequencing reveals molecular differences between progenitor cells with different neurogenic behavior at early stages of corticogenesis, and indicates that Sox9 is critical for the maintenance of radial glial progenitor cells (RGCs) to regulate the generation of upper layer neurons.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Melanie Roussat, Thomas Jungas, Christophe Audouard, Sofiane Omerani, Francois Medevielle, Eric Agius, Alice Davy, Fabienne Pituello, Sophie Bel-Vialar
Summary: During cortical development, the cell cycle regulator CDC25B plays a crucial role in regulating the balance between different types of progenitor cells and their production of neurons. Deleting CDC25B in apical progenitors leads to an increase in TBR1(+) neurons at the expense of TBR2(+) basal progenitors, due to the lengthening of the G(2) phase.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Hong Li, Alvaro Duque, Pasko Rakic
Summary: New studies in rodents have provided insights into the functions of the claustrum, suggesting its involvement in attention, salience detection, slow-wave generation, and neocortical network synchronization. However, the origin and development of the claustrum, particularly in primates, remain poorly understood. This study demonstrates that the claustrum in rhesus macaque embryos expresses neocortical molecular markers and undergoes two waves of neurogenesis, establishing a core and shell cytoarchitecture. Furthermore, the claustrum is found to be an independent pallial region, indicating its potentially unique role in cognitive control.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Oncology
Ming Hou, Suji Wang, Dandan Yu, Xinyi Lu, Xiansen Zhao, Zhangpeng Chen, Chao Yan
Summary: Chronic stress hinders neural stem cell differentiation and hippocampal neurogenesis, while CBD administration can alleviate depressive symptoms and modulate neural differentiation and AHN through signaling pathway modulation.
FRONTIERS OF MEDICINE
(2022)
Article
Developmental Biology
Li He, Jennifer Jones, Weiguo He, Bryan C. Bjork, Jiayu Wen, Qi Dai
Summary: PRDM16 is a crucial transcriptional regulator that promotes the transition from early to late phase of neurogenesis in the mouse neocortex. It regulates a subset of genes involved in neuronal specification, cell cycle regulation, and neuronal migration by limiting chromatin accessibility of permissive enhancers. This study provides evidence to support the temporal shift in gene expression program of neural progenitors to achieve neural cell diversity.
Review
Neurosciences
Luke Parkitny, Mirjana Maletic-Savatic
Summary: Adult neurogenesis in the hippocampal niche is influenced by glial cells' sensing and response to innate immune danger signals, affecting stem cell fate, survival, neuronal maturation, and integration. These responses can be appropriate and on-target, such as in learning-associated synaptic pruning, or excessive and off-target, as seen in neurodegenerative disorders.
Article
Obstetrics & Gynecology
Ashlie A. Tronnes, Jenna Koschnitzky, Ray Daza, Jane Hitti, Jan Marino Ramirez, Robert Hevner
REPRODUCTIVE SCIENCES
(2016)
Article
Cell Biology
Anca B. Mihalas, Gina E. Elsen, Francesco Bedogni, Ray A. M. Daza, Kevyn A. Ramos-Laguna, Sebastian J. Arnold, Robert F. Hevner
Article
Developmental Biology
Simone Probst, Ray A. Daza, Natalie Bader, Jonas F. Hummel, Matthias Weiss, Yakup Tanriver, Robert F. Hevner, Sebastian J. Arnold
Article
Developmental Biology
Inga-Marie Pimeisl, Yakup Tanriver, Ray A. Daza, Franz Vauti, Robert F. Hevner, Hans-Henning Arnold, Sebastian J. Arnold
Article
Clinical Neurology
Jeffrey T. Joseph, A. Micheil Innes, Amanda C. Smith, Megan R. Vanstone, Jeremy A. Schwartzentruber, Dennis E. Bulman, Jacek Majewski, Ray A. Daza, Robert F. Hevner, Jean Michaud, Kym M. Boycott
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2014)
Article
Multidisciplinary Sciences
Gina E. Elsen, Rebecca D. Hodge, Francesco Bedogni, Ray A. M. Daza, Branden R. Nelson, Naoko Shiba, Steven L. Reiner, Robert F. Hevner
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2013)
Article
Immunology
Yu-Chi Chang, Ray Daza, Robert Hevner, Lucio G. Costa, Toby B. Cole
BRAIN BEHAVIOR AND IMMUNITY
(2019)
Article
Genetics & Heredity
Nynke Oosterhof, Irene J. Chang, Ehsan Ghayoor Karimiani, Laura E. Kuil, Dana M. Jensen, Ray Daza, Erica Young, Lee Astle, Herma C. van der Linde, Giridhar M. Shivaram, Jeroen Demmers, Caitlin S. Latimer, C. Dirk Keene, Emily Loter, Reza Maroofian, Tjakko J. van Ham, Robert F. Hevner, James T. Bennett
AMERICAN JOURNAL OF HUMAN GENETICS
(2019)
Article
Biology
Branden R. Nelson, Rebecca D. Hodge, Ray A. M. Daza, Prem Prakash Tripathi, Sebastian J. Arnold, Kathleen J. Millen, Robert F. Hevner
Article
Clinical Neurology
Toby B. Cole, Yu-Chi Chang, Khoi Dao, Ray Daza, Robert Hevner, Lucio G. Costa
JOURNAL OF NEURODEVELOPMENTAL DISORDERS
(2020)
Article
Neurosciences
Ashley McDonough, Gina E. Elsen, Ray M. Daza, Amelia R. Bachleda, Donald Pizzo, Olivia M. DelleTorri, Robert F. Hevner
Summary: Previous studies have shown specific expression of the transcription factor Tbr2 in unipolar brush cells (UBCs) of the cerebellum. Further investigation using transgenic mouse lines revealed that Tbr2 deficiency results in the absence of mature UBCs and impairs migration and differentiation of UBC precursors. Remarkably, Tbr2(+) UBC precursors follow similar migration pathways in humans as in rodent cerebellum, creating the characteristic fountain-like appearance of UBCs exiting the rhombic lip.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Anthony S. Castanza, Sanja Ramirez, Prem P. Tripathi, Ray A. M. Daza, Franck K. Kalume, Jan-Marino Ramirez, Robert F. Hevner
Summary: Human AUTS2 mutations are associated with intellectual disability, autism, epilepsy, and other neurological disorders. By identifying AUTS2 binding partners in neonatal mouse cerebral cortex, it was found that AUTS2 plays a crucial role in regulating RNA transcription. Deletion of AUTS2 isoforms resulted in abnormalities in brain structure and function, indicating its essential role in cerebral cortex and subcortical breathing centers development.
Article
Cell Biology
Regina M. Powers, Ray Daza, Alanna E. Koehler, Julien Courchet, Barbara Calabrese, Robert F. Hevner, Shelley Halpain
Summary: Nav1 is a cytoskeleton-associated protein necessary for proper neuritogenesis. It regulates F-actin and microtubule properties and promotes membrane ruffles and macropinocytosis in growth cones. Nav1 also plays a role in downstream signaling, neurite targeting, and membrane recycling.
MOLECULAR BIOLOGY OF THE CELL
(2022)
Article
Developmental Biology
Seungshin Ha, Prem P. Tripathi, Ray A. Daza, Robert E. Hevner, David R. Beier
JOURNAL OF DEVELOPMENTAL BIOLOGY
(2020)