Vaccine-based immunotherapeutic approaches to gliomas and beyond

A Cancer Research UK First Time in Human Phase I Trial of IMA950 (Novel Multipeptide Therapeutic Vaccine) in Patients with Newly Diagnosed Glioblastoma

(2016) R. Rampling et al.   CLINICAL CANCER RESEARCH

Immune Checkpoint Inhibition for Hypermutant Glioblastoma Multiforme Resulting From Germline Biallelic Mismatch Repair Deficiency

(2016) Eric Bouffet et al.   JOURNAL OF CLINICAL ONCOLOGY

ATIM-03. ACT IV: AN INTERNATIONAL, DOUBLE-BLIND, PHASE 3 TRIAL OF RINDOPEPIMUT IN NEWLY DIAGNOSED, EGFRvIII-EXPRESSING GLIOBLASTOMA

(2016) Michael Weller et al.   NEURO-ONCOLOGY

A Phase II randomized study of galunisertib monotherapy or galunisertib plus lomustine compared with lomustine monotherapy in patients with recurrent glioblastoma

(2016) Alba A. Brandes et al.   NEURO-ONCOLOGY

Cancer immunotherapy: exploiting neoepitopes

(2015) Michael Platten et al.   CELL RESEARCH

Immunotherapy for glioblastoma

(2015) Tobias Weiss et al.   CURRENT OPINION IN NEUROLOGY

VEGF-A modulates expression of inhibitory checkpoints on CD8+T cells in tumors

(2015) Thibault Voron et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The role of STAT3 in tumor-mediated immune suppression

(2015) Sherise D. Ferguson et al.   JOURNAL OF NEURO-ONCOLOGY

Heat shock protein vaccines against glioblastoma: from bench to bedside

(2015) Leonel Ampie et al.   JOURNAL OF NEURO-ONCOLOGY

Immunotherapy response assessment in neuro-oncology: a report of the RANO working group

(2015) Hideho Okada et al.   LANCET ONCOLOGY

Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous non-small-cell lung cancer (CheckMate 063): a phase 2, single-arm trial

(2015) Naiyer A Rizvi et al.   LANCET ONCOLOGY

OX40 ligand expressed in glioblastoma modulates adaptive immunity depending on the microenvironment: a clue for successful immunotherapy

(2015) Ichiyo Shibahara et al.   Molecular Cancer

Tetanus toxoid and CCL3 improve dendritic cell vaccines in mice and glioblastoma patients

(2015) Duane A. Mitchell et al.   NATURE

Prospects of immune checkpoint modulators in the treatment of glioblastoma

(2015) Matthias Preusser et al.   Nature Reviews Neurology

A phase II, multicenter trial of rindopepimut (CDX-110) in newly diagnosed glioblastoma: the ACT III study

(2015) J. Schuster et al.   NEURO-ONCOLOGY

Immunosuppressive mechanisms in glioblastoma: Fig. 1.

(2015) Edjah K. Nduom et al.   NEURO-ONCOLOGY

Isocitrate dehydrogenase mutations in gliomas

(2015) Matthew S. Waitkus et al.   NEURO-ONCOLOGY

PD-L1 expression and prognostic impact in glioblastoma

(2015) Edjah K. Nduom et al.   NEURO-ONCOLOGY

CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2008-2012

(2015) Quinn T. Ostrom et al.   NEURO-ONCOLOGY

Mutation-Specific T Cells for Immunotherapy of Gliomas

(2015) Cornelis J.M. Melief   NEW ENGLAND JOURNAL OF MEDICINE

Pembrolizumab versus Ipilimumab in Advanced Melanoma

(2015) Caroline Robert et al.   NEW ENGLAND JOURNAL OF MEDICINE

Rational development and characterization of humanized anti–EGFR variant III chimeric antigen receptor T cells for glioblastoma

(2015) Laura A. Johnson et al.   Science Translational Medicine

Glioblastoma Eradication Following Immune Checkpoint Blockade in an Orthotopic, Immunocompetent Model

(2015) D. A. Reardon et al.   Cancer Immunology Research

Effective immuno-targeting of the IDH1 mutation R132H in a murine model of intracranial glioma

(2015) Serena Pellegatta et al.   Acta Neuropathologica Communications

MicroRNA-mediated down-regulation of NKG2D ligands contributes to glioma immune escape

(2015) Paula Codo et al.   Oncotarget

Mutant IDH1: An immunotherapeutic target in tumors

(2015) Theresa Schumacher et al.   OncoImmunology

Recognition and Killing of Autologous, Primary Glioblastoma Tumor Cells by Human Cytomegalovirus pp65-Specific Cytotoxic T Cells

(2014) S. K. Nair et al.   CLINICAL CANCER RESEARCH

Induction of Robust Type-I CD8+ T-cell Responses in WHO Grade 2 Low-Grade Glioma Patients Receiving Peptide-Based Vaccines in Combination with Poly-ICLC

(2014) H. Okada et al.   CLINICAL CANCER RESEARCH

Durable Therapeutic Efficacy Utilizing Combinatorial Blockade against IDO, CTLA-4, and PD-L1 in Mice with Brain Tumors

(2014) D. A. Wainwright et al.   CLINICAL CANCER RESEARCH

Absence of cytomegalovirus in high-coverage DNA sequencing of human glioblastoma multiforme

(2014) Ka-Wei Tang et al.   INTERNATIONAL JOURNAL OF CANCER

Antigen-Specific Immune Responses and Clinical Outcome After Vaccination With Glioma-Associated Antigen Peptides and Polyinosinic-Polycytidylic Acid Stabilized by Lysine and Carboxymethylcellulose in Children With Newly Diagnosed Malignant Brainstem and Nonbrainstem Gliomas

(2014) Ian F. Pollack et al.   JOURNAL OF CLINICAL ONCOLOGY

How Stemlike Are Sphere Cultures From Long-term Cancer Cell Lines? Lessons From Mouse Glioma Models

(2014) Mushfika Ahmad et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Immunocompetent murine models for the study of glioblastoma immunotherapy

(2014) Taemin Oh et al.   Journal of Translational Medicine

A vaccine targeting mutant IDH1 induces antitumour immunity

(2014) Theresa Schumacher et al.   NATURE

Human cytomegalovirus infection in tumor cells of the nervous system is not detectable with standardized pathologico-virological diagnostics

(2014) P. Baumgarten et al.   NEURO-ONCOLOGY

Programmed death ligand 1 expression and tumor-infiltrating lymphocytes in glioblastoma

(2014) Anna Sophie Berghoff et al.   NEURO-ONCOLOGY

AT-60 * A RANDOMIZED DOUBLE BLIND PLACEBO-CONTROLLED PHASE 2 TRIAL OF DENDRITIC CELL (DC) VACCINE ICT-107 FOLLOWING STANDARD TREATMENT IN NEWLY DIAGNOSED PATIENTS WITH GBM

(2014) P. Wen et al.   NEURO-ONCOLOGY

A Randomized Trial of Bevacizumab for Newly Diagnosed Glioblastoma

(2014) Mark R. Gilbert et al.   NEW ENGLAND JOURNAL OF MEDICINE

Bevacizumab plus Radiotherapy–Temozolomide for Newly Diagnosed Glioblastoma

(2014) Olivier L. Chinot et al.   NEW ENGLAND JOURNAL OF MEDICINE

MRI-localized biopsies reveal subtype-specific differences in molecular and cellular composition at the margins of glioblastoma

(2014) B. J. Gill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunological challenges for peptide-based immunotherapy in glioblastoma

(2013) Malte Mohme et al.   CANCER TREATMENT REVIEWS

The Somatic Genomic Landscape of Glioblastoma

(2013) Cameron W. Brennan et al.   CELL

Assessment and prognostic significance of the epidermal growth factor receptor vIII mutation in glioblastoma patients treated with concurrent and adjuvant temozolomide radiochemotherapy

(2013) Michael Weller et al.   INTERNATIONAL JOURNAL OF CANCER

The regulatory landscape for actively personalized cancer immunotherapies

(2013) Cedrik M Britten et al.   NATURE BIOTECHNOLOGY

Heat-shock protein peptide complex–96 vaccination for recurrent glioblastoma: a phase II, single-arm trial

(2013) Orin Bloch et al.   NEURO-ONCOLOGY

Age-Specific Signatures of Glioblastoma at the Genomic, Genetic, and Epigenetic Levels

(2013) Serdar Bozdag et al.   PLoS One

CMV-Independent Lysis of Glioblastoma by Ex Vivo Expanded/Activated Vδ1+ γδ T Cells

(2013) Andrea Knight et al.   PLoS One

New prospects on the NKG2D/NKG2DL system for oncology

(2013) Evelyn Ullrich et al.   OncoImmunology

Exploiting the glioblastoma peptidome to discover novel tumour-associated antigens for immunotherapy

(2012) Valérie Dutoit et al.   BRAIN

Hotspot Mutations in H3F3A and IDH1 Define Distinct Epigenetic and Biological Subgroups of Glioblastoma

(2012) Dominik Sturm et al.   CANCER CELL

Integration of autologous dendritic cell-based immunotherapy in the standard of care treatment for patients with newly diagnosed glioblastoma: results of the HGG-2006 phase I/II trial

(2012) Hilko Ardon et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Phase I trial of a multi-epitope-pulsed dendritic cell vaccine for patients with newly diagnosed glioblastoma

(2012) Surasak Phuphanich et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Individual Patient-Specific Immunity against High-Grade Glioma after Vaccination with Autologous Tumor Derived Peptides Bound to the 96 KD Chaperone Protein

(2012) C. A. Crane et al.   CLINICAL CANCER RESEARCH

Sequential Immunotherapy by Vaccination With GM-CSF–expressing Glioma Cells and CTLA-4 Blockade Effectively Treats Established Murine Intracranial Tumors

(2012) Pankaj Agarwalla et al.   JOURNAL OF IMMUNOTHERAPY

HLA-E contributes to an immune-inhibitory phenotype of glioblastoma stem-like cells

(2012) Fabian Wolpert et al.   JOURNAL OF NEUROIMMUNOLOGY

Overexpression of isocitrate dehydrogenase mutant proteins renders glioma cells more sensitive to radiation

(2012) Sichen Li et al.   NEURO-ONCOLOGY

In vivo models of primary brain tumors: pitfalls and perspectives

(2012) P. C. Huszthy et al.   NEURO-ONCOLOGY

Consensus on the role of human cytomegalovirus in glioblastoma

(2012) K. Dziurzynski et al.   NEURO-ONCOLOGY

Current Review of in Vivo GBM Rodent Models: Emphasis on the CNS-1 Tumour Model

(2011) Valerie L. Jacobs et al.   ASN Neuro

Costimulatory Protein 4IgB7H3 Drives the Malignant Phenotype of Glioblastoma by Mediating Immune Escape and Invasiveness

(2011) D. Lemke et al.   CLINICAL CANCER RESEARCH

Significant Association of Multiple Human Cytomegalovirus Genomic Loci with Glioblastoma Multiforme Samples

(2011) P. Ranganathan et al.   JOURNAL OF VIROLOGY

An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor

(2011) Christiane A. Opitz et al.   NATURE

Myeloid-derived suppressor cell accumulation and function in patients with newly diagnosed glioblastoma

(2011) B. Raychaudhuri et al.   NEURO-ONCOLOGY

Patients with IDH1 wild type anaplastic astrocytomas exhibit worse prognosis than IDH1-mutated glioblastomas, and IDH1 mutation status accounts for the unfavorable prognostic effect of higher age: implications for classification of gliomas

(2010) Christian Hartmann et al.   ACTA NEUROPATHOLOGICA

Superior Efficacy of Tumor Cell Vaccines Grown in Physiologic Oxygen

(2010) M. R. Olin et al.   CLINICAL CANCER RESEARCH

Dendritic Cell Vaccination in Combination with Anti-CD25 Monoclonal Antibody Treatment: A Phase I/II Study in Metastatic Melanoma Patients

(2010) J. F. M. Jacobs et al.   CLINICAL CANCER RESEARCH

Gene Expression Profile Correlates with T-Cell Infiltration and Relative Survival in Glioblastoma Patients Vaccinated with Dendritic Cell Immunotherapy

(2010) Robert M. Prins et al.   CLINICAL CANCER RESEARCH

GDF-15 Contributes to Proliferation and Immune Escape of Malignant Gliomas

(2010) P. Roth et al.   CLINICAL CANCER RESEARCH

Immunologic Escape After Prolonged Progression-Free Survival With Epidermal Growth Factor Receptor Variant III Peptide Vaccination in Patients With Newly Diagnosed Glioblastoma

(2010) John H. Sampson et al.   JOURNAL OF CLINICAL ONCOLOGY

Induction of CD8+ T-Cell Responses Against Novel Glioma–Associated Antigen Peptides and Clinical Activity by Vaccinations With α-Type 1 Polarized Dendritic Cells and Polyinosinic-Polycytidylic Acid Stabilized by Lysine and Carboxymethylcellulose in Patients With Recurrent Malignant Glioma

(2010) Hideho Okada et al.   JOURNAL OF CLINICAL ONCOLOGY

Greater chemotherapy-induced lymphopenia enhances tumor-specific immune responses that eliminate EGFRvIII-expressing tumor cells in patients with glioblastoma

(2010) J. H. Sampson et al.   NEURO-ONCOLOGY

Glioma cancer stem cells induce immunosuppressive macrophages/microglia

(2010) Adam Wu et al.   NEURO-ONCOLOGY

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

(2010) F. Stephen Hodi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas

(2009) Christian Hartmann et al.   ACTA NEUROPATHOLOGICA

Systemic Inhibition of Transforming Growth Factor-  in Glioma-Bearing Mice Improves the Therapeutic Efficacy of Glioma-Associated Antigen Peptide Vaccines

(2009) R. Ueda et al.   CLINICAL CANCER RESEARCH

Molecular Predictors of Progression-Free and Overall Survival in Patients With Newly Diagnosed Glioblastoma: A Prospective Translational Study of the German Glioma Network

(2009) Michael Weller et al.   JOURNAL OF CLINICAL ONCOLOGY

IDH1andIDH2Mutations in Gliomas

(2009) Hai Yan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Depletion of human regulatory T cells specifically enhances antigen-specific immune responses to cancer vaccines

(2008) M. A. Morse et al.   BLOOD

Reactivation of Cytomegalovirus Infection in Critically Ill Immunocompetent Patients—Reply

(2008) Ajit P. Limaye   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Cytomegalovirus Immunity after Vaccination with Autologous Glioblastoma Lysate

(2008) Robert M. Prins et al.   NEW ENGLAND JOURNAL OF MEDICINE

Sensitive detection of human cytomegalovirus in tumors and peripheral blood of patients diagnosed with glioblastoma

(2007) Duane A. Mitchell et al.   NEURO-ONCOLOGY