Targeting neural reflex circuits in immunity to treat kidney disease

C1 neurons mediate a stress-induced anti-inflammatory reflex in mice

(2017) Chikara Abe et al.   NATURE NEUROSCIENCE

Neural regulation of immunity: molecular mechanisms and clinical translation

(2017) Valentin A Pavlov et al.   NATURE NEUROSCIENCE

Role of the Immune System in Hypertension

(2017) Bernardo Rodriguez-Iturbe et al.   PHYSIOLOGICAL REVIEWS

Chemogenetics revealed: DREADD occupancy and activation via converted clozapine

(2017) Juan L. Gomez et al.   SCIENCE

Central neural control of the cardiovascular system: current perspectives

(2016) Roger A. L. Dampney   ADVANCES IN PHYSIOLOGY EDUCATION

Transcutaneous Cervical Vagus Nerve Stimulation Ameliorates Acute Ischemic Injury in Rats

(2016) Ilknur Ay et al.   Brain Stimulation

Sensory Neurons that Detect Stretch and Nutrients in the Digestive System

(2016) Erika K. Williams et al.   CELL

Resting Afferent Renal Nerve Discharge and Renal InflammationNovelty and Significance

(2016) Christopher T. Banek et al.   HYPERTENSION

Vagus nerve stimulation mediates protection from kidney ischemia-reperfusion injury through α7nAChR+ splenocytes

(2016) Tsuyoshi Inoue et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondria Protection after Acute Ischemia Prevents Prolonged Upregulation of IL-1βand IL-18 and Arrests CKD

(2016) Hazel H. Szeto et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Endothelial Sphingosine 1-Phosphate Receptor-1 Mediates Protection and Recovery from Acute Kidney Injury

(2016) H. M. Perry et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Silencing spinal interneurons inhibits immune suppressive autonomic reflexes caused by spinal cord injury

(2016) Masaki Ueno et al.   NATURE NEUROSCIENCE

Chronic vagus nerve stimulation in Crohn's disease: a 6-month follow-up pilot study

(2016) B. Bonaz et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Noninvasive Transcutaneous Vagus Nerve Stimulation Decreases Whole Blood Culture-Derived Cytokines and Chemokines: A Randomized, Blinded, Healthy Control Pilot Trial

(2016) Imanuel Lerman et al.   NEUROMODULATION

DREADDs for Neuroscientists

(2016) Bryan L. Roth   NEURON

Vagus nerve stimulation inhibits cytokine production and attenuates disease severity in rheumatoid arthritis

(2016) Frieda A. Koopman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A cholinergic-sympathetic pathway primes immunity in hypertension and mediates brain-to-spleen communication

(2016) Daniela Carnevale et al.   Nature Communications

Vagus Nerve Stimulation Exerts the Neuroprotective Effects in Obese-Insulin Resistant Rats, Leading to the Improvement of Cognitive Function

(2016) Titikorn Chunchai et al.   Scientific Reports

A novel method of selective ablation of afferent renal nerves by periaxonal application of capsaicin

(2015) Jason D. Foss et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Role of renal sensory nerves in physiological and pathophysiological conditions

(2015) Ulla C. Kopp   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Vagal Sensory Neuron Subtypes that Differentially Control Breathing

(2015) Rui B. Chang et al.   CELL

The Neuroimmune Axis in the Kidney

(2015) Rhian M. Touyz   CIRCULATION RESEARCH

Renal Denervation Prevents Immune Cell Activation and Renal Inflammation in Angiotensin II–Induced HypertensionNovelty and Significance

(2015) Liang Xiao et al.   CIRCULATION RESEARCH

Role of T lymphocytes in hypertension

(2015) Jiandong Zhang et al.   CURRENT OPINION IN PHARMACOLOGY

Surgically implanted and non-invasive vagus nerve stimulation: a review of efficacy, safety and tolerability

(2015) E. Ben-Menachem et al.   EUROPEAN JOURNAL OF NEUROLOGY

The crosstalk between the kidney and the central nervous system: the role of renal nerves in blood pressure regulation

(2015) Erika E. Nishi et al.   EXPERIMENTAL PHYSIOLOGY

Sympathetic-mediated activationversussuppression of the immune system: consequences for hypertension

(2015) Adam J. Case et al.   JOURNAL OF PHYSIOLOGY-LONDON

Ultrasound Modulates the Splenic Neuroimmune Axis in Attenuating AKI

(2015) J. C. Gigliotti et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Progression after AKI: Understanding Maladaptive Repair Processes to Predict and Identify Therapeutic Treatments

(2015) D. P. Basile et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Failed Tubule Recovery, AKI-CKD Transition, and Kidney Disease Progression

(2015) M. A. Venkatachalam et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Immune Mechanisms in Arterial Hypertension

(2015) U. Wenzel et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Renal denervation prevents long-term sequelae of ischemic renal injury

(2015) Jinu Kim et al.   KIDNEY INTERNATIONAL

Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease

(2015) M Teresa Grande et al.   NATURE MEDICINE

Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis

(2015) Sara Lovisa et al.   NATURE MEDICINE

Optogenetics: 10 years of microbial opsins in neuroscience

(2015) Karl Deisseroth   NATURE NEUROSCIENCE

Macrophages in Kidney Injury, Inflammation, and Fibrosis

(2015) Qi Cao et al.   PHYSIOLOGY

The Regulation of Immunological Processes by Peripheral Neurons in Homeostasis and Disease

(2015) Jose Ordovas-Montanes et al.   TRENDS IN IMMUNOLOGY

Vagus nerve stimulation: A new bioelectronics approach to treat rheumatoid arthritis?

(2014) F.A. Koopman et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

Catheter-based renal denervation for treatment of patients with treatment-resistant hypertension: 36 month results from the SYMPLICITY HTN-2 randomized clinical trial

(2014) Murray D. Esler et al.   EUROPEAN HEART JOURNAL

The inextricable role of the kidney in hypertension

(2014) Thomas M. Coffman   JOURNAL OF CLINICAL INVESTIGATION

Preclinical research: Make mouse studies work

(2014) Steve Perrin   NATURE

Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development

(2014) Hyun Mi Kang et al.   NATURE MEDICINE

Immune cells in experimental acute kidney injury

(2014) Hye Ryoun Jang et al.   Nature Reviews Nephrology

The Spleen: The Forgotten Organ in Acute Kidney Injury of Critical Illness

(2014) Joseph C. Gigliotti et al.   NEPHRON CLINICAL PRACTICE

Acute Kidney Injury and Chronic Kidney Disease as Interconnected Syndromes

(2014) Lakhmir S. Chawla et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Controlled Trial of Renal Denervation for Resistant Hypertension

(2014) Deepak L. Bhatt et al.   NEW ENGLAND JOURNAL OF MEDICINE

The HPA – Immune Axis and the Immunomodulatory Actions of Glucocorticoids in the Brain

(2014) Marc-André Bellavance et al.   Frontiers in Immunology

C1 neurons: the body's EMTs

(2013) Patrice G. Guyenet et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

AKI: A Path Forward

(2013) J. V. Bonventre et al.   Clinical Journal of the American Society of Nephrology

Differential content of vesicular glutamate transporters in subsets of vagal afferents projecting to the nucleus tractus solitarii in the rat

(2013) Sam M. Hermes et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Ultrasound Prevents Renal Ischemia-Reperfusion Injury by Stimulating the Splenic Cholinergic Anti-Inflammatory Pathway

(2013) J. C. Gigliotti et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Improved tools for the Brainbow toolbox

(2013) Dawen Cai et al.   NATURE METHODS

Vagal stimulation in brain dead donor rats decreases chronic allograft nephropathy in recipients

(2013) S. Hoeger et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Reflex Principles of Immunological Homeostasis

(2012) Ulf Andersson et al.   Annual Review of Immunology

Designing Clinical Trials in Acute Kidney Injury

(2012) B. A. Molitoris et al.   Clinical Journal of the American Society of Nephrology

Design of Clinical Trials in Acute Kidney Injury: A Report from an NIDDK Workshop--Prevention Trials

(2012) M. D. Okusa et al.   Clinical Journal of the American Society of Nephrology

The vagal innervation of the gut and immune homeostasis

(2012) Gianluca Matteoli et al.   GUT

Renal Hemodynamics and Renal Function After Catheter-Based Renal Sympathetic Denervation in Patients With Resistant Hypertension

(2012) Felix Mahfoud et al.   HYPERTENSION

Tonic Postganglionic Sympathetic Inhibition Induced by Afferent Renal Nerves?

(2012) Tilmann Ditting et al.   HYPERTENSION

Neural reflexes in inflammation and immunity

(2012) Ulf Andersson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Renal Nerves Drive Interstitial Fibrogenesis in Obstructive Nephropathy

(2012) J. Kim et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Renal Denervation in Moderate to Severe CKD

(2012) D. Hering et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Temporal Changes in Incidence of Dialysis-Requiring AKI

(2012) R. K. Hsu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Neurogenic inflammation and the peripheral nervous system in host defense and immunopathology

(2012) Isaac M Chiu et al.   NATURE NEUROSCIENCE

Nicotinic Acetylcholine Receptor Agonists Attenuate Septic Acute Kidney Injury in Mice by Suppressing Inflammation and Proteasome Activity

(2012) Prodyot K. Chatterjee et al.   PLoS One

β2-Adrenoreceptors of regulatory lymphocytes are essential for vagal neuromodulation of the innate immune system

(2011) Gergely Vida et al.   FASEB JOURNAL

Distinct Macrophage Phenotypes Contribute to Kidney Injury and Repair

(2011) S. Lee et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Acetylcholine-Synthesizing T Cells Relay Neural Signals in a Vagus Nerve Circuit

(2011) M. Rosas-Ballina et al.   SCIENCE

Modulation of Brain Dead Induced Inflammation by Vagus Nerve Stimulation

(2010) S. Hoeger et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Chronic vagus nerve stimulation: a new and promising therapeutic approach for chronic heart failure

(2010) Gaetano M. De Ferrari et al.   EUROPEAN HEART JOURNAL

Unphosphorylated STAT3 modulates alpha7 nicotinic receptor signaling and cytokine production in sepsis

(2010) Geber Peña et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Sympathetic Nervous System and Blood Pressure in Humans

(2010) Michael J. Joyner et al.   HYPERTENSION

Tumor Necrosis Factor-α Antagonist Etanercept Decreases Blood Pressure and Protects the Kidney in a Mouse Model of Systemic Lupus Erythematosus

(2010) Marcia Venegas-Pont et al.   HYPERTENSION

Interleukin 6 Knockout Prevents Angiotensin II Hypertension

(2010) Michael W. Brands et al.   HYPERTENSION

Robert Koch and the ‘golden age’ of bacteriology

(2010) Steve M. Blevins et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Evidence for neuronal expression of functional Fc (ε and γ) receptors

(2010) Hanneke van der Kleij et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury

(2010) Li Yang et al.   NATURE MEDICINE

Optogenetics

(2010) Karl Deisseroth   NATURE METHODS

The suffocating kidney: tubulointerstitial hypoxia in end-stage renal disease

(2010) Imari Mimura et al.   Nature Reviews Nephrology

Translational medicine: the antihypertensive effect of renal denervation

(2009) Gerald F. DiBona et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

The Nexus of Acute Kidney Injury, Chronic Kidney Disease, and World Kidney Day 2009

(2009) M. D. Okusa et al.   Clinical Journal of the American Society of Nephrology

Interleukin 17 Promotes Angiotensin II–Induced Hypertension and Vascular Dysfunction

(2009) Meena S. Madhur et al.   HYPERTENSION

Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study

(2009) Henry Krum et al.   LANCET

Chronic etanercept treatment prevents the development of hypertension in fructose-fed rats

(2009) Linda T. Tran et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Th17 cells in human disease

(2008) Laura A. Tesmer et al.   IMMUNOLOGICAL REVIEWS

Cholinergic agonists attenuate renal ischemia–reperfusion injury in rats

(2008) M.M. Yeboah et al.   KIDNEY INTERNATIONAL

Splenic nerve is required for cholinergic antiinflammatory pathway control of TNF in endotoxemia

(2008) M. Rosas-Ballina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA