Review
Cell Biology
Kailing Yang, Xiaojia Li, Keping Xie
Summary: Tumorigenesis and senescence, although seemingly contradictory, share similar mechanisms. Pancreatic ductal adenocarcinoma (PDA) is a lethal disease that progresses through multiple steps. Senescence is prevalent in PDA development, but also plays a significant role in promoting tumorigenesis. This review focuses on the dual roles of senescence in PDA, the signaling effectors that regulate senescence, and molecular targets for controlling senescence in PDA treatment.
CELL DEATH & DISEASE
(2023)
Article
Multidisciplinary Sciences
Maximilian Konig, Nikolaus Buchmann, Ute Seeland, Dominik Spira, Elisabeth Steinhagen-Thiessen, Ilja Demuth
Summary: Low handgrip strength and increased arterial stiffness are associated, as shown in the multivariable linear regression analysis where a decrease of 5 kg in handgrip strength led to an increase of 0.08 m/s in PWV. This suggests a connection between low handgrip strength and arterial stiffness, potentially linking to increased cardiovascular morbidity and mortality.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Quentin Alle, Enora Le Borgne, Ollivier Milhavet, Jean-Marc Lemaitre
Summary: Aging is traditionally seen as an unavoidable process, but new strategies have been developed to delay or reverse aging. Some of these approaches may have medical applications to improve healthspan and longevity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Editorial Material
Plant Sciences
Hilary Joan Rogers
Summary: The epigenetic reprogramming through genome-wide histone H3 acetylation (H3K9ac) plays an important role in rice leaf senescence.
JOURNAL OF EXPERIMENTAL BOTANY
(2022)
Article
Biochemistry & Molecular Biology
Hui Xue, Jingjing Meng, Pei Lei, Yongxin Cao, Xue An, Min Jia, Yan Li, Haofeng Liu, Jen Sheen, Xiayan Liu, Fei Yu
Summary: One of the hallmarks of plant senescence is the global transcriptional reprogramming coordinated by multiple transcription factors (TFs). The study reveals that ARF2 and PIF5 are key TFs responsible for transcriptional regulation in the ABS3-mediated senescence pathway. They directly interact and function interdependently to promote senescence, and they share common target genes with ABS3.
Article
Cell Biology
Xia Liu, Celine L. Hartman, Lingyun Li, Carolyn J. Albert, Fusheng Si, Aiqin Gao, Lan Huang, Yangjing Zhao, Wenli Lin, Eddy C. Hsueh, Lizong Shen, Qixiang Shao, Daniel F. Hoft, David A. Ford, Guangyong Peng
Summary: The functional state of T cells is critical for effective antitumor immunity. T cell senescence driven by malignant tumor cells and regulatory T cells is a common feature in cancers, characterized by unbalanced lipid metabolism and accumulation of lipid droplets. Inhibition of group IVA phospholipase A(2) can reprogram effector T cell lipid metabolism, prevent T cell senescence, and enhance antitumor immunity and immunotherapy efficacy.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Anaelle Bailly, Ollivier Milhavet, Jean-Marc Lemaitre
Summary: Cell reprogramming techniques, including RNA-based strategies, have shown great potential in treating various diseases and improving healthspan and longevity.
Review
Chemistry, Multidisciplinary
Marc Ziemba, Christian Schilling, M. Veronica Ganduglia-Pirovano, Christian Hess
Summary: Ceria plays a crucial role in enhancing oxidation activity in catalysts, but identifying active sites remains a challenge. Recent studies have made significant progress in understanding the process of oxygen activation on ceria surfaces through a combination of experimental and theoretical approaches. The facet-dependent adsorption and activation of gas-phase oxygen on ceria has been revealed, providing important insights into the mechanisms involved.
ACCOUNTS OF CHEMICAL RESEARCH
(2021)
Article
Oncology
Svenja Meierjohann
Summary: Melanomas and melanocytes are frequently exposed to UV, resulting in DNA damage and reactive oxygen stress related harm. This can lead to multinucleation or polyploidy, with the cells either experiencing mitotic catastrophe and death or surviving and acquiring new features to adapt to stress. This review focuses on polyploidy inducers in melanoma, their effects on transcriptional reprogramming and phenotypic adaptation, and the significance of polyploid melanoma cells in therapy resistance.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Plant Sciences
Maris Nuhkat, Mikael Brosche, Sonja Stoelzle-Feix, Petra Dietrich, Rainer Hedrich, M. Rob G. Roelfsema, Hannes Kollist
Summary: The study found that plants have a rapid mechanism to respond to ozone signals, with ozone pulses triggering membrane depolarization and an increase in cytosolic calcium ion (Ca2+) levels within seconds. High concentrations of ozone can lead to systemic responses in plants.
Editorial Material
Cell Biology
Feng Zhu, Saleh Alseekh, Weiwei Wen, Yunjiang Cheng, Alisdair R. Fernie
Summary: In plants, dark-induced senescence leads to metabolic and autophagic shifts for nutrient recycling and survival, which is tightly regulated by genetic factors. A genome-wide association approach can be used to analyze metabolic transitions and autophagy processes.
Article
Cell Biology
Feng Cheng, Chenggui Wang, Yufei Ji, Biao Yang, Jiawei Shu, Kesi Shi, Lulu Wang, Shaoke Wang, Yuang Zhang, Xianpeng Huang, Xiaopeng Zhou, Kaishun Xia, Chengzhen Liang, Qixin Chen, Fangcai Li
Summary: The findings of this study suggest that partial reprogramming through short-term induction of OSKM can inhibit IDD progression and reduce senescence in aging NPCs. Mechanistically, this partial reprogramming activates energy metabolism and promotes redistribution of the cytoskeleton to restore the aging state of NPCs.
Article
Chemistry, Multidisciplinary
Milica Markelic, Dijana Draca, Tamara Krajnovic, Zorana Jovic, Milica Vuksanovic, Djuro Koruga, Sanja Mijatovic, Danijela Maksimovic-Ivanic
Summary: This study investigated the application of fullerenes in the field of medicine. The fullerenes complex formulated with a special technique showed promising antitumor activity against melanoma cells, and when combined with short-term irradiation of hyperpolarized light, it facilitated the reprogramming of melanoma cells towards a normal phenotype.
Article
Chemistry, Multidisciplinary
Qian Li, Yu-Heng Zhao, Cheng Xu, Ye-Lin Liang, Yin Zhao, Qing-Mei He, Jun-Yan Li, Kai-Lin Chen, Han Qiao, Na Liu, Jun Ma, Lei Chen, Ying-Qin Li
Summary: This study reveals that circWDR37 deficiency limits the proliferation, migration, and invasion of senescent NPC cells induced by cisplatin or gemcitabine. Mechanistically, circWDR37 binds and dimerizes PKR, leading to PKR autophosphorylation and activation. Activated PKR phosphorylates IKKβ, releasing RELA from IκBα and activating NF-κB, thus promoting the transcription of CCND1 and senescence-associated secretory phenotype component genes in a circWDR37-dependent manner. Low circWDR37 levels are associated with favorable survival and chemotherapy response in NPC patients treated with gemcitabine or cisplatin induction chemotherapy.
Article
Oncology
Ilaria Guccini, Ajinkya Revandkar, Mariantonietta D'Ambrosio, Manuel Colucci, Emiliano Pasquini, Simone Mosole, Martina Troiani, Daniela Brina, Raheleh Sheibani-Tezerji, Angela Rita Elia, Andrea Rinaldi, Nicolo Pernigoni, Jan Hendrik Ruschoff, Susanne Dettwiler, Angelo M. De Marzo, Emmanuel S. Antonarakis, Costanza Borrelli, Andreas E. Moor, Ramon Garcia-Escudero, Abdullah Alajati, Giuseppe Attanasio, Marco Losa, Holger Moch, Peter Wild, Gerda Egger, Andrea Alimonti
Summary: Metastasis in prostate cancer is influenced by senescence with TIMP1 acting as a molecular switch. Elimination of senescent cells can impair tumor metastasis.
Editorial Material
Genetics & Heredity
Kim Baumann
NATURE REVIEWS GENETICS
(2018)
Editorial Material
Cell Biology
Kim Baumann
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2017)
Editorial Material
Cell Biology
Kim Baumann
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2017)
Editorial Material
Cell Biology
Kim Baumann
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2017)
Editorial Material
Cell Biology
Kim Baumann
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2018)
Editorial Material
Cell Biology
Kim Baumann
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2018)
Editorial Material
Cell Biology
Kim Baumann
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2018)
Editorial Material
Cell Biology
Kim Baumann
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2018)
Editorial Material
Cell Biology
Kim Baumann
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2018)
Editorial Material
Cell Biology
Kim Baumann
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2018)
Editorial Material
Cell Biology
Kim Baumann
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2018)
Editorial Material
Cell Biology
Kim Baumann
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2018)
Editorial Material
Cell Biology
Kim Baumann
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2019)
Editorial Material
Cell Biology
Kim Baumann
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2019)
Editorial Material
Cell Biology
Kim Baumann
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2019)
