The role of PfEMP1 as targets of naturally acquired immunity to childhood malaria: prospects for a vaccine

Structural Conservation Despite Huge Sequence Diversity Allows EPCR Binding by the PfEMP1 Family Implicated in Severe Childhood Malaria

(2015) Clinton K.Y. Lau et al.   Cell Host & Microbe

Impact of Malaria Preexposure on Antiparasite Cellular and Humoral Immune Responses after Controlled Human Malaria Infection

(2015) Joshua M. Obiero et al.   INFECTION AND IMMUNITY

RIFINs are adhesins implicated in severe Plasmodium falciparum malaria

(2015) Suchi Goel et al.   NATURE MEDICINE

Gradual acquisition of immunity to severe malaria with increasing exposure

(2015) J. T. Griffin et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Immunogen design for HIV-1 and influenza

(2014) Ujjwal Rathore et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Heterochromatin Protein 1 Secures Survival and Transmission of Malaria Parasites

(2014) Nicolas M.B. Brancucci et al.   Cell Host & Microbe

STEVOR Is a Plasmodium falciparum Erythrocyte Binding Protein that Mediates Merozoite Invasion and Rosetting

(2014) Makhtar Niang et al.   Cell Host & Microbe

A Plasmodium falciparum Histone Deacetylase Regulates Antigenic Variation and Gametocyte Conversion

(2014) Bradley I. Coleman et al.   Cell Host & Microbe

Surface antigens of Plasmodium falciparum-infected erythrocytes as immune targets and malaria vaccine candidates

(2014) Jo-Anne Chan et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Sex: How Malaria Parasites Get Turned On

(2014) Johan Ankarklev et al.   CURRENT BIOLOGY

Conserved immunogens in prime-boost strategies for the next-generation HIV-1 vaccines

(2014) Tomáš Hanke   EXPERT OPINION ON BIOLOGICAL THERAPY

Antigen Reversal Identifies Targets of Opsonizing IgGs against Pregnancy-Associated Malaria

(2014) Lester H. Lambert et al.   INFECTION AND IMMUNITY

Identification of Residues in the C 4 Domain of Polymeric IgM Essential for Interaction with Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1)

(2014) A. Ghumra et al.   JOURNAL OF IMMUNOLOGY

The role of PfEMP1 adhesion domain classification in Plasmodium falciparum pathogenesis research

(2014) Joseph D. Smith   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

A transcriptional switch underlies commitment to sexual development in malaria parasites

(2014) Björn F. C. Kafsack et al.   NATURE

Parasite Burden and Severity of Malaria in Tanzanian Children

(2014) Bronner P. Gonçalves et al.   NEW ENGLAND JOURNAL OF MEDICINE

Sequence variation and structural conservation allows development of novel function and immune evasion in parasite surface protein families

(2014) Matthew K. Higgins et al.   PROTEIN SCIENCE

The sound of sexual commitment breaks the silencing of malaria parasites

(2014) Pietro Alano   TRENDS IN PARASITOLOGY

Genome sequencing of chimpanzee malaria parasites reveals possible pathways of adaptation to human hosts

(2014) Thomas D. Otto et al.   Nature Communications

Llama immunization with full-length VAR2CSA generates cross-reactive and inhibitory single-domain antibodies against the DBL1X domain

(2014) Sofia Nunes-Silva et al.   Scientific Reports

Loss of endothelial protein C receptors links coagulation and inflammation to parasite sequestration in cerebral malaria in African children

(2013) C. A. Moxon et al.   BLOOD

Hypervariable antigen genes in malaria have ancient roots

(2013) Martine M Zilversmit et al.   BMC EVOLUTIONARY BIOLOGY

Rosetting Plasmodium falciparum-Infected Erythrocytes Bind to Human Brain Microvascular Endothelial CellsIn Vitro, Demonstrating a Dual Adhesion Phenotype Mediated by Distinct P. falciparum Erythrocyte Membrane Protein 1 Domains

(2013) Yvonne Adams et al.   INFECTION AND IMMUNITY

Severe malaria is associated with parasite binding to endothelial protein C receptor

(2013) Louise Turner et al.   NATURE

Differential adhesion-inhibitory patterns of antibodies raised against two major variants of the NTS-DBL2X region of VAR2CSA

(2013) Justin Doritchamou et al.   VACCINE

Structural and Functional Insight into How thePlasmodium falciparumVAR2CSA Protein Mediates Binding to Chondroitin Sulfate A in Placental Malaria

(2012) Thomas M. Clausen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targets of antibodies against Plasmodium falciparum–infected erythrocytes in malaria immunity

(2012) Jo-Anne Chan et al.   JOURNAL OF CLINICAL INVESTIGATION

A Novel Domain Cassette Identifies Plasmodium falciparum PfEMP1 Proteins Binding ICAM-1 and Is a Target of Cross-Reactive, Adhesion-Inhibitory Antibodies

(2012) A. Bengtsson et al.   JOURNAL OF IMMUNOLOGY

Epigenetic Dysregulation of Virulence Gene Expression in Severe Plasmodium falciparum Malaria

(2012) Catherine J. Merrick et al.   JOURNAL OF INFECTIOUS DISEASES

A subset of group A-like var genes encodes the malaria parasite ligands for binding to human brain endothelial cells

(2012) A. Claessens et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A restricted subset of var genes mediates adherence of Plasmodium falciparum-infected erythrocytes to brain endothelial cells

(2012) M. Avril et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plasmodium falciparum erythrocyte membrane protein 1 domain cassettes 8 and 13 are associated with severe malaria in children

(2012) T. Lavstsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of Id1-DBL2X of VAR2CSA as a key domain inducing highly inhibitory and cross-reactive antibodies

(2012) Bita Bordbar et al.   VACCINE

The NTS-DBL2X Region of VAR2CSA Induces Cross-Reactive Antibodies That Inhibit Adhesion of Several Plasmodium falciparum Isolates to Chondroitin Sulfate A

(2011) Pascal Bigey et al.   JOURNAL OF INFECTIOUS DISEASES

How selection forces dictate the variant surface antigens used by malaria parasites

(2011) M. Severins et al.   Journal of the Royal Society Interface

var gene transcription and PfEMP1 expression in the rosetting and cytoadhesive Plasmodium falciparum clone FCR3S1.2

(2011) Letusa Albrecht et al.   MALARIA JOURNAL

Evasion of immunity to Plasmodium falciparum malaria by IgM masking of protective IgG epitopes in infected erythrocyte surface-exposed PfEMP1

(2011) L. Barfod et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hierarchical, Domain Type-Specific Acquisition of Antibodies to Plasmodium falciparum Erythrocyte Membrane Protein 1 in Tanzanian Children

(2010) G. K. K. Cham et al.   INFECTION AND IMMUNITY

DifferentialvarGene Expression in Children with Malaria and Antidromic Effects on Host Gene Expression

(2010) Yvonne Kalmbach et al.   JOURNAL OF INFECTIOUS DISEASES

The age patterns of severe malaria syndromes in sub-Saharan Africa across a range of transmission intensities and seasonality settings

(2010) Arantxa Roca-Feltrer et al.   MALARIA JOURNAL

Sequential, Ordered Acquisition of Antibodies to Plasmodium falciparum Erythrocyte Membrane Protein 1 Domains

(2009) G. K. K. Cham et al.   JOURNAL OF IMMUNOLOGY

Analysis ofPlasmodium falciparum varGenes Expressed in Children from Papua New Guinea

(2009) Nicole Falk et al.   JOURNAL OF INFECTIOUS DISEASES

The Plasmodium falciparum var gene transcription strategy at the onset of blood stage infection in a human volunteer

(2009) Christian W. Wang et al.   PARASITOLOGY INTERNATIONAL

Plasmodium falciparum var gene expression is modified by host immunity

(2009) G. M. Warimwe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Failure to respond to the surface of Plasmodium falciparum infected erythrocytes predicts susceptibility to clinical malaria amongst African children

(2008) C.L. Mackintosh et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Plasmodium falciparumantigenic variation. Mapping mosaicvargene sequences onto a network of shared, highly polymorphic sequence blocks

(2008) Peter C. Bull et al.   MOLECULAR MICROBIOLOGY

Immunity to malaria: more questions than answers

(2008) Jean Langhorne et al.   NATURE IMMUNOLOGY

The Cysteine-Rich Interdomain Region from the Highly Variable Plasmodium falciparum Erythrocyte Membrane Protein-1 Exhibits a Conserved Structure

(2008) Michael M. Klein et al.   PLoS Pathogens