Sphingosine 1-Phosphate Activation of EGFR As a Novel Target for Meningitic Escherichia coli Penetration of the Blood-Brain Barrier

ORMDL/serine palmitoyltransferase stoichiometry determines effects of ORMDL3 expression on sphingolipid biosynthesis

(2015) Deanna Siow et al.   JOURNAL OF LIPID RESEARCH

Differential Transcriptional Effects of EGFR Inhibitors

(2014) Miroslav Blumenberg   PLoS One

Heparin-binding epidermal growth factor-like growth factor (HB-EGF) and proteolytic processing by a disintegrin and metalloproteinases (ADAM): A regulator of several pathways

(2014) S.R. Taylor et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Klebsiella pneumoniaetargets an EGF receptor-dependent pathway to subvert inflammation

(2013) Christian G. Frank et al.   CELLULAR MICROBIOLOGY

Synthesis of selective inhibitors of sphingosine kinase 1

(2013) Dong Jae Baek et al.   CHEMICAL COMMUNICATIONS

Mechanism of rapid elimination of lysophosphatidic acid and related lipids from the circulation of mice

(2013) Abdel K. Salous et al.   JOURNAL OF LIPID RESEARCH

Structure–Activity Relationships and Molecular Modeling of Sphingosine Kinase Inhibitors

(2013) Dong Jae Baek et al.   JOURNAL OF MEDICINAL CHEMISTRY

Bioactive Lipids S1P and C1P Are Prometastatic Factors in Human Rhabdomyosarcoma, and Their Tissue Levels Increase in Response to Radio/Chemotherapy

(2013) Gabriela Schneider et al.   MOLECULAR CANCER RESEARCH

RNA-Guided Human Genome Engineering via Cas9

(2013) P. Mali et al.   SCIENCE

Characterization of secretory sphingomyelinase activity, lipoprotein sphingolipid content and LDL aggregation in ldlr−/−mice fed on a high-fat diet

(2012) Gergana M. Deevska et al.   BIOSCIENCE REPORTS

Neisseria gonorrhoeaebreaches the apical junction of polarized epithelial cells for transmigration by activating EGFR

(2012) Vonetta L. Edwards et al.   CELLULAR MICROBIOLOGY

Targeted Chemical-Genetic Regulation of Protein Stability In Vivo

(2012) Susana Rodriguez et al.   CHEMISTRY & BIOLOGY

Current concepts on the pathogenesis of Escherichia coli meningitis

(2012) Kwang S. Kim   CURRENT OPINION IN INFECTIOUS DISEASES

Sphingosine Kinase Inhibitors and Cancer: Seeking the Golden Sword of Hercules

(2011) S. Pyne et al.   CANCER RESEARCH

Neisseria gonorrhoeae-induced transactivation of EGFR enhances gonococcal invasion

(2011) Karen V. Swanson et al.   CELLULAR MICROBIOLOGY

(R)-FTY720 methyl ether is a specific sphingosine kinase 2 inhibitor: Effect on sphingosine kinase 2 expression in HEK 293 cells and actin rearrangement and survival of MCF-7 breast cancer cells

(2011) Keng Gat Lim et al.   CELLULAR SIGNALLING

Plasma levels of sphingosine 1-phosphate are strongly correlated with haematocrit, but variably restored by red blood cell transfusions

(2011) Samy Selim et al.   CLINICAL SCIENCE

Sphingosine-1-phosphate signaling and its role in disease

(2011) Michael Maceyka et al.   TRENDS IN CELL BIOLOGY

Sphingosine-1-Phosphate Receptor-2 Function in Myeloid Cells Regulates Vascular Inflammation and Atherosclerosis

(2010) Athanasia Skoura et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells

(2010) Francesca Tonelli et al.   CELLULAR SIGNALLING

Prevention of Escherichia coli K1 Penetration of the Blood-Brain Barrier by Counteracting the Host Cell Receptor and Signaling Molecule Involved in E. coli Invasion of Human Brain Microvascular Endothelial Cells

(2010) L. Zhu et al.   INFECTION AND IMMUNITY

NlpI Contributes to Escherichia coli K1 Strain RS218 Interaction with Human Brain Microvascular Endothelial Cells

(2010) C.-H. Teng et al.   INFECTION AND IMMUNITY

Arachidonic Acid Metabolism Regulates Escherichia coli Penetration of the Blood-Brain Barrier

(2010) L. Zhu et al.   INFECTION AND IMMUNITY

Intracellular localization of sphingosine kinase 1 alters access to substrate pools but does not affect the degradative fate of sphingosine-1-phosphate

(2010) Deanna L. Siow et al.   JOURNAL OF LIPID RESEARCH

Involvement of Src tyrosine kinase inEscherichia coliinvasion of human brain microvascular endothelial cells

(2009) Wei Liu et al.   FEBS LETTERS

Epidermal Growth Factor Receptor Activation Protects Gastric Epithelial Cells From Helicobacter pylori-Induced Apoptosis

(2009) Fang Yan et al.   GASTROENTEROLOGY

Chiral Vinylphosphonate and Phosphonate Analogues of the Immunosuppressive Agent FTY720

(2009) Xuequan Lu et al.   JOURNAL OF ORGANIC CHEMISTRY

Acute bacterial meningitis in infants and children

(2009) Kwang Sik Kim   LANCET INFECTIOUS DISEASES

All EGF(ErbB) receptors have preformed homo- and heterodimeric structures in living cells

(2008) R.-H. Tao et al.   JOURNAL OF CELL SCIENCE

Preclinical pharmacokinetic/pharmacodynamic models of gefitinib and the design of equivalent dosing regimens in EGFR wild-type and mutant tumor models

(2008) S. Wang et al.   MOLECULAR CANCER THERAPEUTICS

Mechanisms of microbial traversal of the blood–brain barrier

(2008) Kwang Sik Kim   NATURE REVIEWS MICROBIOLOGY