A change of view: homologous recombination at single-molecule resolution

Fluorescence nanoscopy in cell biology

(2017) Steffen J. Sahl et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Superresolution expansion microscopy reveals the three-dimensional organization of theDrosophilasynaptonemal complex

(2017) Cori K. Cahoon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Superresolution microscopy reveals the three-dimensional organization of meiotic chromosome axes in intactCaenorhabditis eleganstissue

(2017) Simone Köhler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The tale of SSB

(2017) Piero R. Bianco   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Chromatin organization revealed by nanostructure of irradiation induced γH2AX, 53BP1 and Rad51 foci

(2017) Judith Reindl et al.   Scientific Reports

Mechanics and Single-Molecule Interrogation of DNA Recombination

(2016) Jason C. Bell et al.   Annual Review of Biochemistry

ATP hydrolysis Promotes Duplex DNA Release by the RecA Presynaptic Complex

(2016) Ja Yil Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA Sequence Alignment during Homologous Recombination

(2016) Eric C. Greene   JOURNAL OF BIOLOGICAL CHEMISTRY

Watching cellular machinery in action, one molecule at a time

(2016) Enrico Monachino et al.   JOURNAL OF CELL BIOLOGY

Navigating challenges in the application of superresolution microscopy

(2016) Talley J. Lambert et al.   JOURNAL OF CELL BIOLOGY

When Genome Maintenance Goes Badly Awry

(2016) Elizabeth M. Kass et al.   MOLECULAR CELL

A Polar and Nucleotide-Dependent Mechanism of Action for RAD51 Paralogs in RAD51 Filament Remodeling

(2016) Martin R.G. Taylor et al.   MOLECULAR CELL

Stability versus exchange: a paradox in DNA replication

(2016) Christoffer Åberg et al.   NUCLEIC ACIDS RESEARCH

Protein dynamics of human RPA and RAD51 on ssDNA during assembly and disassembly of the RAD51 filament

(2016) Chu Jian Ma et al.   NUCLEIC ACIDS RESEARCH

Chemo-mechanical pushing of proteins along single-stranded DNA

(2016) Joshua E. Sokoloski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-molecule imaging reveals the mechanism of Exo1 regulation by single-stranded DNA binding proteins

(2016) Logan R. Myler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RecA: Regulation and Mechanism of a Molecular Search Engine

(2016) Jason C. Bell et al.   TRENDS IN BIOCHEMICAL SCIENCES

Single Molecules, Cells, and Super-Resolution Optics (Nobel Lecture)

(2015) Eric Betzig   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

DNA Sequence Alignment by Microhomology Sampling during Homologous Recombination

(2015) Zhi Qi et al.   CELL

Imaging Live-Cell Dynamics and Structure at the Single-Molecule Level

(2015) Zhe Liu et al.   MOLECULAR CELL

Active displacement of RecA filaments by UvrD translocase activity

(2015) Vessela Petrova et al.   NUCLEIC ACIDS RESEARCH

Elucidation of synaptonemal complex organization by super-resolution imaging with isotropic resolution

(2015) Katharina Schücker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Superresolution imaging reveals structurally distinct periodic patterns of chromatin along pachytene chromosomes

(2015) Kirti Prakash et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineering of a superhelicase through conformational control

(2015) S. Arslan et al.   SCIENCE

Base triplet stepping by the Rad51/RecA family of recombinases

(2015) J. Y. Lee et al.   SCIENCE

Direct observation of structure-function relationship in a nucleic acid-processing enzyme

(2015) M. J. Comstock et al.   SCIENCE

DNA-Pairing and Annealing Processes in Homologous Recombination and Homology-Directed Repair

(2015) Scott W. Morrical   Cold Spring Harbor Perspectives in Biology

Cell Biology of Mitotic Recombination

(2015) Michael Lisby et al.   Cold Spring Harbor Perspectives in Biology

Recombination, Pairing, and Synapsis of Homologs during Meiosis

(2015) Denise Zickler et al.   Cold Spring Harbor Perspectives in Biology

An Overview of the Molecular Mechanisms of Recombinational DNA Repair

(2015) Stephen C. Kowalczykowski   Cold Spring Harbor Perspectives in Biology

Meiotic Recombination: The Essence of Heredity

(2015) Neil Hunter   Cold Spring Harbor Perspectives in Biology

Homologous Recombination and Human Health: The Roles of BRCA1, BRCA2, and Associated Proteins

(2015) Rohit Prakash et al.   Cold Spring Harbor Perspectives in Biology

Concentration- and chromosome-organization-dependent regulator unbinding from DNA for transcription regulation in living cells

(2015) Tai-Yen Chen et al.   Nature Communications

Small Rad51 and Dmc1 Complexes Often Co-occupy Both Ends of a Meiotic DNA Double Strand Break

(2015) M. Scott Brown et al.   PLoS Genetics

Imaging and energetics of single SSB-ssDNA molecules reveal intramolecular condensation and insight into RecOR function

(2015) Jason C Bell et al.   eLife

Human RecQ Helicases in DNA Repair, Recombination, and Replication

(2014) Deborah L. Croteau et al.   Annual Review of Biochemistry

Self-Organization of Meiotic Recombination Initiation: General Principles and Molecular Pathways

(2014) Scott Keeney et al.   Annual Review of Genetics

Replication protein A: Single-stranded DNA's first responder

(2014) Ran Chen et al.   BIOESSAYS

RPA-coated single-stranded DNA as a platform for post-translational modifications in the DNA damage response

(2014) Alexandre Maréchal et al.   CELL RESEARCH

Superresolution Imaging of Biological Systems Using Photoactivated Localization Microscopy

(2014) Prabuddha Sengupta et al.   CHEMICAL REVIEWS

Mechanisms and Regulation of Mitotic Recombination in Saccharomyces cerevisiae

(2014) L. S. Symington et al.   GENETICS

Mechanisms and principles of homology search during recombination

(2014) Jörg Renkawitz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Protein dynamics during presynaptic-complex assembly on individual single-stranded DNA molecules

(2014) Bryan Gibb et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RPA antagonizes microhomology-mediated repair of DNA double-strand breaks

(2014) Sarah K Deng et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RecA-mediated sequence homology recognition as an example of how searching speed in self-assembly systems can be optimized by balancing entropic and enthalpic barriers

(2014) Lili Jiang et al.   PHYSICAL REVIEW E

Concentration-Dependent Exchange of Replication Protein A on Single-Stranded DNA Revealed by Single-Molecule Imaging

(2014) Bryan Gibb et al.   PLoS One

RTEL1: functions of a disease-associated helicase

(2014) Jean-Baptiste Vannier et al.   TRENDS IN CELL BIOLOGY

DNA Strand Exchange and RecA Homologs in Meiosis

(2014) M. Scott Brown et al.   Cold Spring Harbor Perspectives in Biology

Sources of DNA Double-Strand Breaks and Models of Recombinational DNA Repair

(2014) A. Mehta et al.   Cold Spring Harbor Perspectives in Biology

Single-Molecule Approaches Embrace Molecular Cohorts

(2013) Taekjip Ha   CELL

DNA unwinding heterogeneity by RecBCD results from static molecules able to equilibrate

(2013) Bian Liu et al.   NATURE

RecA bundles mediate homology pairing between distant sisters during DNA break repair

(2013) Christian Lesterlin et al.   NATURE

Simplified biased random walk model for RecA-protein-mediated homology recognition offers rapid and accurate self-assembly of long linear arrays of binding sites

(2013) Julian Kates-Harbeck et al.   PHYSICAL REVIEW E

Single-molecule views on homologous recombination

(2013) Andrea Candelli et al.   QUARTERLY REVIEWS OF BIOPHYSICS

Repair of Strand Breaks by Homologous Recombination

(2013) M. Jasin et al.   Cold Spring Harbor Perspectives in Biology

Single-Stranded DNA Curtains for Real-Time Single-Molecule Visualization of Protein–Nucleic Acid Interactions

(2012) Bryan Gibb et al.   ANALYTICAL CHEMISTRY

Extending Microscopic Resolution with Single-Molecule Imaging and Active Control

(2012) Michael A. Thompson et al.   Annual Review of Biophysics

Visualizing Cell Structure and Function with Point-Localization Superresolution Imaging

(2012) Prabuddha Sengupta et al.   DEVELOPMENTAL CELL

How RecBCD Enzyme and Chi Promote DNA Break Repair and Recombination: a Molecular Biologist's View

(2012) G. R. Smith   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Mechanism of Homology Recognition in DNA Recombination from Dual-Molecule Experiments

(2012) Iwijn De Vlaminck et al.   MOLECULAR CELL

Direct imaging of RecA nucleation and growth on single molecules of SSB-coated ssDNA

(2012) Jason C. Bell et al.   NATURE

Single-molecule imaging of DNA pairing by RecA reveals a three-dimensional homology search

(2012) Anthony L. Forget et al.   NATURE

Bacterial DNA repair: recent insights into the mechanism of RecBCD, AddAB and AdnAB

(2012) Dale B. Wigley   NATURE REVIEWS MICROBIOLOGY

PcrA-mediated disruption of RecA nucleoprotein filaments—essential role of the ATPase activity of RecA

(2012) Matt V. Fagerburg et al.   NUCLEIC ACIDS RESEARCH

The Recombinases DMC1 and RAD51 Are Functionally and Spatially Separated during Meiosis in Arabidopsis

(2012) M.-T. Kurzbauer et al.   PLANT CELL

RecA filament sliding on DNA facilitates homology search

(2012) Kaushik Ragunathan et al.   eLife

RecA homology search is promoted by mechanical stress along the scanned duplex DNA

(2011) Claudia Danilowicz et al.   NUCLEIC ACIDS RESEARCH

Combining optical trapping, fluorescence microscopy and micro-fluidics for single molecule studies of DNA–protein interactions

(2011) Andrea Candelli et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Real-Time Observation of Strand Exchange Reaction with High Spatiotemporal Resolution

(2011) Kaushik Ragunathan et al.   STRUCTURE

Regulation of Homologous Recombination in Eukaryotes

(2010) Wolf-Dietrich Heyer et al.   Annual Review of Genetics

The RecQ DNA Helicases in DNA Repair

(2010) Kara A. Bernstein et al.   Annual Review of Genetics

PcrA Helicase Dismantles RecA Filaments by Reeling in DNA in Uniform Steps

(2010) Jeehae Park et al.   CELL

Srs2: The “Odd-Job Man” in DNA repair

(2010) Victoria Marini et al.   DNA REPAIR

A guide to super-resolution fluorescence microscopy

(2010) Lothar Schermelleh et al.   JOURNAL OF CELL BIOLOGY

Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis

(2010) Mary Ellen Moynahan et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Concentration-dependent exchange accelerates turnover of proteins bound to double-stranded DNA

(2010) J. S. Graham et al.   NUCLEIC ACIDS RESEARCH

SSB protein diffusion on single-stranded DNA stimulates RecA filament formation

(2009) Rahul Roy et al.   NATURE

Mechanism of Eukaryotic Homologous Recombination

(2008) Joseph San Filippo et al.   Annual Review of Biochemistry

Advances in Single-Molecule Fluorescence Methods for Molecular Biology

(2008) Chirlmin Joo et al.   Annual Review of Biochemistry

Translocation and Unwinding Mechanisms of RNA and DNA Helicases

(2008) Anna Marie Pyle   Annual Review of Biophysics

SSB as an Organizer/Mobilizer of Genome Maintenance Complexes

(2008) Robert D. Shereda et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

RecBCD Enzyme and the Repair of Double-Stranded DNA Breaks

(2008) M. S. Dillingham et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Counting RAD51 proteins disassembling from nucleoprotein filaments under tension

(2008) Joost van Mameren et al.   NATURE

Do-it-yourself guide: how to use the modern single-molecule toolkit

(2008) Nils G Walter et al.   NATURE METHODS

High-density mapping of single-molecule trajectories with photoactivated localization microscopy

(2008) Suliana Manley et al.   NATURE METHODS

A practical guide to single-molecule FRET

(2008) Rahul Roy et al.   NATURE METHODS

Non-hexameric DNA helicases and translocases: mechanisms and regulation

(2008) Timothy M. Lohman et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

See me, feel me: methods to concurrently visualize and manipulate single DNA molecules and associated proteins

(2008) J. van Mameren et al.   NUCLEIC ACIDS RESEARCH

Video-Rate Far-Field Optical Nanoscopy Dissects Synaptic Vesicle Movement

(2008) V. Westphal et al.   SCIENCE

Three-Dimensional Super-Resolution Imaging by Stochastic Optical Reconstruction Microscopy

(2008) B. Huang et al.   SCIENCE

Subdiffraction Multicolor Imaging of the Nuclear Periphery with 3D Structured Illumination Microscopy

(2008) L. Schermelleh et al.   SCIENCE

Finding a match: how do homologous sequences get together for recombination?

(2007) Adi Barzel et al.   NATURE REVIEWS GENETICS