p21WAF1/Cip1limits senescence and acinar-to-ductal metaplasia formation during pancreatitis

p53 Protein Regulates Hsp90 ATPase Activity and Thereby Wnt Signaling by Modulating Aha1 Expression

(2014) Sachiyo Okayama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glucocorticoids induce senescence in primary human tenocytes by inhibition of sirtuin 1 and activation of the p53/p21 pathway: in vivo and in vitro evidence

(2013) Raewyn C Poulsen et al.   ANNALS OF THE RHEUMATIC DISEASES

The matricellular protein CCN1 suppresses lung cancer cell growth by inducing senescence via the p53/p21 pathway

(2013) Shr-Jeng Jim Leu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

p16INK4a protects against dysfunctional telomere–induced ATR-dependent DNA damage responses

(2013) Yang Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Wnt/β-catenin signaling mediates the senescence of bone marrow-mesenchymal stem cells from systemic lupus erythematosus patients through the p53/p21 pathway

(2013) Zhifeng Gu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Systems Biology Approach Identifies the Kinase Csnk1a1 as a Regulator of the DNA Damage Response in Embryonic Stem Cells

(2013) J. Carreras Puigvert et al.   Science Signaling

p21 Both Attenuates and Drives Senescence and Aging in BubR1 Progeroid Mice

(2013) Darren J. Baker et al.   Cell Reports

 -catenin is selectively required for the expansion and regeneration of mature pancreatic acinar cells in mice

(2012) M. D. Keefe et al.   Disease Models & Mechanisms

Bmi1 Is Required for Regeneration of the Exocrine Pancreas in Mice

(2012) Akihisa Fukuda et al.   GASTROENTEROLOGY

Lymphotoxin β Receptor Signaling Promotes Development of Autoimmune Pancreatitis

(2012) Gitta M. Seleznik et al.   GASTROENTEROLOGY

EZH2 couples pancreatic regeneration to neoplastic progression

(2012) J. Mallen-St. Clair et al.   GENES & DEVELOPMENT

Senescence determines the fate of activated rat pancreatic stellate cells

(2012) Brit Fitzner et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Wnt/β-catenin signaling induces the aging of mesenchymal stem cells through promoting the ROS production

(2012) Da-yong Zhang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Role of the Beta Catenin Destruction Complex in Mediating Chemotherapy-Induced Senescence-Associated Secretory Phenotype

(2012) Dipanjan Basu et al.   PLoS One

COX-2 is not required for the development of murine chronic pancreatitis

(2011) Alberto Silva et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Pancreatitis-Induced Inflammation Contributes to Pancreatic Cancer by Inhibiting Oncogene-Induced Senescence

(2011) Carmen Guerra et al.   CANCER CELL

Loss of p21CDKN1Aimpairs entry to quiescence and activates a DNA damage response in normal fibroblasts induced to quiescence

(2011) Paola Perucca et al.   CELL CYCLE

Pancreatic ductal cells in development, regeneration, and neoplasia

(2011) Maximilian Reichert et al.   JOURNAL OF CLINICAL INVESTIGATION

Visualization of CD44 and CD133 in Normal Pancreas and Pancreatic Ductal Adenocarcinomas

(2011) Heike Immervoll et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

EZH2-Dependent Suppression of a Cellular Senescence Phenotype in Melanoma Cells by Inhibition of p21/CDKN1A Expression

(2011) T. Fan et al.   MOLECULAR CANCER RESEARCH

Cellular features of senescence during the evolution of human and murine ductal pancreatic cancer

(2011) M E Caldwell et al.   ONCOGENE

p53 and MicroRNA-34 Are Suppressors of Canonical Wnt Signaling

(2011) N. H. Kim et al.   Science Signaling

Cancer Statistics, 2010

(2010) A. Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Senescent cells as a source of inflammatory factors for tumor progression

(2010) Albert R. Davalos et al.   CANCER AND METASTASIS REVIEWS

Oncogenic KRas Suppresses Inflammation-Associated Senescence of Pancreatic Ductal Cells

(2010) Kyoung Eun Lee et al.   CANCER CELL

The essence of senescence

(2010) T. Kuilman et al.   GENES & DEVELOPMENT

Adult pancreatic acinar cells dedifferentiate to an embryonic progenitor phenotype with concomitant activation of a senescence programme that is present in chronic pancreatitis

(2010) A. V. Pinho et al.   GUT

Cerulein Pancreatitis: Oxidative Stress, Inflammation, and Apoptosis

(2010) Hyeyoung Kim   Gut and Liver

β-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice

(2010) John P. Morris et al.   JOURNAL OF CLINICAL INVESTIGATION

Bmi-1 regulates self-renewal, proliferation and senescence of human fetal neural stem cells in vitro

(2010) Yang Wang et al.   NEUROSCIENCE LETTERS

Genetic Variants of p21 and p27 and Pancreatic Cancer Risk in Non-Hispanic Whites

(2009) Jinyun Chen et al.   PANCREAS

A genomewide study identifies the Wnt signaling pathway as a major target of p53 in murine embryonic stem cells

(2009) K.-H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer

(2009) J. P. Morton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hyperoxia-induced premature senescence requires p53 and pRb, but not mitochondrial matrix ROS

(2008) Tatyana A. Klimova et al.   FASEB JOURNAL

Stabilization of β-Catenin Induces Pancreas Tumor Formation

(2008) Patrick W. Heiser et al.   GASTROENTEROLOGY

Hedgehog Signaling Is Required for Effective Regeneration of Exocrine Pancreas

(2008) Volker Fendrich et al.   GASTROENTEROLOGY

Notch Signaling Is Required for Exocrine Regeneration After Acute Pancreatitis

(2008) Jens T. Siveke et al.   GASTROENTEROLOGY

Mist1 Regulates Pancreatic Acinar Cell Proliferation Through p21CIP1/WAF1

(2008) Di Jia et al.   GASTROENTEROLOGY

Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia

(2008) J.-P. De La O et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA