A human APOC3 missense variant and monoclonal antibody accelerate apoC-III clearance and lower triglyceride-rich lipoprotein levels

Very-Low-Density Lipoprotein–Associated Apolipoproteins Predict Cardiovascular Events and Are Lowered by Inhibition of APOC-III

(2017) Raimund Pechlaner et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Stable liver-specific expression of human IDOL in humanized mice raises plasma cholesterol

(2016) Salam Ibrahim et al.   CARDIOVASCULAR RESEARCH

Surprises From Genetic Analyses of Lipid Risk Factors for Atherosclerosis

(2016) Kiran Musunuru et al.   CIRCULATION RESEARCH

Targeting ApoC-III to Reduce Coronary Disease Risk

(2016) Sumeet A. Khetarpal et al.   Current Atherosclerosis Reports

ApoC-III inhibits clearance of triglyceride-rich lipoproteins through LDL family receptors

(2016) Philip L.S.M. Gordts et al.   JOURNAL OF CLINICAL INVESTIGATION

Reduction in lipoprotein-associated apoC-III levels following volanesorsen therapy: phase 2 randomized trial results

(2016) Xiaohong Yang et al.   JOURNAL OF LIPID RESEARCH

Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease

(2016)   NEW ENGLAND JOURNAL OF MEDICINE

Inactivating Variants in ANGPTL4 and Risk of Coronary Artery Disease

(2016) Frederick E. Dewey et al.   NEW ENGLAND JOURNAL OF MEDICINE

Plasma Apolipoprotein C-III Levels, Triglycerides, and Coronary Artery Calcification in Type 2 DiabeticsSignificance

(2015) Arman Qamar et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The risk of cardiovascular events with increased apolipoprotein CIII: A systematic review and meta-analysis

(2015) Moritz C. Wyler von Ballmoos et al.   Journal of Clinical Lipidology

Developing Medicines That Mimic the Natural Successes of the Human Genome

(2015) Sekar Kathiresan   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Antisense Inhibition of Apolipoprotein C-III in Patients with Hypertriglyceridemia

(2015) Daniel Gaudet et al.   NEW ENGLAND JOURNAL OF MEDICINE

Association of Low-Frequency and Rare Coding-Sequence Variants with Blood Lipids and Coronary Heart Disease in 56,000 Whites and Blacks

(2014) Gina M. Peloso et al.   AMERICAN JOURNAL OF HUMAN GENETICS

AAV Vectors Expressing LDLR Gain-of-Function Variants Demonstrate Increased Efficacy in Mouse Models of Familial Hypercholesterolemia

(2014) Suryanarayan Somanathan et al.   CIRCULATION RESEARCH

Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction

(2014) Ron Do et al.   NATURE

Loss-of-Function Mutations in APOC3 and Risk of Ischemic Vascular Disease

(2014) Anders Berg Jørgensen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Loss-of-Function Mutations in APOC3, Triglycerides, and Coronary Disease

(2014)   NEW ENGLAND JOURNAL OF MEDICINE

Antisense Oligonucleotide Inhibition of Apolipoprotein C-III Reduces Plasma Triglycerides in Rodents, Nonhuman Primates, and Humans

(2013) Mark J. Graham et al.   CIRCULATION RESEARCH

Apolipoproteins C-I and C-III Inhibit Lipoprotein Lipase Activity by Displacement of the Enzyme from Lipid Droplets

(2013) Mikael Larsson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery and refinement of loci associated with lipid levels

(2013) Cristen J Willer et al.   NATURE GENETICS

Biodistribution of AAV8 Vectors Expressing Human Low-Density Lipoprotein Receptor in a Mouse Model of Homozygous Familial Hypercholesterolemia

(2013) Shu-Jen Chen et al.   Human Gene Therapy Clinical Development

Adeno-Associated Virus Serotype 8 Gene Therapy Leads to Significant Lowering of Plasma Cholesterol Levels in Humanized Mouse Models of Homozygous and Heterozygous Familial Hypercholesterolemia

(2012) Sadik H. Kassim et al.   HUMAN GENE THERAPY

Apolipoprotein CIII

(2011) Henry N. Ginsberg et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Plasma apolipoprotein C-III metabolism in patients with chronic kidney disease

(2011) Esther M. M. Ooi et al.   JOURNAL OF LIPID RESEARCH

Investigations of apoC-III metabolism using stable isotopes: what information can you acquire and how can you interpret your results?

(2011) Henry N. Ginsberg et al.   JOURNAL OF LIPID RESEARCH

Transcriptional Activation of Apolipoprotein CIII Expression by Glucose May Contribute to Diabetic Dyslipidemia

(2010) Sandrine Caron et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Apolipoprotein CIII bound to apoB-containing lipoproteins is associated with small, dense LDL independent of plasma triglyceride levels in healthy men

(2010) Min-Jeong Shin et al.   ATHEROSCLEROSIS

Skyline: an open source document editor for creating and analyzing targeted proteomics experiments

(2010) Brendan MacLean et al.   BIOINFORMATICS

Functional analysis of the missenseAPOC3mutation Ala23Thr associated with human hypotriglyceridemia

(2010) Meenakshi Sundaram et al.   JOURNAL OF LIPID RESEARCH

Kinetic Studies of the Metabolism of Rapidly Exchangeable Apolipoproteins May Leave Investigators and Readers With Exchangeable Results

(2008) Henry N. Ginsberg et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Apolipoprotein C-III: understanding an emerging cardiovascular risk factor

(2008) Esther M. M. Ooi et al.   CLINICAL SCIENCE

Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodents

(2008) Tsuguhito Ota et al.   JOURNAL OF CLINICAL INVESTIGATION

A Null Mutation in Human APOC3 Confers a Favorable Plasma Lipid Profile and Apparent Cardioprotection

(2008) T. I. Pollin et al.   SCIENCE