Stable liver-specific expression of human IDOL in humanized mice raises plasma cholesterol

The LXR–Idol Axis Differentially Regulates Plasma LDL Levels in Primates and Mice

(2014) Cynthia Hong et al.   Cell Metabolism

AAV Vectors Expressing LDLR Gain-of-Function Variants Demonstrate Increased Efficacy in Mouse Models of Familial Hypercholesterolemia

(2014) Suryanarayan Somanathan et al.   CIRCULATION RESEARCH

Hepatic TRAP80 selectively regulates lipogenic activity of liver X receptor

(2014) Geun Hyang Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of a loss-of-function inducible degrader of the low-density lipoprotein receptor variant in individuals with low circulating low-density lipoprotein

(2013) V. Sorrentino et al.   EUROPEAN HEART JOURNAL

Discovery and refinement of loci associated with lipid levels

(2013) Cristen J Willer et al.   NATURE GENETICS

Feedback Regulation of Cholesterol Uptake by the LXR–IDOL–LDLR Axis

(2012) Li Zhang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Adeno-Associated Virus Serotype 8 Gene Therapy Leads to Significant Lowering of Plasma Cholesterol Levels in Humanized Mouse Models of Homozygous and Heterozygous Familial Hypercholesterolemia

(2012) Sadik H. Kassim et al.   HUMAN GENE THERAPY

The N342S MYLIP polymorphism is associated with high total cholesterol and increased LDL receptor degradation in humans

(2011) Daphna Weissglas-Volkov et al.   JOURNAL OF CLINICAL INVESTIGATION

Genetic Variants Influencing Circulating Lipid Levels and Risk of Coronary Artery Disease

(2010) Dawn M. Waterworth et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The E3 Ubiquitin Ligase IDOL Induces the Degradation of the Low Density Lipoprotein Receptor Family Members VLDLR and ApoER2

(2010) Cynthia Hong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reduced VLDL clearance inApoe−/−Npc1−/−mice is associated with increasedPcsk9andIdolexpression and decreased hepatic LDL-receptor levels

(2010) Minako Ishibashi et al.   JOURNAL OF LIPID RESEARCH

Biological, clinical and population relevance of 95 loci for blood lipids

(2010) Tanya M. Teslovich et al.   NATURE

LXR Regulates Cholesterol Uptake Through Idol-Dependent Ubiquitination of the LDL Receptor

(2009) Noam Zelcer et al.   SCIENCE