Global survey of the immunomodulatory potential of common drugs

Development of immuno-oncology drugs — from CTLA4 to PD1 to the next generations

(2016) Axel Hoos   NATURE REVIEWS DRUG DISCOVERY

Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential

(2015) Padmanee Sharma et al.   CELL

Safety and activity of blinatumomab for adult patients with relapsed or refractory B-precursor acute lymphoblastic leukaemia: a multicentre, single-arm, phase 2 study

(2015) Max S Topp et al.   LANCET ONCOLOGY

Combination cancer immunotherapy and new immunomodulatory targets

(2015) Kathleen M. Mahoney et al.   NATURE REVIEWS DRUG DISCOVERY

The future of immune checkpoint therapy

(2015) P. Sharma et al.   SCIENCE

The RON Receptor Tyrosine Kinase Regulates IFN-  Production and Responses in Innate Immunity

(2014) C. B. Wilson et al.   JOURNAL OF IMMUNOLOGY

Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy

(2014) Kilian V. M. Huber et al.   NATURE

Rationale for co-targeting IGF-1R and ALK in ALK fusion–positive lung cancer

(2014) Christine M Lovly et al.   NATURE MEDICINE

Role of natural and adaptive immunity in renal cell carcinoma response to VEGFR-TKIs and mTOR inhibitor

(2013) Matteo Santoni et al.   INTERNATIONAL JOURNAL OF CANCER

Inhibition of Ron Kinase Blocks Conversion of Micrometastases to Overt Metastases by Boosting Antitumor Immunity

(2013) H. Eyob et al.   Cancer Discovery

An Optimized microRNA Backbone for Effective Single-Copy RNAi

(2013) Christof Fellmann et al.   Cell Reports

TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions

(2013) Daehwan Kim et al.   GENOME BIOLOGY

Viral infection triggers rapid differentiation of human blood monocytes into dendritic cells

(2012) W. Hou et al.   BLOOD

Differential analysis of gene regulation at transcript resolution with RNA-seq

(2012) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

Systems-pharmacology dissection of a drug synergy in imatinib-resistant CML

(2012) Georg E Winter et al.   Nature Chemical Biology

A Decade of Imaging Cellular Motility and Interaction Dynamics in the Immune System

(2012) R. N. Germain et al.   SCIENCE

Oral GABA treatment downregulates inflammatory responses in a mouse model of rheumatoid arthritis

(2011) Jide Tian et al.   AUTOIMMUNITY

The beta2-adrenergic receptor on T and B lymphocytes: Do we understand it yet?

(2011) Virginia M. Sanders   BRAIN BEHAVIOR AND IMMUNITY

Hydroxychloroquine: From Malaria to Autoimmunity

(2011) Ilan Ben-Zvi et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Immunomodulatory and Protective Roles of Quorum-Sensing Signaling MoleculesN-Acyl Homoserine Lactones during Infection of Mice with Aeromonas hydrophila

(2011) Bijay K. Khajanchi et al.   INFECTION AND IMMUNITY

Synthesis and Structure−Affinity Relationships of Novel Dibenzylideneacetone Derivatives as Probes for β-Amyloid Plaques

(2011) Mengchao Cui et al.   JOURNAL OF MEDICINAL CHEMISTRY

Immunomodulatory effects of anti-angiogenic drugs

(2011) A Heine et al.   LEUKEMIA

Comprehensive analysis of kinase inhibitor selectivity

(2011) Mindy I Davis et al.   NATURE BIOTECHNOLOGY

Enforced viral replication activates adaptive immunity and is essential for the control of a cytopathic virus

(2011) Nadine Honke et al.   NATURE IMMUNOLOGY

Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation

(2010) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

Inhibitory role for GABA in autoimmune inflammation

(2010) R. Bhat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CellClassifier: supervised learning of cellular phenotypes

(2009) Pauli Rämö et al.   BIOINFORMATICS

Discovery ofN-(4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (BMS-777607), a Selective and Orally Efficacious Inhibitor of the Met Kinase Superfamily

(2009) Gretchen M. Schroeder et al.   JOURNAL OF MEDICINAL CHEMISTRY

Population context determines cell-to-cell variability in endocytosis and virus infection

(2009) Berend Snijder et al.   NATURE

Lipid-mediated presentation of MHC class II molecules guides thymocytes to the CD4 lineage

(2008) Satoshi Komaniwa et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Arachidonic-acid-derived eicosanoids: roles in biology and immunopathology

(2008) Hedi Harizi et al.   TRENDS IN MOLECULAR MEDICINE