Article
Biophysics
Ya Bin Cui, Hang Yan, Zhe Sun, Yu Ling, Hong Qun Luo, Nian Bing Li
Summary: Researchers have designed a bipedal DNA walker with multiple recognition sites, which undergoes a transition from dumbbell-shaped DNA nanostructure to an annular bipedal DNA walker. This design enables dual amplification of the signal and achieves ultrasensitive photoelectrochemical (PEC) detection of circulating tumor DNA (ctDNA).
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Thermodynamics
M. Razali Hanipah, R. Mikalsen, A. P. Roskilly
Summary: This paper presents a real-time interaction model between the dynamics of the piston motion and the thermodynamics of the in-cylinder combustion of a free-piston engine generator. By validating the simulation model, it shows good agreement with experimental results. This model is important for achieving realistic transient operation control and performance prediction.
APPLIED THERMAL ENGINEERING
(2022)
Article
Chemistry, Analytical
Liyan Zhang, Xiaoting Liu, Xiaowen Xu, Nan Zhang, Wei Jiang
Summary: A bipedal-unequivalent three-dimensional DNA walker was designed and applied for biosensing, showing twice the sustainable operation capability compared to other types of DNA walkers. Using let-7a as a model target, it demonstrated a detection limit of 68 pM and satisfactory reproducibility in biological fluids, making it a potential analytical tool in clinical diagnosis.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Thermodynamics
Zhiyuan Zhang, Huihua Feng, Boru Jia, Zhengxing Zuo, Andrew Smallbone, Anthony Paul Roskilly
Summary: The study investigates the impact of stroke-to-bore ratio on the operation and performance of a free piston engine generator, finding that S/B ratio and compression ratio significantly affect parameters such as operating frequency, indicated power, and thermal efficiency, providing important design guidance for improving engine performance.
APPLIED THERMAL ENGINEERING
(2021)
Article
Physics, Applied
Like Zhang, Huayao Tu, Yanxiang Luo, Kexin Zeng, Xu Tao, Dong Zhao, Bin Fang, Zhongming Zeng
Summary: Spin-torque diodes (STDs) with highly sensitive and ultralow current density based on a magnetic tunnel junction with perpendicular magnetic anisotropy are demonstrated. The sensitivity exceeds 3785 V/W at zero magnetic field with a low current of -20 mu A, and can be further increased by five times to 20,000 V/W with a weak external magnetic field. An artificial neural network constructed with STD neurons achieves a recognition accuracy of up to 94.92% for handwritten digits in the Mixed National Institute of Standards and Technology database. This work provides a pathway to develop low-power consumption high-sensitivity STDs for Internet of Things applications and neuromorphic computing.
APPLIED PHYSICS LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Mariam Bayoumi, Stefanos K. Nomidis, Kherim Willems, Enrico Carlon, Giovanni Maglia
Summary: The synthetic nanoscale piston presented in the study uses chemical energy to transport molecules against applied bias, allowing for selected DNA molecules to be transported across a nanopore through hybridization and strand displacement reactions. The device demonstrates multiple automated and reciprocating cycles without the need for external bias force, exhibiting characteristics of biological transporters.
Article
Chemistry, Analytical
Dongmei Wang, Huan Zhou, Fei Liu, Yongxin Li
Summary: This paper presents a robust and highly integrated DNA bipedal walker based electrochemical biosensor for ultrasensitive miRNA-21 detection. Using click chemistry, enzyme-free target recycling amplification strategy and programmed catalysis hairpin assembly, the biosensor demonstrated high analysis performance with wide detection range, low detection limit, and high selectivity. The nanosensor, with proximity-dependent hybridization and programmed catalysis hairpin assembly, offers a promising approach for miRNA biomarker expression in cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Biochemistry & Molecular Biology
Jihua Wei, Kezhen Ge, Yuanxun Gong, Liqing Li, Qianli Tang, Xianjiu Liao, Guanqun Zhang, Fenglei Gao
Summary: In this study, a novel signal-on and label-free electrochemical aptamer sensor was developed for the selective detection of A beta O. Compared with common DNA walkers, the bipedal DNA walker exhibited larger walking areas and faster walking kinetics, providing higher amplification efficiency. The sensor showed remarkable specificity, high reproducibility, and practical application value in detecting human serum A beta O.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Analytical
Changrui Feng, Chi Zhang, Jiaxin Guo, Gaiping Li, Baoxian Ye, Lina Zou
Summary: A novel strategy for preparing BDW based on HCR with the assistance of Exo III was proposed in this work. By utilizing one-step CHA reaction and HCR for amplification, an electrochemical biosensor was constructed for sensitive detection of CYFRA 21-1 DNA, achieving a detection limit as low as 3.01 aM.
ANALYTICA CHIMICA ACTA
(2021)
Article
Chemistry, Multidisciplinary
Xin Liu, Fanyu Meng, Rui Sun, Kangnan Wang, Zhiqiang Yu, Peng Miao
Summary: The work has developed a simple and reliable platform for simultaneous analysis of telomerase and miRNA using a three-dimensional bipedal DNA walking strategy. With the advantages of fast, sensitive and selective analysis, the method has great potential for early clinical diagnosis applications.
CHEMICAL COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Carlos E. Alvarez, Manuel Camargo, Gabriel Tellez
Summary: This article proposes a variation of the classical Szilard engine that uses a porous piston. The engine does not require information about the position of the particle or the removal and insertion of the piston during the reset process. It operates in contact with a single thermal reservoir, but the reset mechanism acts as a second reservoir by dissipating energy when lifting a mass against a gravitational field.
SCIENTIFIC REPORTS
(2022)
Article
Automation & Control Systems
Marko Mihalec, Jingang Yi
Summary: This study proposes a motion and gait control design for bipedal robotic walkers to address the motion challenge on low-friction ground surfaces. By explicitly considering slipping dynamics and using an inverted pendulum model and a multi-link model, the controlled joint torques can be computed to achieve gait control. The experimental results demonstrate that considering foot slip improves performance and enables stable gait on low-friction ground surfaces.
IEEE-ASME TRANSACTIONS ON MECHATRONICS
(2023)
Article
Chemistry, Analytical
Chenyi Zhuo, Zheng Li, Jiuying Cui, Zichun Song, Qianli Tang, Yiming Yin, Guanqun Zhang, Xianjiu Liao, Zhao Liu, Fenglei Gao
Summary: Researchers developed an innovative enzyme-free electrochemical aptasensor for the selective detection of Amyloid-beta oligomer. The DNAzyme-driven DNA bipedal walker tactics showed high sensitivity and low cost, and were successfully used to detect Amyloid-beta oligomer in human serum.
ANALYTICA CHIMICA ACTA
(2023)
Article
Thermodynamics
Yidi Wei, Zhengxing Zuo, Boru Jia, Kun Liang, Huihua Feng
Summary: The study indicates that the system with triangle curve trajectory exhibits the best performance in the dual-piston linear compressor. The output characteristics heavily depend on the operating frequency and the stroke of the piston, and the overall efficiency can reach up to 57.59% under specific conditions.
INTERNATIONAL JOURNAL OF REFRIGERATION
(2021)
Article
Automation & Control Systems
Hanying Jiang, Zhaohua Li, Kun Liang
Summary: A novel sensorless stroke detection technique using low-cost inductive coil for free-piston machines is proposed in this article. Experimental results show that this technique can achieve low error rates, making it suitable for the commercialization of high-efficiency free-piston machines.
IEEE TRANSACTIONS ON INDUSTRIAL ELECTRONICS
(2021)
Article
Biochemistry & Molecular Biology
Ruizheng Hou, Zhisong Wang
Summary: The FOF1 ATP synthase is an extremely efficient molecular machine in biology, and a thermodynamic model has been constructed to analyze its performance under various conditions. Experimental data has confirmed the model's prediction of a specific relationship between ATP synthesis rate and proton-motive force, indicating the machine operates near the universal limit of the 2nd law of thermodynamics. Additionally, the model suggests two symmetries of heat production that can be tested experimentally, providing quantitative constraints on the mechanisms behind FOF1's high efficiency.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
(2021)
Article
Cell Biology
Yong Zhou, Nicholas Ariotti, James Rae, Hong Liang, Vikas Tillu, Shern Tee, Michele Bastiani, Adekunle T. Bademosi, Brett M. Collins, Frederic A. Meunier, John F. Hancock, Robert G. Parton
Summary: Caveolae, specialized domains of the cell membrane, play crucial roles in lipid sorting and creating a unique lipid environment. Caveolin-1 (CAV1) and cavinl sort distinct plasma membrane lipids individually, while together they generate a unique lipid nano-environment. The selective lipid sorting by caveolae, regulated by lipid metabolism and acyl chain remodeling, may facilitate communication among lipid metabolism, vesicular trafficking, and signaling.
JOURNAL OF CELL BIOLOGY
(2021)
Article
Chemistry, Physical
Shern R. Tee, Debra J. Searles
Summary: Molecular dynamics (MD) simulations of complex electrochemical systems, such as ionic liquid supercapacitors, often use the constant potential method (CPM) to model conductive electrodes. However, the inclusion of CPM can be computationally expensive. This study demonstrates the computational savings available in CPM MD simulations of ionic liquid supercapacitors by using fully periodic boundary conditions instead of the traditional non-periodic slab geometry. Furthermore, it shows that fully periodic CPM MD simulations produce comparable results to traditional simulations with a nearly double speedup in computational time using the doubled cell approach or a finite field approach.
JOURNAL OF CHEMICAL PHYSICS
(2022)
Article
Chemistry, Physical
Ludwig J. Ahrens-Iwers, Mathijs Janssen, Shern R. Tee, Robert H. Meissner
Summary: Researchers have developed a feature-rich implementation of constant potential methods (CPMs) called ELECTRODE for large-scale electrochemical simulations. This implementation includes various corrections and models to more accurately simulate the behavior of conducting electrodes, such as non-periodic boundary conditions, nonideal metal electrodes, and long-range electrostatics. By using different methods for simulations, the researchers revealed the relationship between water and ionic dipole relaxations and verified the effectiveness of the one-dimensional correction.
JOURNAL OF CHEMICAL PHYSICS
(2022)
Article
Chemistry, Physical
Hon Lin Too, Na Guo, Chun Zhang, Zhisong Wang
Summary: DFT-based first-principles calculations were performed to investigate the adsorption difference of a backbone-free nucleobase, a backbone-containing Na counterion nucleotide, and a backbone-containing H counterion nucleotide on 2D materials. It was found that the inclusion of a sugar-phosphate backbone alters the electronic affinity of nucleobases and the backbone should be considered in the study of DNA nucleobase adsorption. It was also demonstrated that the H counterion model is superior to the Na counterion model in terms of adsorption on 2D materials.
JOURNAL OF PHYSICAL CHEMISTRY B
(2022)
Article
Chemistry, Physical
Ruizheng Hou, Zhisong Wang
Summary: This study introduces a method to deduce the effective potential from motor trajectories and finds that it can yield a motor's stall force. This finding reduces the difficulty of stall force measurement and provides a method for measuring an important quantity relevant to efficient energy conversion of molecular motors.
JOURNAL OF PHYSICAL CHEMISTRY B
(2022)
Article
Chemistry, Physical
Xiao Rui Liu, Long Ying Loh, Winna Siti, Hon Lin Too, Tommy Anderson, Zhisong Wang
Summary: This study reports an integrated system of DNA walker and DNA origami platform, which combines an advanced light-powered bipedal walker and a rod-like DNA origami platform. By tailor-designing the origami to match with the walker, the self-directed and processive motion of the walker is achieved. This integrated system serves as a 'seed' system for future development of advanced light-powered DNA nanorobots and bio-mimicking nano-muscles.
NANOSCALE HORIZONS
(2023)
Article
Chemistry, Multidisciplinary
Xiao Rui Liu, Xinpeng Hu, Iong Ying Loh, Zhisong Wang
Summary: The study demonstrates a novel strategy for transforming chemical nanomotors into optical nanomotors, achieving high directional fidelity through optomechanical control while retaining high efficiency performance similar to chemical nanomotors.
Article
Chemistry, Multidisciplinary
Xinpeng Hu, Xiaodan Zhao, Iong Ying Loh, Jie Yan, Zhisong Wang
Summary: This study demonstrates the sustained force generation capability of an artificial molecular motor at the single-molecule level, showcasing its autonomous chemically fueled operation and self-directed walking. The results suggest a reasonably efficient chemomechanical conversion of the motor compared to biomotors, with implications for similar force-demanding applications.
Article
Physics, Applied
Huijuan Xu, Ruizheng Hou, Hongrong Li, Zhisong Wang
JOURNAL OF APPLIED PHYSICS
(2020)
Review
Chemistry, Multidisciplinary
Zhisong Wang, Ruizheng Hou, Iong Ying Loh
Article
Chemistry, Multidisciplinary
Ruizheng Hou, Nan Wang, Weizhu Bao, Zhisong Wang
Article
Chemistry, Multidisciplinary
Laetitia Bardet, Herve Roussel, Stefano Saroglia, Masoud Akbari, David Munoz-Rojas, Carmen Jimenez, Aurore Denneulin, Daniel Bellet
Summary: The thermal instability of silver nanowires leads to increased electrical resistance in AgNW networks. Understanding the relationship between structural and electrical properties of AgNW networks is crucial for their integration as transparent electrodes in flexible optoelectronics. In situ X-ray diffraction measurements were used to study the crystallographic evolution of Ag-specific Bragg peaks during thermal ramping, revealing differences in thermal and structural transitions between bare and SnO2-coated AgNW networks.
Article
Chemistry, Multidisciplinary
Nathalia Cancino-Fuentes, Arnau Manasanch, Joana Covelo, Alex Suarez-Perez, Enrique Fernandez, Stratis Matsoukis, Christoph Guger, Xavi Illa, Anton Guimera-Brunet, Maria V. Sanchez-Vives
Summary: This study provides a comprehensive characterization of graphene-based solution-gated field-effect transistors (gSGFETs) for brain recordings, highlighting their potential clinical applications.
Article
Chemistry, Multidisciplinary
Sikandar Aftab, Hailiang Liu, Dhanasekaran Vikraman, Sajjad Hussain, Jungwon Kang, Abdullah A. Al-Kahtani
Summary: This study examines the effects of hybrid nanoparticles made of NiO@rGO and NiO@CNT on the active layers of polymer solar cells and X-ray photodetectors. The findings show that these hybrid nanoparticles can enhance the charge carrier capacities and exciton dissociation properties of the active layers. Among the tested configurations, the NiO@CNT device demonstrates superior performance in converting sunlight into electricity, and achieves the best sensitivity for X-ray detection.
Article
Chemistry, Multidisciplinary
Hyo Jung Shin, Seung Gyu Choi, Fengrui Qu, Min-Hee Yi, Choong-Hyun Lee, Sang Ryong Kim, Hyeong-Geug Kim, Jaewon Beom, Yoonyoung Yi, Do Kyung Kim, Eun-Hye Joe, Hee-Jung Song, Yonghyun Kim, Dong Woon Kim
Summary: This study investigates the role of SOX9 in reactive astrocytes following ischemic brain damage using a PLGA nanoparticle plasmid delivery system. The results demonstrate that PLGA nanoparticles can reduce ischemia-induced neurological deficits and infarct volume, providing a potential opportunity for stroke treatment.
Article
Chemistry, Multidisciplinary
Anurag Chaudhury, Koushik Debnath, Nikhil R. Jana, Jaydeep K. Basu
Summary: The study investigates the interaction between nanoparticles and cell membranes, and identifies key parameters, including charge, crowding, and membrane fluidity, that determine the adsorbed concentration and unbinding transition of nanoparticles.
Article
Chemistry, Multidisciplinary
Sina Sadeghi, Fazel Bateni, Taekhoon Kim, Dae Yong Son, Jeffrey A. Bennett, Negin Orouji, Venkat S. Punati, Christine Stark, Teagan D. Cerra, Rami Awad, Fernando Delgado-Licona, Jinge Xu, Nikolai Mukhin, Hannah Dickerson, Kristofer G. Reyes, Milad Abolhasani
Summary: In this study, an autonomous approach for the development of lead-free metal halide perovskite nanocrystals is presented, which integrates a modular microfluidic platform with machine learning-assisted synthesis modeling. This approach enables rapid and optimized synthesis of copper-based lead-free nanocrystals.
Article
Chemistry, Multidisciplinary
Zahir Abbas, Nissar Hussain, Surender Kumar, Shaikh M. Mobin
Summary: The rational construction of free-standing and flexible electrodes for electrochemical energy storage devices is an emerging research focus. In this study, a redox-active metal-organic framework (MOF) was prepared on carbon nanofibers using an in situ approach, resulting in a flexible electrode with high redox-active behavior and unique properties such as high flexibility and lightweight. The prepared electrode showed excellent cyclic retention and rate capability in supercapacitor applications. Additionally, it could be used as a freestanding electrode in flexible devices at different bending angles.
Article
Chemistry, Multidisciplinary
Lishan Zhang, Xiaoting Zhang, Hui Ran, Ze Chen, Yicheng Ye, Jiamiao Jiang, Ziwei Hu, Miral Azechi, Fei Peng, Hao Tian, Zhili Xu, Yingfeng Tu
Summary: Photodynamic therapy (PDT) is a promising local treatment modality in cancer therapy, but its therapeutic efficacy is restricted by ineffective delivery of photosensitizers and tumor hypoxia. In this study, a phototactic Chlorella-based near-infrared (NIR) driven green affording-oxygen microrobot system was developed for enhanced PDT. The system exhibited desirable phototaxis and continuous oxygen generation, leading to the inhibition of tumor growth in mice. This study demonstrates the potential of using a light-driven green affording-oxygen microrobot to enhance photodynamic therapy.
Article
Chemistry, Multidisciplinary
Yujin Li, Jing Xu, Xinqi Luo, Futing Wang, Zhong Dong, Ke-Jing Huang, Chengjie Hu, Mengyi Hou, Ren Cai
Summary: In this study, hollow heterostructured materials were constructed using an innovative template-engaged method as cathodes for zinc-ion batteries. The materials exhibited fast Zn2+ transport channels, improved electrical conductivity, and controlled volume expansion during cycling. The designed structure allowed for an admirable reversible capacity and high coulombic efficiency.
Article
Chemistry, Multidisciplinary
Paritosh Mahato, Shashi Shekhar, Rahul Yadav, Saptarshi Mukherjee
Summary: This study comprehensively elucidates the role of the core and electrostatic surface of metal nanoclusters in catalytic reduction reactions. The electrostatic surface dramatically modulates the reactivity of metal nanoclusters.
Article
Chemistry, Multidisciplinary
Pei Liu, Mengdi Liang, Zhengwei Liu, Haiyu Long, Han Cheng, Jiahe Su, Zhongbiao Tan, Xuewen He, Min Sun, Xiangqian Li, Shuai He
Summary: This study demonstrates a simple and environmentally-friendly method for the synthesis of zinc oxide nanozymes (ZnO NZs) using wasted hop extract (WHE). The WHE-ZnO NZs exhibit exceptional peroxidase-like activity and serve as effective catalysts for the oxidation of 3,3,5,5-tetramethylbenzidine (TMB) in the presence of hydrogen peroxide (H2O2). In addition, a straightforward colorimetric technique for detecting both H2O2 and glucose was developed using the WHE-ZnO NZs as peroxidase-like catalysts.
Article
Chemistry, Multidisciplinary
Hyunkyu Oh, Young Jun Lee, Eun Ji Kim, Jinseok Park, Hee-Eun Kim, Hyunsoo Lee, Hyunjoo Lee, Bumjoon J. Kim
Summary: Mesoporous carbon particles have unique structural properties that make them suitable as support materials for catalytic applications. This study investigates the impact of channel nanostructures on the catalytic activity of porous carbon particles (PCPs) by fabricating PCPs with controlled channel exposure on the carbon surface. The results show that PCPs with highly open channel nanostructures exhibit significantly higher catalytic activity compared to those with closed channel nanostructures.
Article
Chemistry, Multidisciplinary
Yunjie Lu, Zhaohui Li, Zewei Li, Shihao Zhou, Ning Zhang, Jianming Zhang, Lu Zong
Summary: A tough, long-lasting adhesive and highly conductive nanocomposite hydrogel (PACPH) was fabricated via the synergy of interfacial entanglement and adhesion group densification. PACPH possesses excellent mechanical properties, interfacial adhesion strength, and conductivity, making it a promising material for long-term monitoring of human activities and electrocardiogram signals.
Article
Chemistry, Multidisciplinary
Zichao Wei, Audrey Vandergriff, Chung-Hao Liu, Maham Liaqat, Mu-Ping Nieh, Yu Lei, Jie He
Summary: We have developed a simple method to prepare polymer-grafted plasmonic metal nanoparticles with pH-responsive surface-enhanced Raman scattering. By using pH-responsive polymers as ligands, the aggregation of nanoparticles can be controlled, leading to enhanced SERS. The pH-responsive polymer-grafted nanoparticles show high reproducibility and sensitivity in solution, providing a novel approach for SERS without the need for sample pre-concentration.
Article
Chemistry, Multidisciplinary
Melis Ozge Alas Colak, Ahmet Gungor, Merve Buldu Akturk, Emre Erdem, Rukan Genc
Summary: This research investigates the effect of functionalizing carbon dots with hydroxyl polymers on their performance as electrode materials in a supercapacitor. The results show that the functionalized carbon dots exhibit excellent electrochemical performance and improved stability.
