Vaginal lactic acid elicits an anti-inflammatory response from human cervicovaginal epithelial cells and inhibits production of pro-inflammatory mediators associated with HIV acquisition

Lactobacillus -Deficient Cervicovaginal Bacterial Communities Are Associated with Increased HIV Acquisition in Young South African Women

(2017) Christina Gosmann et al.   IMMUNITY

Genital inflammation, immune activation and risk of sexual HIV acquisition

(2016) Jo-Ann S. Passmore et al.   Current Opinion in HIV and AIDS

Rationale and Safety Assessment of a Novel Intravaginal Drug-Delivery System with Sustained DL-Lactic Acid Release, Intended for Long-Term Protection of the Vaginal Microbiome

(2016) Hans Verstraelen et al.   PLoS One

Lactic acid delays the inflammatory response of human monocytes

(2015) Katrin Peter et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Genital Inflammation and the Risk of HIV Acquisition in Women

(2015) Lindi Masson et al.   CLINICAL INFECTIOUS DISEASES

Cervicovaginal Bacteria Are a Major Modulator of Host Inflammatory Responses in the Female Genital Tract

(2015) Melis N. Anahtar et al.   IMMUNITY

Increased levels of inflammatory cytokines in the female reproductive tract are associated with altered expression of proteases, mucosal barrier proteins and an influx of HIV-susceptible target cells

(2015) Kelly B Arnold et al.   Mucosal Immunology

Cervicovaginal microbiome dysbiosis is associated with proteome changes related to alterations of the cervicovaginal mucosal barrier

(2015) H Borgdorff et al.   Mucosal Immunology

Antimicrobial and immune modulatory effects of lactic acid and short chain fatty acids produced by vaginal microbiota associated with eubiosis and bacterial vaginosis

(2015) Muriel Aldunate et al.   Frontiers in Physiology

The Structure of the Human VaginalStratum Corneumand its Role in Immune Defense

(2014) Deborah J. Anderson et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Effects of Tenofovir on Cytokines and Nucleotidases in HIV-1 Target Cells and the Mucosal Tissue Environment in the Female Reproductive Tract

(2014) Nabanita Biswas et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Lactobacillus-dominated cervicovaginal microbiota associated with reduced HIV/STI prevalence and genital HIV viral load in African women

(2014) Hanneke Borgdorff et al.   ISME Journal

Bacteria in the Vaginal Microbiome Alter the Innate Immune Response and Barrier Properties of the Human Vaginal Epithelia in a Species-Specific Manner

(2014) Sylvie Y. Doerflinger et al.   JOURNAL OF INFECTIOUS DISEASES

Cultivated Vaginal Microbiomes Alter HIV-1 Infection and Antiretroviral Efficacy in Colonized Epithelial Multilayer Cultures

(2014) Richard B. Pyles et al.   PLoS One

Defining genital tract cytokine signatures of sexually transmitted infections and bacterial vaginosis in women at high risk of HIV infection: a cross-sectional study

(2014) Lindi Masson et al.   SEXUALLY TRANSMITTED INFECTIONS

Vaginal concentrations of lactic acid potently inactivate HIV

(2013) Muriel Aldunate et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

HIV-1 gp120 Induces TLR2- and TLR4-Mediated Innate Immune Activation in Human Female Genital Epithelium

(2013) A. Nazli et al.   JOURNAL OF IMMUNOLOGY

Vaginal pH and Microbicidal Lactic Acid When Lactobacilli Dominate the Microbiota

(2013) Deirdre E. O’Hanlon et al.   PLoS One

Influence of Vaginal Bacteria and D- and L-Lactic Acid Isomers on Vaginal Extracellular Matrix Metalloproteinase Inducer: Implications for Protection against Upper Genital Tract Infections

(2013) S. S. Witkin et al.   mBio

Innate Immune Activation Enhances HIV Acquisition in Women, Diminishing the Effectiveness of Tenofovir Microbicide Gel

(2012) Vivek Naranbhai et al.   JOURNAL OF INFECTIOUS DISEASES

Commensal Bacteria Modulate Innate Immune Responses of Vaginal Epithelial Cell Multilayer Cultures

(2012) William A. Rose et al.   PLoS One

Phase I Randomized Safety Study of Twice Daily Dosing of Acidform Vaginal Gel: Candidate Antimicrobial Contraceptive

(2012) Marla J. Keller et al.   PLoS One

Bacterial Vaginosis Associated with Increased Risk of Female-to-Male HIV-1 Transmission: A Prospective Cohort Analysis among African Couples

(2012) Craig R. Cohen et al.   PLOS MEDICINE

In vaginal fluid, bacteria associated with bacterial vaginosis can be suppressed with lactic acid but not hydrogen peroxide

(2011) Deirdre E O'Hanlon et al.   BMC INFECTIOUS DISEASES

Endometrial Epithelial Cell Responses to Coinfecting Viral and Bacterial Pathogens in the Genital Tract Can Activate the HIV-1 LTR in an NFκB-and AP-1–Dependent Manner

(2011) Victor H. Ferreira et al.   JOURNAL OF INFECTIOUS DISEASES

Influence of Lactic Acid on Endogenous and Viral RNA-Induced Immune Mediator Production by Vaginal Epithelial Cells

(2011) Hannah Mossop et al.   OBSTETRICS AND GYNECOLOGY

SPL7013 Gel (VivaGel®) Retains Potent HIV-1 and HSV-2 Inhibitory Activity following Vaginal Administration in Humans

(2011) Clare F. Price et al.   PLoS One

Preventing HIV Infection in Women: A Global Health Imperative

(2010) Quarraisha Abdool Karim et al.   CLINICAL INFECTIOUS DISEASES

Structure Activity Relationship of Dendrimer Microbicides with Dual Action Antiviral Activity

(2010) David Tyssen et al.   PLoS One

Vaginal microbiome of reproductive-age women

(2010) J. Ravel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effectiveness and Safety of Tenofovir Gel, an Antiretroviral Microbicide, for the Prevention of HIV Infection in Women

(2010) Q. Abdool Karim et al.   SCIENCE

Phase 2a Study Assessing Colonization Efficiency, Safety, and Acceptability of Lactobacillus crispatus CTV-05 in Women With Bacterial Vaginosis

(2010) Anke Hemmerling et al.   SEXUALLY TRANSMITTED DISEASES

Glycerol monolaurate prevents mucosal SIV transmission

(2009) Qingsheng Li et al.   NATURE

ORIGINAL ARTICLE: Quantification and Comparison of Toll-Like Receptor Expression and Responsiveness in Primary and Immortalized Human Female Lower Genital Tract Epithelia

(2008) Melissa M. Herbst-Kralovetz et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Human lactobacilli as supplementation of clindamycin to patients with bacterial vaginosis reduce the recurrence rate; a 6-month, double-blind, randomized, placebo-controlled study

(2008) Per-Göran Larsson et al.   BMC Womens Health