Rationale and Safety Assessment of a Novel Intravaginal Drug-Delivery System with Sustained DL-Lactic Acid Release, Intended for Long-Term Protection of the Vaginal Microbiome

Exploratory comparison of vaginal glycogen and Lactobacillus levels in premenopausal and postmenopausal women

(2015) Paria Mirmonsef et al.   MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY

α-Amylase in Vaginal Fluid

(2015) Dimitrios Nasioudis et al.   Reproductive Sciences

A quantitative multiplex nuclease protection assay reveals immunotoxicity gene expression profiles in the rabbit model for vaginal drug safety evaluation

(2015) Raina N. Fichorova et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Metabolic Signatures of Bacterial Vaginosis

(2015) Sujatha Srinivasan et al.   mBio

Antimicrobial and immune modulatory effects of lactic acid and short chain fatty acids produced by vaginal microbiota associated with eubiosis and bacterial vaginosis

(2015) Muriel Aldunate et al.   Frontiers in Physiology

Effect of pH on Cleavage of Glycogen by Vaginal Enzymes

(2015) Greg T. Spear et al.   PLoS One

Unexpected Inflammatory Effects of Intravaginal Gels (Universal Placebo Gel and Nonoxynol-9) on the Upper Female Reproductive Tract: A Randomized Crossover Study

(2015) Karen Smith-McCune et al.   PLoS One

Microbes Central to Human Reproduction

(2014) Gregor Reid et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

The vaginal microbiome, vaginal anti-microbial defence mechanisms and the clinical challenge of reducing infection-related preterm birth

(2014) SS Witkin   BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

Comparative genomics of Lactobacillus crispatus suggests novel mechanisms for the competitive exclusion of Gardnerella vaginalis

(2014) Teija Ojala et al.   BMC GENOMICS

Primate vaginal microbiomes exhibit species specificity without universal Lactobacillus dominance

(2014) Suleyman Yildirim et al.   ISME Journal

Comparative Functional Genomics of Lactobacillus spp. Reveals Possible Mechanisms for Specialization of Vaginal Lactobacilli to Their Environment

(2014) H. Mendes-Soares et al.   JOURNAL OF BACTERIOLOGY

Human α-amylase Present in Lower-Genital-Tract Mucosal Fluid Processes Glycogen to Support Vaginal Colonization by Lactobacillus

(2014) Gregory T. Spear et al.   JOURNAL OF INFECTIOUS DISEASES

Lactobacilli Inactivate Chlamydia trachomatis through Lactic Acid but Not H2O2

(2014) Zheng Gong et al.   PLoS One

Free Glycogen in Vaginal Fluids Is Associated with Lactobacillus Colonization and Low Vaginal pH

(2014) Paria Mirmonsef et al.   PLoS One

The Vaginal Microbiota: What Have We Learned after a Decade of Molecular Characterization?

(2014) Janneke H. H. M. van de Wijgert et al.   PLoS One

Potential Influence of the Microbiome on Infertility and Assisted Reproductive Technology

(2014) Ido Sirota et al.   SEMINARS IN REPRODUCTIVE MEDICINE

The primate vaginal microbiome: Comparative context and implications for human health and disease

(2013) Rebecca M. Stumpf et al.   AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY

Effects of probiotics for the treatment of bacterial vaginosis in adult women: a meta-analysis of randomized clinical trials

(2013) Haohai Huang et al.   ARCHIVES OF GYNECOLOGY AND OBSTETRICS

Risks associated with bacterial vaginosis in infertility patients: a systematic review and meta-analysis

(2013) N. van Oostrum et al.   HUMAN REPRODUCTION

Vaginal concentrations of lactic acid potently inactivate HIV

(2013) Muriel Aldunate et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Effects of Probiotics on the Recurrence of Bacterial Vaginosis

(2013) Aziz Homayouni et al.   Journal of Lower Genital Tract Disease

A Multi-Omic Systems-Based Approach Reveals Metabolic Markers of Bacterial Vaginosis and Insight into the Disease

(2013) Carl J. Yeoman et al.   PLoS One

The Burden of Bacterial Vaginosis: Women’s Experience of the Physical, Emotional, Sexual and Social Impact of Living with Recurrent Bacterial Vaginosis

(2013) Jade E. Bilardi et al.   PLoS One

Vaginal pH and Microbicidal Lactic Acid When Lactobacilli Dominate the Microbiota

(2013) Deirdre E. O’Hanlon et al.   PLoS One

Influence of Vaginal Bacteria and D- and L-Lactic Acid Isomers on Vaginal Extracellular Matrix Metalloproteinase Inducer: Implications for Protection against Upper Genital Tract Infections

(2013) S. S. Witkin et al.   mBio

The biofilm in bacterial vaginosis

(2012) Hans Verstraelen et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Structure, function and diversity of the healthy human microbiome

(2012)   NATURE

Longitudinal qPCR Study of the Dynamics of L. crispatus, L. iners, A. vaginae, (Sialidase Positive) G. vaginalis, and P. bivia in the Vagina

(2012) Guido Lopes dos Santos Santiago et al.   PLoS One

Twice-Daily Application of HIV Microbicides Alter the Vaginal Microbio

(2012) J. Ravel et al.   mBio

A Comparison of Lower Genital Tract Glycogen and Lactic Acid Levels in Women and Macaques: Implications for HIV and SIV Susceptibility

(2011) Paria Mirmonsef et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

The Microbiota of the Vagina and Its Influence on Women’s Health and Disease

(2011) David H. Martin   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

In vaginal fluid, bacteria associated with bacterial vaginosis can be suppressed with lactic acid but not hydrogen peroxide

(2011) Deirdre E O'Hanlon et al.   BMC INFECTIOUS DISEASES

Vaginal microbiome and sexually transmitted infections: an epidemiologic perspective

(2011) Rebecca M. Brotman   JOURNAL OF CLINICAL INVESTIGATION

Contemporary perspectives on vaginal pH and lactobacilli

(2010) Iara M. Linhares et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Contraceptive vaginal rings: a review

(2010) Vivian Brache et al.   CONTRACEPTION

Evidence of African-American women's frustrations with chronic recurrent bacterial vaginosis

(2010) Sandra C. Payne et al.   Journal of the American Academy of Nurse Practitioners

At the crossroads of vaginal health and disease, the genome sequence of Lactobacillus iners AB-1

(2010) J. M. Macklaim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Longitudinal analysis of the vaginal microflora in pregnancy suggests that L. crispatus promotes the stability of the normal vaginal microflora and that L. gasseri and/or L. iners are more conducive to the occurrence of abnormal vaginal microflora

(2009) Hans Verstraelen et al.   BMC MICROBIOLOGY

Bacterial vaginosis: an update on diagnosis and treatment

(2009) Hans Verstraelen et al.   Expert Review of Anti-Infective Therapy

What are the consequences of the disappearing human microbiota?

(2009) Martin J. Blaser et al.   NATURE REVIEWS MICROBIOLOGY

Recurrent bacterial vaginosis

(2008) Phillip Hay   CURRENT OPINION IN INFECTIOUS DISEASES

Mucosal Irritation Potential of Personal Lubricants Relates to Product Osmolality as Detected by the Slug Mucosal Irritation Assay

(2008) Els Adriaens et al.   SEXUALLY TRANSMITTED DISEASES