Comparison of human cytochrome P450 1A1-catalysed oxidation of benzo[a]pyrene in prokaryotic and eukaryotic expression systems

NADH:Cytochrome b5 Reductase and Cytochrome b5 Can Act as Sole Electron Donors to Human Cytochrome P450 1A1-Mediated Oxidation and DNA Adduct Formation by Benzo[a]pyrene

(2016) Marie Stiborová et al.   CHEMICAL RESEARCH IN TOXICOLOGY

The impact of individual cytochrome P450 enzymes on oxidative metabolism of benzo[a]pyrene in human livers

(2016) Miroslav Šulc et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Co-expression of active human cytochrome P450 1A2 and cytochrome P450 reductase on the cell surface of Escherichia coli

(2016) Paul Quehl et al.   Microbial Cell Factories

NADPH- and NADH-dependent metabolism of and DNA adduct formation by benzo[a]pyrene catalyzed with rat hepatic microsomes and cytochrome P450 1A1

(2016) Marie Stiborová et al.   MONATSHEFTE FUR CHEMIE

The impact of p53 on DNA damage and metabolic activation of the environmental carcinogen benzo[a]pyrene: effects in Trp53(+/+), Trp53(+/–) and Trp53(−/−) mice

(2015) Annette M. Krais et al.   ARCHIVES OF TOXICOLOGY

TP53 mutations induced by BPDE in Xpa-WT and Xpa-Null human TP53 knock-in (Hupki) mouse embryo fibroblasts

(2015) Jill E. Kucab et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Carcinogenic polycyclic aromatic hydrocarbons induce CYP1A1 in human cells via a p53-dependent mechanism

(2014) Laura E. Wohak et al.   ARCHIVES OF TOXICOLOGY

Correlation between CYP1A1 transcript, protein level, enzyme activity and DNA adduct formation in normal human mammary epithelial cell strains exposed to benzo[a]pyrene

(2014) R. L. Divi et al.   MUTAGENESIS

A Novel Methodology for Enhanced and Consistent Heterologous Expression of Unmodified Human Cytochrome P450 1B1 (CYP1B1)

(2014) Muneeb A. Faiq et al.   PLoS One

Cytochrome b5 and epoxide hydrolase contribute to benzo[a]pyrene-DNA adduct formation catalyzed by cytochrome P450 1A1 under low NADPH:P450 oxidoreductase conditions

(2014) Marie Stiborová et al.   TOXICOLOGY

Heterologous expression of human cytochrome P450 (CYP) 2C19 inEscherichia coliand establishment of RP-HPLC method to serve as activity marker

(2013) Yan Pan et al.   BIOMEDICAL CHROMATOGRAPHY

The relationship between DNA adduct formation by benzo[a]pyrene and expression of its activation enzyme cytochrome P450 1A1 in rat

(2013) Petr Hodek et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Human Cytochrome P450 1A1 Structure and Utility in Understanding Drug and Xenobiotic Metabolism

(2013) Agnes A. Walsh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cytochrome b5 Increases Cytochrome P450 3A4-Mediated Activation of Anticancer Drug Ellipticine to 13-Hydroxyellipticine Whose Covalent Binding to DNA Is Elevated by Sulfotransferases and N,O-Acetyltransferases

(2012) Marie Stiborová et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Dioxin suppresses benzo[a]pyrene-induced mutations and DNA adduct formation through cytochrome P450 1A1 induction and (±)-anti-benzo[a]pyrene-7,8-diol-9,10-epoxide inactivation in human hepatoma cells

(2012) Kazuhiro Shiizaki et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Exposure to benzo[a]pyrene of Hepatic Cytochrome P450 Reductase Null (HRN) and P450 Reductase Conditional Null (RCN) mice: Detection of benzo[a]pyrene diol epoxide-DNA adducts by immunohistochemistry and 32P-postlabelling

(2012) Volker M. Arlt et al.   TOXICOLOGY LETTERS

Cytochrome b5 shifts oxidation of the anticancer drug ellipticine by cytochromes P450 1A1 and 1A2 from its detoxication to activation, thereby modulating its pharmacological efficacy

(2011) Věra Kotrbová et al.   BIOCHEMICAL PHARMACOLOGY

Microsomal monooxygenase as a multienzyme system: the role of P450-P450 interactions

(2011) Dmitri R Davydov   Expert Opinion on Drug Metabolism & Toxicology

Heterologous Expression of Human Cytochromes P450 2D6 and CYP3A4 in Escherichia coli and Their Functional Characterization

(2011) Yan Pan et al.   PROTEIN JOURNAL

Mechanisms of the Different DNA Adduct Forming Potentials of the Urban Air Pollutants 2-Nitrobenzanthrone and Carcinogenic 3-Nitrobenzanthrone

(2010) Marie Stiborová et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Deletion of Microsomal Cytochrome b5 Profoundly Affects Hepatic and Extrahepatic Drug Metabolism

(2010) L. A. McLaughlin et al.   MOLECULAR PHARMACOLOGY

Studying cytochrome P450 kinetics in drug metabolism

(2008) Melissa A Kramer et al.   Expert Opinion on Drug Metabolism & Toxicology

Simultaneous determination of benzo[a]pyrene and eight of its metabolites in Fundulus heteroclitus bile using ultra-performance liquid chromatography with mass spectrometry

(2008) Shiqian Zhu et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Cytochrome P450 and Chemical Toxicology

(2007) F. Peter Guengerich   CHEMICAL RESEARCH IN TOXICOLOGY