Structural Probing and Molecular Modeling of the A3 Adenosine Receptor: A Focus on Agonist Binding

Structure-Based Screening of Uncharted Chemical Space for Atypical Adenosine Receptor Agonists

(2016) David Rodríguez et al.   ACS Chemical Biology

Identification of A3adenosine receptor agonists as novel non-narcotic analgesics

(2016) K Janes et al.   BRITISH JOURNAL OF PHARMACOLOGY

Kinetic Aspects of the Interaction between Ligand and G Protein-Coupled Receptor: The Case of the Adenosine Receptors

(2016) Dong Guo et al.   CHEMICAL REVIEWS

Deciphering the Complexity of Ligand–Protein Recognition Pathways Using Supervised Molecular Dynamics (SuMD) Simulations

(2016) Alberto Cuzzolin et al.   Journal of Chemical Information and Modeling

Purine (N)-Methanocarba Nucleoside Derivatives Lacking an Exocyclic Amine as Selective A3 Adenosine Receptor Agonists

(2016) Dilip K. Tosh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure of the adenosine A2A receptor bound to an engineered G protein

(2016) Byron Carpenter et al.   NATURE

Adenosine as a Multi-Signalling Guardian Angel in Human Diseases: When, Where and How Does it Exert its Protective Effects?

(2016) Pier Andrea Borea et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Understanding allosteric interactions in G protein-coupled receptors using Supervised Molecular Dynamics: A prototype study analysing the human A3 adenosine receptor positive allosteric modulator LUF6000

(2015) Giuseppe Deganutti et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Molecular Docking Screening Using Agonist-Bound GPCR Structures: Probing the A2A Adenosine Receptor

(2015) David Rodríguez et al.   Journal of Chemical Information and Modeling

Structure-based design, synthesis by click chemistry and in vivo activity of highly selective A3 adenosine receptor agonists

(2015) Dilip K. Tosh et al.   MedChemComm

John Daly Lecture: Structure-guided Drug Design for Adenosine and P2Y Receptors

(2015) Kenneth A. Jacobson et al.   Computational and Structural Biotechnology Journal

Synthesis and evaluation of N6-substituted apioadenosines as potential adenosine A3 receptor modulators

(2014) Kiran S. Toti et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Different efficacy of adenosine and NECA derivatives at the human A3 adenosine receptor: Insight into the receptor activation switch

(2013) Diego Dal Ben et al.   BIOCHEMICAL PHARMACOLOGY

Class A G-Protein-Coupled Receptor (GPCR) Dimers and Bivalent Ligands

(2013) Christine Hiller et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ligand-Dependent Activation and Deactivation of the Human Adenosine A2A Receptor

(2013) Jianing Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure-Guided Design of A3 Adenosine Receptor-Selective Nucleosides: Combination of 2-Arylethynyl and Bicyclo[3.1.0]hexane Substitutions

(2012) Dilip K. Tosh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Limits of Ligand Selectivity from Docking to Models: In Silico Screening for A1 Adenosine Receptor Antagonists

(2012) Peter Kolb et al.   PLoS One

Truncated Nucleosides as A3 Adenosine Receptor Ligands: Combined 2-Arylethynyl and Bicyclohexane Substitutions

(2012) Dilip K. Tosh et al.   ACS Medicinal Chemistry Letters

Pharmacological and therapeutic effects of A3 adenosine receptor agonists

(2011) Pnina Fishman et al.   DRUG DISCOVERY TODAY

Allosteric interactions across native adenosine-A3 receptor homodimers: quantification using single-cell ligand-binding kinetics

(2011) Lauren T. May et al.   FASEB JOURNAL

The A3adenosine receptor as multifaceted therapeutic target: pharmacology, medicinal chemistry, and in silico approaches

(2011) Siew Lee Cheong et al.   MEDICINAL RESEARCH REVIEWS

Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation

(2011) Guillaume Lebon et al.   NATURE

International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and Classification of Adenosine Receptors--An Update

(2011) B. B. Fredholm et al.   PHARMACOLOGICAL REVIEWS

Predicted structures of agonist and antagonist bound complexes of adenosine A3 receptor

(2011) Soo-Kyung Kim et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Structure of an Agonist-Bound Human A2A Adenosine Receptor

(2011) F. Xu et al.   SCIENCE

Recent developments in adenosine receptor ligands and their potential as novel drugs

(2010) Christa E. Müller et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Pyrimidine Derivatives as Potent and Selective A3Adenosine Receptor Antagonists

(2010) Vicente Yaziji et al.   JOURNAL OF MEDICINAL CHEMISTRY

Hydration Site Thermodynamics Explain SARs for Triazolylpurines Analogues Binding to the A2A Receptor

(2010) Christopher Higgs et al.   ACS Medicinal Chemistry Letters

Synthesis and pharmacological characterization of [ 125 I]MRS5127, a high affinity, selective agonist radioligand for the A 3 adenosine receptor

(2009) John A. Auchampach et al.   BIOCHEMICAL PHARMACOLOGY

Human A3 Adenosine Receptor as Versatile G Protein-Coupled Receptor Example to Validate the Receptor Homology Modeling Technology

(2009) Erika Morizzo et al.   CURRENT PHARMACEUTICAL DESIGN

Nucleoside-derived antagonists to A3 adenosine receptors lower mouse intraocular pressure and act across species

(2009) Zhao Wang et al.   EXPERIMENTAL EYE RESEARCH

Adenosine receptors and asthma

(2008) R A Brown et al.   BRITISH JOURNAL OF PHARMACOLOGY

The 2.6 Angstrom Crystal Structure of a Human A2A Adenosine Receptor Bound to an Antagonist

(2008) V.-P. Jaakola et al.   SCIENCE

Molecular modeling of adenosine receptors: new results and trends

(2007) Adriano Martinelli et al.   MEDICINAL RESEARCH REVIEWS