Heparin and Heparin-Derivatives in Post-Subarachnoid Hemorrhage Brain Injury: A Multimodal Therapy for a Multimodal Disease

Effect of heparin on secondary brain injury in patients with subarachnoid hemorrhage: an additional ‘H’ therapy in vasospasm treatment

(2017) Markus Bruder et al.   Journal of NeuroInterventional Surgery

Advanced glycation end-products produced systemically and by macrophages: A common contributor to inflammation and degenerative diseases

(2017) Kyunghee Byun et al.   PHARMACOLOGY & THERAPEUTICS

Loss of Consciousness at Onset of Aneurysmal Subarachnoid Hemorrhage is Associated with Functional Outcomes in Good-Grade Patients

(2017) Justin Wang et al.   World Neurosurgery

Neutrophil depletion after subarachnoid hemorrhage improves memory via NMDA receptors

(2016) Jose Javier Provencio et al.   BRAIN BEHAVIOR AND IMMUNITY

Early CSF and Serum S100B Concentrations for Outcome Prediction in Traumatic Brain Injury and Subarachnoid Hemorrhage

(2016) Isabel Kellermann et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

Microglia in the TBI brain: The good, the bad, and the dysregulated

(2016) David J. Loane et al.   EXPERIMENTAL NEUROLOGY

Aneurysmal Subarachnoid Hemorrhage and Neuroinflammation: A Comprehensive Review

(2016) Brandon Lucke-Wold et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Expression of high-mobility group box-1 (HMGB1) in the basilar artery after experimental subarachnoid hemorrhage

(2016) Xu Dong Zhao et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Inhibition of mammalian target of rapamycin attenuates early brain injury through modulating microglial polarization after experimental subarachnoid hemorrhage in rats

(2016) Wanchun You et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Does enoxaparin interfere with HMGB1 signaling after TBI? A potential mechanism for reduced cerebral edema and neurologic recovery

(2016) Shengjie Li et al.   Journal of Trauma and Acute Care Surgery

Unfractionated heparin after TBI reduces in vivo cerebrovascular inflammation, brain edema and accelerates cognitive recovery

(2016) Katsuhiro Nagata et al.   Journal of Trauma and Acute Care Surgery

Inhibition of the Receptor for Advanced Glycation End-Products (RAGE) Attenuates Neuroinflammation While Sensitizing Cortical Neurons Towards Death in Experimental Subarachnoid Hemorrhage

(2016) Hua Li et al.   MOLECULAR NEUROBIOLOGY

Rutin Inhibits Neuroinflammation and Provides Neuroprotection in an Experimental Rat Model of Subarachnoid Hemorrhage, Possibly Through Suppressing the RAGE–NF-κB Inflammatory Signaling Pathway

(2016) Guangzhi Hao et al.   NEUROCHEMICAL RESEARCH

Mechanisms of Global Cerebral Edema Formation in Aneurysmal Subarachnoid Hemorrhage

(2016) Erik G. Hayman et al.   Neurocritical Care

Risk of Ventriculostomy-Associated Hemorrhage in Patients with Aneurysmal Subarachnoid Hemorrhage Treated with Anticoagulant Thromboprophylaxis

(2016) Joseph Zachariah et al.   Neurocritical Care

Does enoxaparin interfere with HMGB1 signaling after TBI? A potential mechanism for reduced cerebral edema and neurologic recovery

(2016) Shengjie Li et al.   Journal of Trauma and Acute Care Surgery

Unfractionated heparin after TBI reduces in vivo cerebrovascular inflammation, brain edema and accelerates cognitive recovery

(2016) Katsuhiro Nagata et al.   Journal of Trauma and Acute Care Surgery

Loss of Consciousness at Onset of Subarachnoid Hemorrhage as an Important Marker of Early Brain Injury

(2016) Sureerat Suwatcharangkoon et al.   JAMA Neurology

Early Elevation of Serum Tumor Necrosis Factor-α Is Associated With Poor Outcome in Subarachnoid Hemorrhage

(2016) Sherry H.-Y. Chou et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Thioredoxin-Mimetic-Peptides Protect Cognitive Function after Mild Traumatic Brain Injury (mTBI)

(2016) Renana Baratz-Goldstein et al.   PLoS One

Anti-high mobility group box-1 (HMGB1) antibody attenuates delayed cerebral vasospasm and brain injury after subarachnoid hemorrhage in rats

(2016) Jun Haruma et al.   Scientific Reports

Evaluating Blood-Brain Barrier Permeability in Delayed Cerebral Infarction after Aneurysmal Subarachnoid Hemorrhage

(2015) J. Ivanidze et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

4′-O-β-d-glucosyl-5-O-methylvisamminol, an active ingredient of Saposhnikovia divaricata, attenuates high-mobility group box 1 and subarachnoid hemorrhage-induced vasospasm in a rat model

(2015) Chih-Zen Chang et al.   Behavioral and Brain Functions

VAP-1 blockade prevents subarachnoid hemorrhage-associated cerebrovascular dilating dysfunction via repression of a neutrophil recruitment-related mechanism

(2015) Haoliang Xu et al.   BRAIN RESEARCH

Heparin derivatives for the targeting of multiple activities in the inflammatory response

(2015) Noemi Veraldi et al.   CARBOHYDRATE POLYMERS

Selectins: initiators of leucocyte adhesion and signalling at the vascular wall

(2015) Rodger P. McEver   CARDIOVASCULAR RESEARCH

804

(2015) Punkaj Gupta et al.   CRITICAL CARE MEDICINE

Current structural biology of the heparin interactome

(2015) Vitor H Pomin et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Heparin inhibits the inflammatory response induced by LPS and HMGB1 by blocking the binding of HMGB1 to the surface of macrophages

(2015) Li Li et al.   CYTOKINE

Methemoglobin Is an Endogenous Toll-Like Receptor 4 Ligand—Relevance to Subarachnoid Hemorrhage

(2015) Min Kwon et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Microglia regulate blood clearance in subarachnoid hemorrhage by heme oxygenase-1

(2015) Nils Schallner et al.   JOURNAL OF CLINICAL INVESTIGATION

HMGB1 Level in Cerebrospinal Fluid as a Marker of Treatment Outcome in Patients with Acute Hydrocephalus Following Aneurysmal Subarachnoid Hemorrhage

(2015) Bartosz Sokół et al.   Journal of Stroke & Cerebrovascular Diseases

Enoxaparin ameliorates post–traumatic brain injury edema and neurologic recovery, reducing cerebral leukocyte endothelial interactions and vessel permeability in vivo

(2015) Shengjie Li et al.   Journal of Trauma and Acute Care Surgery

Can We Produce Heparin/Heparan Sulfate Biomimetics Using “Mother-Nature” as the Gold Standard?

(2015) Brooke Farrugia et al.   MOLECULES

Orally Administered Enoxaparin Ameliorates Acute Colitis by Reducing Macrophage-Associated Inflammatory Responses

(2015) Qi Ying Lean et al.   PLoS One

Non-Anticoagulant Fractions of Enoxaparin Suppress Inflammatory Cytokine Release from Peripheral Blood Mononuclear Cells of Allergic Asthmatic Individuals

(2015) Madhur D. Shastri et al.   PLoS One

White Matter Injury After Subarachnoid Hemorrhage

(2015) Yusuke Egashira et al.   STROKE

Ventriculostomy-Related Hemorrhage After Treatment of Acutely Ruptured Aneurysms: The Influence of Anticoagulation and Antiplatelet Treatment

(2015) Markus Bruder et al.   World Neurosurgery

HMGB1 Level in Cerebrospinal Fluid as a Marker of Treatment Outcome in Patients with Acute Hydrocephalus Following Aneurysmal Subarachnoid Hemorrhage

(2015) Bartosz Sokół et al.   Journal of Stroke & Cerebrovascular Diseases

Enoxaparin ameliorates post–traumatic brain injury edema and neurologic recovery, reducing cerebral leukocyte endothelial interactions and vessel permeability in vivo

(2015) Shengjie Li et al.   Journal of Trauma and Acute Care Surgery

Heparin Interaction with the Primed Polymorphonuclear Leukocyte CD11b Induces Apoptosis and Prevents Cell Activation

(2015) Meital Cohen-Mazor et al.   Journal of Immunology Research

Immune cells subpopulations in cerebrospinal fluid and peripheral blood of patients with Aneurysmal Subarachnoid Hemorrhage

(2015) Leandro Moraes et al.   SpringerPlus

Pharmacologic blockade of vascular adhesion protein-1 lessens neurologic dysfunction in rats subjected to subarachnoid hemorrhage

(2014) Hao-Liang Xu et al.   BRAIN RESEARCH

Early release of high-mobility group box 1 (HMGB1) from neurons in experimental subarachnoid hemorrhage in vivo and in vitro

(2014) Qing Sun et al.   Journal of Neuroinflammation

Microglia Enhance Neurogenesis and Oligodendrogenesis in the Early Postnatal Subventricular Zone

(2014) Y. Shigemoto-Mogami et al.   JOURNAL OF NEUROSCIENCE

Long-Term Functional Consequences and Ongoing Cerebral Inflammation after Subarachnoid Hemorrhage in the Rat

(2014) Elke Kooijman et al.   PLoS One

N-Acetyl-Heparin Attenuates Acute Lung Injury Caused by Acid Aspiration Mainly by Antagonizing Histones in Mice

(2014) Yanlin Zhang et al.   PLoS One

Safety of Preprocedural Antiplatelet Medication in Coil Embolization of Ruptured Cerebral Aneurysms at the Acute Stage

(2014) Norihito Shimamura et al.   INTERVENTIONAL NEURORADIOLOGY

To Look Beyond Vasospasm in Aneurysmal Subarachnoid Haemorrhage

(2014) Giulia Cossu et al.   Biomed Research International

Expression and cell distribution of receptor for advanced glycation end-products in the rat cortex following experimental subarachnoid hemorrhage

(2013) Hua Li et al.   BRAIN RESEARCH

Low molecular weight heparin suppresses receptor for advanced glycation end products-mediated expression of malignant phenotype in human fibrosarcoma cells

(2013) Akihiko Takeuchi et al.   CANCER SCIENCE

Unfractionated Heparin Ameliorates Lipopolysaccharide-Induced Lung Inflammation by Downregulating Nuclear Factor-κB Signaling Pathway

(2013) Xu Li et al.   INFLAMMATION

Neuroprotective Effects of Ultra-Low-Molecular-Weight Heparin on Cerebral Ischemia/Reperfusion Injury in Rats: Involvement of Apoptosis, Inflammatory Reaction and Energy Metabolism

(2013) Zhi-Guo Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The role of microglia and the TLR4 pathway in neuronal apoptosis and vasospasm after subarachnoid hemorrhage

(2013) Khalid A Hanafy   Journal of Neuroinflammation

Low-dose intravenous heparin infusion in patients with aneurysmal subarachnoid hemorrhage: a preliminary assessment

(2013) J. Marc Simard et al.   JOURNAL OF NEUROSURGERY

Impact of global cerebral atrophy on clinical outcome after subarachnoid hemorrhage

(2013) Alan K. H. Tam et al.   JOURNAL OF NEUROSURGERY

Delayed cerebral ischaemia after subarachnoid haemorrhage: looking beyond vasospasm

(2012) M.J. Rowland et al.   BRITISH JOURNAL OF ANAESTHESIA

Inhibitory effect of non-anticoagulant heparin (S-NACH) on pancreatic cancer cell adhesion and metastasis in human umbilical cord vessel segment and in mouse model

(2012) Thangirala Sudha et al.   CLINICAL & EXPERIMENTAL METASTASIS

Unfractionated heparin inhibits lipopolysaccharide-induced inflammatory response through blocking p38 MAPK and NF-κB activation on endothelial cell

(2012) Xu Li et al.   CYTOKINE

Mast Cell Proteoglycans

(2012) Elin Rönnberg et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Heme activates TLR4-mediated inflammatory injury via MyD88/TRIF signaling pathway in intracerebral hemorrhage

(2012) Sen Lin et al.   Journal of Neuroinflammation

Inflammation as a predictor for delayed cerebral ischemia after aneurysmal subarachnoid haemorrhage

(2012) Catherine J McMahon et al.   Journal of NeuroInterventional Surgery

Ultra-early endovascular embolization of ruptured cerebral aneurysm and the increased risk of hematoma growth unrelated to aneurysmal rebleeding

(2012) Yusuke Egashira et al.   JOURNAL OF NEUROSURGERY

New Paradigms in Type 2 Immunity

(2012) B. Pulendran et al.   SCIENCE

Heparin Reduces Neuroinflammation and Transsynaptic Neuronal Apoptosis in a Model of Subarachnoid Hemorrhage

(2012) J. Marc Simard et al.   Translational Stroke Research

Mast Cells Increase Vascular Permeability by Heparin-Initiated Bradykinin Formation In Vivo

(2011) Chris Oschatz et al.   IMMUNITY

Unfractionated or low molecular weight heparin for induction of remission in ulcerative colitis: A cochrane inflammatory bowel disease and functional bowel disorders systematic review of randomized trials

(2011) Nilesh Chande et al.   INFLAMMATORY BOWEL DISEASES

Low anticoagulant heparin targets multiple sites of inflammation, suppresses heparin-induced thrombocytopenia, and inhibits interaction of RAGE with its ligands

(2010) Narayanam V. Rao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Neuroprotective effects of ultra-low-molecular-weight heparin in vitro and vivo models of ischemic injury

(2010) Zhi-guo Zhang et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Heparin changes the conformation of high-mobility group protein 1 and decreases its affinity toward receptor for advanced glycation endproducts in vitro

(2010) Yan Ling et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Vasospasm after subarachnoid hemorrhage in haptoglobin 2-2 mice can be prevented with a glutathione peroxidase mimetic

(2010) Michael T. Froehler et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Unfractionated Heparin: Multitargeted Therapy for Delayed Neurological Deficits Induced by Subarachnoid Hemorrhage

(2010) J. Marc Simard et al.   Neurocritical Care

Impact of Systemic Inflammatory Response Syndrome on Vasospasm, Cerebral Infarction, and Outcome After Subarachnoid Hemorrhage: Exploratory Analysis of CONSCIOUS-1 Database

(2010) Alan K. H. Tam et al.   Neurocritical Care

Cognitive and Functional Outcome After Aneurysmal Subarachnoid Hemorrhage

(2010) Timour Al-Khindi et al.   STROKE

Subarachnoid Hemorrhage Induces Gliosis and Increased Expression of the Pro-inflammatory Cytokine High Mobility Group Box 1 Protein

(2010) Kentaro Murakami et al.   Translational Stroke Research

Inhibition of bradykinin B2 receptors before, not after onset of experimental subarachnoid hemorrhage prevents brain edema formation and improves functional outcome

(2009) Serge C. Thal et al.   CRITICAL CARE MEDICINE

Neutralization of Interleukin-1β Reduces Vasospasm and Alters Cerebral Blood Vessel Density Following Experimental Subarachnoid Hemorrhage in Rats

(2009) Halina Jedrzejowska-Szypulka et al.   CURRENT NEUROVASCULAR RESEARCH

N-acetylcysteine suppresses oxidative stress in experimental rats with subarachnoid hemorrhage

(2009) Hua Lu et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Cerebral inflammatory response and predictors of admission clinical grade after aneurysmal subarachnoid hemorrhage

(2009) Khalid A. Hanafy et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Ym1/2 Promotes Th2 Cytokine Expression by Inhibiting 12/15(S)-Lipoxygenase: Identification of a Novel Pathway for Regulating Allergic Inflammation

(2009) Y. Cai et al.   JOURNAL OF IMMUNOLOGY

The blood-brain barrier in neurodegenerative disease: a rhetorical perspective

(2009) Paul M. Carvey et al.   JOURNAL OF NEUROCHEMISTRY

CSF Neutrophils Are Implicated in the Development of Vasospasm in Subarachnoid Hemorrhage

(2009) J. J. Provencio et al.   Neurocritical Care

High-Mobility Group Box 1 Protein in CSF of Patients with Subarachnoid Hemorrhage

(2009) Takashi Nakahara et al.   Neurocritical Care

Role of Interleukin-1β in Early Brain Injury After Subarachnoid Hemorrhage in Mice

(2009) Takumi Sozen et al.   STROKE

Sex-Specific Role of Thioredoxin in Neuroprotection Against Iron-Induced Brain Injury Conferred by Estradiol

(2009) Tzu-Yin Chen et al.   STROKE

The effect of IVX-0142, a heparin-derived hypersulfated disaccharide, on the allergic airway responses in asthma

(2008) M. Duong et al.   ALLERGY

The story of the discovery of heparin and warfarin

(2008) Douglas Wardrop et al.   BRITISH JOURNAL OF HAEMATOLOGY

Glibenclamide Reduces Inflammation, Vasogenic Edema, and Caspase-3 Activation after Subarachnoid Hemorrhage

(2008) J Marc Simard et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The incidence of heparin-induced thrombocytopenia Type II in patients with subarachnoid hemorrhage treated with heparin versus enoxaparin

(2008) Grace H. Kim et al.   JOURNAL OF NEUROSURGERY

Tumor Necrosis Factor-α Modulates Survival, Proliferation, and Neuronal Differentiation in Neonatal Subventricular Zone Cell Cultures

(2008) Liliana Bernardino et al.   STEM CELLS

Heparin and low-molecular-weight heparin

(2008) Barbara Mulloy et al.   THROMBOSIS AND HAEMOSTASIS

Endothelial capillary tube formation and cell proliferation induced by tumor cells are affected by low molecular weight heparins and unfractionated heparin

(2007) Marina Marchetti et al.   THROMBOSIS RESEARCH