Can We Produce Heparin/Heparan Sulfate Biomimetics Using “Mother-Nature” as the Gold Standard?

Structural and Functional Study of d-Glucuronyl C5-epimerase

(2015) Yi Qin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

6-O-Sulfated Chitosan Promoting the Neural Differentiation of Mouse Embryonic Stem Cells

(2014) Kaiguo Ding et al.   ACS Applied Materials & Interfaces

Heparin-Like Properties of Sulfated Alginates with Defined Sequences and Sulfation Degrees

(2014) Øystein Arlov et al.   BIOMACROMOLECULES

Bone regeneration using photocrosslinked hydrogel incorporating rhBMP-2 loaded 2-N, 6-O-sulfated chitosan nanoparticles

(2014) Lingyan Cao et al.   BIOMATERIALS

De novo synthesis of a narrow size distribution low-molecular-weight heparin

(2014) Kasemsiri Chandarajoti et al.   GLYCOBIOLOGY

Chemoenzymatic synthesis and structural characterization of 2-O-sulfated glucuronic acid-containing heparan sulfate hexasaccharides

(2014) Po-Hung Hsieh et al.   GLYCOBIOLOGY

Preparation of carboxymethyl cellulose sulfates and its application as anticoagulant and wound dressing

(2014) Lihong Fan et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Fibroblast Growth Factor-based Signaling through Synthetic Heparan Sulfate Blocks Copolymers Studied Using High Cell Density Three-dimensional Cell Printing

(2014) Eric Sterner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sulfation of Hydroxyethyl Cellulose by N(SO3Na)3and the Anticoagulant Activity of Sulfated Hydroxyethyl Cellulose

(2014) Lihong Fan et al.   JOURNAL OF CARBOHYDRATE CHEMISTRY

Synthesis and Biological Evaluation of a Unique Heparin Mimetic Hexasaccharide for Structure–Activity Relationship Studies

(2014) Sucharita Roy et al.   JOURNAL OF MEDICINAL CHEMISTRY

The role of vascular-derived perlecan in modulating cell adhesion, proliferation and growth factor signaling

(2014) Megan S. Lord et al.   MATRIX BIOLOGY

Homogeneous low-molecular-weight heparins with reversible anticoagulant activity

(2014) Yongmei Xu et al.   Nature Chemical Biology

New glucuronic acid donors for the modular synthesis of heparan sulfate oligosaccharides

(2014) Omkar P. Dhamale et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Fluorous-Assisted Chemoenzymatic Synthesis of Heparan Sulfate Oligosaccharides

(2014) Chao Cai et al.   ORGANIC LETTERS

Synthesis and characterization of water soluble biomimetic chitosans for bone and cartilage tissue regeneration

(2014) Megan S. Lord et al.   Journal of Materials Chemistry B

Tailored Design and Synthesis of Heparan Sulfate Oligosaccharide Analogues Using Sequential One-Pot Multienzyme Systems

(2013) Yi Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Vascularization and bone regeneration in a critical sized defect using 2-N,6-O-sulfated chitosan nanoparticles incorporating BMP-2

(2013) Lingyan Cao et al.   BIOMATERIALS

Synthesis of Fondaparinux: modular synthesis investigation for heparin synthesis

(2013) Feng Lin et al.   CARBOHYDRATE RESEARCH

Synthesis of a Targeted Library of Heparan Sulfate Hexa- to Dodecasaccharides as Inhibitors of β-Secretase: Potential Therapeutics for Alzheimer’s Disease

(2013) Ralf Schwörer et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthetic heparin and heparan sulfate oligosaccharides and their protein interactions

(2013) Medel Manuel L Zulueta et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Recombinant production of proteoglycans and their bioactive domains

(2013) Megan S. Lord et al.   FEBS Journal

Chemoenzymatic synthesis of glycosaminoglycans: Re-creating, re-modeling and re-designing nature's longest or most complex carbohydrate chains

(2013) P. L. DeAngelis et al.   GLYCOBIOLOGY

Bioengineering murine mastocytoma cells to produce anticoagulant heparin

(2013) L. Gasimli et al.   GLYCOBIOLOGY

Bioengineered Chinese Hamster Ovary Cells with Golgi-targeted 3-O-Sulfotransferase-1 Biosynthesize Heparan Sulfate with an Antithrombin-binding Site

(2013) Payel Datta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Toward the Solid-Phase Synthesis of Heparan Sulfate Oligosaccharides: Evaluation of Iduronic Acid and Idose Building Blocks

(2013) Nerea Guedes et al.   JOURNAL OF ORGANIC CHEMISTRY

Heparan sulfate 3-O-sulfation: A rare modification in search of a function

(2013) Bryan E. Thacker et al.   MATRIX BIOLOGY

Fluorous Supported Modular Synthesis of Heparan Sulfate Oligosaccharides

(2013) Chengli Zong et al.   ORGANIC LETTERS

Toward the chemoenzymatic synthesis of heparan sulfate oligosaccharides: oxidative cleavage of p-nitrophenyl group with ceric ammonium salts

(2013) Chao Cai et al.   TETRAHEDRON LETTERS

Chondrocyte Culture in Three Dimensional Alginate Sulfate Hydrogels Promotes Proliferation While Maintaining Expression of Chondrogenic Markers

(2013) Rami Mhanna et al.   TISSUE ENGINEERING PART A

Efficient chemical synthesis of heparin-like octa-, deca- and dodecasaccharides and inhibition of FGF2- and VEGF165-mediated endothelial cell functions

(2013) Gavin J. Miller et al.   Chemical Science

Use of biosynthetic enzymes in heparin and heparan sulfate synthesis

(2012) Elizabeth P. Chappell et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Perlecan domain 1 recombinant proteoglycan augments BMP-2 activity and osteogenesis

(2012) Arthur A DeCarlo et al.   BMC BIOTECHNOLOGY

Fell-Muir Lecture: Chondroitin sulphate glycosaminoglycans: fun for some and confusion for others

(2012) Bruce Caterson   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Synthesis, characterization, and anticoagulant activity of carboxymethyl starch sulfates

(2012) Lihong Fan et al.   JOURNAL OF APPLIED POLYMER SCIENCE

Chemoenzymatic Synthesis of Heparin Oligosaccharides with both Anti-factor Xa and Anti-factor IIa Activities

(2012) Yongmei Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Uncovering Biphasic Catalytic Mode of C5-epimerase in Heparan Sulfate Biosynthesis

(2012) Juzheng Sheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure/Function Analysis ofPasteurella multocidaHeparosan Synthases

(2012) Nigel J. Otto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mast Cells Produce Novel Shorter Forms of Perlecan That Contain Functional Endorepellin

(2012) MoonSun Jung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heparan Sulfate Biosynthesis

(2012) Hinke A. B. Multhaupt et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Heparan Sulfate Biosynthesis

(2012) Johan Kreuger et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Divergent Synthesis of 48 Heparan Sulfate-Based Disaccharides and Probing the Specific Sugar–Fibroblast Growth Factor-1 Interaction

(2012) Yu-Peng Hu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

α-Glycosylation by d-Glucosamine-Derived Donors: Synthesis of Heparosan and Heparin Analogues That Interact with Mycobacterial Heparin-Binding Hemagglutinin

(2012) Medel Manuel L. Zulueta et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Metabolic engineering of Chinese hamster ovary cells: Towards a bioengineered heparin

(2012) Jong Youn Baik et al.   METABOLIC ENGINEERING

Toward a bioengineered heparin

(2012) Jong Youn Baik et al.   Bioengineered

Modulation of osteogenic activity of BMP-2 by cellulose and chitosan derivatives

(2011) D. Peschel et al.   Acta Biomaterialia

Chondrogenesis of hMSC in affinity-bound TGF-beta scaffolds

(2011) Tali Re’em et al.   BIOMATERIALS

Directing the biological activities of heparan sulfate oligosaccharides using a chemoenzymatic approach

(2011) Yongmei Xu et al.   GLYCOBIOLOGY

Serglycin: A Structural and Functional Chameleon with Wide Impact on Immune Cells

(2011) Svein O. Kolset et al.   JOURNAL OF IMMUNOLOGY

Chemoenzymatic Synthesis of Uridine Diphosphate-GlcNAc and Uridine Diphosphate-GalNAc Analogs for the Preparation of Unnatural Glycosaminoglycans

(2011) Sayaka Masuko et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of 3-O-sulfonated heparan sulfate octasaccharides that inhibit the herpes simplex virus type 1 host–cell interaction

(2011) Yu-Peng Hu et al.   Nature Chemistry

Chemoenzymatic Synthesis of Homogeneous Ultralow Molecular Weight Heparins

(2011) Y. Xu et al.   SCIENCE

Heparan sulfate proteoglycans in healthy and diseased systems

(2011) John Whitelock et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

The effects of controlled HGF delivery from an affinity-binding alginate biomaterial on angiogenesis and blood perfusion in a hindlimb ischemia model

(2010) Emil Ruvinov et al.   BIOMATERIALS

Soluble Perlecan Domain I Enhances Vascular Endothelial Growth Factor-165 Activity and Receptor Phosphorylation in Human Bone Marrow Endothelial Cells

(2010) Arivalagan Muthusamy et al.   BMC BIOCHEMISTRY

Similarity of Recombinant Human Perlecan Domain 1 by Alternative Expression Systems Bioactive Heterogenous Recombinant Human Perlecan D1

(2010) April L Ellis et al.   BMC BIOTECHNOLOGY

Preactivation-Based, One-Pot Combinatorial Synthesis of Heparin-like Hexasaccharides for the Analysis of Heparin-Protein Interactions

(2010) Zhen Wang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Chemoenzymatic Design of Heparan Sulfate Oligosaccharides

(2010) Renpeng Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthetic Heparan Sulfate Oligosaccharides Inhibit Endothelial Cell Functions Essential for Angiogenesis

(2010) Claire L. Cole et al.   PLoS One

Synthesis of novel celluloses derivatives and investigation of their mitogenic activity in the presence and absence of FGF2

(2009) D. Peschel et al.   Acta Biomaterialia

Modifications of Hyaluronan Influence the Interaction with Human Bone Morphogenetic Protein-4 (hBMP-4)

(2009) Vera Hintze et al.   BIOMACROMOLECULES

The influence of the sequential delivery of angiogenic factors from affinity-binding alginate scaffolds on vascularization

(2009) Inbar Freeman et al.   BIOMATERIALS

Enhanced bioactivity of bone morphogenetic protein-2 with low dose of 2-N, 6-O-sulfated chitosan in vitro and in vivo

(2009) Huanjun Zhou et al.   BIOMATERIALS

S-Nitrosylation of secreted recombinant human glypican-1

(2009) Gabriel Svensson et al.   GLYCOCONJUGATE JOURNAL

Modular Synthesis of Heparan Sulfate Oligosaccharides for Structure−Activity Relationship Studies

(2009) Sailaja Arungundram et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The repertoire of glycan determinants in the human glycome

(2009) Richard D. Cummings   Molecular BioSystems

Design of biologically active heparan sulfate and heparin using an enzyme-based approach

(2009) Sherket Peterson et al.   NATURAL PRODUCT REPORTS

A synthetic CD4–heparan sulfate glycoconjugate inhibits CCR5 and CXCR4 HIV-1 attachment and entry

(2009) Françoise Baleux et al.   Nature Chemical Biology

Opportunities and challenges in synthetic oligosaccharide and glycoconjugate research

(2009) Thomas J. Boltje et al.   Nature Chemistry

Diverse Cell Signaling Events Modulated by Perlecan†

(2008) John M. Whitelock et al.   BIOCHEMISTRY

The effect of sulfation of alginate hydrogels on the specific binding and controlled release of heparin-binding proteins

(2008) Inbar Freeman et al.   BIOMATERIALS

Recombinant heparan sulfate for use in tissue engineering applications

(2008) John Whitelock et al.   JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY

Mixture Synthesis and “Charge Tagging” Based Demixing: An Efficient Strategy for the Preparation of Heparan Sulfate Libraries

(2008) Anna Dilhas et al.   JOURNAL OF COMBINATORIAL CHEMISTRY

Synthesis of Uridine 5′-diphosphoiduronic Acid: A Potential Substrate for the Chemoenzymatic Synthesis of Heparin

(2008) Michel Weïwer et al.   JOURNAL OF ORGANIC CHEMISTRY

Oversulfated chondroitin sulfate is a contaminant in heparin associated with adverse clinical events

(2008) Marco Guerrini et al.   NATURE BIOTECHNOLOGY

Contaminated Heparin Associated with Adverse Clinical Events and Activation of the Contact System

(2008) Takashi Kei Kishimoto et al.   NEW ENGLAND JOURNAL OF MEDICINE

Heparan sulfate biosynthesis enzymes EXT1 and EXT2 affect NDST1 expression and heparan sulfate sulfation

(2008) J. Presto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA