Regulation of T Cell Activation and Differentiation by Extracellular Vesicles and Their Pathogenic Role in Systemic Lupus Erythematosus and Multiple Sclerosis

Role of extracellular vesicles in autoimmune diseases

(2016) Delphine Turpin et al.   AUTOIMMUNITY REVIEWS

MicroRNAs contribution in tumor microenvironment of esophageal cancer

(2016) Nazila Nouraee et al.   Cancer Biomarkers

Digestion of Chromatin in Apoptotic Cell Microparticles Prevents Autoimmunity

(2016) Vanja Sisirak et al.   CELL

Contribution of MicroRNAs to autoimmune diseases

(2016) Lucien P. Garo et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Identification of a novel mechanism of blood–brain communication during peripheral inflammation via choroid plexus‐derived extracellular vesicles

(2016) Sriram Balusu et al.   EMBO Molecular Medicine

The biology and function of exosomes in cancer

(2016) Raghu Kalluri   JOURNAL OF CLINICAL INVESTIGATION

From pathogenesis to clinical application: insights into exosomes as transfer vectors in cancer

(2016) Wenting Xu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Exosomal miR-24-3p impedes T-cell function by targetingFGF11and serves as a potential prognostic biomarker for nasopharyngeal carcinoma

(2016) Shu-Biao Ye et al.   JOURNAL OF PATHOLOGY

Exosomes as a potential novel therapeutic tools against neurodegenerative diseases

(2016) Akvilė Jarmalavičiūtė et al.   PHARMACOLOGICAL RESEARCH

EpCAM-dependent extracellular vesicles from intestinal epithelial cells maintain intestinal tract immune balance

(2016) Lingling Jiang et al.   Nature Communications

Colorectal cancer cell-derived extracellular vesicles induce phenotypic alteration of T cells into tumor-growth supporting cells with transforming growth factor-β1-mediated suppression

(2016) Nami Yamada et al.   Oncotarget

The SNARE VAMP7 Regulates Exocytic Trafficking of Interleukin-12 in Dendritic Cells

(2016) Giulia Chiaruttini et al.   Cell Reports

ATP Induces Disruption of Tight Junction Proteins via IL-1 Beta-Dependent MMP-9 Activation of Human Blood-Brain BarrierIn Vitro

(2016) Fuxing Yang et al.   NEURAL PLASTICITY

TCR Signal Strength Alters T–DC Activation and Interaction Times and Directs the Outcome of Differentiation

(2016) Nicholas van Panhuys   Frontiers in Immunology

The Autoimmune Ecology

(2016) Juan-Manuel Anaya et al.   Frontiers in Immunology

Breaking Free of Control: How Conventional T Cells Overcome Regulatory T Cell Suppression

(2016) Emily R. Mercadante et al.   Frontiers in Immunology

Is It worth Considering Circulating microRNAs in Multiple Sclerosis?

(2016) Ferdinand Jagot et al.   Frontiers in Immunology

The Dendritic Cell Synapse: A Life Dedicated to T Cell Activation

(2016) Federica Benvenuti   Frontiers in Immunology

Cholera Toxin Promotes Th17 Cell Differentiation by Modulating Expression of Polarizing Cytokines and the Antigen-Presenting Potential of Dendritic Cells

(2016) Jung-Ok Kang et al.   PLoS One

Mechanisms of human autoimmunity

(2015) Michael D. Rosenblum et al.   JOURNAL OF CLINICAL INVESTIGATION

Acid Sphingomyelinase–Derived Ceramide Regulates ICAM-1 Function during T Cell Transmigration across Brain Endothelial Cells

(2015) Melissa A. Lopes Pinheiro et al.   JOURNAL OF IMMUNOLOGY

Galectin-3 binding protein links circulating microparticles with electron dense glomerular deposits in lupus nephritis

(2015) C T Nielsen et al.   LUPUS

Exosomes and their roles in immune regulation and cancer

(2015) David W. Greening et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Organizing Polarized Delivery of Exosomes at Synapses

(2015) Maria Mittelbrunn et al.   TRAFFIC

Immunosuppression of breast cancer cells mediated by transforming growth factor-β in exosomes from cancer cells

(2015) LEI RONG et al.   Oncology Letters

Biodistribution and function of extracellular miRNA-155 in mice

(2015) Shashi Bala et al.   Scientific Reports

Microvesicles: What is the Role in Multiple Sclerosis?

(2015) Tiziana Carandini et al.   Frontiers in Neurology

Tumor-derived exosomes promote tumor progression and T-cell dysfunction through the regulation of enriched exosomal microRNAs in human nasopharyngeal carcinoma

(2015) Shu-biao Ye et al.   Oncotarget

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

(2014) Marina Colombo et al.   Annual Review of Cell and Developmental Biology

Th17 and regulatory T cell balance in autoimmune and inflammatory diseases

(2014) Mélissa Noack et al.   AUTOIMMUNITY REVIEWS

Circulating microparticles reflect treatment effects and clinical status in multiple sclerosis

(2014) Matías Sáenz-Cuesta et al.   Biomarkers in Medicine

Microparticles in multiple sclerosis and clinically isolated syndrome: effect on endothelial barrier function

(2014) Beatriz Marcos-Ramiro et al.   BMC NEUROSCIENCE

MicroRNA-Containing T-Regulatory-Cell-Derived Exosomes Suppress Pathogenic T Helper 1 Cells

(2014) Isobel S. Okoye et al.   IMMUNITY

T-Cell-Receptor-Dependent Signal Intensity Dominantly Controls CD4+ T Cell Polarization In Vivo

(2014) Nicholas van Panhuys et al.   IMMUNITY

Defining a Role for Acid Sphingomyelinase in the p38/Interleukin-6 Pathway

(2014) David M. Perry et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endothelial Microparticles Interact with and Support the Proliferation of T Cells

(2014) Julie Wheway et al.   JOURNAL OF IMMUNOLOGY

Effect of Nasopharyngeal Carcinoma-Derived Exosomes on Human Regulatory T Cells

(2014) Dhafer Mrizak et al.   JNCI-Journal of the National Cancer Institute

Polarized release of T-cell-receptor-enriched microvesicles at the immunological synapse

(2014) Kaushik Choudhuri et al.   NATURE

Emerging role of extracellular vesicles in inflammatory diseases

(2014) Edit I. Buzas et al.   Nature Reviews Rheumatology

CD4+ T Cell Subset Differentiation and Avidity Setpoint Are Dictated by the Interplay of Cytokine and Antigen Mediated Signals

(2014) Erin K. Shiner et al.   PLoS One

Extracellular Vesicle-Mediated Transfer of Genetic Information between the Hematopoietic System and the Brain in Response to Inflammation

(2014) Kirsten Ridder et al.   PLOS BIOLOGY

Unique protein signature of circulating microparticles in systemic lupus erythematosus

(2013) Ole Østergaard et al.   ARTHRITIS AND RHEUMATISM

Immune modulation of T-cell and NK (natural killer) cell activities by TEXs (tumour-derived exosomes)

(2013) Theresa L. Whiteside   BIOCHEMICAL SOCIETY TRANSACTIONS

Exosomes with membrane-associated TGF-β1 from gene-modified dendritic cells inhibit murine EAE independently of MHC restriction

(2013) Lei Yu et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

CD73 expression on extracellular vesicles derived from CD4+CD25+Foxp3+T cells contributes to their regulatory function

(2013) Lesley Ann Smyth et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Early signaling events that underlie fate decisions of naive CD4+T cells toward distinct T-helper cell subsets

(2013) Hidehiro Yamane et al.   IMMUNOLOGICAL REVIEWS

p66Shc regulates vesicle-mediated secretion in mast cells by affecting F-actin dynamics

(2013) Giulia Masi et al.   JOURNAL OF LEUKOCYTE BIOLOGY

MicroRNA-155 modulates Th1 and Th17 cell differentiation and is associated with multiple sclerosis and experimental autoimmune encephalomyelitis

(2013) Jing Zhang et al.   JOURNAL OF NEUROIMMUNOLOGY

Choroid plexus transcytosis and exosome shuttling deliver folate into brain parenchyma

(2013) Marcel Grapp et al.   Nature Communications

Myeloid microvesicles are a marker and therapeutic target for neuroinflammation

(2012) Claudia Verderio et al.   ANNALS OF NEUROLOGY

Increased IgG on cell-derived plasma microparticles in systemic lupus erythematosus is associated with autoantibodies and complement activation

(2012) Christoffer T. Nielsen et al.   ARTHRITIS AND RHEUMATISM

microRNA-301a regulation of a T-helper 17 immune response controls autoimmune demyelination

(2012) M. P. Mycko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epistasis between MicroRNAs 155 and 146a during T Cell-Mediated Antitumor Immunity

(2012) Thomas B. Huffaker et al.   Cell Reports

Immunosuppressive exosomes from TGF-β1 gene-modified dendritic cells attenuate Th17-mediated inflammatory autoimmune disease by inducing regulatory T cells

(2011) Zhijian Cai et al.   CELL RESEARCH

Microparticles as antigenic targets of antibodies to DNA and nucleosomes in systemic lupus erythematosus

(2011) Anirudh J. Ullal et al.   JOURNAL OF AUTOIMMUNITY

p66Shc Is a Negative Regulator of Fc RI-Dependent Signaling in Mast Cells

(2011) C. Ulivieri et al.   JOURNAL OF IMMUNOLOGY

Silencing MicroRNA-155 Ameliorates Experimental Autoimmune Encephalomyelitis

(2011) G. Murugaiyan et al.   JOURNAL OF IMMUNOLOGY

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

Loss-of-function variant in DNASE1L3 causes a familial form of systemic lupus erythematosus

(2011) Sulaiman M Al-Mayouf et al.   NATURE GENETICS

Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells

(2011) María Mittelbrunn et al.   Nature Communications

Low-strength T-cell activation promotes Th17 responses

(2010) H. A. Purvis et al.   BLOOD

MicroRNA-155 Promotes Autoimmune Inflammation by Enhancing Inflammatory T Cell Development

(2010) Ryan M. O'Connell et al.   IMMUNITY

Cdc42-mediated MTOC polarization in dendritic cells controls targeted delivery of cytokines at the immune synapse

(2010) Julian Pulecio et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tumor-Derived Microvesicles Induce, Expand and Up-Regulate Biological Activities of Human Regulatory T Cells (Treg)

(2010) Marta Szajnik et al.   PLoS One

Platelet CD154 Potentiates Interferon-  Secretion by Plasmacytoid Dendritic Cells in Systemic Lupus Erythematosus

(2010) P. Duffau et al.   Science Translational Medicine

Exosomes: immune properties and potential clinical implementations

(2010) Nathalie Chaput et al.   Seminars in Immunopathology

Acid sphingomyelinase activity triggers microparticle release from glial cells

(2009) Fabio Bianco et al.   EMBO JOURNAL

Differential vesicular distribution and trafficking of MMP-2, MMP-9, and their inhibitors in astrocytes

(2009) Oualid Sbai et al.   GLIA

Foxp3-Dependent MicroRNA155 Confers Competitive Fitness to Regulatory T Cells by Targeting SOCS1 Protein

(2009) Li-Fan Lu et al.   IMMUNITY

Mechanisms of Foxp3+ T Regulatory Cell-Mediated Suppression

(2009) Ethan M. Shevach   IMMUNITY

Tumor-Derived Microvesicles Promote Regulatory T Cell Expansion and Induce Apoptosis in Tumor-Reactive Activated CD8+ T Lymphocytes

(2009) E. U. Wieckowski et al.   JOURNAL OF IMMUNOLOGY

MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis

(2009) Changsheng Du et al.   NATURE IMMUNOLOGY

The proapoptotic and antimitogenic protein p66SHC acts as a negative regulator of lymphocyte activation and autoimmunity

(2008) F. Finetti et al.   BLOOD

MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer

(2008) Douglas D. Taylor et al.   GYNECOLOGIC ONCOLOGY

Tumor-derived microvesicles in sera of patients with head and neck cancer and their role in tumor progression

(2008) Christoph Bergmann et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

Systemic Lupus Erythematosus

(2008) Anisur Rahman et al.   NEW ENGLAND JOURNAL OF MEDICINE