Chroman-4-One Derivatives Targeting Pteridine Reductase 1 and Showing Anti-Parasitic Activity

Methoxylated 2'-hydroxychalcones as antiparasitic hit compounds

(2017) Chiara Borsari et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Comparing Drug Images and Repurposing Drugs with BioGPS and FLAPdock: The Thymidylate Synthase Case

(2016) Lydia Siragusa et al.   ChemMedChem

Profiling of Flavonol Derivatives for the Development of Antitrypanosomatidic Drugs

(2016) Chiara Borsari et al.   JOURNAL OF MEDICINAL CHEMISTRY

Vorinostat, a histone deacetylase (HDAC) inhibitor, promotes cell cycle arrest and re-sensitizes rituximab- and chemo-resistant lymphoma cells to chemotherapy agents

(2015) Kai Xue et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

New perspectives for leishmaniasis chemotherapy over current anti-leishmanial drugs: a patent landscape

(2014) Alice Machado-Silva et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Structure-Based Design and Synthesis of Antiparasitic Pyrrolopyrimidines Targeting Pteridine Reductase 1

(2014) Abedawn I. Khalaf et al.   JOURNAL OF MEDICINAL CHEMISTRY

Drug Discovery for Neglected Diseases: Molecular Target-Based and Phenotypic Approaches

(2013) Ian H. Gilbert   JOURNAL OF MEDICINAL CHEMISTRY

Biochemical effects of riluzole on Leishmania parasites

(2012) Davide Guerrieri et al.   EXPERIMENTAL PARASITOLOGY

An Image-Based High-Content Screening Assay for Compounds Targeting Intracellular Leishmania donovani Amastigotes in Human Macrophages

(2012) Jair L. Siqueira-Neto et al.   PLoS Neglected Tropical Diseases

Application of a resazurin-based high-throughput screening assay for the identification and progression of new treatments for human African trypanosomiasis

(2012) Tana Bowling et al.   International Journal for Parasitology-Drugs and Drug Resistance

X-ray crystallography: assessment and validation of protein–small molecule complexes for drug discovery

(2011) David R Cooper et al.   Expert Opinion on Drug Discovery

Drug resistance in human African trypanosomiasis

(2011) Michael P Barrett et al.   Future Microbiology

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Structure of recombinantLeishmania donovanipteridine reductase reveals a disordered active site

(2010) Keri L. Barrack et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Comparison of Bioluminescent Kinase Assays Using Substrate Depletion and Product Formation

(2010) Cordelle Tanega et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Fragment-based screening by X-ray crystallography, MS and isothermal titration calorimetry to identify PNMT (phenylethanolamine N-methyltransferase) inhibitors

(2010) Nyssa Drinkwater et al.   BIOCHEMICAL JOURNAL

The Kinetoplastid Chemotherapy Revisited: Current Drugs, Recent Advances and Future Perspectives

(2010) E. Castillo et al.   CURRENT MEDICINAL CHEMISTRY

Virtual Screening Identification of Nonfolate Compounds, Including a CNS Drug, as Antiparasitic Agents Inhibiting Pteridine Reductase

(2010) Stefania Ferrari et al.   JOURNAL OF MEDICINAL CHEMISTRY

Trypanosoma brucei pteridine reductase 1 is essential for survival in vitro and for virulence in mice

(2010) Natasha Sienkiewicz et al.   MOLECULAR MICROBIOLOGY

One Scaffold, Three Binding Modes: Novel and Selective Pteridine Reductase 1 Inhibitors Derived from Fragment Hits Discovered by Virtual Screening

(2009) Chidochangu P. Mpamhanga et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure-Based Design of Pteridine Reductase Inhibitors Targeting African Sleeping Sickness and the Leishmaniases

(2009) Lindsay B. Tulloch et al.   JOURNAL OF MEDICINAL CHEMISTRY

Development of the Predictor hERG Fluorescence Polarization Assay Using a Membrane Protein Enrichment Approach

(2008) David R. Piper et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Automated macromolecular model building for X-ray crystallography using ARP/wARP version 7

(2008) Gerrit Langer et al.   Nature Protocols

Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development

(2008) A. Cavazzuti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA