Cymantrenyl-Nucleobases: Synthesis, Anticancer, Antitrypanosomal and Antimicrobial Activity Studies

Front-line glioblastoma chemotherapeutic temozolomide is toxic to Trypanosoma brucei and potently enhances melarsoprol and eflornithine

(2017) Dietmar Steverding et al.   EXPERIMENTAL PARASITOLOGY

ROS-modulated therapeutic approaches in cancer treatment

(2017) Muhammad Hassan Raza et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Predictive compound accumulation rules yield a broad-spectrum antibiotic

(2017) Michelle F. Richter et al.   NATURE

Antibacterial Properties of Metallocenyl-7-ADCA Derivatives and Structure in Complex with CTX-M β-Lactamase

(2017) Eric M. Lewandowski et al.   ORGANOMETALLICS

Kinetic Resolution of Planar-Chiral (η5-Bromocyclopentadienyl)manganese(I) Complexes by Molybdenum-Catalyzed Asymmetric Ring-Closing Metathesis

(2017) Masamichi Ogasawara et al.   ORGANOMETALLICS

Induction of apoptosis and cell cycle arrest by flavokawain C on HT-29 human colon adenocarcinoma via enhancement of reactive oxygen species generation, upregulation of p21, p27, and Gadd153, and inactivation of inhibitor of apoptosis proteins

(2017) SriNurestri Abd Malek et al.   Pharmacognosy Magazine

Organometallic tosyl hydrazones: Synthesis, characterization, crystal structures and in vitro evaluation for anti- Mycobacterium tuberculosis and antiproliferative activities

(2017) Camila Concha et al.   POLYHEDRON

The medicinal chemistry of ferrocene and its derivatives

(2017) Malay Patra et al.   Nature Reviews Chemistry

Insights into the in vitro Anticancer Effects of Diruthenium-1

(2016) Aneta Koceva-Chyła et al.   ChemMedChem

Interactions between proteins and Ru compounds of medicinal interest: A structural perspective

(2016) Antonello Merlino   COORDINATION CHEMISTRY REVIEWS

Ferrocenyl-nucleobase complexes: Synthesis, chemistry and applications

(2016) Konrad Kowalski   COORDINATION CHEMISTRY REVIEWS

Substitution of Metallocenes with [2.2]Paracyclophane to Enable Confocal Microscopy Imaging in Living Cells

(2016) Joanna Skiba et al.   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

Doxorubicin–transferrin conjugate triggers pro-oxidative disorders in solid tumor cells

(2016) Marzena Szwed et al.   TOXICOLOGY IN VITRO

Cymantrene, Cyrhetrene and Ferrocene Nucleobase Conjugates: Synthesis, Structure, Computational Study, Electrochemistry and Antitrypanosomal Activity

(2016) Konrad Kowalski et al.   ChemPlusChem

Ferrocifen type anti cancer drugs

(2015) Gérard Jaouen et al.   CHEMICAL SOCIETY REVIEWS

Antibacterial and Antiparasitic Activity of Manganese(I) Tricarbonyl Complexes with Ketoconazole, Miconazole, and Clotrimazole Ligands

(2015) Peter V. Simpson et al.   ORGANOMETALLICS

Medicinal organometallic chemistry – an emerging strategy for the treatment of neglected tropical diseases

(2015) Ronald W. Brown et al.   MedChemComm

Interplay between ROS and autophagy in cancer cells, from tumor initiation to cancer therapy

(2015) Laura Poillet-Perez et al.   Redox Biology

Quantitative Analyses of ROS and RNS Production in Breast Cancer Cell Lines Incubated with Ferrocifens

(2014) Cong Lu et al.   ChemMedChem

Cymantrene–Triazole “Click” Products: Structural Characterization and Electrochemical Properties

(2014) David P. Day et al.   ORGANOMETALLICS

Natural small-molecule enhancers of autophagy induce autophagic cell death in apoptosis-defective cells

(2014) Betty Yuen Kwan Law et al.   Scientific Reports

Analysis of the Mechanism of Action of Potent Antibacterial Hetero-tri-organometallic Compounds: A Structurally New Class of Antibiotics

(2013) Michaela Wenzel et al.   ACS Chemical Biology

Crosstalk between apoptosis, necrosis and autophagy

(2013) Vassiliki Nikoletopoulou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Synthesis, characterization and antibacterial studies of ferrocenyl and cymantrenyl hydrazone compounds

(2013) Vijaylakshmi Tirkey et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Metallocene-Modified Uracils: Synthesis, Structure, and Biological Activity

(2013) Konrad Kowalski et al.   ORGANOMETALLICS

Lighting the way to see inside the live cell with luminescent transition metal complexes

(2012) Elizabeth Baggaley et al.   COORDINATION CHEMISTRY REVIEWS

Synthesis and biological activity of cymantrene and cyrhetrene 4-aminoquinoline conjugates against malaria, leishmaniasis, and trypanosomiasis

(2012) Lotta Glans et al.   DALTON TRANSACTIONS

Small organometallic compounds as antibacterial agents

(2012) Malay Patra et al.   DALTON TRANSACTIONS

Ferrocenyl bioconjugates of ampicillin and 6-aminopenicillinic acid – Synthesis, electrochemistry and biological activity

(2012) Joanna Skiba et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

WinGXandORTEP for Windows: an update

(2012) Louis J. Farrugia   JOURNAL OF APPLIED CRYSTALLOGRAPHY

Anodic properties of diarylethene derivatives having organometallic piano-stool tags

(2011) Kan Wu et al.   CHEMICAL COMMUNICATIONS

The synthesis, structure, electrochemistry and in vitro anticancer activity studies of ferrocenyl-thymine conjugates

(2011) Konrad Kowalski et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Advances in metal–carbene complexes as potent anti-cancer agents

(2011) Arnaud Gautier et al.   Metallomics

Cymantrene- and Ferrocene-Based Complexes with Perfluorinated Bridging Moieties

(2011) Max Roemer et al.   ORGANOMETALLICS

Engineering Femtosecond Organometallic Chemistry: Photochemistry and Dynamics of Ultrafast Chelation of Cyclopentadienylmanganese Tricarbonyl Derivatives with Pendant Benzenecarbonyl and Pyridinecarbonyl Groups

(2011) Edwin J. Heilweil et al.   ORGANOMETALLICS

Protease-Activatable Organometal−Peptide Bioconjugates with Enhanced Cytotoxicity on Cancer Cells

(2010) Katrin Splith et al.   BIOCONJUGATE CHEMISTRY

Cancer cell killing via ROS: To increase or decrease, that is the question

(2010) Jie Wang et al.   CANCER BIOLOGY & THERAPY

Regulation of autophagy in mammals and its interplay with apoptosis

(2010) Gian Maria Fimia et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Influence of the metal complex-to-peptide linker on the synthesis and properties of bioactive CpMn(CO)3 peptide conjugates

(2010) Katrin Splith et al.   DALTON TRANSACTIONS

Triple-Negative Breast Cancer

(2010) William D. Foulkes et al.   NEW ENGLAND JOURNAL OF MEDICINE

Synthesis and Biological Evaluation of Ferrocene-Containing Bioorganometallics Inspired by the Antibiotic Platensimycin Lead Structure

(2010) Malay Patra et al.   ORGANOMETALLICS

Structure validation in chemical crystallography

(2009) Anthony L. Spek   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

On the medicinal chemistry of gold complexes as anticancer drugs

(2009) Ingo Ott   COORDINATION CHEMISTRY REVIEWS

OLEX2: a complete structure solution, refinement and analysis program

(2009) Oleg V. Dolomanov et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

Photochemistry of Cymantrenyl Scorpionates: Formation of a Novel Tritopic Cyclopentadienyl/Scorpionate Hybrid Ligand

(2009) Kerstin Kunz et al.   ORGANOMETALLICS

Trypanocidal activity of the proteasome inhibitor and anti-cancer drug bortezomib

(2009) Dietmar Steverding et al.   Parasites & Vectors

Cymantrene conjugation modulates the intracellular distribution and induces high cytotoxicity of a cell-penetrating peptide

(2008) Ines Neundorf et al.   CHEMICAL COMMUNICATIONS