Article
Endocrinology & Metabolism
Miaomiao Du, Xueyun Li, Fangyi Xiao, Yinxu Fu, Yu Shi, Sihan Guo, Lifang Chen, Lu Shen, Lan Wang, Huang Cheng, Hao Li, Anran Xie, Yaping Zhou, Kaiqiang Yang, Hezhi Fang, Jianxin Lyu, Qiongya Zhao
Summary: This study demonstrates the importance of SERAC1 protein in lipid metabolism in mice. Serac1 deficiency prevents high-fat diet-induced obesity without affecting energy expenditure. It impairs cholesterol transfer from the liver to the serum and leads to an imbalance in cholesterol distribution. Moreover, Serac1 deficiency may decrease the risk of diet-induced hepatic steatosis.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2022)
Article
Endocrinology & Metabolism
Arthe Raajendiran, Christoph Krisp, David P. De Souza, Geraldine Ooi, Paul R. Burton, Renea A. Taylor, Mark P. Molloy, Matthew J. Watt
Summary: Adipose tissue plays a crucial role in energy balance and metabolism regulation, with differences in protein composition leading to metabolic variation in different regions. Upper-body adipocytes are associated with glycolysis, lipogenesis, and oxidative stress, while lower-body adipocytes show enhanced activation of PPARa and mitochondrial oxidative phosphorylation processes.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Food Science & Technology
Yan Zhu, Xianghui Zhou, Nan Ling, Qiming Yu, Huijuan Wang, Qizhen Du
Summary: This study aimed to investigate the effect of Guisangyou tea (GSY tea) on abnormal lipid metabolism in mice with obesity induced by a high-fat diet (HFD). The results showed that GSY tea decreased serum lipid levels, regulated antioxidant enzyme activities and inflammatory factors, and modulated mRNA and protein expression levels related to lipid synthesis and bile acid production in the liver. These findings indicate that GSY tea can improve abnormal lipid metabolism by enhancing antioxidant capacity, regulating inflammation, and modulating lipid synthesis and bile acid production.
Review
Food Science & Technology
Chao Tang, Liangyu Kong, Mengyuan Shan, Zhaoxin Lu, Yingjian Lu
Summary: Obesity and obesity-related chronic diseases are closely related to dysregulation of metabolism, oxidative stress, endoplasmic reticulum stress, abnormal gut microbiome, and chronic low-grade inflammation. Probiotics are considered as a novel strategy for preventing and ameliorating obesity and related diseases, with mechanisms including effects on lipid, glucose, cholesterol metabolism, as well as antioxidative and anti-inflammatory activities.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Nutrition & Dietetics
Changbao Sun, Ang Li, Huan Wang, Jiage Ma, Juncai Hou
Summary: Acetate is associated with adipocyte differentiation and lipid deposition. In a study on obese mice and mouse adipose mesenchymal stem cells, it was found that acetate significantly increased body weight, food intake, and fatty lesions, while decreasing anti-inflammatory factors levels and liver function. The mRNA expression levels of several genes in adipose tissue and stem cells were also significantly altered.
Review
Endocrinology & Metabolism
Thomas Guerbette, Gaelle Boudry, Annaig Lan
Summary: This review discusses the impact of high-fat diet on mitochondrial function in intestinal epithelial cells and its role in regulating intestinal homeostasis. The findings suggest that high-fat diet may disrupt intestinal epithelial barrier, dysbiosis, and loss of epithelial homeostasis through its effects on mitochondrial function.
MOLECULAR METABOLISM
(2022)
Review
Endocrinology & Metabolism
Thomas Guerbette, Gaelle Boudry, Annaig Lan
Summary: Systemic low-grade inflammation in diet-induced obesity is associated with dysbiosis and disturbance of intestinal homeostasis, potentially due to impaired IEC mitochondrial function. HFD consumption may affect IEC mitochondrial function through gut-derived metabolite production and fatty acids, leading to altered homeostasis in the small intestine and colon.
MOLECULAR METABOLISM
(2022)
Article
Nutrition & Dietetics
Jiabao Yan, Cuiru Ren, Yunlong Dong, Jibran A. A. Wali, Hongjie Song, Ying Zhang, Hengrui Zhang, Guangning Kou, David Raubenheimer, Zhenwei Cui
Summary: Ketogenic diet combined with moderate aerobic exercise effectively reduces body weight and fat mass, with no significant adverse effects except for an increase in circulating triglyceride level. Aerobic exercise further improves blood parameters and hepatic condition in mice fed with ketogenic diet.
Article
Biotechnology & Applied Microbiology
Qionghua Long, Hongyan Chen, Wenhui Yang, Li Yang, Lijuan Zhang
Summary: The study found that Dp3-Sam can reduce body weight gain, visceral fat, and hepatic lipid deposits in rats, as well as improving lipid metabolism dysfunction. This indicates the potential of Dp3-Sam as a therapy for the prevention of obesity and dyslipidemia.
Article
Food Science & Technology
Yangmian Yuan, Chengyu Liu, Xingrui Chen, Yuyan Sun, Mingrui Xiong, Yu Fan, Robert B. Petersen, Hong Chen, Kun Huang, Ling Zheng
Summary: The study suggests that Tet1 plays a crucial role in obesity by promoting lipolysis and reducing obesity. Vitamin C can treat obesity by enhancing Tet1 activity, thus decreasing hepatic steatosis.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Endocrinology & Metabolism
Yi-Fan Guo, Jing-Yi Sun, Ya Liu, Zhe-Yu Liu, Yan Huang, Yuan Xiao, Tian Su
Summary: This article reveals that the long noncoding RNA (lncRNA) Hnscr is involved in lipid metabolism during obesity. Deletion of Hnscr promotes weight gain and increase in adipose tissue weight, while overexpression of Hnscr has the opposite effect. Hnscr regulates adipose lipid metabolism by mediating the cyclic adenosine monophosphate/protein kinase A signaling pathway.
Article
Agriculture, Multidisciplinary
Xinbo Zhou, Junjie Zhang, Yutong Sun, Jian Shen, Bo Sun, Qingquan Ma
Summary: This study found that glutamine (Gln) has a positive effect on liver steatosis and promotes hepatic homeostasis by improving glucose metabolism and regulating signaling pathways. Obese mice fed with Gln had higher levels of colonic short-chain fatty acids (SCFAs) and lower levels of inflammation factor proteins, and a decrease in the abundance of Firmicutes bacteria was observed.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Cell Biology
Hee Jung Kim, Dong-Hoon Kim, Sung Hee Um
Summary: YM976, a pyrimidine derivative, has anti-inflammatory and anti-asthmatic effects. It can reduce lipid accumulation and suppress adipocyte differentiation by increasing the phosphorylation of AMPK. Therefore, YM976 may be a potential compound for controlling lipid accumulation and formation of adipocytes in obesity.
Article
Pharmacology & Pharmacy
Xiaoxian Xie, Mengya Zhang, Lei Sun, Ting Wang, Zhengyan Zhu, Ruonan Shu, Fengchun Wu, Zezhi Li
Summary: This study demonstrates that crocin-I may inhibit obesity by reducing body weight, improving glucose resistance, and alleviating intestinal microbial disorders in HFD-induced obese mice. Crocin-I also helps in restoring SCFAs levels and repairing altered intestinal barrier functioning and inflammation in HFD-induced obese mice.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Shiyue Luo, Lixiao Zhou, Xuejun Jiang, Yinyin Xia, Lishuang Huang, Run Ling, Shixin Tang, Zhen Zou, Chengzhi Chen, Jingfu Qiu
Summary: Asparagus cochinchinensis, a traditional Chinese medicine, has shown anti-inflammatory properties and the ability to regulate gut microbiota. In a study on obese mice, it was found that the aqueous extract from Asparagus cochinchinensis root (ACE) reduced weight gain and relieved dyslipidemia induced by a high-fat diet. ACE treatment also improved glucose tolerance and insulin resistance, reduced inflammation and lipogenesis in the liver and adipose tissues, and reshaped the gut microbiota of obese mice.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Food Science & Technology
Jia Wang, Tonghui Geng, Qianhui Zou, Ningru Yang, Weiyang Zhao, Yitong Li, Xintong Tan, Tian Yuan, Xuebo Liu, Zhigang Liu
JOURNAL OF FUNCTIONAL FOODS
(2020)
Article
Biochemistry & Molecular Biology
Xin Zhang, Qianhui Zou, Beita Zhao, Jingwen Zhang, Weiyang Zhao, Yitong Li, Ruihai Liu, Xuebo Liu, Zhigang Liu
Article
Biochemistry & Molecular Biology
Luanfeng Wang, Bo Ren, Qian Zhang, Chuanqi Chu, Zhenting Zhao, Jianbin Wu, Weiyang Zhao, Zhigang Liu, Xuebo Liu
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2020)
Article
Food Science & Technology
Luanfeng Wang, Bo Ren, Yan Hui, Chuanqi Chu, Zhenting Zhao, Yuyu Zhang, Beita Zhao, Renjie Shi, Junli Ren, Xiaoshuang Dai, Zhigang Liu, Xuebo Liu
MOLECULAR NUTRITION & FOOD RESEARCH
(2020)
Article
Cell Biology
Xiaoning Liu, Xiang Li, Bing Xia, Xin Jin, Qianhui Zou, Zhenhua Zeng, Weiyang Zhao, Shikai Yan, Ling Li, Shufen Yuan, Shancen Zhao, Xiaoshuang Dai, Fei Yin, Enrique Cadenas, Rui Hai Liu, Beita Zhao, Min Hou, Zhigang Liu, Xuebo Liu
Summary: Maternal obesity has been found to be associated with lower cognition and sociality in children. The study demonstrated a causal relationship between microbiota and behavioral changes, and showed that microbiota-derived short-chain fatty acids can alleviate behavioral deficits in offspring of obese dams. High dietary fiber intake may be a promising intervention for maternal obesity-induced cognitive and social dysfunctions.
Article
Biochemistry & Molecular Biology
Bo Ren, Luanfeng Wang, Lin Shi, Xin Jin, Yan Liu, Rui Hai Liu, Fei Yin, Enrique Cadenas, Xiaoshuang Dai, Zhigang Liu, Xuebo Liu
Summary: Methionine restriction has shown protective effects against age-related cognitive decline in mice through preserving synaptic ultrastructure, increasing mitochondrial biogenesis, and reducing brain MDA levels. The role of FGF21 in this process is crucial.
Article
Immunology
Qing Liu, Yujia Xi, Qianxu Wang, Jinhui Liu, Peiran Li, Xue Meng, Kai Liu, Weixuan Chen, Xuebo Liu, Zhigang Liu
Summary: The study demonstrated that prebiotic mannan oligosaccharide (MOS) significantly improved cognitive function and mental symptoms, reduced anxiety and obsessive behaviors, and enhanced neuroprotection in the 5xFAD transgenic AD mice model. MOS treatment also balanced brain oxidative status, suppressed neuroinflammatory responses, alleviated HPA-axis disorders, and prevented gut barrier damage.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Agriculture, Multidisciplinary
Qing Liu, Tianzhi Xie, Yujia Xi, Ling Li, Fengfeng Mo, Xuebo Liu, Zhigang Liu, Jin-Ming Gao, Tian Yuan
Summary: The study showed that sesamol has significant neuroprotective effects on Alzheimer's disease (AD) mice, improving memory and learning abilities, reducing neuronal damage and protein accumulation, and acting through the microbiota-gut-brain axis.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Food Science & Technology
Lei Wang, Weixuan Chen, Yujie Tian, Xiaorong Duan, Yi Yuan, Na Wang, Chao Xu, Xuebo Liu, Zhigang Liu
Summary: Sesamol can suppress the production of harmful components in edible oil and improve the effects of deep-fried food on liver lipid metabolism and gut homeostasis.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Ying Lan, Qingyang Sun, Zhiyuan Ma, Jing Peng, Mengqi Zhang, Chi Wang, Xiaotian Zhang, Xianfang Yan, Lili Chang, Xinglin Hou, Ruixue Qiao, Aiziguli Mulati, Yuan Zhou, Qiang Zhang, Zhigang Liu, Xuebo Liu
Summary: Seabuckthorn polysaccharide (SP) has shown significant amelioration effects on obesity induced by a high-fat diet (HFD) in mice. The effects of SP are mediated through modulation of the gut microbiota and its metabolites, leading to reductions in body weight gain, serum lipid levels, and liver triglyceride levels. SP regulates liver lipid metabolism by influencing the composition of the gut microbiome and increasing the production of short-chain fatty acids (SCFAs). These findings suggest that SP could be a potential nutraceutical for alleviating obesity by targeting the gut-liver axis.
Article
Nutrition & Dietetics
Bo Ren, Luanfeng Wang, Aiziguli Mulati, Yan Liu, Zhigang Liu, Xuebo Liu
Summary: Dietary methionine restriction (MR) reduces inflammatory factors in aged mice, decreases gut permeability, and increases tight junction protein levels; moreover, MR promotes short-chain fatty acid production and dampens oscillations of inflammation-related microbes.
FRONTIERS IN NUTRITION
(2021)
Review
Biochemistry & Molecular Biology
Yihang Zhao, Mengzhen Jia, Weixuan Chen, Zhigang Liu
Summary: This review focuses on the mechanisms by which intermittent fasting (IF) improves mitochondrial function in brain aging and neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's. IF activates adaptive cellular stress responses and signaling pathways, enhancing mitochondrial function by promoting energy metabolism and reducing oxidant production.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Yue Wang, Shixiang Wei, Hui Lian, Lingling Tong, Linhui Yang, Bo Ren, Dongsheng Guo, He Huang
Summary: In this study, a neutral heteropolysaccharide (GSP-1a) was isolated from spores of Ophiocordyceps gracilis (O. gracilis). GSP-1a exhibited strong antioxidant capacities and alleviated oxidative stress in cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemical Research Methods
Yue Wang, Lingling Tong, Linhui Yang, Bo Ren, Dongsheng Guo
Summary: This study analyzed the metabolic variations and antioxidant activities of O. gracilis cultures and natural O. gracilis. The results showed differences in metabolite compositions between natural O. gracilis and natural O. sinensis, and O. gracilis cultures generally had higher levels of metabolites and antioxidant capacity.
PHYTOCHEMICAL ANALYSIS
(2023)
Article
Biochemistry & Molecular Biology
Aiziguli Mulati, Xin Zhang, Tong Zhao, Bo Ren, Luanfeng Wang, Xiaoning Liu, Ying Lan, Xuebo Liu
Summary: Isorhamnetin (ISO) showed protective effects on cognitive impairment induced by a high-fat and high fructose diet in obese mice by reducing body weight, liver weight, liver lipid level, serum lipid level, preventing neuronal memory impairment, activating neurotrophic factors, inhibiting inflammatory responses, and modulating signaling pathways. These findings suggest that ISO may be a promising nutritional intervention for cognitive complications related to metabolic syndrome.
