SVCT2 Expression and Function in Reactive Astrocytes Is a Common Event in Different Brain Pathologies

SVCT2 Is Expressed by Cerebellar Precursor Cells, Which Differentiate into Neurons in Response to Ascorbic Acid

(2017) Karina Oyarce et al.   MOLECULAR NEUROBIOLOGY

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Caveolin-1–mediated internalization of the vitamin C transporter SVCT2 in microglia triggers an inflammatory phenotype

(2017) Camila C. Portugal et al.   Science Signaling

Caveolin-1–mediated internalization of the vitamin C transporter SVCT2 in microglia triggers an inflammatory phenotype

(2017) Camila C. Portugal et al.   Science Signaling

SVCT2, a potential therapeutic target, protects against oxidative stress during ethanol-induced neurotoxicity via JNK/p38 MAPKs, NF-κB and miRNA125a-5p

(2016) Hua Tian et al.   FREE RADICAL BIOLOGY AND MEDICINE

Apical Polarization of SVCT2 in Apical Radial Glial Cells and Progenitors During Brain Development

(2016) C. Silva-Álvarez et al.   MOLECULAR NEUROBIOLOGY

Enhanced astroglial Ca2+signaling increases excitatory synaptic strength in the epileptic brain

(2015) Carla Álvarez-Ferradas et al.   GLIA

Dehydroascorbic Acid Promotes Cell Death in Neurons Under Oxidative Stress: a Protective Role for Astrocytes

(2015) Andrea García-Krauss et al.   MOLECULAR NEUROBIOLOGY

SVCT2 transporter expression is post-natally induced in cortical neurons and its function is regulated by its short isoform

(2014) Katterine Salazar et al.   JOURNAL OF NEUROCHEMISTRY

The oxidized form of vitamin C, dehydroascorbic acid, regulates neuronal energy metabolism

(2014) Pedro Cisternas et al.   JOURNAL OF NEUROCHEMISTRY

A new rapid kindling variant for induction of cortical epileptogenesis in freely moving rats

(2014) Juan Carlos Morales et al.   Frontiers in Cellular Neuroscience

Orally Administrated Ascorbic Acid Suppresses Neuronal Damage and Modifies Expression of SVCT2 and GLUT1 in the Brain of Diabetic Rats with Cerebral Ischemia-Reperfusion

(2014) Naohiro Iwata et al.   Nutrients

Human choroid plexus papilloma cells efficiently transport glucose and vitamin C

(2013) Viviana Ulloa et al.   JOURNAL OF NEUROCHEMISTRY

SVCT2 vitamin C transporter expression in progenitor cells of the postnatal neurogenic niche

(2013) Patricia Pastor et al.   Frontiers in Cellular Neuroscience

Typical and atypical stem cells in the brain, vitamin C effect and neuropathology

(2012) Francisco Nualart et al.   BIOLOGICAL RESEARCH

Differential regulation of the ascorbic acid transporter SVCT2 during development and in response to ascorbic acid depletion

(2011) M. Elizabeth Meredith et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Nitric Oxide Modulates Sodium Vitamin C Transporter 2 (SVCT-2) Protein Expression via Protein Kinase G (PKG) and Nuclear Factor-κB (NF-κB)

(2011) Camila Cabral Portugal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sodium-Dependent Vitamin C Transporter 2 (SVCT2) Expression and Activity in Brain Capillary Endothelial Cells after Transient Ischemia in Mice

(2011) Burkhard Gess et al.   PLoS One

Astrocyte–neuron metabolic relationships: for better and for worse

(2011) Igor Allaman et al.   TRENDS IN NEUROSCIENCES

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

Sodium-dependent vitamin C transporter 2 (SVCT2) is necessary for the uptake of L-ascorbic acid into Schwann cells

(2009) Burkhard Gess et al.   GLIA

Nrf2-induced antioxidant protection: A promising target to counteract ROS-mediated damage in neurodegenerative disease?

(2008) Helga E. de Vries et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Na+-dependent l-ascorbic acid transporter SVCT2 expressed in brainstem cells, neurons, and neuroblastoma cells is inhibited by flavonoids

(2008) Teresa Caprile et al.   JOURNAL OF NEUROCHEMISTRY

Nrf2 Activation in Astrocytes Protects against Neurodegeneration in Mouse Models of Familial Amyotrophic Lateral Sclerosis

(2008) M. R. Vargas et al.   JOURNAL OF NEUROSCIENCE

The Mystery and Magic of Glia: A Perspective on Their Roles in Health and Disease

(2008) Ben A. Barres   NEURON

Dysfunctional astrocytes as key players in the pathogenesis of central nervous system disorders

(2007) Jacques De Keyser et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES