A New Hope for a Devastating Disease: Hydrogen Sulfide in Parkinson’s Disease

Hydrogen sulfide reduces RAGE toxicity through inhibition of its dimer formation

(2017) Hong Zhou et al.   FREE RADICAL BIOLOGY AND MEDICINE

DNA methylation in cystathionine-γ-lyase (CSE) gene promoter induced by ox-LDL in macrophages and in apoE knockout mice

(2016) Hua-Ping Du et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Reduced Production of Hydrogen Sulfide and Sulfane Sulfur Due to Low Cystathionine β-Synthase Levels in Brain Astrocytes of Stroke-Prone Spontaneously Hypertensive Rats

(2016) Sachiko Juman et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

The hydrogen sulfide releasing compounds ATB-346 and diallyl trisulfide attenuate streptozotocin-induced cognitive impairment, neuroinflammation, and oxidative stress in rats: involvement of asymmetric dimethylarginine

(2016) Dalia K. Mostafa et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Hydrogen Sulfide Induces Keap1 S-sulfhydration and Suppresses Diabetes-Accelerated Atherosclerosis via Nrf2 Activation

(2016) Liping Xie et al.   DIABETES

Garlic-derived natural polysulfanes as hydrogen sulfide donors: Friend or foe?

(2016) Esma Yagdi et al.   FOOD AND CHEMICAL TOXICOLOGY

GYY4137, a Slow-Releasing Hydrogen Sulfide Donor, Ameliorates Renal Damage Associated with Chronic Obstructive Uropathy

(2016) Shouzhe Lin et al.   JOURNAL OF UROLOGY

Pharmacological postconditioning against myocardial infarction with a slow-releasing hydrogen sulfide donor, GYY4137

(2016) Qutuba G. Karwi et al.   PHARMACOLOGICAL RESEARCH

S-Propargyl-Cysteine, a Novel Hydrogen Sulfide Donor, Inhibits Inflammatory Hepcidin and Relieves Anemia of Inflammation by Inhibiting IL-6/STAT3 Pathway

(2016) Minjun Wang et al.   PLoS One

Allicin Protects PC12 Cells Against 6-OHDA-Induced Oxidative Stress and Mitochondrial Dysfunction via Regulating Mitochondrial Dynamics

(2015) Hao Liu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Diallyl Sulfide: Potential Use in Novel Therapeutic Interventions in Alcohol, Drugs, and Disease Mediated Cellular Toxicity by Targeting Cytochrome P450 2E1

(2015) PSS Rao et al.   CURRENT DRUG METABOLISM

Discovery of New H2S Releasing Phosphordithioates and 2,3-Dihydro-2-phenyl-2-sulfanylenebenzo[d][1,3,2]oxazaphospholes with Improved Antiproliferative Activity

(2015) Wei Feng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of H2S3 and H2S produced by 3-mercaptopyruvate sulfurtransferase in the brain

(2015) Yuka Kimura et al.   Scientific Reports

Hydrogen Sulfide: A Neuromodulator and Neuroprotectant in the Central Nervous System

(2014) Xingzhou Zhang et al.   ACS Chemical Neuroscience

Sulfhydration of p66Shc at Cysteine59 Mediates the Antioxidant Effect of Hydrogen Sulfide

(2014) Zhi-Zhong Xie et al.   ANTIOXIDANTS & REDOX SIGNALING

Utilizing hydrogen sulfide as a novel anti-cancer agent by targeting cancer glycolysis and pH imbalance

(2014) Z-W Lee et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cystathionine γ-lyase deficiency mediates neurodegeneration in Huntington’s disease

(2014) Bindu D. Paul et al.   NATURE

Working with “H2S”: Facts and apparent artifacts

(2014) Rudolf Wedmann et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

The physiological role of hydrogen sulfide and beyond

(2014) Hideo Kimura   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Anti-Cancer Activity of New Designer Hydrogen Sulfide-Donating Hybrids

(2013) Khosrow Kashfi   ANTIOXIDANTS & REDOX SIGNALING

Physiological role of hydrogen sulfide and polysulfide in the central nervous system

(2013) Hideo Kimura   NEUROCHEMISTRY INTERNATIONAL

Hydrogen sulfide chemical biology: Pathophysiological roles and detection

(2013) Gopi K. Kolluru et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Chemical foundations of hydrogen sulfide biology

(2013) Qian Li et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Therapeutic Effect of Hydrogen Sulfide-Releasing L-Dopa Derivative ACS84 on 6-OHDA-Induced Parkinson’s Disease Rat Model

(2013) Li Xie et al.   PLoS One

Oxygen-sensitive mitochondrial accumulation of cystathionine  -synthase mediated by Lon protease

(2013) H. Teng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sulfhydration mediates neuroprotective actions of parkin

(2013) M. Scott Vandiver et al.   Nature Communications

A novel pathway for the production of hydrogen sulfide from D-cysteine in mammalian cells

(2013) Norihiro Shibuya et al.   Nature Communications

Hydrogen sulfide protects SH-SY5Y cells against 6-hydroxydopamine-induced endoplasmic reticulum stress

(2012) Li Xie et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Hydrogen Sulfide in the Mammalian Cardiovascular System

(2012) Yi-Hong Liu et al.   ANTIOXIDANTS & REDOX SIGNALING

The Neuroprotection of Hydrogen Sulfide Against MPTP-Induced Dopaminergic Neuron Degeneration Involves Uncoupling Protein 2 Rather Than ATP-Sensitive Potassium Channels

(2012) Ming Lu et al.   ANTIOXIDANTS & REDOX SIGNALING

Hydrogen Sulfide Protects Against Cellular Senescence via S-Sulfhydration of Keap1 and Activation of Nrf2

(2012) Guangdong Yang et al.   ANTIOXIDANTS & REDOX SIGNALING

Biology and therapeutic potential of hydrogen sulfide and hydrogen sulfide-releasing chimeras

(2012) Khosrow Kashfi et al.   BIOCHEMICAL PHARMACOLOGY

Chemical Characterization of the Smallest S-Nitrosothiol, HSNO; Cellular Cross-talk of H2S and S-Nitrosothiols

(2012) Milos R. Filipovic et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Hydrogen sulfide (H2S) metabolism in mitochondria and its regulatory role in energy production

(2012) M. Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A fluorescent probe for rapid detection of hydrogen sulfide in blood plasma and brain tissues in mice

(2012) Yong Qian et al.   Chemical Science

Biochemical insight into physiological effects of H2S: reaction with peroxynitrite and formation of a new nitric oxide donor, sulfinyl nitrite

(2011) Milos R. Filipovic et al.   BIOCHEMICAL JOURNAL

Hydrogen Sulfide as Endothelium-Derived Hyperpolarizing Factor Sulfhydrates Potassium Channels

(2011) Asif K. Mustafa et al.   CIRCULATION RESEARCH

Hydrogen sulfide gas has cell growth regulatory role

(2011) Rajamanickam Baskar et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The Slow-Releasing Hydrogen Sulfide Donor, GYY4137, Exhibits Novel Anti-Cancer Effects In Vitro and In Vivo

(2011) Zheng Wei Lee et al.   PLoS One

H2S Donor, S-Propargyl-Cysteine, Increases CSE in SGC-7901 and Cancer-Induced Mice: Evidence for a Novel Anti-Cancer Effect of Endogenous H2S?

(2011) Kaium MA et al.   PLoS One

Hydrogen sulfide replacement therapy protects the vascular endothelium in hyperglycemia by preserving mitochondrial function

(2011) K. Suzuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhaled Hydrogen Sulfide Prevents Neurodegeneration and Movement Disorder in a Mouse Model of Parkinson's Disease

(2010) Kotaro Kida et al.   ANTIOXIDANTS & REDOX SIGNALING

S-Propargyl-cysteine, a novel hydrogen sulfide-modulated agent, attenuates lipopolysaccharide-induced spatial learning and memory impairment: Involvement of TNF signaling and NF-κB pathway in rats

(2010) Qi-Hai Gong et al.   BRAIN BEHAVIOR AND IMMUNITY

Protective effect of hydrogen sulphide against 6-OHDA-induced cell injury in SH-SY5Y cells involves PKC/PI3K/Akt pathway

(2010) Chi Xin Tiong et al.   BRITISH JOURNAL OF PHARMACOLOGY

Hydrogen Sulfide

(2010) Tee L. Guidotti   INTERNATIONAL JOURNAL OF TOXICOLOGY

Redox Biochemistry of Hydrogen Sulfide

(2010) Omer Kabil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Allicin Purified From Fresh Garlic Cloves Induces Apoptosis in Colon Cancer Cells Via Nrf2

(2010) Wolf Bat-Chen et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Hydrogen sulfide in the endocrine and reproductive systems

(2010) Xiao-Yan Zhu et al.   Expert Review of Clinical Pharmacology

Neuroprotective effects of hydrogen sulfide on Parkinson’s disease rat models

(2009) Li-Fang Hu et al.   AGING CELL

The Effect of Hydrogen Sulfide Donors on Lipopolysaccharide-Induced Formation of Inflammatory Mediators in Macrophages

(2009) Matthew Whiteman et al.   ANTIOXIDANTS & REDOX SIGNALING

Hydrogen sulfide-releasing NSAIDs attenuate neuroinflammation induced by microglial and astrocytic activation

(2009) Moonhee Lee et al.   GLIA

S-propargyl-cysteine Protects Both Adult Rat Hearts and Neonatal Cardiomyocytes From Ischemia/Hypoxia Injury: The Contribution of the Hydrogen Sulfide-Mediated Pathway

(2009) Qian Wang et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Neuroprotective Effects of Garlic: A Review

(2009) B Mathew et al.   Libyan Journal of Medicine

Hydrogen sulfide inhibits MPP+-induced apoptosis in PC12 cells

(2009) Wei-Lan Yin et al.   LIFE SCIENCES

Effect of hydrogen sulfide on intracellular calcium homeostasis in neuronal cells

(2009) Qian Chen Yong et al.   NEUROCHEMISTRY INTERNATIONAL

Hydrogen sulfide regulates intracellular pH in rat primary cultured glia cells

(2009) Ming Lu et al.   NEUROSCIENCE RESEARCH

Actions and interactions of nitric oxide, carbon monoxide and hydrogen sulphide in the cardiovascular system and in inflammation — a tale of three gases!

(2009) Ling Li et al.   PHARMACOLOGY & THERAPEUTICS

No facilitator required for membrane transport of hydrogen sulfide

(2009) J. C. Mathai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

3-Mercaptopyruvate Sulfurtransferase Produces Hydrogen Sulfide and Bound Sulfane Sulfur in the Brain

(2008) Norihiro Shibuya et al.   ANTIOXIDANTS & REDOX SIGNALING

Characterization of a Novel, Water-Soluble Hydrogen Sulfide–Releasing Molecule (GYY4137)

(2008) Ling Li et al.   CIRCULATION

Can overexpression of parkin provide a novel strategy for neuroprotection in Parkinson's disease?

(2008) Ayse Ulusoy et al.   EXPERIMENTAL NEUROLOGY

Hydrogen sulphide is pro-inflammatory in haemorrhagic shock

(2008) Y.-Y. P. Mok et al.   INFLAMMATION RESEARCH