Synaptic NMDA Receptor Activation Induces Ubiquitination and Degradation of STEP61

Inhibition of STEP61 ameliorates deficits in mouse and hiPSC-based schizophrenia models

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The increasing complexity of the ubiquitin code

(2016) Richard Yau et al.   NATURE CELL BIOLOGY

PSD-95 stabilizes NMDA receptors by inducing the degradation of STEP61

(2016) Sehoon Won et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of the tyrosine phosphatase STEP61 restores BDNF expression and reverses motor and cognitive deficits in phencyclidine-treated mice

(2015) Jian Xu et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The NMDA receptor ‘glycine modulatory site’ in schizophrenia: d-serine, glycine, and beyond

(2015) Darrick T Balu et al.   CURRENT OPINION IN PHARMACOLOGY

Down-regulation of BDNF in cell and animal models increases striatal-enriched protein tyrosine phosphatase 61 (STEP61) levels

(2015) Jian Xu et al.   JOURNAL OF NEUROCHEMISTRY

Synaptic and Extrasynaptic NMDA Receptors Are Gated by Different Endogenous Coagonists

(2012) Thomas Papouin et al.   CELL

NMDA Neurotransmission Dysfunction in Behavioral and Psychological Symptoms of Alzheimer's Disease

(2012) Yu-Jhen Huang et al.   Current Neuropharmacology

Striatal-enriched Protein-tyrosine Phosphatase (STEP) Regulates Pyk2 Kinase Activity

(2012) Jian Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NAAG peptidase inhibitors block cognitive deficit induced by MK-801 and motor activation induced by d-amphetamine in animal models of schizophrenia

(2012) R T Olszewski et al.   Translational Psychiatry

The tyrosine phosphatase STEP: implications in schizophrenia and the molecular mechanism underlying antipsychotic medications

(2012) N C Carty et al.   Translational Psychiatry

Effects of the cognition impairer MK-801 on learning and memory in mice and rats

(2011) F. Josef van der Staay et al.   BEHAVIOURAL BRAIN RESEARCH

From Revolution to Evolution: The Glutamate Hypothesis of Schizophrenia and its Implication for Treatment

(2011) Bita Moghaddam et al.   NEUROPSYCHOPHARMACOLOGY

Effects of low-dose d-serine on recognition and working memory in mice

(2011) Patricia Bado et al.   PSYCHOPHARMACOLOGY

Cortical parvalbumin interneurons and cognitive dysfunction in schizophrenia

(2011) David A. Lewis et al.   TRENDS IN NEUROSCIENCES

Reducing Prefrontal Gamma-Aminobutyric Acid Activity Induces Cognitive, Behavioral, and Dopaminergic Abnormalities That Resemble Schizophrenia

(2010) Takeshi Enomoto et al.   BIOLOGICAL PSYCHIATRY

Autophosphorylated CaMKIIα Acts as a Scaffold to Recruit Proteasomes to Dendritic Spines

(2010) Baris Bingol et al.   CELL

Strategies to Enhance N-Methyl-D-Aspartate Receptor-Mediated Neurotransmission in Schizophrenia, a Critical Review and Meta-Analysis

(2010) Guochuan Tsai et al.   CURRENT PHARMACEUTICAL DESIGN

A -Mediated NMDA Receptor Endocytosis in Alzheimer's Disease Involves Ubiquitination of the Tyrosine Phosphatase STEP61

(2010) P. Kurup et al.   JOURNAL OF NEUROSCIENCE

Genetic reduction of striatal-enriched tyrosine phosphatase (STEP) reverses cognitive and cellular deficits in an Alzheimer's disease mouse model

(2010) Y. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dopaminergic Dysfunction in Schizophrenia: Salience Attribution Revisited

(2010) A. Heinz et al.   SCHIZOPHRENIA BULLETIN

Regulation of the Proteasome by Neuronal Activity and Calcium/Calmodulin-dependent Protein Kinase II

(2009) Stevan N. Djakovic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extrasynaptic NMDA Receptors Couple Preferentially to Excitotoxicity via Calpain-Mediated Cleavage of STEP

(2009) J. Xu et al.   JOURNAL OF NEUROSCIENCE

Schizophrenia

(2009) Jim van Os et al.   LANCET

Building ubiquitin chains: E2 enzymes at work

(2009) Yihong Ye et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Metabolic profiles of second-generation antipsychotics in early psychosis: Findings from the CAFE study

(2009) Jayendra K. Patel et al.   SCHIZOPHRENIA RESEARCH

The Tyrosine Phosphatase STEP Mediates AMPA Receptor Endocytosis after Metabotropic Glutamate Receptor Stimulation

(2008) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Second-generation versus first-generation antipsychotic drugs for schizophrenia: a meta-analysis

(2008) Stefan Leucht et al.   LANCET

Knockout of STriatal enriched protein tyrosine phosphatase in mice results in increased ERK1/2 phosphorylation

(2008) Deepa V. Venkitaramani et al.   SYNAPSE

d-Serine and a glycine transporter inhibitor improve MK-801-induced cognitive deficits in a novel object recognition test in rats

(2007) Jun-ichi Karasawa et al.   BEHAVIOURAL BRAIN RESEARCH

Effects of selective inhibition of N-acetylated-α-linked-acidic dipeptidase (NAALADase) on mice in learning and memory tasks

(2007) Krzysztof Łukawski et al.   EUROPEAN JOURNAL OF PHARMACOLOGY