In Silico Identification of Proteins Associated with Drug-induced Liver Injury Based on the Prediction of Drug-target Interactions

Can Humanized Mice Predict Drug “Behavior” in Humans?

(2016) Dan Xu et al.   Annual Review of Pharmacology and Toxicology

In silico assessment of adverse drug reactions and associated mechanisms

(2016) Sergey M. Ivanov et al.   DRUG DISCOVERY TODAY

Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9

(2016) Irma Garcia-Martinez et al.   JOURNAL OF CLINICAL INVESTIGATION

In silicoPrediction of Drug Induced Liver Toxicity Using Substructure Pattern Recognition Method

(2016) Chen Zhang et al.   Molecular Informatics

TLR2 and TLR9 contribute to alcohol-mediated liver injury through induction of CXCL1 and neutrophil infiltration

(2015) Yoon Seok Roh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Prediction of Drug Induced Liver Injury Using Molecular and Biological Descriptors

(2015) Christophe Muller et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

DataWarrior: An Open-Source Program For Chemistry Aware Data Visualization And Analysis

(2015) Thomas Sander et al.   Journal of Chemical Information and Modeling

Drug-induced liver injury: Interactions between drug properties and host factors

(2015) Minjun Chen et al.   JOURNAL OF HEPATOLOGY

The Role ofPTPN22Risk Variant in the Development of Autoimmunity: Finding Common Ground between Mouse and Human

(2015) David J. Rawlings et al.   JOURNAL OF IMMUNOLOGY

Chronic liver injury induced by drugs: a systematic review

(2015) Jonathan G. Stine et al.   LIVER INTERNATIONAL

Screening Chemicals for Receptor-Mediated Toxicological and Pharmacological Endpoints: Using Public Data to Build Screening Tools within a KNIME Workflow

(2015) F. P. Steinmetz et al.   Molecular Informatics

Curation of chemogenomics data

(2015) Denis Fourches et al.   Nature Chemical Biology

PASS Targets: Ligand-based multi-target computational system based on a public data and naïve Bayes approach

(2015) P.V. Pogodin et al.   SAR AND QSAR IN ENVIRONMENTAL RESEARCH

Identification of Drug Targets Related to the Induction of Ventricular Tachyarrhythmia Through a Systems Chemical Biology Approach

(2015) Sergey M. Ivanov et al.   TOXICOLOGICAL SCIENCES

PCB126-Induced Disruption in Gluconeogenesis and Fatty Acid Oxidation Precedes Fatty Liver in Male Rats

(2015) Gopi S. Gadupudi et al.   TOXICOLOGICAL SCIENCES

Prediction of Drug-Induced Liver Injury in Micropatterned Co-cultures Containing iPSC-Derived Human Hepatocytes

(2015) Brenton R. Ware et al.   TOXICOLOGICAL SCIENCES

Mechanistic review of drug-induced steatohepatitis

(2015) Justin D. Schumacher et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Involvement of oxidative stress and mitochondrial/lysosomal cross-talk in olanzapine cytotoxicity in freshly isolated rat hepatocytes

(2015) Aziz Eftekhari et al.   XENOBIOTICA

Autophagy protects against dasatinib-induced hepatotoxicity via p38 signaling

(2015) Xiaochun Yang et al.   Oncotarget

Cytoplasmic Tyrosine Phosphatase Shp2 Coordinates Hepatic Regulation of Bile Acid and FGF15/19 Signaling to Repress Bile Acid Synthesis

(2014) Shuangwei Li et al.   Cell Metabolism

Identification of Drug-Induced Myocardial Infarction-Related Protein Targets through the Prediction of Drug–Target Interactions and Analysis of Biological Processes

(2014) Sergey M. Ivanov et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Classification of Hepatotoxicants Using HepG2 Cells: A Proof of Principle Study

(2014) Wim F. P. M. Van den Hof et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Prediction of the Biological Activity Spectra of Organic Compounds Using the Pass Online Web Resource

(2014) D. A. Filimonov et al.   Chemistry of Heterocyclic Compounds

The human liver-specific proteome defined by transcriptomics and antibody-based profiling

(2014) Caroline Kampf et al.   FASEB JOURNAL

Drug-Induced Hepatotoxicity: Metabolic, Genetic and Immunological Basis

(2014) Dolores Njoku   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Construction and analysis of a human hepatotoxicity database suitable for QSAR modeling using post-market safety data

(2014) Xiao Zhu et al.   TOXICOLOGY

Investigation of the hepatotoxicity of flutamide: Pro-survival/apoptotic and necrotic switch in primary rat hepatocytes characterized by metabolic and transcriptomic profiles in microfluidic liver biochips

(2014) Audrey Legendre et al.   TOXICOLOGY IN VITRO

Exploratory toxicology as an integrated part of drug discovery. Part I: Why and how

(2013) Jorrit J. Hornberg et al.   DRUG DISCOVERY TODAY

Hybridin silicomodels for drug-induced liver injury using chemical descriptors andin vitrocell-imaging information

(2013) Xiang-Wei Zhu et al.   JOURNAL OF APPLIED TOXICOLOGY

Disruption of uridine homeostasis links liver pyrimidine metabolism to lipid accumulation

(2013) Thuc T. Le et al.   JOURNAL OF LIPID RESEARCH

Analysis of the Human Tissue-specific Expression by Genome-wide Integration of Transcriptomics and Antibody-based Proteomics

(2013) Linn Fagerberg et al.   MOLECULAR & CELLULAR PROTEOMICS

Quantitative Prediction of Antitarget Interaction Profiles for Chemical Compounds

(2012) Alexey V. Zakharov et al.   CHEMICAL RESEARCH IN TOXICOLOGY

In silicomodels for drug-induced liver injury – current status

(2012) Katarzyna R Przybylak et al.   Expert Opinion on Drug Metabolism & Toxicology

High lipophilicity and high daily dose of oral medications are associated with significant risk for drug-induced liver injury

(2012) Minjun Chen et al.   HEPATOLOGY

Reducing safety-related drug attrition: the use of in vitro pharmacological profiling

(2012) Joanne Bowes et al.   NATURE REVIEWS DRUG DISCOVERY

The TissueNet database of human tissue protein–protein interactions

(2012) Ruth Barshir et al.   NUCLEIC ACIDS RESEARCH

VirtualToxLab — A platform for estimating the toxic potential of drugs, chemicals and natural products

(2012) Angelo Vedani et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Ten Years of Pathway Analysis: Current Approaches and Outstanding Challenges

(2012) Purvesh Khatri et al.   PLoS Computational Biology

Predicting Drug-Induced Hepatotoxicity Using QSAR and Toxicogenomics Approaches

(2011) Yen Low et al.   CHEMICAL RESEARCH IN TOXICOLOGY

FDA-approved drug labeling for the study of drug-induced liver injury

(2011) Minjun Chen et al.   DRUG DISCOVERY TODAY

Susceptibility to Amoxicillin-Clavulanate-Induced Liver Injury Is Influenced by Multiple HLA Class I and II Alleles

(2011) M. Isabel Lucena et al.   GASTROENTEROLOGY

Autophagy Suppresses Age-Dependent Ischemia and Reperfusion Injury in Livers of Mice

(2011) Jin–Hee Wang et al.   GASTROENTEROLOGY

Activation of autophagy protects against acetaminophen-induced hepatotoxicity

(2011) Hong-Min Ni et al.   HEPATOLOGY

Alteration of Gene Expression Profile in Niemann-Pick Type C Mice Correlates with Tissue Damage and Oxidative Stress

(2011) Mary C. Vázquez et al.   PLoS One

Aryl Hydrocarbon Receptor–Mediated Induction of Stearoyl-CoA Desaturase 1 Alters Hepatic Fatty Acid Composition in TCDD-Elicited Steatosis

(2011) Michelle M. Angrish et al.   TOXICOLOGICAL SCIENCES

Translating Clinical Findings into Knowledge in Drug Safety Evaluation - Drug Induced Liver Injury Prediction System (DILIps)

(2011) Zhichao Liu et al.   PLoS Computational Biology

Developing Structure−Activity Relationships for the Prediction of Hepatotoxicity

(2010) Nigel Greene et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Cheminformatics approaches to analyze diversity in compound screening libraries

(2010) Lakshmi B Akella et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Autophagy Reduces Acute Ethanol-Induced Hepatotoxicity and Steatosis in Mice

(2010) Wen–Xing Ding et al.   GASTROENTEROLOGY

Drug-induced acute liver failure: Results of a U.S. multicenter, prospective study

(2010) Adrian Reuben et al.   HEPATOLOGY

The Mitochondrial Disulfide Relay System Protein GFER Is Mutated in Autosomal-Recessive Myopathy with Cataract and Combined Respiratory-Chain Deficiency

(2009) Alessio Di Fonzo et al.   AMERICAN JOURNAL OF HUMAN GENETICS

SePreSA: a server for the prediction of populations susceptible to serious adverse drug reactions implementing the methodology of a chemical–protein interactome

(2009) Lun Yang et al.   NUCLEIC ACIDS RESEARCH

Identification of structure–activity relationships for adverse effects of pharmaceuticals in humans: Part C: Use of QSAR and an expert system for the estimation of the mechanism of action of drug-induced hepatobiliary and urinary tract toxicities

(2009) Edwin J. Matthews et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Relationship between daily dose of oral medications and idiosyncratic drug-induced liver injury: Search for signals

(2008) Craig Lammert et al.   HEPATOLOGY

Cellular Imaging Predictions of Clinical Drug-Induced Liver Injury

(2008) Jinghai J. Xu et al.   TOXICOLOGICAL SCIENCES